BacMap

Definition	Streptococcus pyogenes MGAS5005 chromosome, complete genome.
Accession	NC_007297
Length	1,838,554

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The map label for this gene is dnaJ [H]

Identifier: 71911310

GI number: 71911310

Start: 1451679

End: 1452836

Strand: Reverse

Name: dnaJ [H]

Synonym: M5005_Spy_1497

Alternate gene names: 71911310

Gene position: 1452836-1451679 (Counterclockwise)

Preceding gene: 71911311

Following gene: 71911309

Centisome position: 79.02

GC content: 43.52

Gene sequence:

>1158_bases
ATGAACAATACAGAATATTACGATCGTCTGGGGGTTTCTAAGGACGCTTCTCAGGACGATATCAAAAAAGCTTATCGAAA
AATGTCTAAAAAATATCATCCAGATATCAATAAAGAAGCTGGAGCGGAGCAAAAGTATAAGGATGTTCAAGAAGCTTACG
AAACCTTAAGTGATTCACAAAAGCGTGCTGCTTATGATCAATACGGCGCTGCAGGTGCTCAAGGCGGCTTTGGTGGCGGA
GCAGGCGGCTTTGGTGGCGGAGCAGGCGGCTTTGGTGGTTTTGACGGAGGTGGCTTTGGTGGTTTTGAAGATATCTTCTC
AAGCTTCTTTGGTGGCGGTGGAAGCCGAAACCCAAATGCCCCTCGTCAAGGTGACGATTTGCAATATCGTGTTAATTTAT
CTTTTGAAGAGGCTGTATTTGGTGTTGAAAAAGAAGTTAGCTATAATCGCGAAGCAACCTGCGGCACTTGTTTAGGCTCA
GGTGCAAAACCTGGTACCGCTCCAGTAACTTGTCGTAAGTGCCATGGTTCAGGTGTAATGACAATTGACACCCAAACACC
ACTTGGTATGATGCGTCGACAAGTCACCTGCGATATTTGTCATGGTAGTGGTAAGGAAATTAAAGAACCCTGTCAAACCT
GTCACGGTACTGGTCATGAAAAGCAAGCTCATAAAGTGTCTGTTAAGATTCCAGCTGGTGTAGAGACTGGTCAGCAAATC
CGTTTACAAGGTCAAGGAGAAGCTGGCTTTAATGGCGGACCTTATGGTGATTTATTTGTTATTTTGAATGTCTTACCAAG
TAAGCAATTTGAACGCAATGGTTCCACTATTTACTACAACTTAGATATTTCTTTTACTCAAGCAGCCTTAGGAGATACTG
TTGAAATTCCAACGGTTCATGGCGATGTTGAGATGGCTATCCCTGCTGGGACACAAACAGGTAAAACCTTCCGCCTCAAA
GGCAAAGGAGCACCAAAACTCCGTGGTGGAGGTCAAGGGGATCAACATGTTACCGTTAATATTGTGACCCCAACCAAACT
CAATGACGCTCAAAGGGAAGCCTTGCAAGCATTTGCAGAAGCGAGTGGTGAAAAAATGTTACATCCAAAGAAAAAAGGTT
TTTTTGATAAAGTGAAAGATGCCTTAGAGGATATTTAA

Upstream 100 bases:

>100_bases
CGACTCTGCGAAAAAAGAGAAATACCTCCTAGATACGAGAGTATCTTTGTCGGATTTCCTATTTTTCATTAAGTCGTTTT
ACAGCTTGGTATCTTACATT

Downstream 100 bases:

>100_bases
AGATGTCAAACGTATAATTTCAGGATAATTTTCCCGAAGTTATACGTTTTTTTACGTCAAAACAGTTAGAGAAAACGTTT
TCTTTTATAGATATCGTTTT

Product: chaperone protein DnaJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQKRAAYDQYGAAGAQGGFGGG
AGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGS
GAKPGTAPVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQI
RLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVHGDVEMAIPAGTQTGKTFRLK
GKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAEASGEKMLHPKKKGFFDKVKDALEDI

Sequences:

>Translated_385_residues
MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQKRAAYDQYGAAGAQGGFGGG
AGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGS
GAKPGTAPVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQI
RLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVHGDVEMAIPAGTQTGKTFRLK
GKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAEASGEKMLHPKKKGFFDKVKDALEDI
>Mature_385_residues
MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQKRAAYDQYGAAGAQGGFGGG
AGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGS
GAKPGTAPVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQI
RLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVHGDVEMAIPAGTQTGKTFRLK
GKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAEASGEKMLHPKKKGFFDKVKDALEDI

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon

COG id: COG0484

COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain [H]

Homologues:

Organism=Homo sapiens, GI205360838, Length=373, Percent_Identity=35.9249329758713, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI205360840, Length=373, Percent_Identity=35.9249329758713, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI194328760, Length=306, Percent_Identity=31.3725490196078, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI194328758, Length=306, Percent_Identity=31.3725490196078, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI4504511, Length=302, Percent_Identity=33.112582781457, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI201862587, Length=361, Percent_Identity=30.7479224376731, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI201862518, Length=361, Percent_Identity=30.7479224376731, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI56549115, Length=367, Percent_Identity=30.5177111716621, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI5031741, Length=370, Percent_Identity=30.2702702702703, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI6631085, Length=368, Percent_Identity=29.0760869565217, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7706495, Length=374, Percent_Identity=29.144385026738, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI5453690, Length=362, Percent_Identity=27.0718232044199, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI194328762, Length=268, Percent_Identity=27.2388059701493, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI47777312, Length=111, Percent_Identity=45.945945945946, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI39204547, Length=357, Percent_Identity=24.3697478991597, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI88501736, Length=111, Percent_Identity=45.945945945946, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI27151736, Length=111, Percent_Identity=45.945945945946, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI23503241, Length=110, Percent_Identity=47.2727272727273, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI56687498, Length=66, Percent_Identity=57.5757575757576, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI9558755, Length=121, Percent_Identity=39.6694214876033, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI194306642, Length=110, Percent_Identity=43.6363636363636, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194306640, Length=110, Percent_Identity=43.6363636363636, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI17388799, Length=117, Percent_Identity=47.8632478632479, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4885495, Length=117, Percent_Identity=47.8632478632479, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI21553335, Length=75, Percent_Identity=52, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI68077166, Length=112, Percent_Identity=36.6071428571429, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI68077168, Length=76, Percent_Identity=48.6842105263158, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI72534740, Length=108, Percent_Identity=40.7407407407407, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI217035105, Length=78, Percent_Identity=41.025641025641, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI22749377, Length=107, Percent_Identity=38.3177570093458, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI45504382, Length=67, Percent_Identity=47.7611940298507, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786197, Length=390, Percent_Identity=46.4102564102564, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1787235, Length=364, Percent_Identity=30.4945054945055, Blast_Score=158, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17553098, Length=368, Percent_Identity=37.7717391304348, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17553096, Length=368, Percent_Identity=37.7717391304348, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17507263, Length=354, Percent_Identity=31.638418079096, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534355, Length=391, Percent_Identity=29.923273657289, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17538236, Length=113, Percent_Identity=43.3628318584071, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI212645553, Length=70, Percent_Identity=48.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554644, Length=119, Percent_Identity=36.9747899159664, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=94, Percent_Identity=37.2340425531915, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324265, Length=349, Percent_Identity=34.3839541547278, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321094, Length=395, Percent_Identity=37.4683544303797, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323870, Length=362, Percent_Identity=33.1491712707182, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323119, Length=378, Percent_Identity=28.3068783068783, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324252, Length=433, Percent_Identity=25.4041570438799, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323813, Length=125, Percent_Identity=40, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322194, Length=112, Percent_Identity=42.8571428571429, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324321, Length=74, Percent_Identity=48.6486486486487, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320888, Length=109, Percent_Identity=39.4495412844037, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45552813, Length=371, Percent_Identity=36.1185983827493, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI45549272, Length=371, Percent_Identity=36.1185983827493, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI45552811, Length=371, Percent_Identity=36.1185983827493, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI20129487, Length=295, Percent_Identity=31.864406779661, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24584014, Length=295, Percent_Identity=31.864406779661, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI85726398, Length=368, Percent_Identity=31.7934782608696, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646562, Length=324, Percent_Identity=29.9382716049383, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646560, Length=324, Percent_Identity=29.9382716049383, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646558, Length=324, Percent_Identity=29.9382716049383, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646556, Length=324, Percent_Identity=29.9382716049383, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357547, Length=324, Percent_Identity=29.9382716049383, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574949, Length=375, Percent_Identity=27.7333333333333, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19920464, Length=366, Percent_Identity=27.8688524590164, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18858081, Length=302, Percent_Identity=27.8145695364238, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24658562, Length=182, Percent_Identity=33.5164835164835, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24658555, Length=182, Percent_Identity=33.5164835164835, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24654066, Length=118, Percent_Identity=37.2881355932203, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654070, Length=118, Percent_Identity=37.2881355932203, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654068, Length=118, Percent_Identity=37.2881355932203, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654072, Length=118, Percent_Identity=37.2881355932203, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24668492, Length=70, Percent_Identity=44.2857142857143, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737735, Length=67, Percent_Identity=50.7462686567164, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668523, Length=67, Percent_Identity=50.7462686567164, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574723, Length=67, Percent_Identity=50.7462686567164, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161077138, Length=65, Percent_Identity=44.6153846153846, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012724
- InterPro:   IPR002939
- InterPro:   IPR001623
- InterPro:   IPR018253
- InterPro:   IPR008971
- InterPro:   IPR015609
- InterPro:   IPR003095
- InterPro:   IPR001305 [H]

Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG [H]

EC number: NA

Molecular weight: Translated: 40998; Mature: 40998

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00636 DNAJ_1 ; PS50076 DNAJ_2 ; PS00637 DNAJ_CXXCXGXG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQ
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KRAAYDQYGAAGAQGGFGGGAGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
PRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGSGAKPGTAPVTCRKCHGSGVM
CCCCCCEEEEEECCHHHHHHCHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCEE
TIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQI
EEECCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEE
RLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVH
EEEECCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCEEEEEEEEEEHHHHCCCEEECCEEC
GDVEMAIPAGTQTGKTFRLKGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAE
CCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
ASGEKMLHPKKKGFFDKVKDALEDI
CCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQ
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
KRAAYDQYGAAGAQGGFGGGAGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
PRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGSGAKPGTAPVTCRKCHGSGVM
CCCCCCEEEEEECCHHHHHHCHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCEE
TIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQI
EEECCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCEE
RLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVH
EEEECCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCEEEEEEEEEEHHHHCCCEEECCEEC
GDVEMAIPAGTQTGKTFRLKGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAE
CCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
ASGEKMLHPKKKGFFDKVKDALEDI
CCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]