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The map label for this gene is shlB [H]

Identifier: 73539800

GI number: 73539800

Start: 121375

End: 123099

Strand: Direct

Name: shlB [H]

Synonym: Reut_A0094

Alternate gene names: 73539800

Gene position: 121375-123099 (Clockwise)

Preceding gene: 73539799

Following gene: 73539801

Centisome position: 3.19

GC content: 65.86

Gene sequence:

>1725_bases
ATGAGTTCGATTCTTTCTAACGCGCGCCGCAAGGCGCGCGGTGTCTTCCCCTTTGCCCCTTTCGCCTTGGCATTGCCGTC
ACTAGTGGCCGCCCAGGCTCTGCCGTTCTTCCCGAACGTCACGCCCAACGACGCCATCAAGCAGCGCCAGGAGCAGCAGG
ACGCGGCCAAGCAGCGCGCCATGGCCCGGCCCGACGTGCTGTCGCGAGCCGCCAGCGGTCCCACTTCTGGCCCGCTGATC
CTCCCCACCGAATCGCCGTGCTTCCCGATCAAGGCGGTGGTGTGGGATGACGCGCAGGCGTTCGGCTGGCTCACGCCCGA
ATCCGAAATCCTCGTCGGTCAGTGCGCCGGCACCAAGGGCCTGCAGGCCATCCGCGATTACTTCGCGACGCGCCTGGTCA
ACGAGGGCTTCGTCACCACGCGCGTGCTGATTCCGGGACAGAACCTGTCCACGGGCACGTTGCGCCTGCAGGCGGTCGCG
GGTCGCATCGAGCACGTCAAGTCCGATGACACCATTGGCCGGTGGCGCACGGCCTTGCCGACCGGTGCCGGCGGCCTCGT
GAACCAGCGCGACTTGGATCAGGGCATGGAGAACATCCGCCGCCTGCAGGGCCAGGCCGACGCTACCATCGACCTCGTGC
CCGGCGACGAGCCCGGCGAGGCCGACTTGGTGGTCAAGCCCGGTACCGGCAAGCGCTGGCATGGCCTGATCACAGCCGAC
AACGCCGGCCTGCAGAACACCGGCAAGTACCAGATGGGCGGCACCCTGACGGTCGACTCGCCACTCTTCCTCTACGACAG
CCTCACGATTTCGGGGAACACCAATGCGAACGTCGGCAACGGCGCTGCGGGCACGCGCTCGTCGGCGATCAACTACAGTG
TCCCGTTTGGCTACTGGAATGCTTTCTTCAACGCCAATCAGTCTCGCTACAAGCAGACCGTTGCGGGCTTCGAGGACGAT
ATCGTCTATGGTGGGCGCAGTGCGCAAGTCGAGGCGGGAGTGGGCTACGTGCCTTTCCGCAATGCGTCGGGCAAGACGTC
TGTCTACGGCAAGGTGTTCCGCAAGTCGGCCAGCAGCAGCATCAATGGGTTGGATCTGAGCGTCCAGCACCGCGATTTCG
TCGGCTTCGAGGTCGGCGCCTCGCATCGCCAGTATTTCGGCAACAGCGTCTTCGACATCGGCGCCGCGTGGCGCCAGTCG
TTGCCGGATCATTCCAAGGCCCCCGGATTCGTGCTGGGCCAGCCCGACTGGGACGGCAAGTCGGAGATCCTGCAGGGCAA
CCTGGGCCTGATGGTGCCGTTCCAGGTGAGCGGGCAGCGCCTGCGCTACCAAGGCAGCGTGCGCCTGCAATACTCGCCCA
CGCGCATCCTGCCGTCCGACTACTTCGCGATCGGCAACCGCTACTCGGTGCGAGGCTTCGATGAGCAACTGACGCTGGCT
GCCGAGAACGGCGCGCTCATGCGCAATGACGTCGCCTGGTCAATCGGCAACACCGGACACGAGGGCTTCGTCGGCTTCGA
CATGGGCCATGTCAGCGGCCCGTCGGCAGCGTTCCTGGTCGGCCAGACCCTGATGGGAGCCGTGATTGGAGCGCGCGGGC
GCTGGCGCTTGGGGCACTGGGCGGCGCTCTCCTACGAGGTCACGCTCGGCACGCCGGTCAGGAAGCCGGACAACTTCCGC
ACCCATCGCACCAACATTGCGGCCCAACTTGGACTGGAGGTCTGA

Upstream 100 bases:

>100_bases
GAGAATGTCTAAGGCAAGAAGGAACGATCTATTGGATCGTGTTCGCTGCATTTTCGATCGTCTTCTTGAACCTAGCAATA
CGTAAATTCCTCGGTCATTG

Downstream 100 bases:

>100_bases
ATGCGACGAATCAGATGGAGGCCAGCCATGACGATCGCCGCCTCCGTGGCCGGGCTCGCAGCGTGCGGCATTGCGGGCGT
GACGCACACGCAGTTCAATT

Product: hemolysin activator HlyB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSSILSNARRKARGVFPFAPFALALPSLVAAQALPFFPNVTPNDAIKQRQEQQDAAKQRAMARPDVLSRAASGPTSGPLI
LPTESPCFPIKAVVWDDAQAFGWLTPESEILVGQCAGTKGLQAIRDYFATRLVNEGFVTTRVLIPGQNLSTGTLRLQAVA
GRIEHVKSDDTIGRWRTALPTGAGGLVNQRDLDQGMENIRRLQGQADATIDLVPGDEPGEADLVVKPGTGKRWHGLITAD
NAGLQNTGKYQMGGTLTVDSPLFLYDSLTISGNTNANVGNGAAGTRSSAINYSVPFGYWNAFFNANQSRYKQTVAGFEDD
IVYGGRSAQVEAGVGYVPFRNASGKTSVYGKVFRKSASSSINGLDLSVQHRDFVGFEVGASHRQYFGNSVFDIGAAWRQS
LPDHSKAPGFVLGQPDWDGKSEILQGNLGLMVPFQVSGQRLRYQGSVRLQYSPTRILPSDYFAIGNRYSVRGFDEQLTLA
AENGALMRNDVAWSIGNTGHEGFVGFDMGHVSGPSAAFLVGQTLMGAVIGARGRWRLGHWAALSYEVTLGTPVRKPDNFR
THRTNIAAQLGLEV

Sequences:

>Translated_574_residues
MSSILSNARRKARGVFPFAPFALALPSLVAAQALPFFPNVTPNDAIKQRQEQQDAAKQRAMARPDVLSRAASGPTSGPLI
LPTESPCFPIKAVVWDDAQAFGWLTPESEILVGQCAGTKGLQAIRDYFATRLVNEGFVTTRVLIPGQNLSTGTLRLQAVA
GRIEHVKSDDTIGRWRTALPTGAGGLVNQRDLDQGMENIRRLQGQADATIDLVPGDEPGEADLVVKPGTGKRWHGLITAD
NAGLQNTGKYQMGGTLTVDSPLFLYDSLTISGNTNANVGNGAAGTRSSAINYSVPFGYWNAFFNANQSRYKQTVAGFEDD
IVYGGRSAQVEAGVGYVPFRNASGKTSVYGKVFRKSASSSINGLDLSVQHRDFVGFEVGASHRQYFGNSVFDIGAAWRQS
LPDHSKAPGFVLGQPDWDGKSEILQGNLGLMVPFQVSGQRLRYQGSVRLQYSPTRILPSDYFAIGNRYSVRGFDEQLTLA
AENGALMRNDVAWSIGNTGHEGFVGFDMGHVSGPSAAFLVGQTLMGAVIGARGRWRLGHWAALSYEVTLGTPVRKPDNFR
THRTNIAAQLGLEV
>Mature_573_residues
SSILSNARRKARGVFPFAPFALALPSLVAAQALPFFPNVTPNDAIKQRQEQQDAAKQRAMARPDVLSRAASGPTSGPLIL
PTESPCFPIKAVVWDDAQAFGWLTPESEILVGQCAGTKGLQAIRDYFATRLVNEGFVTTRVLIPGQNLSTGTLRLQAVAG
RIEHVKSDDTIGRWRTALPTGAGGLVNQRDLDQGMENIRRLQGQADATIDLVPGDEPGEADLVVKPGTGKRWHGLITADN
AGLQNTGKYQMGGTLTVDSPLFLYDSLTISGNTNANVGNGAAGTRSSAINYSVPFGYWNAFFNANQSRYKQTVAGFEDDI
VYGGRSAQVEAGVGYVPFRNASGKTSVYGKVFRKSASSSINGLDLSVQHRDFVGFEVGASHRQYFGNSVFDIGAAWRQSL
PDHSKAPGFVLGQPDWDGKSEILQGNLGLMVPFQVSGQRLRYQGSVRLQYSPTRILPSDYFAIGNRYSVRGFDEQLTLAA
ENGALMRNDVAWSIGNTGHEGFVGFDMGHVSGPSAAFLVGQTLMGAVIGARGRWRLGHWAALSYEVTLGTPVRKPDNFRT
HRTNIAAQLGLEV

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 61856; Mature: 61725

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSILSNARRKARGVFPFAPFALALPSLVAAQALPFFPNVTPNDAIKQRQEQQDAAKQRA
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
MARPDVLSRAASGPTSGPLILPTESPCFPIKAVVWDDAQAFGWLTPESEILVGQCAGTKG
CCCHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEECCCCCEEECCCCCCEEEEECCCCHH
LQAIRDYFATRLVNEGFVTTRVLIPGQNLSTGTLRLQAVAGRIEHVKSDDTIGRWRTALP
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHCCCCCCHHHHHHCCC
TGAGGLVNQRDLDQGMENIRRLQGQADATIDLVPGDEPGEADLVVKPGTGKRWHGLITAD
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEECCCCCCEEEEEEEC
NAGLQNTGKYQMGGTLTVDSPLFLYDSLTISGNTNANVGNGAAGTRSSAINYSVPFGYWN
CCCCCCCCCEECCCEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCHHHH
AFFNANQSRYKQTVAGFEDDIVYGGRSAQVEAGVGYVPFRNASGKTSVYGKVFRKSASSS
HHHCCCHHHHHHHHCCCCCCEEECCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHCCC
INGLDLSVQHRDFVGFEVGASHRQYFGNSVFDIGAAWRQSLPDHSKAPGFVLGQPDWDGK
CCCEEEEEECCCEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCC
SEILQGNLGLMVPFQVSGQRLRYQGSVRLQYSPTRILPSDYFAIGNRYSVRGFDEQLTLA
HHHHCCCCCEEEEEEECCCEEEEECCEEEEECCCCCCCCCHHCCCCEEEECCCCCEEEEE
AENGALMRNDVAWSIGNTGHEGFVGFDMGHVSGPSAAFLVGQTLMGAVIGARGRWRLGHW
ECCCCEEECCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEECCEE
AALSYEVTLGTPVRKPDNFRTHRTNIAAQLGLEV
EEEEEEEEECCCCCCCCCCCHHHHCCCEECCCCC
>Mature Secondary Structure 
SSILSNARRKARGVFPFAPFALALPSLVAAQALPFFPNVTPNDAIKQRQEQQDAAKQRA
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
MARPDVLSRAASGPTSGPLILPTESPCFPIKAVVWDDAQAFGWLTPESEILVGQCAGTKG
CCCHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEECCCCCEEECCCCCCEEEEECCCCHH
LQAIRDYFATRLVNEGFVTTRVLIPGQNLSTGTLRLQAVAGRIEHVKSDDTIGRWRTALP
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHCCCCCCHHHHHHCCC
TGAGGLVNQRDLDQGMENIRRLQGQADATIDLVPGDEPGEADLVVKPGTGKRWHGLITAD
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEECCCCCCEEEEEEEC
NAGLQNTGKYQMGGTLTVDSPLFLYDSLTISGNTNANVGNGAAGTRSSAINYSVPFGYWN
CCCCCCCCCEECCCEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCHHHH
AFFNANQSRYKQTVAGFEDDIVYGGRSAQVEAGVGYVPFRNASGKTSVYGKVFRKSASSS
HHHCCCHHHHHHHHCCCCCCEEECCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHCCC
INGLDLSVQHRDFVGFEVGASHRQYFGNSVFDIGAAWRQSLPDHSKAPGFVLGQPDWDGK
CCCEEEEEECCCEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCC
SEILQGNLGLMVPFQVSGQRLRYQGSVRLQYSPTRILPSDYFAIGNRYSVRGFDEQLTLA
HHHHCCCCCEEEEEEECCCEEEEECCEEEEECCCCCCCCCHHCCCCEEEECCCCCEEEEE
AENGALMRNDVAWSIGNTGHEGFVGFDMGHVSGPSAAFLVGQTLMGAVIGARGRWRLGHW
ECCCCEEECCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEECCEE
AALSYEVTLGTPVRKPDNFRTHRTNIAAQLGLEV
EEEEEEEEECCCCCCCCCCCHHHHCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]