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The map label for this gene is mraY

Identifier: 71911178

GI number: 71911178

Start: 1334856

End: 1335866

Strand: Reverse

Name: mraY

Synonym: M5005_Spy_1365

Alternate gene names: 71911178

Gene position: 1335866-1334856 (Counterclockwise)

Preceding gene: 71911179

Following gene: 71911177

Centisome position: 72.66

GC content: 37.78

Gene sequence:

>1011_bases
ATGTTTTTAACCCTTATTGCAGCAATCATATCCTTTATGGTATCTGCTTTCACAATGCCTTATTTTATCAAATTCTATCA
ATTGAAAAAAATTGGTGGGCAACAAATGCATGAAGATGTCAAGCAACATTTAGCTAAAGCTGGAACACCGACTATGGGGG
GAACTGTTTTTCTTTTAGTAGCTACGGCAGTATCGTTATTGGTTAGTCTATTTTCGATCAAAAACACTCAAAGTTTAGCT
TTGATTTCAGGCATTTTATCAATTGTTGTCATTTACGGGATTATCGGATTTTTGGATGATTTTTTAAAAATTTTTAAGCA
AATCAATGAAGGATTGACAGCCAAACAAAAGTTAGCCTTGCAGTTGGTTGGAGGATTGATGTTCTATTTTTTACATGTTA
GTCCAAGTGGCATTTCCTCTATTAATGTGTTTGGTTATCAGCTGCCGCTGGGAATTTTCTACCTATTCTTTGTTTTGTTT
TGGGTGGTTGGTTTTTCAAATGCCGTTAATTTGACAGATGGTATCGATGGCTTAGCTTCTATCTCAGTGGTGATTAGTCT
AGTGACTTACGGCGTTATTGCCTACGTTCAGAGTCAATTTGATGTTTTGTTACTGATTGGAGCAATGATTGGAGCCTTGC
TTGGCTTCTTCTGCTTTAATCACAAACCTGCTAAAGTATTTATGGGAGATGTAGGTAGTTTAGCCCTTGGAGCTATGTTG
GCTGCCATTTCTATTGCGCTTCGTCAAGAATGGACTCTCCTGATTATTGGGATCGTTTATGTTCTTGAAACAAGTTCTGT
GATGTTGCAAGTGTCCTATTTCAAGTACACCAAGAAAAAATATGGAGAAGGTCGTCGTATTTTTAGAATGACGCCTTTCC
ACCACCATTTGGAATTGGGAGGCTTGTCTGGTAAAGGCAAGAAGTGGTCAGAATGGCAGGTAGATGCTTTTTTGTGGGGA
GTAGGAAGTCTAGCTAGTTTACTAGTTTTAGCTATCTTATACGTGTTCTAA

Upstream 100 bases:

>100_bases
TTTAAAGGAACAGATTCTGGTCGTGTTATGAAACAAAGTGTTGATGTTGGTAAGTCCTTGAAAAAAATAAAAAAAATGAC
CATTACTTTAGGAGATTAAC

Downstream 100 bases:

>100_bases
GGGGGATTATCAAGAATAGTCACCAATAGCATTTTGATTAACATCATCAATAAGAGAGTGGAGATGACCCACAAATGCTG
ATTTTGCGAGTGTTGTCCCA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MFLTLIAAIISFMVSAFTMPYFIKFYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLLVATAVSLLVSLFSIKNTQSLA
LISGILSIVVIYGIIGFLDDFLKIFKQINEGLTAKQKLALQLVGGLMFYFLHVSPSGISSINVFGYQLPLGIFYLFFVLF
WVVGFSNAVNLTDGIDGLASISVVISLVTYGVIAYVQSQFDVLLLIGAMIGALLGFFCFNHKPAKVFMGDVGSLALGAML
AAISIALRQEWTLLIIGIVYVLETSSVMLQVSYFKYTKKKYGEGRRIFRMTPFHHHLELGGLSGKGKKWSEWQVDAFLWG
VGSLASLLVLAILYVF

Sequences:

>Translated_336_residues
MFLTLIAAIISFMVSAFTMPYFIKFYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLLVATAVSLLVSLFSIKNTQSLA
LISGILSIVVIYGIIGFLDDFLKIFKQINEGLTAKQKLALQLVGGLMFYFLHVSPSGISSINVFGYQLPLGIFYLFFVLF
WVVGFSNAVNLTDGIDGLASISVVISLVTYGVIAYVQSQFDVLLLIGAMIGALLGFFCFNHKPAKVFMGDVGSLALGAML
AAISIALRQEWTLLIIGIVYVLETSSVMLQVSYFKYTKKKYGEGRRIFRMTPFHHHLELGGLSGKGKKWSEWQVDAFLWG
VGSLASLLVLAILYVF
>Mature_336_residues
MFLTLIAAIISFMVSAFTMPYFIKFYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLLVATAVSLLVSLFSIKNTQSLA
LISGILSIVVIYGIIGFLDDFLKIFKQINEGLTAKQKLALQLVGGLMFYFLHVSPSGISSINVFGYQLPLGIFYLFFVLF
WVVGFSNAVNLTDGIDGLASISVVISLVTYGVIAYVQSQFDVLLLIGAMIGALLGFFCFNHKPAKVFMGDVGSLALGAML
AAISIALRQEWTLLIIGIVYVLETSSVMLQVSYFKYTKKKYGEGRRIFRMTPFHHHLELGGLSGKGKKWSEWQVDAFLWG
VGSLASLLVLAILYVF

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=362, Percent_Identity=35.3591160220994, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_STRP1 (Q99YK2)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269704.1
- RefSeq:   YP_282728.1
- EnsemblBacteria:   EBSTRT00000001520
- EnsemblBacteria:   EBSTRT00000029071
- GeneID:   3571519
- GeneID:   901912
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1662
- KEGG:   spz:M5005_Spy_1365
- GeneTree:   EBGT00050000027583
- HOGENOM:   HBG708263
- OMA:   TFWQFRN
- ProtClustDB:   PRK00108
- BioCyc:   SPYO160490:SPY1662-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1365-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 36925; Mature: 36925

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe5ccd14)-; HASH(0xe9068a4)-; HASH(0xe710a34)-; HASH(0xd6c40b0)-; HASH(0xdc72b30)-; HASH(0xe9038e4)-; HASH(0xe903938)-; HASH(0xe903a10)-; HASH(0xe918d60)-; HASH(0xe90398c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure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CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296