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The map label for this gene is ahcY [H]

Identifier: 73539919

GI number: 73539919

Start: 239674

End: 241092

Strand: Direct

Name: ahcY [H]

Synonym: Reut_A0213

Alternate gene names: 73539919

Gene position: 239674-241092 (Clockwise)

Preceding gene: 73539916

Following gene: 73539920

Centisome position: 6.3

GC content: 63.85

Gene sequence:

>1419_bases
ATGAACGCCGTGACCGACCTCAAGCAAGACTACCTCGTCGCCGACATCAGTTTGGCCGGCTGGGGCCGCAAGGAAATCGC
CATCGCCGAGACCGAAATGCCGGGCCTGATGGCAATCCGCGACGAATTCGCCGCCGCTCAGCCGCTCAAGGGCGCGCGCA
TTGCCGGTTCGCTGCACATGACGATCCAGACCGCCGTGCTGATCGAGACGCTCAAGGCGCTCGGCGCCGACGTGCGCTGG
GCCTCGTGCAACATCTTCTCGACGCAGGACCACGCCGCTGCCGCGATCGCCGCGGGCGGCACGCCCGTGTTCGCGTTCAA
GGGCGAGTCGCTCAAGGAATACTGGGACTTCACGCACCGCATCTTCGACTGGGTCGACGGTGGCACCCCGAACATGATCC
TGGACGACGGCGGCGATGCCACGCTGCTGCTGCACCTGGGCGCCAAGGCCGAGAAGGACGCTTCGCTGATCGCCAACCCC
GGCAGCGAGGAAGAGACCTTCCTGTTCGCGGCGATCAAGGAAAAGCTGGCCAAGGACCCGTCGTGGTACAGCCGCAACCT
GGCCGCCATCCGCGGCGTGACCGAGGAAACCACGACCGGCGTGCACCGCCTGTACCAGATGGCGCAAAAGGGCGACCTCA
AGTTCCCGGCCATCAACGTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACCTGTACGGCTGCCGTGAGTCGCTGGTG
GACGGCATCAAGCGCGCCACCGATGTGATGATCGCCGGCAAGATCGCCATCGTGGCCGGCTACGGCGACGTGGGCAAGGG
CAGCGCGCAGGCGCTGCGCGCGCTGTCGGCACAAGTGTGGGTCACCGAAATCGACCCCATCTGCGCGCTCCAGGCTGCCA
TGGAAGGCTACCGCGTGGTGACCATGGACTACGCTGCCGAACACGGCGACATCTTCGTGACCTGCACCGGCAACTACCAC
GTCATTACGCATGACCACATGGCCAGGATGAAGGACCAGGCCATCGTCTGCAATATCGGCCACTTCGACAACGAGATCGA
CATCGCGTCGATCGAGAAGTACGAGTGGGACGAGATCAAGCCGCAGGTTGACCACGTCAAGTTCCCGGACGGCAAGAAGA
TCATCATCCTGGCCAAGGGCCGCCTCGTGAACCTGGGCTGCGCCACGGGCCACCCGTCGTACGTGATGAGCTCGTCGTTC
GCCAACCAGACCATCGCGCAGATCGAACTCTGGCAAGAGCGCGACAGCGGCAAGTACCCCGTGGGTGTCTACACGCTGCC
GAAGCACCTGGATGAAAAGGTCGCCCGCCTGCAACTGCGCAAGCTGAACGCGCAGCTGACCGAGCTGACCGAGCAGCAGG
CCGCGTACATCGGCGTGAAGAAGGAAGGCCCGTACAAGGCCGATCACTACCGTTATTGA

Upstream 100 bases:

>100_bases
TCGACCTATCCGCCCGCTTCACGCATGGCATCCATGCATATGGGAAGCGCGGCCTGATCTCCGCCCGTCACCGTCATCCA
CTCTTCACCGGGAGTGATAC

Downstream 100 bases:

>100_bases
TACCGTTGCCGCGCACCCCTCTCCCGCTTGCGGGAGAGGGGAGAAACCGATTCCAAGGAGCCGTCATGAGACTGCTGATC
GTCTGGATCATCAACGCCGT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNAVTDLKQDYLVADISLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAAGGTPVFAFKGESLKEYWDFTHRIFDWVDGGTPNMILDDGGDATLLLHLGAKAEKDASLIANP
GSEEETFLFAAIKEKLAKDPSWYSRNLAAIRGVTEETTTGVHRLYQMAQKGDLKFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKIAIVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMARMKDQAIVCNIGHFDNEIDIASIEKYEWDEIKPQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWQERDSGKYPVGVYTLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY

Sequences:

>Translated_472_residues
MNAVTDLKQDYLVADISLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAAGGTPVFAFKGESLKEYWDFTHRIFDWVDGGTPNMILDDGGDATLLLHLGAKAEKDASLIANP
GSEEETFLFAAIKEKLAKDPSWYSRNLAAIRGVTEETTTGVHRLYQMAQKGDLKFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKIAIVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMARMKDQAIVCNIGHFDNEIDIASIEKYEWDEIKPQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWQERDSGKYPVGVYTLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY
>Mature_472_residues
MNAVTDLKQDYLVADISLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAAGGTPVFAFKGESLKEYWDFTHRIFDWVDGGTPNMILDDGGDATLLLHLGAKAEKDASLIANP
GSEEETFLFAAIKEKLAKDPSWYSRNLAAIRGVTEETTTGVHRLYQMAQKGDLKFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKIAIVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMARMKDQAIVCNIGHFDNEIDIASIEKYEWDEIKPQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWQERDSGKYPVGVYTLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=60.2564102564103, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=443, Percent_Identity=60.0451467268623, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.4623655913978, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=49.4623655913978, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=49.4623655913978, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.4623655913978, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=48.3870967741936, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506425, Length=468, Percent_Identity=58.5470085470086, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=58.2463465553236, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=59.5289079229122, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=47.6394849785408, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=48.8172043010753, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=48.7068965517241, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51844; Mature: 51844

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTDLKQDYLVADISLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHM
CCCHHHHCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEECEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAFKGESLKEYWDFTHR
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHH
IFDWVDGGTPNMILDDGGDATLLLHLGAKAEKDASLIANPGSEEETFLFAAIKEKLAKDP
HHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCC
SWYSRNLAAIRGVTEETTTGVHRLYQMAQKGDLKFPAINVNDSVTKSKFDNLYGCRESLV
CHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKIAIVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
HHHHHHHHEEEEEEEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEE
TMDYAAEHGDIFVTCTGNYHVITHDHMARMKDQAIVCNIGHFDNEIDIASIEKYEWDEIK
EEEECCCCCCEEEEEECCEEEEECHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCCC
PQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWQERDSGKYP
CCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHCCCHHHHEEEEECCCCCCCC
VGVYTLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNAVTDLKQDYLVADISLAGWGRKEIAIAETEMPGLMAIRDEFAAAQPLKGARIAGSLHM
CCCHHHHCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEECEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAFKGESLKEYWDFTHR
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHH
IFDWVDGGTPNMILDDGGDATLLLHLGAKAEKDASLIANPGSEEETFLFAAIKEKLAKDP
HHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCC
SWYSRNLAAIRGVTEETTTGVHRLYQMAQKGDLKFPAINVNDSVTKSKFDNLYGCRESLV
CHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKIAIVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
HHHHHHHHEEEEEEEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEE
TMDYAAEHGDIFVTCTGNYHVITHDHMARMKDQAIVCNIGHFDNEIDIASIEKYEWDEIK
EEEECCCCCCEEEEEECCEEEEECHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCCCCC
PQVDHVKFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWQERDSGKYP
CCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHCCCHHHHEEEEECCCCCCCC
VGVYTLPKHLDEKVARLQLRKLNAQLTELTEQQAAYIGVKKEGPYKADHYRY
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA