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The map label for this gene is gpwA [H]

Identifier: 73539748

GI number: 73539748

Start: 56453

End: 57091

Strand: Direct

Name: gpwA [H]

Synonym: Reut_A0042

Alternate gene names: 73539748

Gene position: 56453-57091 (Clockwise)

Preceding gene: 73539747

Following gene: 73539749

Centisome position: 1.48

GC content: 64.79

Gene sequence:

>639_bases
ATGAACCGCCGTCAGACCGCCTTCGCCGCTTCCGTGCGCCGTGCCATGTTTGCCACCGCGCTTGCACTCGCCGCCGCCAG
TGCTGCACTGTTGCCGCATCCGGCGCGCGCCGCCGACAAGCCTGCCGCCATGCCGGCCGCAGCGCCGGCCGGCAACTGCC
CGGCTTCGCTCAACTTCCAGTTCCCGCGCCTGCAGGACGAGGCCCCGCAGAACCTGTGCCAGTACGCGGGCAAGGTCGTG
CTGGTGGTCAACACCGCGAGCTATTGCGGTTTCACGCCGCAATATGAAGGGCTGGAAGCGCTGTACAGCAAGTACCGCGA
CCGCGGGCTGGTGGTGCTGGGCTTCCCGTCCAACGACTTCTCGCAGGAGCCGGGCTCGTCCAAGGAGATCGCAGACTTCT
GCTACAACACCTACGGCGTCAAGTTCCCAATGCTGGGCAAGTCCCACGTGCGTGGCGGTGATGTCAATCCGATGTACGCG
CTGCTGGCAAAGGAAACCGGCACCGCGCCGAAGTGGAACTTCTACAAGTACCTGATCGACCGCAGCGGCAACGTGGTGGG
CAGCTACAACAGCATGACGAAGCCCGACGACAAGCAGTTCGTGGCGAAGATCGAGCAGTTGCTGTCCAGCCCGCGCTGA

Upstream 100 bases:

>100_bases
CCATGGACTGAGCTGCCTGCCGGCGCCGAGGCCGGCATCGGCGTAGACTATCGCGTACCCGATACAGCGAGCCGCCCCTT
ATGGAGACAGGAGACATCGC

Downstream 100 bases:

>100_bases
GCGGCCCGCATCCTGTCTTTCGCTTGCGACAGCCCGGCTTTGGCCGGGCTGTTTTGCTTGTGGAGCTTGATTTGCATCAA
GCACACATTGCCGCGCGCTG

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNRRQTAFAASVRRAMFATALALAAASAALLPHPARAADKPAAMPAAAPAGNCPASLNFQFPRLQDEAPQNLCQYAGKVV
LVVNTASYCGFTPQYEGLEALYSKYRDRGLVVLGFPSNDFSQEPGSSKEIADFCYNTYGVKFPMLGKSHVRGGDVNPMYA
LLAKETGTAPKWNFYKYLIDRSGNVVGSYNSMTKPDDKQFVAKIEQLLSSPR

Sequences:

>Translated_212_residues
MNRRQTAFAASVRRAMFATALALAAASAALLPHPARAADKPAAMPAAAPAGNCPASLNFQFPRLQDEAPQNLCQYAGKVV
LVVNTASYCGFTPQYEGLEALYSKYRDRGLVVLGFPSNDFSQEPGSSKEIADFCYNTYGVKFPMLGKSHVRGGDVNPMYA
LLAKETGTAPKWNFYKYLIDRSGNVVGSYNSMTKPDDKQFVAKIEQLLSSPR
>Mature_212_residues
MNRRQTAFAASVRRAMFATALALAAASAALLPHPARAADKPAAMPAAAPAGNCPASLNFQFPRLQDEAPQNLCQYAGKVV
LVVNTASYCGFTPQYEGLEALYSKYRDRGLVVLGFPSNDFSQEPGSSKEIADFCYNTYGVKFPMLGKSHVRGGDVNPMYA
LLAKETGTAPKWNFYKYLIDRSGNVVGSYNSMTKPDDKQFVAKIEQLLSSPR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=146, Percent_Identity=41.0958904109589, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI192455698, Length=141, Percent_Identity=36.1702127659575, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI75709200, Length=175, Percent_Identity=37.1428571428571, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI90903240, Length=133, Percent_Identity=42.1052631578947, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI90903238, Length=115, Percent_Identity=40.8695652173913, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4557629, Length=126, Percent_Identity=37.3015873015873, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1788003, Length=164, Percent_Identity=39.0243902439024, Blast_Score=116, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71993584, Length=143, Percent_Identity=38.4615384615385, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI193210707, Length=151, Percent_Identity=39.0728476821192, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17535473, Length=132, Percent_Identity=37.8787878787879, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506887, Length=132, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550320, Length=182, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193209493, Length=181, Percent_Identity=28.7292817679558, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322228, Length=143, Percent_Identity=49.6503496503497, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319721, Length=142, Percent_Identity=47.887323943662, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322826, Length=141, Percent_Identity=44.6808510638298, Blast_Score=121, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24656772, Length=146, Percent_Identity=42.4657534246575, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI85726443, Length=130, Percent_Identity=38.4615384615385, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656777, Length=146, Percent_Identity=43.8356164383562, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656767, Length=146, Percent_Identity=43.8356164383562, Blast_Score=87, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 23032; Mature: 23032

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRQTAFAASVRRAMFATALALAAASAALLPHPARAADKPAAMPAAAPAGNCPASLNFQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FPRLQDEAPQNLCQYAGKVVLVVNTASYCGFTPQYEGLEALYSKYRDRGLVVLGFPSNDF
CCCCCCCHHHHHHHHCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCC
SQEPGSSKEIADFCYNTYGVKFPMLGKSHVRGGDVNPMYALLAKETGTAPKWNFYKYLID
CCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHH
RSGNVVGSYNSMTKPDDKQFVAKIEQLLSSPR
CCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNRRQTAFAASVRRAMFATALALAAASAALLPHPARAADKPAAMPAAAPAGNCPASLNFQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FPRLQDEAPQNLCQYAGKVVLVVNTASYCGFTPQYEGLEALYSKYRDRGLVVLGFPSNDF
CCCCCCCHHHHHHHHCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCC
SQEPGSSKEIADFCYNTYGVKFPMLGKSHVRGGDVNPMYALLAKETGTAPKWNFYKYLID
CCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHH
RSGNVVGSYNSMTKPDDKQFVAKIEQLLSSPR
CCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA