Click here to switch to the map view.

The map label for this gene is dut

Identifier: 71892379

GI number: 71892379

Start: 761788

End: 762237

Strand: Direct

Name: dut

Synonym: BPEN_638

Alternate gene names: 71892379

Gene position: 761788-762237 (Clockwise)

Preceding gene: 71892378

Following gene: 71892380

Centisome position: 96.23

GC content: 32.89

Gene sequence:

>450_bases
ATGAAAATAATTAATGTTAAAATTATTGATAATCGAATTTATAAGCATTTTTATTTACCAAAATATGCTACGTCAGGATC
TGCTGGATTAGATTTATCAGCTTGTTTAGATAAACCTTTGACCATTTATCCCGGGAAAACTCATTTAATTTCTACCGGTA
TTGCGATACATATTTCCGATACAAAGATAGCAGGTGTTATTTTACCTCGATCAGGTTTGGGACACAAGTATGGTATTGTC
TTGGGAAATTTGGTGGGACTAATTGATTCAGATTATCAAGGAGAATTGATAGTGTCTTTATGGAATCGTGGGCCAAAAAA
GTATATTGTATATCCTGGGAAACGAATAGCACAATTAGTTTTTATGCCAATAATTCAAGTTAGATTTTCTATAGTTAAAT
CATTTATACCTACTGAACGTGGGCCACATGGTTTTGGGCATTCGATGTAA

Upstream 100 bases:

>100_bases
GCTTTATATTTATTTTGGAATAAAGGAAGCGTTATATTGCCTTTAAGAAAAAAAAAATTGTTAGCACAACAACTTATTAA
CGAAATTATTGATCGTTATA

Downstream 100 bases:

>100_bases
AATACTGTTAATTACATATTAATAACGTGTAATGCATATTTTCAAATTATCAATGTATATAATTTTATTATATATCTCAT
TAAGATAATAATATTAAATT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MKIINVKIIDNRIYKHFYLPKYATSGSAGLDLSACLDKPLTIYPGKTHLISTGIAIHISDTKIAGVILPRSGLGHKYGIV
LGNLVGLIDSDYQGELIVSLWNRGPKKYIVYPGKRIAQLVFMPIIQVRFSIVKSFIPTERGPHGFGHSM

Sequences:

>Translated_149_residues
MKIINVKIIDNRIYKHFYLPKYATSGSAGLDLSACLDKPLTIYPGKTHLISTGIAIHISDTKIAGVILPRSGLGHKYGIV
LGNLVGLIDSDYQGELIVSLWNRGPKKYIVYPGKRIAQLVFMPIIQVRFSIVKSFIPTERGPHGFGHSM
>Mature_149_residues
MKIINVKIIDNRIYKHFYLPKYATSGSAGLDLSACLDKPLTIYPGKTHLISTGIAIHISDTKIAGVILPRSGLGHKYGIV
LGNLVGLIDSDYQGELIVSLWNRGPKKYIVYPGKRIAQLVFMPIIQVRFSIVKSFIPTERGPHGFGHSM

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=137, Percent_Identity=36.4963503649635, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4503423, Length=137, Percent_Identity=36.4963503649635, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI70906441, Length=137, Percent_Identity=36.4963503649635, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=60.8108108108108, Blast_Score=201, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71988561, Length=131, Percent_Identity=40.4580152671756, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319729, Length=131, Percent_Identity=33.587786259542, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_BLOPB (Q491W8)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278113.1
- ProteinModelPortal:   Q491W8
- SMR:   Q491W8
- STRING:   Q491W8
- GeneID:   3562715
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_638
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   LDLRACI
- ProtClustDB:   PRK00601
- BioCyc:   CBLO291272:BPEN_638-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 16461; Mature: 16461

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: BINDING 83-83

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIINVKIIDNRIYKHFYLPKYATSGSAGLDLSACLDKPLTIYPGKTHLISTGIAIHISD
CEEEEEEEECCCEEHEEECCCCCCCCCCCCCHHHHHCCCEEEECCCCEEEECCEEEEECC
TKIAGVILPRSGLGHKYGIVLGNLVGLIDSDYQGELIVSLWNRGPKKYIVYPGKRIAQLV
CEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHH
FMPIIQVRFSIVKSFIPTERGPHGFGHSM
HHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIINVKIIDNRIYKHFYLPKYATSGSAGLDLSACLDKPLTIYPGKTHLISTGIAIHISD
CEEEEEEEECCCEEHEEECCCCCCCCCCCCCHHHHHCCCEEEECCCCEEEECCEEEEECC
TKIAGVILPRSGLGHKYGIVLGNLVGLIDSDYQGELIVSLWNRGPKKYIVYPGKRIAQLV
CEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHH
FMPIIQVRFSIVKSFIPTERGPHGFGHSM
HHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA