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The map label for this gene is dfp [H]

Identifier: 71892378

GI number: 71892378

Start: 760593

End: 761801

Strand: Direct

Name: dfp [H]

Synonym: BPEN_637

Alternate gene names: 71892378

Gene position: 760593-761801 (Clockwise)

Preceding gene: 71892375

Following gene: 71892379

Centisome position: 96.08

GC content: 32.92

Gene sequence:

>1209_bases
ATGACGGGATTAATTAATAAACATATCATATTAGGAGTAAGCGGTGGTATCGCAGCATATAAAACTATAGATCTTGTACG
ATGTTTAAAAGAACAAGGTTCAGAAGTGAGAGTGATAATGACAAAATCTGCAAAAAAATTTGTTACCCCCTTAAGTTTAC
AAACAATATCGTGTCATCCAGTTTTGGATAATTTTCTTACCCCTCAAATAGAAACCACAATGCCTCACATAAAGTTAGCT
AAATGGGCTGATTTAGTTTTACTTGCTCCGGCTACAGCCAATTTATTAGCTAGATTATCTGTAGGATTAGCTAATGATTT
ATTATGTAGTTTATGTTTAGCTACAACAGCTCCTATTGCTGTAGCTCCATCTATGAATCAACAAATGTATAAAGCTATTG
CAACTCAAACAAATTTAGATATTCTACGAAAAAGAGGAGTTTTAATATGGGGTCCGGATTACGGATGTCAAGCTTGTAAT
GATATTGGTTATGGACGCATGACGGACCCCAAAGTACTTTCTGAATACGTAAAACATTACTTTTCTCATGATAGTTCTTT
AAGTCATCTTAATATCATGATTACTGCTGGTCCTACTCACGAAGCCTTAGATCCCGTTCGTTTTTTTACTAATTATAGTT
CAGGAAAAATGGGATTTGCTATCGCTCAAGCCGCTGCAGATAAAGGAGCAAAAGTTACATTAATTACAGGTCCGGTGAAC
TTACGTACTCCTATTCGAGTGCAACGTATTAATGTTATTTCCGCTTTAGACATGCAAGAAGCAGTTATGCGAGACATTAG
TAATCAACAAATTTTTATCGGTTGTGCAGCGGTATCAGATTACCGCATTTGTCATGTTTCTCTTGACAAGATTAAAAAGA
ATAAAAATACTTTAAAAATAATTATGGTTAAGAACCCCGATATTGTGGCGAAAGTAGGGTCGTTAATTGAAAACCGTCCT
TATGTCGTTGGATTTGCCGCTGAAACTAATAATATACAAAAATATGCTCAAGATAAACGTATTAGTAAACATTTAGATTT
AATTTGTGCTAATAATATTTCTCGTATAAACCAAGGATTCAATAGTGATAATAATGCTTTATATTTATTTTGGAATAAAG
GAAGCGTTATATTGCCTTTAAGAAAAAAAAAATTGTTAGCACAACAACTTATTAACGAAATTATTGATCGTTATAATGAA
AATAATTAA

Upstream 100 bases:

>100_bases
CATGTGAAGATGATTTAATTTTATTTATACTAACAAAAACTAACAGTTTTTGTTAGTATAAATAAAATTAAATCATCTTC
AATATCATGTGAAATATAAT

Downstream 100 bases:

>100_bases
TGTTAAAATTATTGATAATCGAATTTATAAGCATTTTTATTTACCAAAATATGCTACGTCAGGATCTGCTGGATTAGATT
TATCAGCTTGTTTAGATAAA

Product: 4'-phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTGLINKHIILGVSGGIAAYKTIDLVRCLKEQGSEVRVIMTKSAKKFVTPLSLQTISCHPVLDNFLTPQIETTMPHIKLA
KWADLVLLAPATANLLARLSVGLANDLLCSLCLATTAPIAVAPSMNQQMYKAIATQTNLDILRKRGVLIWGPDYGCQACN
DIGYGRMTDPKVLSEYVKHYFSHDSSLSHLNIMITAGPTHEALDPVRFFTNYSSGKMGFAIAQAAADKGAKVTLITGPVN
LRTPIRVQRINVISALDMQEAVMRDISNQQIFIGCAAVSDYRICHVSLDKIKKNKNTLKIIMVKNPDIVAKVGSLIENRP
YVVGFAAETNNIQKYAQDKRISKHLDLICANNISRINQGFNSDNNALYLFWNKGSVILPLRKKKLLAQQLINEIIDRYNE
NN

