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The map label for this gene is arcB [H]

Identifier: 71911086

GI number: 71911086

Start: 1228084

End: 1229097

Strand: Reverse

Name: arcB [H]

Synonym: M5005_Spy_1273

Alternate gene names: 71911086

Gene position: 1229097-1228084 (Counterclockwise)

Preceding gene: 71911087

Following gene: 71911085

Centisome position: 66.85

GC content: 41.91

Gene sequence:

>1014_bases
ATGACACAAGTATTTCAAGGACGTAGCTTCCTAGCAGAAAAAGATTTTACACGCGCTGAATTAGAATACCTTATTGATTT
TTCAGCACATTTGAAAGATTTGAAAAAACGTGGTGTGCCTCATCACTACTTAGAAGGTAAAAACATTGCCCTCTTGTTTG
AAAAAACATCAACTCGTACGCGTGCAGCTTTTACAACAGCAGCCATTGACCTAGGTGCTCACCCAGAATACCTCGGTGCC
AATGACATCCAACTTGGTAAAAAAGAATCAACAGAAGACACTGCTAAAGTATTGGGTCGTATGTTTGATGGGATTGAATT
CCGTGGCTTTAGCCAACGCATGGTTGAAGAATTGGCAGAATTCTCAGGTGTGCCAGTTTGGAATGGTTTGACTGATGAAT
GGCACCCAACCCAAATGCTTGCTGACTATTTAACAGTGAAAGAAAACTTTGGCAAACTTGAAGGCCTTACCCTTGTTTAC
TGTGGTGACGGGCGTAATAACGTTGCCAATTCCCTTCTTGTGACTGGTGCTATCCTTGGTGTTAATGTTCATATCTTCTC
ACCAAAAGAACTTTTCCCAGAAGAAGAGATTGTGACATTGGCTGAAGGCTATGCTAAAGAAAGTGGCGCTCGTATCCTTA
TCACAGAAGATGCTGACGAAGCTGTTAAAGGCGCAGACGTGCTTTACACAGATGTTTGGGTATCAATGGGTGAAGAAGAC
AAATTCAAAGAACGTGTTGAATTGCTTCAACCATATCAAGTCAACATGGACCTTGTTCAAAAAGCAGGAAATGACAAGCT
TATCTTCTTGCACTGCTTGCCAGCTTTCCATGACACAAATACCGTTTATGGTAAAGACGTTGCTGAAAAATTCGGCGTGA
AAGAAATGGAAGTCACTGATGAAGTCTTCCGCAGCAAATACGCTCGTCATTTTGACCAAGCTGAAAACCGCATGCACACT
ATCAAAGCGGTTATGGCAGCAACCCTTGGTAACCTCTTTATTCCAAAAGTGTAA

Upstream 100 bases:

>100_bases
GCTAATTGCGATTGTTGGTGGTCTATTAGGCTGCTATCTCTATCTCACAAAAAATAATTAATCAAAACAGATTACAGTTA
ACACTCGAAGGAGACAATAG

Downstream 100 bases:

>100_bases
TAAGGACTGGTACTCCTTAACTCATTTCACATATCAATGTGACCCCTTTAATTTAACAATTTAACTACTTAAAAACGTAC
TTTAACTACATGACAAGTCG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase 2 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGA
NDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVY
CGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEEEIVTLAEGYAKESGARILITEDADEAVKGADVLYTDVWVSMGEED
KFKERVELLQPYQVNMDLVQKAGNDKLIFLHCLPAFHDTNTVYGKDVAEKFGVKEMEVTDEVFRSKYARHFDQAENRMHT
IKAVMAATLGNLFIPKV

Sequences:

>Translated_337_residues
MTQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGA
NDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVY
CGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEEEIVTLAEGYAKESGARILITEDADEAVKGADVLYTDVWVSMGEED
KFKERVELLQPYQVNMDLVQKAGNDKLIFLHCLPAFHDTNTVYGKDVAEKFGVKEMEVTDEVFRSKYARHFDQAENRMHT
IKAVMAATLGNLFIPKV
>Mature_336_residues
TQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGAN
DIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVYC
GDGRNNVANSLLVTGAILGVNVHIFSPKELFPEEEIVTLAEGYAKESGARILITEDADEAVKGADVLYTDVWVSMGEEDK
FKERVELLQPYQVNMDLVQKAGNDKLIFLHCLPAFHDTNTVYGKDVAEKFGVKEMEVTDEVFRSKYARHFDQAENRMHTI
KAVMAATLGNLFIPKV

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=326, Percent_Identity=41.7177914110429, Blast_Score=247, Evalue=9e-66,
Organism=Homo sapiens, GI18105007, Length=336, Percent_Identity=23.5119047619048, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=54.7112462006079, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1786469, Length=327, Percent_Identity=53.5168195718654, Blast_Score=342, Evalue=1e-95,
Organism=Escherichia coli, GI48994908, Length=377, Percent_Identity=23.8726790450928, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI2367364, Length=345, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322373, Length=335, Percent_Identity=33.134328358209, Blast_Score=166, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322331, Length=332, Percent_Identity=25.3012048192771, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24642586, Length=332, Percent_Identity=26.8072289156627, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37898; Mature: 37766

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRT
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCH
RAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAE
HHHHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVYCGDGRNNVANSLLVTGAILG
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHEEEE
VNVHIFSPKELFPEEEIVTLAEGYAKESGARILITEDADEAVKGADVLYTDVWVSMGEED
EEEEEECHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCEEEEHHHHHCCCCH
KFKERVELLQPYQVNMDLVQKAGNDKLIFLHCLPAFHDTNTVYGKDVAEKFGVKEMEVTD
HHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHH
EVFRSKYARHFDQAENRMHTIKAVMAATLGNLFIPKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRT
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCH
RAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAE
HHHHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVYCGDGRNNVANSLLVTGAILG
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHEEEE
VNVHIFSPKELFPEEEIVTLAEGYAKESGARILITEDADEAVKGADVLYTDVWVSMGEED
EEEEEECHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCEEEEHHHHHCCCCH
KFKERVELLQPYQVNMDLVQKAGNDKLIFLHCLPAFHDTNTVYGKDVAEKFGVKEMEVTD
HHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHH
EVFRSKYARHFDQAENRMHTIKAVMAATLGNLFIPKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12354221 [H]