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The map label for this gene is ffh [H]

Identifier: 71910728

GI number: 71910728

Start: 901479

End: 903041

Strand: Reverse

Name: ffh [H]

Synonym: M5005_Spy_0915

Alternate gene names: 71910728

Gene position: 903041-901479 (Counterclockwise)

Preceding gene: 71910729

Following gene: 71910726

Centisome position: 49.12

GC content: 40.05

Gene sequence:

>1563_bases
ATGGCTTTTGAAAGCTTAACCCAACGTTTGCAAGATGTGTTTAAACACATTCGCGGTAAAAAGAAATTATCAGAATCAGA
TGTTCAAGAAGTGACAAAAGAGATTCGTCTAGCTCTTTTAGAAGCCGATGTCGCTTTACCAGTTGTTAAAACCTTTATTA
AGCGCGTACGTGAGCGCGCTATTGGCCATGAGATTATTGATACTCTTGATCCAACACAACAAATTCTTAAGATTGTTAAT
GAAGAATTAACGAGTATTTTAGGCTCAGAAACTGCAGAGATTGATAAATCTCCAAAAATTCCAACTATTATCATGATGGT
CGGTTTGCAAGGGGCTGGTAAAACAACTTTTGCAGGAAAACTCGCTAATAAATTAATTAAAGAAGAAAACGCGCGACCAC
TGATGATTGCTGCCGATATTTACCGTCCAGCGGCCATTGATCAGTTAAAAACACTGGGGCAACAAATCAATGTACCTGTT
TTTGATATGGGGACAGACCACTCAGCAGTCGATATTGTCAGAAAAGGTTTGGAACAAGCTCGTGAAAACCACAATGACTA
TGTCTTGATTGATACTGCGGGTCGCTTGCAAATTGATGAAAAACTGATGGGAGAGCTGCGCGATGTCAAGGCTTTAGCAC
AACCAAATGAAATTCTTTTGGTTGTAGATAGCATGATTGGTCAAGAAGCTGCCAATGTAGCCTACGAGTTTAATCATCAG
TTGAGCATCACAGGGGTTGTGTTAACAAAGATTGATGGTGATACACGTGGAGGTGCGGCGCTATCTGTCCGTGAAATCAC
TGGGAAACCAATTAAATTTACAGGTATTGGTGAAAAAATCACAGATATTGAAACATTTCACCCAGACCGCATGTCCAGTC
GGATTTTGGGAATGGGGGATTTGCTTACCCTCATTGAAAAAGCTAGCCAGGAATATGATGAGAAAAAATCCTTAGAGTTA
GCTGAAAAAATGCGTGAAAACACCTTTGATTTCAATGATTTTATTGAACAGTTAGATCAAGTGCAAAATATGGGGCCTAT
GGAAGACCTCTTGAAAATGATTCCAGGAATGGCTGGTAACCCAGCTTTGGCCAATATCAAAGTTGACGAAAACCAAATTG
CTCGCAAACGTGCTATTGTCTCTTCAATGACACCCGCTGAACGTGAAAATCCTGACTTACTAAACCCGAGTCGTCGCCGT
CGTATTGCAGCTGGTTCCGGGAACAGCTTTGTAGAAGTTAATAAATTTATCAAAGACTTTAACCAAGCCAAAAGCATGAT
GCAAGGGGTTATGTCGGGCGATATGTCTAAAATGATGAAAGATATGGGTATTAATCCCAATAATCTTCCTAAAAACATGC
CTGCTGGTATGCCAGATATGTCTTCCTTAGAAGGAATGATGGGACAAGGTGGTATGCCTGATTTATCTGGCCTTGGTGGT
GATATGGATATGAGTCAACTATTTGGTAAAGGGTTTAAAGGAAAAATTGGCCAATTTGCCATGAAACAGGCCATGAAACG
GCAGGCTAACAAACTAAAAAAAGCAAAGAAAAAACGAAAATAA

Upstream 100 bases:

>100_bases
TTGACGACATGATTGCTCACTACCCTCATGATGAGTATTTGCAAGAAAAAATTTCCATTCTAACCAGTATTGACAATAGA
GAGTAAGAGGAGTTTTGACT

Downstream 100 bases:

>100_bases
AAGAGACGAAAATTTTCGTCTCTTTTTGATGTGAAATTCATTTATCTTGTATACAAGATTATTAAAATTACGGAAGACCG
TGTTACATACCATGATGAGT

Product: signal recognition particle, subunit FFH/SRP54

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Sequences:

>Translated_520_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
>Mature_519_residues
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVNE
ELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVF
DMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQL
SITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLELA
EKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRR
IAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGD
MDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=30.5309734513274, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=31.6195372750643, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=35.6164383561644, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=48.3333333333333, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1789874, Length=269, Percent_Identity=33.0855018587361, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=494, Percent_Identity=27.1255060728745, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=299, Percent_Identity=29.4314381270903, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=467, Percent_Identity=30.406852248394, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=26.031746031746, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17647949, Length=497, Percent_Identity=29.9798792756539, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24641198, Length=311, Percent_Identity=30.2250803858521, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57530; Mature: 57399

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CCHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]