Sequences:

>Translated_402_residues
MTGLINKHIILGVSGGIAAYKTIDLVRCLKEQGSEVRVIMTKSAKKFVTPLSLQTISCHPVLDNFLTPQIETTMPHIKLA
KWADLVLLAPATANLLARLSVGLANDLLCSLCLATTAPIAVAPSMNQQMYKAIATQTNLDILRKRGVLIWGPDYGCQACN
DIGYGRMTDPKVLSEYVKHYFSHDSSLSHLNIMITAGPTHEALDPVRFFTNYSSGKMGFAIAQAAADKGAKVTLITGPVN
LRTPIRVQRINVISALDMQEAVMRDISNQQIFIGCAAVSDYRICHVSLDKIKKNKNTLKIIMVKNPDIVAKVGSLIENRP
YVVGFAAETNNIQKYAQDKRISKHLDLICANNISRINQGFNSDNNALYLFWNKGSVILPLRKKKLLAQQLINEIIDRYNE
NN
>Mature_401_residues
TGLINKHIILGVSGGIAAYKTIDLVRCLKEQGSEVRVIMTKSAKKFVTPLSLQTISCHPVLDNFLTPQIETTMPHIKLAK
WADLVLLAPATANLLARLSVGLANDLLCSLCLATTAPIAVAPSMNQQMYKAIATQTNLDILRKRGVLIWGPDYGCQACND
IGYGRMTDPKVLSEYVKHYFSHDSSLSHLNIMITAGPTHEALDPVRFFTNYSSGKMGFAIAQAAADKGAKVTLITGPVNL
RTPIRVQRINVISALDMQEAVMRDISNQQIFIGCAAVSDYRICHVSLDKIKKNKNTLKIIMVKNPDIVAKVGSLIENRPY
VVGFAAETNNIQKYAQDKRISKHLDLICANNISRINQGFNSDNNALYLFWNKGSVILPLRKKKLLAQQLINEIIDRYNEN
N

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=30.8108108108108, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87082301, Length=402, Percent_Identity=60.9452736318408, Blast_Score=501, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322762, Length=188, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44434; Mature: 44302

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLINKHIILGVSGGIAAYKTIDLVRCLKEQGSEVRVIMTKSAKKFVTPLSLQTISCHP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHCCCCEEEEEEECH
VLDNFLTPQIETTMPHIKLAKWADLVLLAPATANLLARLSVGLANDLLCSLCLATTAPIA
HHHHHCCCCHHHCCCCEEHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VAPSMNQQMYKAIATQTNLDILRKRGVLIWGPDYGCQACNDIGYGRMTDPKVLSEYVKHY
ECCCCCHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHH
FSHDSSLSHLNIMITAGPTHEALDPVRFFTNYSSGKMGFAIAQAAADKGAKVTLITGPVN
HCCCCCCCEEEEEEEECCCCHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
LRTPIRVQRINVISALDMQEAVMRDISNQQIFIGCAAVSDYRICHVSLDKIKKNKNTLKI
CCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEHHHHHCCCCEEEE
IMVKNPDIVAKVGSLIENRPYVVGFAAETNNIQKYAQDKRISKHLDLICANNISRINQGF
EEEECCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
NSDNNALYLFWNKGSVILPLRKKKLLAQQLINEIIDRYNENN
CCCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGLINKHIILGVSGGIAAYKTIDLVRCLKEQGSEVRVIMTKSAKKFVTPLSLQTISCHP
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHCCCCEEEEEEECH
VLDNFLTPQIETTMPHIKLAKWADLVLLAPATANLLARLSVGLANDLLCSLCLATTAPIA
HHHHHCCCCHHHCCCCEEHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VAPSMNQQMYKAIATQTNLDILRKRGVLIWGPDYGCQACNDIGYGRMTDPKVLSEYVKHY
ECCCCCHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHH
FSHDSSLSHLNIMITAGPTHEALDPVRFFTNYSSGKMGFAIAQAAADKGAKVTLITGPVN
HCCCCCCCEEEEEEEECCCCHHCCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
LRTPIRVQRINVISALDMQEAVMRDISNQQIFIGCAAVSDYRICHVSLDKIKKNKNTLKI
CCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEHHHHHCCCCEEEE
IMVKNPDIVAKVGSLIENRPYVVGFAAETNNIQKYAQDKRISKHLDLICANNISRINQGF
EEEECCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
NSDNNALYLFWNKGSVILPLRKKKLLAQQLINEIIDRYNENN
CCCCCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]