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The map label for this gene is glyA [H]

Identifier: 71910680

GI number: 71910680

Start: 856123

End: 857379

Strand: Direct

Name: glyA [H]

Synonym: M5005_Spy_0867

Alternate gene names: 71910680

Gene position: 856123-857379 (Clockwise)

Preceding gene: 71910679

Following gene: 71910681

Centisome position: 46.57

GC content: 42.64

Gene sequence:

>1257_bases
ATGATTTTTGATAAAGGTAATGTTGAAGACTTTGATAAAGAGCTTTGGGATGCCATTCATGCTGAAGAAGAAAGACAAGA
ACATCATATCGAATTGATTGCATCTGAAAACATGGTTTCAAAAGCTGTCATGGCAGCTCAAGGTTCTGTTTTAACCAATA
AGTATGCAGAAGGCTATCCAGGTAATCGCTATTATGGTGGAACAGAATGTGTGGATATTGTCGAAACGCTTGCTATTGAA
CGTGCTAAGAAACTTTTCGGTGCCGCATTTGCCAATGTTCAAGCCCATTCCGGAAGTCAAGCCAATGCAGCAGCTTATAT
GGCCTTGATTGAGGCTGGTGACACCGTATTAGGAATGGATTTGGCTGCAGGTGGTCATCTCACGCATGGCTCTCCAGTAA
ATTTTTCTGGAAAAACCTACCATTTTGTGGGTTACTCAGTAGATACTGATACTGAAATGTTAAATTATGAGGCGATTTTA
GAACAAGCAAAGGCGGTCCAACCAAAGCTTATCGTTGCAGGGGCTTCGGCCTACTCTAGAAGCATTGATTTTGAAAAGTT
TCGTGCCATTGCTGATCACGTAGGTGCTTACTTAATGGTGGACATGGCTCACATCGCTGGCCTTGTAGCAGCAGGTGTGC
ACCCGAGTCCTGTCCCTTATGCGCATATTGTGACATCAACAACCCATAAAACCTTACGTGGTCCTCGTGGAGGCTTGATA
TTAACCAATGACGAAGCTCTTGCTAAAAAGATTAATTCGGCCGTTTTCCCTGGTTTACAAGGAGGACCTCTGGAACACGT
GATTGCTGCCAAAGCGGTTGCCTTCAAAGAAGCCTTGGATCCAGCCTTTAAAGACTATGCACAAGCTATTATTGATAATA
CTGCGGCTATGGCAGCAGTTTTTGCACAAGATGATCGTTTCCGTCTGATCTCAGGTGGTACAGATAATCATGTCTTTTTA
GTAGATGTCACTAAGGTTATTGCTAATGGTAAACTAGCGCAAAATCTTCTGGATGAGGTTAATATTACCCTTAATAAAAA
TGCCATTCCTTTTGAAACCTTGTCGCCATTTAAAACCTCAGGTATTCGCATTGGTTGTGCTGCCATAACCAGCCGTGGTA
TGGGTGTTAAAGAGAGTCAGACCATTGCCCGTCTTATCATCAAAGCCTTGGTTAATCATGATCAAGAAACTATTCTTGAA
GAAGTCCGTCAGGAAGTGCGTCAGTTAACCGATGCCTTCCCACTCTATAAAAAGTAA

Upstream 100 bases:

>100_bases
GCCAGTCATCGTAAAGAAGCGCATGCTTTTTACCGAAACCTCGACTATGCAGATGATAAAACACAATTACGATTCATCAA
AAACTTACAAGGAGATGACA

Downstream 100 bases:

>100_bases
GGAATCATGTTAGATAGTTATATAAAACGTATTGTCATTCATCAATTTTCTCCCAATGACACTGAGTTACTGTTATCAGA
TCGTTTAGTGAGCATTACAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIE
RAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDTDTEMLNYEAIL
EQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLI
LTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFL
VDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMGVKESQTIARLIIKALVNHDQETILE
EVRQEVRQLTDAFPLYKK

Sequences:

>Translated_418_residues
MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIE
RAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDTDTEMLNYEAIL
EQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLI
LTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFL
VDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMGVKESQTIARLIIKALVNHDQETILE
EVRQEVRQLTDAFPLYKK
>Mature_418_residues
MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIE
RAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDTDTEMLNYEAIL
EQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLI
LTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFL
VDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMGVKESQTIARLIIKALVNHDQETILE
EVRQEVRQLTDAFPLYKK

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=41.8502202643172, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=41.8502202643172, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=41.8502202643172, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=41.8502202643172, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=42.9203539823009, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI22547186, Length=457, Percent_Identity=41.3566739606127, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI22547189, Length=440, Percent_Identity=38.4090909090909, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1788902, Length=418, Percent_Identity=58.133971291866, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI25144732, Length=402, Percent_Identity=44.7761194029851, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI25144729, Length=402, Percent_Identity=44.7761194029851, Blast_Score=331, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6319739, Length=406, Percent_Identity=45.5665024630542, Blast_Score=346, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=440, Percent_Identity=42.0454545454545, Blast_Score=317, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24640005, Length=449, Percent_Identity=41.4253897550111, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI221329721, Length=449, Percent_Identity=41.4253897550111, Blast_Score=328, Evalue=3e-90,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45097; Mature: 45097

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYP
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHEEEEECCHHHHHHHHHHCCCHHHHHHHCCCC
GNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEE
LAAGGHLTHGSPVNFSGKTYHFVGYSVDTDTEMLNYEAILEQAKAVQPKLIVAGASAYSR
ECCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHH
SIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCCEE
LTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAV
EECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHH
FAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTS
HCCCCCEEEEECCCCCEEEEEEHHHHHHCCHHHHHHHHHCCEEECCCCCCCCCCCCCCCC
GIRIGCAAITSRGMGVKESQTIARLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
CEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYP
CCCCCCCCCHHHHHHHHHHCCHHHHHHHHEEEEECCHHHHHHHHHHCCCHHHHHHHCCCC
GNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEE
LAAGGHLTHGSPVNFSGKTYHFVGYSVDTDTEMLNYEAILEQAKAVQPKLIVAGASAYSR
ECCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHH
SIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCCEE
LTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAV
EECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHH
FAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTS
HCCCCCEEEEECCCCCEEEEEEHHHHHHCCHHHHHHHHHCCEEECCCCCCCCCCCCCCCC
GIRIGCAAITSRGMGVKESQTIARLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
CEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA