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The map label for this gene is glyA

Identifier: 71892309

GI number: 71892309

Start: 665893

End: 667143

Strand: Reverse

Name: glyA

Synonym: BPEN_556

Alternate gene names: 71892309

Gene position: 667143-665893 (Counterclockwise)

Preceding gene: 71892310

Following gene: 71892307

Centisome position: 84.27

GC content: 33.57

Gene sequence:

>1251_bases
ATGTCCATATGTACGAGTTATGATATTGAATTGTGGAAAATAATACAACAAGAAACTATTAGACAAGAGGAACATATTGA
ATTAATAGCATCTGAAAATTATGTTAGCACTCAAGTTATGAAAGCACAAGGCTCTCAACTTACTAATAAATACGCTGAAG
GTTATCCAGGTAAACGTTATTATGGTGGATGCGAATATGTCGACATGATTGAACAATTAGGCATTAATCGTGCAAAAGAA
TTATTTTCTGCAGACTATGCAAATATACAACCACATTCTGGATCACAAGCTAATTTTTCTGTTTATAATGCTTTATTGCA
CCCTGGCGATACAATTTTAAGTATGCATCTAAATCATGGAGGACATTTAACGCATGGCTCACAAGTAAACTTTTCAGGAA
AATTATATAACGCTGTATTTTATGGAGTTGACGAAAATGGTTGTATTAATTATGAAAAAGTACATCATTTAGCTGTAAAA
CATCGACCGAAAATGATCGTAGGGGGGTTTTCTGCATATTCTGGTATTATAAATTGGTCTAATCTGCGTCAGATTGCAGA
TGCTGTTCAAGCATATCTATTTATTGACATGGCTCATATCACGGGATTAGTTGCGGCGGGTATATATCCAAATCCACTAC
CACACGCACATGTAGTGACTGCTACTACTCATAAAACATTAGCGGGGCCCAGAGGTGGTTTAATTTTAGCTAGTGGAGGT
AATGATGCATTGTACAAAAAATTAGATGCTTCGGTTTTCCCTGGTTCTCAAGGAGGTCCTTTGATGCATGTTATCGCAGC
CAAAGCAATTGCTTTAAAAGAAGCAATGGATCCATCTTTTAAGGTATATCAACAAAAAATTGTTCAAAATGCTAAGATAA
TGGTTAAGGAGTTTGCATTACGCGAATTTAAGATTATCTCTGGAATGACTCATAATCATCTTTTTTTATTAGATTTAAGA
GATAAAAATATCACTGGGAAAGATGCCAGCACAGCTTTAGAGCGAGCTAATATCATTGTTAATAAAAATAGCATACCAAA
TGATTTTAGAAGTCCTTTTATTACCTCTGGTATACGTATTGGTACGCCAGCAATAACTAGACGTAATTTTAATGAAAACG
ATGTACGAAAACTATCTCATTGGATCTGTGACATATTAAATCATATCGATAACAACGAAATTATTTTTTCCATAAAAAAT
AAAGTTTTACGTATATGTTCTCAGTATCCCATATATAACAAAAGTTATTAA

Upstream 100 bases:

>100_bases
TGTTATTAAAAGTAATTCTTGCTTCATTTCAATTAAAATAGACTGATGTATTTTTACGCATACAATGTATTTTTTATTTA
GACAAGATAAGAGGTTATAC

Downstream 100 bases:

>100_bases
AGTAACATCACTATATAAATTATATCTAGAATATAAAAATACAAGTTGTTCTTTCAAAATATAGGAATTTATTAATATCT
TATTGAGGCAGATATTCAAA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSICTSYDIELWKIIQQETIRQEEHIELIASENYVSTQVMKAQGSQLTNKYAEGYPGKRYYGGCEYVDMIEQLGINRAKE
LFSADYANIQPHSGSQANFSVYNALLHPGDTILSMHLNHGGHLTHGSQVNFSGKLYNAVFYGVDENGCINYEKVHHLAVK
HRPKMIVGGFSAYSGIINWSNLRQIADAVQAYLFIDMAHITGLVAAGIYPNPLPHAHVVTATTHKTLAGPRGGLILASGG
NDALYKKLDASVFPGSQGGPLMHVIAAKAIALKEAMDPSFKVYQQKIVQNAKIMVKEFALREFKIISGMTHNHLFLLDLR
DKNITGKDASTALERANIIVNKNSIPNDFRSPFITSGIRIGTPAITRRNFNENDVRKLSHWICDILNHIDNNEIIFSIKN
KVLRICSQYPIYNKSY

Sequences:

>Translated_416_residues
MSICTSYDIELWKIIQQETIRQEEHIELIASENYVSTQVMKAQGSQLTNKYAEGYPGKRYYGGCEYVDMIEQLGINRAKE
LFSADYANIQPHSGSQANFSVYNALLHPGDTILSMHLNHGGHLTHGSQVNFSGKLYNAVFYGVDENGCINYEKVHHLAVK
HRPKMIVGGFSAYSGIINWSNLRQIADAVQAYLFIDMAHITGLVAAGIYPNPLPHAHVVTATTHKTLAGPRGGLILASGG
NDALYKKLDASVFPGSQGGPLMHVIAAKAIALKEAMDPSFKVYQQKIVQNAKIMVKEFALREFKIISGMTHNHLFLLDLR
DKNITGKDASTALERANIIVNKNSIPNDFRSPFITSGIRIGTPAITRRNFNENDVRKLSHWICDILNHIDNNEIIFSIKN
KVLRICSQYPIYNKSY
>Mature_415_residues
SICTSYDIELWKIIQQETIRQEEHIELIASENYVSTQVMKAQGSQLTNKYAEGYPGKRYYGGCEYVDMIEQLGINRAKEL
FSADYANIQPHSGSQANFSVYNALLHPGDTILSMHLNHGGHLTHGSQVNFSGKLYNAVFYGVDENGCINYEKVHHLAVKH
RPKMIVGGFSAYSGIINWSNLRQIADAVQAYLFIDMAHITGLVAAGIYPNPLPHAHVVTATTHKTLAGPRGGLILASGGN
DALYKKLDASVFPGSQGGPLMHVIAAKAIALKEAMDPSFKVYQQKIVQNAKIMVKEFALREFKIISGMTHNHLFLLDLRD
KNITGKDASTALERANIIVNKNSIPNDFRSPFITSGIRIGTPAITRRNFNENDVRKLSHWICDILNHIDNNEIIFSIKNK
VLRICSQYPIYNKSY

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=420, Percent_Identity=42.6190476190476, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI261862350, Length=420, Percent_Identity=42.6190476190476, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI261862348, Length=420, Percent_Identity=42.6190476190476, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI19923315, Length=420, Percent_Identity=42.6190476190476, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI261862346, Length=415, Percent_Identity=42.6506024096386, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI22547186, Length=397, Percent_Identity=44.5843828715365, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI22547189, Length=385, Percent_Identity=42.8571428571429, Blast_Score=283, Evalue=3e-76,
Organism=Escherichia coli, GI1788902, Length=408, Percent_Identity=69.1176470588235, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=42.9292929292929, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI25144729, Length=396, Percent_Identity=42.9292929292929, Blast_Score=315, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6319739, Length=406, Percent_Identity=44.3349753694581, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=42.3173803526448, Blast_Score=314, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=42.6767676767677, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=42.6767676767677, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_BLOPB (Q492D5)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278043.1
- ProteinModelPortal:   Q492D5
- SMR:   Q492D5
- STRING:   Q492D5
- GeneID:   3562923
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_556
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   ITHINDD
- BioCyc:   CBLO291272:BPEN_556-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 46393; Mature: 46262

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSICTSYDIELWKIIQQETIRQEEHIELIASENYVSTQVMKAQGSQLTNKYAEGYPGKRY
CCCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCCCCC
YGGCEYVDMIEQLGINRAKELFSADYANIQPHSGSQANFSVYNALLHPGDTILSMHLNHG
CCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCC
GHLTHGSQVNFSGKLYNAVFYGVDENGCINYEKVHHLAVKHRPKMIVGGFSAYSGIINWS
CCCCCCCEECCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHCCCCHH
NLRQIADAVQAYLFIDMAHITGLVAAGIYPNPLPHAHVVTATTHKTLAGPRGGLILASGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHCCCCCCCEEEEECC
NDALYKKLDASVFPGSQGGPLMHVIAAKAIALKEAMDPSFKVYQQKIVQNAKIMVKEFAL
CHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
REFKIISGMTHNHLFLLDLRDKNITGKDASTALERANIIVNKNSIPNDFRSPFITSGIRI
HHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCEEEEECCCCCCHHCCCHHHCCEEE
GTPAITRRNFNENDVRKLSHWICDILNHIDNNEIIFSIKNKVLRICSQYPIYNKSY
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SICTSYDIELWKIIQQETIRQEEHIELIASENYVSTQVMKAQGSQLTNKYAEGYPGKRY
CCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCCCCC
YGGCEYVDMIEQLGINRAKELFSADYANIQPHSGSQANFSVYNALLHPGDTILSMHLNHG
CCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCC
GHLTHGSQVNFSGKLYNAVFYGVDENGCINYEKVHHLAVKHRPKMIVGGFSAYSGIINWS
CCCCCCCEECCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHCCCCHH
NLRQIADAVQAYLFIDMAHITGLVAAGIYPNPLPHAHVVTATTHKTLAGPRGGLILASGG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHCCCCCCCEEEEECC
NDALYKKLDASVFPGSQGGPLMHVIAAKAIALKEAMDPSFKVYQQKIVQNAKIMVKEFAL
CHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
REFKIISGMTHNHLFLLDLRDKNITGKDASTALERANIIVNKNSIPNDFRSPFITSGIRI
HHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCEEEEECCCCCCHHCCCHHHCCEEE
GTPAITRRNFNENDVRKLSHWICDILNHIDNNEIIFSIKNKVLRICSQYPIYNKSY
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA