The gene/protein map for NC_007297 is currently unavailable.
Definition Streptococcus pyogenes MGAS5005 chromosome, complete genome.
Accession NC_007297
Length 1,838,554

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The map label for this gene is ddh

Identifier: 71910703

GI number: 71910703

Start: 878778

End: 879770

Strand: Direct

Name: ddh

Synonym: M5005_Spy_0890

Alternate gene names: 71910703

Gene position: 878778-879770 (Clockwise)

Preceding gene: 71910702

Following gene: 71910704

Centisome position: 47.8

GC content: 38.87

Gene sequence:

>993_bases
ATGAAATTAAAATTATATAATGTTAGAGGCGAAGAAGCAGTCTTAGCAAAAAAATGGGCTGATGACAATGGGATTGAGAT
TTCCTTGACGGAGTCTCCCTTAACTCCTGAAACGGTTAAAGAAGCTGAAGGCTTTGACGGGATTGCCAATGCCCAAATTG
GTCCTTTAGATGATGCGATTTATCCTCTCTTAAAGGAAATGGGGATTAAACAAATCGCTCAGCACAGTGCTAGTGTCGAT
ATGTATAACCTTGATTTGGCCACCGAAAATGACATTATTATCACAAATGTTCCTAGCTATTCTCCAGAATCCATTGCAGA
ATTTACGGTTACTATTGTCCTTAATTTAATTCGTCATGTGGAGTTGATTCGTGAAAATGTTAAAAAACAAAATTTCACTT
GGGGACTCCCTATCCGCGGCCGTGTTTTAGGTGATATGACAGTTGCGATTATCGGAACTGGACGTATTGGTCTAGCTACT
GCTAAAATCTTTAAAGGTTTTGGCTGCAAGGTCGTTGGATATGATATTTACCAAAGCGATGCTGCCAAAGCTGTCTTGGA
CTATAAGGAATCTGTAGAAGAAGCGATTAAAGATGCTGATCTTGTTTCCTTACACATGCCACCAACTGCAGAGAACACAC
ACCTTTTCAATTCTGATTTATTTAAATCATTCAAAAAAGGGGCTATTTTGATGAATATGGCGCGTGGTGCCGTCATTGAG
ACGCAAGATTTACTGGATGCTTTGGATGCAGGCTTACTGAGCGGAGCTGGTATTGACACTTACGAATTTGAAGGACCTTA
TATACCTAAGAATTTTGAAGGTCAAGAAATTACAGATTCACTATTTAAAGCTTTGATTAACCATCCTAAGGTTATTTATA
CACCTCATGCAGCTTATTATACTGATGAAGCCGTTAAAAACCTAGTTGAAGGTGCCCTTAATGCTACAGTAGAGATTATC
AAAACTGGGACAACGACAACTCGTGTTAACTAA

Upstream 100 bases:

>100_bases
CAATTGTTCTCAATATGATCTTTAACTACCTTTTTATCAAGGTGCTTAAAGTGATTGATCCAATGGATTACAAACTTGAT
ATCTAAGAAAGGAACTTTTG

Downstream 100 bases:

>100_bases
CAACTGATTTGACGTCCATTATAAAGGAATAATTCTAAAAATTCCTTTATAATGGACTTTTTTGTATTAGTCCGTTATAA
TAGACTGTAAGAAAGGGGAC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKLKLYNVRGEEAVLAKKWADDNGIEISLTESPLTPETVKEAEGFDGIANAQIGPLDDAIYPLLKEMGIKQIAQHSASVD
MYNLDLATENDIIITNVPSYSPESIAEFTVTIVLNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLAT
AKIFKGFGCKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNSDLFKSFKKGAILMNMARGAVIE
TQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEII
KTGTTTTRVN

Sequences:

>Translated_330_residues
MKLKLYNVRGEEAVLAKKWADDNGIEISLTESPLTPETVKEAEGFDGIANAQIGPLDDAIYPLLKEMGIKQIAQHSASVD
MYNLDLATENDIIITNVPSYSPESIAEFTVTIVLNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLAT
AKIFKGFGCKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNSDLFKSFKKGAILMNMARGAVIE
TQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEII
KTGTTTTRVN
>Mature_330_residues
MKLKLYNVRGEEAVLAKKWADDNGIEISLTESPLTPETVKEAEGFDGIANAQIGPLDDAIYPLLKEMGIKQIAQHSASVD
MYNLDLATENDIIITNVPSYSPESIAEFTVTIVLNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLAT
AKIFKGFGCKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNSDLFKSFKKGAILMNMARGAVIE
TQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEII
KTGTTTTRVN

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

Homologues:

Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557497, Length=245, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=28.7313432835821, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=30.4182509505703, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI6912396, Length=200, Percent_Identity=30.5, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787645, Length=318, Percent_Identity=30.8176100628931, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI87082289, Length=303, Percent_Identity=26.7326732673267, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=26.8482490272374, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081824, Length=249, Percent_Identity=24.8995983935743, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=31.8181818181818, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=26.171875, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=260, Percent_Identity=28.0769230769231, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=263, Percent_Identity=26.615969581749, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=207, Percent_Identity=28.0193236714976, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=208, Percent_Identity=24.5192307692308, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921140, Length=237, Percent_Identity=31.6455696202532, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=32.4324324324324, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=32.4324324324324, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=32.4324324324324, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=32.4324324324324, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=32.4324324324324, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585516, Length=329, Percent_Identity=24.3161094224924, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=26.4227642276423, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=27.5303643724696, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=27.5303643724696, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45552429, Length=247, Percent_Identity=27.5303643724696, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=27.5303643724696, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=27.5303643724696, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LDHD_STRP1 (Q99ZM2)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269316.1
- RefSeq:   YP_282253.1
- ProteinModelPortal:   Q99ZM2
- SMR:   Q99ZM2
- EnsemblBacteria:   EBSTRT00000000715
- EnsemblBacteria:   EBSTRT00000028763
- GeneID:   3572021
- GeneID:   901282
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1170
- KEGG:   spz:M5005_Spy_0890
- GeneTree:   EBGT00050000027840
- HOGENOM:   HBG731446
- OMA:   TWGLPIR
- ProtClustDB:   PRK08605
- BioCyc:   SPYO160490:SPY1170-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0890-MONOMER
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.28

Molecular weight: Translated: 36127; Mature: 36127

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 235-235 ACT_SITE 264-264 ACT_SITE 296-296 BINDING 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKLKLYNVRGEEAVLAKKWADDNGIEISLTESPLTPETVKEAEGFDGIANAQIGPLDDAI
CEEEEEECCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHH
YPLLKEMGIKQIAQHSASVDMYNLDLATENDIIITNVPSYSPESIAEFTVTIVLNLIRHV
HHHHHHHCHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
ELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLATAKIFKGFGCKVVGYDIYQSD
HHHHHHHHHCCCEECCCCCCEEECCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEHHHHH
AAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNSDLFKSFKKGAILMNMARGAVIE
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCHHHHHHHHCCEEEEECCCCCEEE
TQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYY
HHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHH
TDEAVKNLVEGALNATVEIIKTGTTTTRVN
HHHHHHHHHHHHHHCEEEEEECCCEEECCC
>Mature Secondary Structure
MKLKLYNVRGEEAVLAKKWADDNGIEISLTESPLTPETVKEAEGFDGIANAQIGPLDDAI
CEEEEEECCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHH
YPLLKEMGIKQIAQHSASVDMYNLDLATENDIIITNVPSYSPESIAEFTVTIVLNLIRHV
HHHHHHHCHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
ELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLATAKIFKGFGCKVVGYDIYQSD
HHHHHHHHHCCCEECCCCCCEEECCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEHHHHH
AAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNSDLFKSFKKGAILMNMARGAVIE
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCHHHHHHHHCCEEEEECCCCCEEE
TQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYY
HHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHH
TDEAVKNLVEGALNATVEIIKTGTTTTRVN
HHHHHHHHHHHHHHCEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296