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The map label for this gene is cysK [H]

Identifier: 71892278

GI number: 71892278

Start: 627934

End: 628881

Strand: Direct

Name: cysK [H]

Synonym: BPEN_525

Alternate gene names: 71892278

Gene position: 627934-628881 (Clockwise)

Preceding gene: 71892275

Following gene: 71892279

Centisome position: 79.32

GC content: 35.23

Gene sequence:

>948_bases
ATGTATAAAATTTATCAAGATAATTCTTACACTATTGGTCATACTCCATTAGTCCGTCTTAATAATATTGGCAATGGTCA
TATTGCTGTTAAAATAGAATCTAGAAATCCTAGCTTTAGCGTTAAATGTCGTATTGGCGCTAATATGATTTGGGATGCAG
AAAAAAGAAACTTATTAAAATTAGATACGAGACTTATAGAAGCAACGAGCGGTAATACTGGAATTGCTCTAGCTTACGTA
GCGGCCGCGCGACATTATAAATTAACGTTAACCATGCCAGAAACCATGAGCGTTGAACGTCTTAAACTAATTAAAGCTCT
AGGAGCCGAAATTATATTGACAGAAGGATGTGATGGAATGAAAGGAGCCATTGCTAAAGCAGAAGAAATTGTTGCTGCTG
ATCCTAAACATTATTTATTATTACAACAATTTAGCAATCCTGCAAATCCAGAAATTCATGAAAAAACCACAGGACCTGAA
ATTTGGAATGACTCGGACGGACAAATAGATGTATTTGTAGCTGGAGTTGGTACAGGAGGTACTATCACCGGAGTTGGACG
ATTTTTCAAACATACCAAAAAAAATAAAAAAATTATTATCGTGGCAGTAGAACCAGAAGAATCTCCAGTCATTACACAGA
CGTTATCAGGTCAAAACATAAAACCAGCACCACATAAAATCCAAGGTATTGGTGCTGGTTTTGTTCCAAAAAATCTCGAC
TTAACTTTAATTGATCATGTAGAAACAGTAACCATAGATGCAGCTGTTAGCTACGCTAAATATTTAATGGAAAAAGAAGG
AATTTTAGCTGGAATTTCTTCAGGCGCCGCATTAGCGGCAGCGGTACAACTACAAAAAAACAAAGCCTATACTGATAAAA
ATATAGTAGTTATACTTCCATCGTCTGGTGAACGATATTTAAGTACTGTATTATTTTCAAAGTTATAA

Upstream 100 bases:

>100_bases
AAAATTTATATTTTTATTTGATCCAGACTATATATAAAAGATATTCTATACCCCAAACCCATCATTATAGTGATGCATAA
CACTTGAGGAATTATTAAAT

Downstream 100 bases:

>100_bases
AAATAAATTTTTATTTTCTATTAACATTCAAAAAATAGAAAACATTCATGTACGATGTTTTCTATATTTATTTTTACATA
AATAAAAACAATTTGTATAT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; Sulfate starvation-induced protein 5; SSI5 [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MYKIYQDNSYTIGHTPLVRLNNIGNGHIAVKIESRNPSFSVKCRIGANMIWDAEKRNLLKLDTRLIEATSGNTGIALAYV
AAARHYKLTLTMPETMSVERLKLIKALGAEIILTEGCDGMKGAIAKAEEIVAADPKHYLLLQQFSNPANPEIHEKTTGPE
IWNDSDGQIDVFVAGVGTGGTITGVGRFFKHTKKNKKIIIVAVEPEESPVITQTLSGQNIKPAPHKIQGIGAGFVPKNLD
LTLIDHVETVTIDAAVSYAKYLMEKEGILAGISSGAALAAAVQLQKNKAYTDKNIVVILPSSGERYLSTVLFSKL

Sequences:

>Translated_315_residues
MYKIYQDNSYTIGHTPLVRLNNIGNGHIAVKIESRNPSFSVKCRIGANMIWDAEKRNLLKLDTRLIEATSGNTGIALAYV
AAARHYKLTLTMPETMSVERLKLIKALGAEIILTEGCDGMKGAIAKAEEIVAADPKHYLLLQQFSNPANPEIHEKTTGPE
IWNDSDGQIDVFVAGVGTGGTITGVGRFFKHTKKNKKIIIVAVEPEESPVITQTLSGQNIKPAPHKIQGIGAGFVPKNLD
LTLIDHVETVTIDAAVSYAKYLMEKEGILAGISSGAALAAAVQLQKNKAYTDKNIVVILPSSGERYLSTVLFSKL
>Mature_315_residues
MYKIYQDNSYTIGHTPLVRLNNIGNGHIAVKIESRNPSFSVKCRIGANMIWDAEKRNLLKLDTRLIEATSGNTGIALAYV
AAARHYKLTLTMPETMSVERLKLIKALGAEIILTEGCDGMKGAIAKAEEIVAADPKHYLLLQQFSNPANPEIHEKTTGPE
IWNDSDGQIDVFVAGVGTGGTITGVGRFFKHTKKNKKIIIVAVEPEESPVITQTLSGQNIKPAPHKIQGIGAGFVPKNLD
LTLIDHVETVTIDAAVSYAKYLMEKEGILAGISSGAALAAAVQLQKNKAYTDKNIVVILPSSGERYLSTVLFSKL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=320, Percent_Identity=37.1875, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI295821200, Length=320, Percent_Identity=37.1875, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4557415, Length=320, Percent_Identity=37.1875, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=73.968253968254, Blast_Score=463, Evalue=1e-132,
Organism=Escherichia coli, GI2367138, Length=307, Percent_Identity=42.3452768729642, Blast_Score=208, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=308, Percent_Identity=51.9480519480519, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17562970, Length=316, Percent_Identity=46.8354430379747, Blast_Score=260, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI32566674, Length=308, Percent_Identity=47.4025974025974, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI115535073, Length=317, Percent_Identity=48.8958990536278, Blast_Score=238, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17561720, Length=316, Percent_Identity=46.2025316455696, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=45.5357142857143, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=37.5, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=34.8242811501597, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17561716, Length=129, Percent_Identity=41.0852713178295, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=36.3057324840764, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=31.044776119403, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=36.0655737704918, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=36.0655737704918, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34107; Mature: 34107

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKIYQDNSYTIGHTPLVRLNNIGNGHIAVKIESRNPSFSVKCRIGANMIWDAEKRNLLK
CEEEEECCCEEECCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCEEEECCCCCEEE
LDTRLIEATSGNTGIALAYVAAARHYKLTLTMPETMSVERLKLIKALGAEIILTEGCDGM
EEEEEEEECCCCCCEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCC
KGAIAKAEEIVAADPKHYLLLQQFSNPANPEIHEKTTGPEIWNDSDGQIDVFVAGVGTGG
HHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
TITGVGRFFKHTKKNKKIIIVAVEPEESPVITQTLSGQNIKPAPHKIQGIGAGFVPKNLD
CHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCC
LTLIDHVETVTIDAAVSYAKYLMEKEGILAGISSGAALAAAVQLQKNKAYTDKNIVVILP
EEEECCEEEEEEHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEECCCCCCCCCEEEEEC
SSGERYLSTVLFSKL
CCCHHHHHHHHHHCC
>Mature Secondary Structure
MYKIYQDNSYTIGHTPLVRLNNIGNGHIAVKIESRNPSFSVKCRIGANMIWDAEKRNLLK
CEEEEECCCEEECCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCEEEECCCCCEEE
LDTRLIEATSGNTGIALAYVAAARHYKLTLTMPETMSVERLKLIKALGAEIILTEGCDGM
EEEEEEEECCCCCCEEEEEEEECCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCC
KGAIAKAEEIVAADPKHYLLLQQFSNPANPEIHEKTTGPEIWNDSDGQIDVFVAGVGTGG
HHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
TITGVGRFFKHTKKNKKIIIVAVEPEESPVITQTLSGQNIKPAPHKIQGIGAGFVPKNLD
CHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCCCC
LTLIDHVETVTIDAAVSYAKYLMEKEGILAGISSGAALAAAVQLQKNKAYTDKNIVVILP
EEEECCEEEEEEHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEECCCCCCCCCEEEEEC
SSGERYLSTVLFSKL
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]