Click here to switch to the map view.

The map label for this gene is mtlA [H]

Identifier: 71893905

GI number: 71893905

Start: 717638

End: 719113

Strand: Reverse

Name: mtlA [H]

Synonym: MHJ_0554

Alternate gene names: 71893905

Gene position: 719113-717638 (Counterclockwise)

Preceding gene: 71893907

Following gene: 71893904

Centisome position: 80.13

GC content: 32.93

Gene sequence:

>1476_bases
ATGGCTAATTTGTTCAAAATGCTTAAAACTAAAATTCAGGCATTCGGCTCACTTTTAGGCCAAATGATTATGCCAATTAT
TGGGATTTTTATAGCCTGAGGTTTGTTGACATCCTTTTTTATCCCAACAGGCTGAACCCCAAATAAAGAACTAGCAACAA
TGGTCAAAATCGGGATTGTCTATATTATTCCAATTTTAATTTGTTTTTTAGGAGGATATAAAATTTATAAAATGCGGGGC
GGAGCAATTGCTGGTATTGTTGCAATTGCATCAGTCGCCGCTGGCCAATCAGAGACTTTTTCCCAAATCACTGGCGGAAC
CGCACCGATGCTAGTTTCAGTTATGCTTTTTGGCCCAGTTTCTGCACTTATTTTAAAACATAGCGAAAAATTTTGGATTC
ATAAAATTCCAAGTGGCTATCAAATGTTGGTGAATAATTTTTACCTTGGCATTCTCGGCTTTGTTCTGCTTCTTCCAGTT
TATTATTTATCAATTTATTTTATTGGATATTTTATAAAATCACTCGGGATTCTAACAGCAAAAATGGGACAGTGAAAATT
ATACCCACTAATTGCTTTAATTGTCGAACCCGCAAAAATACTCTTTTTAAATAATGCTATAAATCACGGCGTTTTTACAA
CTTTGGGTGCAATTCAAGTCACTGAAACCGGCAAGTCAATTTTGTTTTTATTAGAATCAAATCCCGGACCGGGGTTAGGA
CTTTTGCTGTTTTATTTAATTTTTTCAAAAGAGAAAATTATTAAAGGTCAAGCAACCTCGTCAATTCCTATTCATTTTTT
AGGCGGAATTCACGAAGTTTATTTCCCTTTTGCACTTTTAAGGCCAATTTTGATTTTGGCCTTAATTGCAGGCGGGGTTT
TTGCGAATGCAATTTTCCAAATTTTTAATGTTGGTGCAGTTGCTCCTGTTTCGCCAGGTTCAATTATTGCTCAATATCTT
CAAGTTGAAAAATCAACAAATTCACTAGTTGGGCTTACAATTGGAATTTTTGGCTCTGCGGTAGCGACTTTAGTTGCCGC
TTGAGGAGTTAATTTTTTGGCTAAGTTGATTAATAGAAAAAAAACAAAAAAAGAAACTTTTGCCTTAGAAAGTGCCAAAA
AATTAGTAGAAAGTGAAAAAATAAAACTAAAAAAACCAACTGAAAATAATCTAAATTGAAAACAAATTGTTTTTGCTTGC
GATGCAGGAATGGGTTCTTCAGTGATGGCGGCCTCAATTTTTCGAAAAATTTTAAAGGAAAATGGAATTAGAAATGTTGA
AATTACTAATTTAGCAATTGCAGATTTAACAGGGGCTGAAGAAATTATCATCACAATTCAAAGTCTTGAGGATCGTGTTA
AAGCGAAAAATTCAACAGCAAAAATTATTACTTTAACTCAATTTTTAGATAAAAAATCTTATGAAAATTTAGCAAAAAAA
ATTAAAAAAATACAAGAAAAAGAAGGATTTTTGTAA

Upstream 100 bases:

>100_bases
TCCTTATCAATAAAATTCCGATTTTGCTTTAATAACAATGAAAGTTGATCAATTAAATTACTATTCATTTTTAAAAATTA
TACCAAGAAAAAGGAGTTTT

Downstream 100 bases:

>100_bases
TGAAAGTGGTTCATTTTGGCGCCGGAAATATCGGGCGCGGGTTGATTGCAAAACTATACCATCAAAATCAATTTGAAATT
ATTTTTGTCGATGTTAATCA

Product: PTS system mannitol-specific transporter subunit IIBC

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MANLFKMLKTKIQAFGSLLGQMIMPIIGIFIAWGLLTSFFIPTGWTPNKELATMVKIGIVYIIPILICFLGGYKIYKMRG
GAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSALILKHSEKFWIHKIPSGYQMLVNNFYLGILGFVLLLPV
YYLSIYFIGYFIKSLGILTAKMGQWKLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLG
LLLFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFNVGAVAPVSPGSIIAQYL
QVEKSTNSLVGLTIGIFGSAVATLVAAWGVNFLAKLINRKKTKKETFALESAKKLVESEKIKLKKPTENNLNWKQIVFAC
DAGMGSSVMAASIFRKILKENGIRNVEITNLAIADLTGAEEIIITIQSLEDRVKAKNSTAKIITLTQFLDKKSYENLAKK
IKKIQEKEGFL

Sequences:

>Translated_491_residues
MANLFKMLKTKIQAFGSLLGQMIMPIIGIFIA*GLLTSFFIPTG*TPNKELATMVKIGIVYIIPILICFLGGYKIYKMRG
GAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSALILKHSEKFWIHKIPSGYQMLVNNFYLGILGFVLLLPV
YYLSIYFIGYFIKSLGILTAKMGQ*KLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLG
LLLFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFNVGAVAPVSPGSIIAQYL
QVEKSTNSLVGLTIGIFGSAVATLVAA*GVNFLAKLINRKKTKKETFALESAKKLVESEKIKLKKPTENNLN*KQIVFAC
DAGMGSSVMAASIFRKILKENGIRNVEITNLAIADLTGAEEIIITIQSLEDRVKAKNSTAKIITLTQFLDKKSYENLAKK
IKKIQEKEGFL
>Mature_490_residues
ANLFKMLKTKIQAFGSLLGQMIMPIIGIFIA*GLLTSFFIPTG*TPNKELATMVKIGIVYIIPILICFLGGYKIYKMRGG
AIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSALILKHSEKFWIHKIPSGYQMLVNNFYLGILGFVLLLPVY
YLSIYFIGYFIKSLGILTAKMGQ*KLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLGL
LLFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFNVGAVAPVSPGSIIAQYLQ
VEKSTNSLVGLTIGIFGSAVATLVAA*GVNFLAKLINRKKTKKETFALESAKKLVESEKIKLKKPTENNLN*KQIVFACD
AGMGSSVMAASIFRKILKENGIRNVEITNLAIADLTGAEEIIITIQSLEDRVKAKNSTAKIITLTQFLDKKSYENLAKKI
KKIQEKEGFL

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=492, Percent_Identity=38.2113821138211, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1789301, Length=474, Percent_Identity=37.1308016877637, Blast_Score=276, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 52602; Mature: 52471

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLFKMLKTKIQAFGSLLGQMIMPIIGIFIAGLLTSFFIPTGTPNKELATMVKIGIVYI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
IPILICFLGGYKIYKMRGGAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSA
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
LILKHSEKFWIHKIPSGYQMLVNNFYLGILGFVLLLPVYYLSIYFIGYFIKSLGILTAKM
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQKLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLGLLL
CHHHHHHHHHHHCCHHHEEECCHHCCCHHHHHCCEEEEECCCEEEEEEECCCCCCHHHHH
FYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAVAPVSPGSIIAQYLQVEKSTNSLVGLTIGIFGSAVATLVAAGVNFLAKLINRKKTKK
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETFALESAKKLVESEKIKLKKPTENNLNKQIVFACDAGMGSSVMAASIFRKILKENGIRN
HHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCE
VEITNLAIADLTGAEEIIITIQSLEDRVKAKNSTAKIITLTQFLDKKSYENLAKKIKKIQ
EEEEEEEEECCCCCHHHEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EKEGFL
HHCCCC
>Mature Secondary Structure 
ANLFKMLKTKIQAFGSLLGQMIMPIIGIFIAGLLTSFFIPTGTPNKELATMVKIGIVYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
IPILICFLGGYKIYKMRGGAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSA
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
LILKHSEKFWIHKIPSGYQMLVNNFYLGILGFVLLLPVYYLSIYFIGYFIKSLGILTAKM
HHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQKLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLGLLL
CHHHHHHHHHHHCCHHHEEECCHHCCCHHHHHCCEEEEECCCEEEEEEECCCCCCHHHHH
FYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFN
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAVAPVSPGSIIAQYLQVEKSTNSLVGLTIGIFGSAVATLVAAGVNFLAKLINRKKTKK
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETFALESAKKLVESEKIKLKKPTENNLNKQIVFACDAGMGSSVMAASIFRKILKENGIRN
HHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCE
VEITNLAIADLTGAEEIIITIQSLEDRVKAKNSTAKIITLTQFLDKKSYENLAKKIKKIQ
EEEEEEEEECCCCCHHHEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EKEGFL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]