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The map label for this gene is mutY [H]

Identifier: 71911370

GI number: 71911370

Start: 1516461

End: 1517462

Strand: Direct

Name: mutY [H]

Synonym: M5005_Spy_1557

Alternate gene names: 71911370

Gene position: 1516461-1517462 (Clockwise)

Preceding gene: 71911365

Following gene: 71911371

Centisome position: 82.48

GC content: 38.52

Gene sequence:

>1002_bases
ATGTTGCAACAAACACAAGTTAATACGGTAATCCCTTATTATAAACGTTTTCTAGAGTGGTTTCCTCAAATAAAAGATTT
GGCAGACGCTCCTGAAGAACAATTACTAAAGGCATGGGAGGGACTAGGCTATTATTCTCGGGTGCGTAATATGCAAAAGG
CTGCACAGCAAGTGATGGTTGATTTTGGTGGCATATTTCCTCACACTTATGATGATATTGCTTCATTAAAAGGGATTGGT
CCTTATACTGCAGGTGCTATCGCCAGCATCTCATTCAACTTACCAGAGCCTGCTGTTGATGGCAATGTGATGCGTGTCAT
GGCTCGTTTGTTTGAAGTTAATTATGATATCGGTGACCCTAAAAATCGTAAAATTTTTCAAGCTATTATGGAAATACTAA
TTGACCCTGACAGACCCGGTGATTTTAACCAGGCACTTATGGATCTAGGTACAGACATCGAATCCGCTAAGACACCTAGG
CCTGATGAAAGCCCTATTCGTTTCTTTAACGCTGCTTATTTGAATGGTACTTATGGTAAATACCCCATAAAAAATCCAAA
GAAAAAGCCTAAACCAATGCGAATTCAGGCTTTTGTCATTCGTAACCAAAATGGCCAGTATCTACTGGAGAAAAATACTA
AAGGGAGACTTCTAGGAGGATTTTGGTCATTTCCTATTATCGAAACATCACCTCTTTCTCAACAATTAGATTTATTTGAT
GACAATCAATCCAACCCCATAATCTGGCAAACCCAAAATGAAACTTTCGAAAGAGAATATCAATTAAAGCCACAATGGAC
TGATAATCACTTTCCAAATATTAAGCACACTTTTAGTCACCAGAAGTGGACAATAGAACTCATAGAGGGGGTGGTCAAAG
CAACAGATTTACCTAATGCTCCTCACCTAAAGTGGGTAGCAATTGAGGACTTTTCTCTTTATCCCTTTGCAACACCACAA
AAGAAAATGCTAGAGACCTACTTAAAACAGAAAAATGCTTAA

Upstream 100 bases:

>100_bases
TTCTTTTCGTCGCACACTTTTAGAGTGGTATGACCAAGAAAAACGTGATCTCCCTTGGCGAAGAACTACTAATCCATATT
ATATTTGGGTTTCTGAAATC

Downstream 100 bases:

>100_bases
TCGCAAGTGAACTATAACGGTTCACTTTTTGTTTACAATTCCTTTACGCCGCTGTAAAGTTTTTCGGTGATATTTATGGA
AATTGGTCAGCAAATTATTC

Product: A/G-specific adenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIG
PYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPR
PDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFD
DNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQ
KKMLETYLKQKNA

Sequences:

>Translated_333_residues
MLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIG
PYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPR
PDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFD
DNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQ
KKMLETYLKQKNA
>Mature_333_residues
MLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIG
PYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPR
PDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFD
DNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQ
KKMLETYLKQKNA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=380, Percent_Identity=31.0526315789474, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI115298648, Length=380, Percent_Identity=31.0526315789474, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI6912520, Length=380, Percent_Identity=31.0526315789474, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI115298650, Length=380, Percent_Identity=31.0526315789474, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI115298654, Length=380, Percent_Identity=31.0526315789474, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI115298652, Length=380, Percent_Identity=31.0526315789474, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789331, Length=225, Percent_Identity=41.3333333333333, Blast_Score=174, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 38411; Mature: 38411

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDP
HHCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
KNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGK
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHEEECCCCCC
YPIKNPKKKPKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFD
CCCCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCEEECEECCCCEECCCCHHHHHCCC
DNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNA
CCCCCCEEEECCCCCHHHHEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCC
PHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA
CCEEEEEEECCEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDP
HHCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
KNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGK
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHEEECCCCCC
YPIKNPKKKPKPMRIQAFVIRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFD
CCCCCCCCCCCCEEEEEEEEECCCCCEEEECCCCCCEEECEECCCCEECCCCHHHHHCCC
DNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNA
CCCCCCEEEECCCCCHHHHEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCC
PHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA
CCEEEEEEECCEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]