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The map label for this gene is yngE [H]

Identifier: 73539851

GI number: 73539851

Start: 170417

End: 172057

Strand: Direct

Name: yngE [H]

Synonym: Reut_A0145

Alternate gene names: 73539851

Gene position: 170417-172057 (Clockwise)

Preceding gene: 73539850

Following gene: 73539852

Centisome position: 4.48

GC content: 64.17

Gene sequence:

>1641_bases
ATGACAGGGGTGACAAGCAGGAAGGGACAAACCATGCCCACGCTGGAAACCAAACTCAACGCGCGCTCCGAATCGTTCAA
GTCGAATGCCGAAGCCATGCAGGCGCTGGTCGCCGACCTCAAGGCCAAGGTCGCCAAGCTCGCCGAAGGCGGCGGCGATG
CCGCGCGCGACAAGCACCTGTCGCGCGGCAAGCTGCTGCCGCGCGATCGCGTGCAGCAACTACTGGACCCCGGCACGCCG
TTCCTGGAACTGTCGCAGCTCGCCGCGTACGACATGTACGACAACGCCGCGCCGGGCGCGGGCATCATCACCGGCATCGG
GCGCGTGGCCGGGCAGGAATGCGTGATCGTCTGCAACGACGCGACCGTCAAGGGCGGCACGTACTACCCGATGACGGTCA
AGAAGCACGTGCGTGCGCAGGAGATCGCCGAGCAGAACAACCTGCCGTGCATCTATCTGGTGGACTCGGGCGGTGCGAAT
CTGCCGAACCAGGACGATGTATTCCCCGACCGCGATCACTTCGGGCGCATCTTCTACAACCAGGCCAACCTGTCCAAGCA
GGGCATCCCGCAGATCGCCGTGGTGATGGGCTCTTGCACGGCCGGCGGCGCCTATGTGCCGGCAATGAGCGATGAGTCGA
TCATCGTCAAGAACCAGGGCACGATTTTCCTCGGCGGCCCACCGCTGGTGAAGGCCGCTACGGGCGAAGAAGTCACGGCC
GAAGATCTCGGCGGCGCCGATGTGCATACGCGCCTGTCAGGCGTGGCGGATTACTTCGCGCAGAACGATCATCACGCGCT
GTCGCTGGCCCGGAACATCGTGCAGCATCTGAACCGGCGCAAGCCCGACCAGATCCGCCTGCATGAGCCGGCCGATCCGC
TGTATCCGGTAGAAGAACTGTACGGGGTGATCCCGACCGATACGCGCAAGCCGTTCGATGTACGCGAGGTCATCGCGCGC
ATTGTCGATGGCTCCGAGTTCGACGAATTCAAGGCGCGCTACGGCACGACGCTCGTCTGCGGCTTCGCACGCATCTGGGG
CTACCCGGTCGGCATCATCGCCAACAACGGCATCCTGTTTTCCGAATCGGCGCTCAAGGGCGCGCACTTCATCGAACTGT
GCTGCCAGCGCAAGATTCCGCTGGTGTTCCTGCAGAACATCACGGGCTTCATGGTAGGCCGCAAGTACGAGAACGAAGGC
ATCGCACGCAATGGTGCCAAGATGGTCACGGCGGTCGCTACGGCACAGGTGCCGAAGTTCACGGTGATCATTGGCGGCTC
GTTCGGTGCGGGCAACTACGGCATGTGCGGCCGTGCGTATTCGCCGCGCTTCCTGTGGATGTGGCCGAACGCGCGTATCT
CCGTGATGGGCGGCGAGCAGGCCGCAAGCGTGCTGGCGACGGTGCGCCGCGACGGCATCGAGGCCAAGGGCGGTAATTGG
AGCGCGGAGGAAGAAGAGGCATTCAAGCAGCCGATCCGCGACCAGTACGAGCATCAGGGTCATCCGTACTACGCGAGCGC
GCGGCTGTGGGACGACGGGGTCATCGATCCCGCGCAGACGCGCACGGTGCTCGGGCTGGGCCTGTCGGCCAGCCTCAACG
CGCCGATCGACGACATGAAGTTCGGCGTGTTCCGCATGTAA

Upstream 100 bases:

>100_bases
ACATCCGCTTAACAAGCCCGTCGTTCCCGCGTAGGCGGGAACCCAGTGACTTCTTAGGACGCTGGATTCCCGCCCACGTG
CCCTTTGGGTATGCGCGGGA

Downstream 100 bases:

>100_bases
GGGCGTCAGAAAAACTCGCCTTGCGCGATTGTCATGGGTTGTCCTGCCTTGCTGTTTCGATGTCTTTCCCTACTGCCGGT
GATCGGCCTGCTGGTGTATG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTGVTSRKGQTMPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRVQQLLDPGTP
FLELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGAN
LPNQDDVFPDRDHFGRIFYNQANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTA
EDLGGADVHTRLSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPADPLYPVEELYGVIPTDTRKPFDVREVIAR
IVDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEG
IARNGAKMVTAVATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNW
SAEEEEAFKQPIRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM

Sequences:

>Translated_546_residues
MTGVTSRKGQTMPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRVQQLLDPGTP
FLELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGAN
LPNQDDVFPDRDHFGRIFYNQANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTA
EDLGGADVHTRLSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPADPLYPVEELYGVIPTDTRKPFDVREVIAR
IVDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEG
IARNGAKMVTAVATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNW
SAEEEEAFKQPIRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM
>Mature_545_residues
TGVTSRKGQTMPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHLSRGKLLPRDRVQQLLDPGTPF
LELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANL
PNQDDVFPDRDHFGRIFYNQANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAE
DLGGADVHTRLSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPADPLYPVEELYGVIPTDTRKPFDVREVIARI
VDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILFSESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGI
ARNGAKMVTAVATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNWS
AEEEEAFKQPIRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMKFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=545, Percent_Identity=66.2385321100917, Blast_Score=743, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=529, Percent_Identity=33.2703213610586, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI295821216, Length=549, Percent_Identity=32.0582877959927, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI310133460, Length=156, Percent_Identity=56.4102564102564, Blast_Score=159, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.0393996247655, Blast_Score=726, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=484, Percent_Identity=34.297520661157, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25147359, Length=484, Percent_Identity=34.7107438016529, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=64.4283121597096, Blast_Score=736, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 59301; Mature: 59170

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGVTSRKGQTMPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHL
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
SRGKLLPRDRVQQLLDPGTPFLELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCND
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECC
ATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDRDHFGRIFYN
CEECCCEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEE
QANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTA
CCCCCCCCCCEEEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCCCCH
EDLGGADVHTRLSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPADPLYPVEEL
HHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHH
YGVIPTDTRKPFDVREVIARIVDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILF
HCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEE
SESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAQVPKF
ECHHHCCHHHHHHHHCCCCCEEEECCCHHHHHCCEECCCCCCCCCCHHEEHHHHCCCCEE
TVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNW
EEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCC
SAEEEEAFKQPIRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMK
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCEEEEECCCCCCCCCHHHHC
FGVFRM
CCCCCC
>Mature Secondary Structure 
TGVTSRKGQTMPTLETKLNARSESFKSNAEAMQALVADLKAKVAKLAEGGGDAARDKHL
CCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
SRGKLLPRDRVQQLLDPGTPFLELSQLAAYDMYDNAAPGAGIITGIGRVAGQECVIVCND
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEECC
ATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDDVFPDRDHFGRIFYN
CEECCCEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEE
QANLSKQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTA
CCCCCCCCCCEEEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCCCCH
EDLGGADVHTRLSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPADPLYPVEEL
HHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHH
YGVIPTDTRKPFDVREVIARIVDGSEFDEFKARYGTTLVCGFARIWGYPVGIIANNGILF
HCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEE
SESALKGAHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAQVPKF
ECHHHCCHHHHHHHHCCCCCEEEECCCHHHHHCCEECCCCCCCCCCHHEEHHHHCCCCEE
TVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGNW
EEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCC
SAEEEEAFKQPIRDQYEHQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIDDMK
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCEEEEECCCCCCCCCHHHHC
FGVFRM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]