The gene/protein map for NC_007292 is currently unavailable.
Definition Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome.
Accession NC_007292
Length 791,654

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The map label for this gene is pdxB

Identifier: 71892270

GI number: 71892270

Start: 614374

End: 615498

Strand: Reverse

Name: pdxB

Synonym: BPEN_513

Alternate gene names: 71892270

Gene position: 615498-614374 (Counterclockwise)

Preceding gene: 71892271

Following gene: 71892269

Centisome position: 77.75

GC content: 31.64

Gene sequence:

>1125_bases
TTGAGAATTTTGGCTGATAAAAATATACCACATATTTTTAAATTATTTGGTCTACATAACACAGTGACAATTTGTGAAGG
GCGTGGCATTTCTGCTAAAGATGTAAGAGATATTGATATTTTGATAGTACGTTCAGTGACAAAAGTTAATAAACTATTAT
TAGATGATAGTTCTGTAAAATTTGTGGGTACTGCAACCGCTGGAGTTGATCATATTGACCAAAATTATTTAAAAAAATAT
GGAATTAATTTTGTTTATGCTCCAGGAAACAATGCTGTAGCAGTAGTAGAATATGTTTTTTCAGCACTACTTTGGCTGGC
ACAGCGTGGTAGATTCTTTTTGCGTGACAAAATTGTTGGAATTGTGGGAGTAGGACATATTGGTAGTTTGTTGAATGAGA
GATTACGTAACTTCGGTATACATACTTTGTTGTGCGATCCGCCATTAGAAAAAATAAACTCAAGTAAACCTTGGAAGTCT
TTTGAAACATTAGTTGCTGAAGCAGATATTTTAACTTTTCACACTCCTTTAATTTATTATGGAGATTATCCTACATGGCA
TATGGTTGATATTGATGTGTTAGAGGCGTTGCCTTCTAATCGTATTTTAATTAATACTTGCCGAGGTTCTGTAATAGATA
ATAATGCCTTACTAAAAGTTTTAGAAAACGGTAAAAAATTAAACGTGATATTGGATGTATGGGAAACAGAGCCAGAATTA
TCTTTACCTCTTCTATCTTATGCGGATATAGGGACCCCTCATATTGCTGGATACTCTACTGAAAGCAAGACACGCAGCAT
TCTACAAATATATAATGCATATTGTAATTTTTTTAATATTTTTAATGTAATTAATTTATCTGCGTTAGATTCTCCTGTGA
TTTATTATTTAAGAGTTCAGAAAGAAATCGATGAAACGTTGTTACATAAATTAGTTAAATTTGTGTATAACATACAATAT
GATGACGTTATATTAAGACGATTTGCTGCTAAATCAGGAGGATTTGATAAGATACGTAAACACTATTTAGCTCGTAGAGA
GTGGTCTTCATTACGCGTAGAAACATACATAGATTCTAATAATGAAATATTAACTAAGTTGGGTTTTAATGTATGTTGTG
TGTAA

Upstream 100 bases:

>100_bases
ATACTTGTATGATCGGGTATGACGAAATCATGCAATCGTGGTGAGTGGTTATTATGATTATTTTAATCTTTACATATAGT
AATTTGTTTGGAGTGTTAAT

Downstream 100 bases:

>100_bases
AATTATATTTGCATATGTGTTGTATTGCGTCCATGTTTACTAGTTTTTGTATTATAATGTGCATATTGAGTGATTGAGTG
GGTTATAACTGTATTTTTAT

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRILADKNIPHIFKLFGLHNTVTICEGRGISAKDVRDIDILIVRSVTKVNKLLLDDSSVKFVGTATAGVDHIDQNYLKKY
GINFVYAPGNNAVAVVEYVFSALLWLAQRGRFFLRDKIVGIVGVGHIGSLLNERLRNFGIHTLLCDPPLEKINSSKPWKS
FETLVAEADILTFHTPLIYYGDYPTWHMVDIDVLEALPSNRILINTCRGSVIDNNALLKVLENGKKLNVILDVWETEPEL
SLPLLSYADIGTPHIAGYSTESKTRSILQIYNAYCNFFNIFNVINLSALDSPVIYYLRVQKEIDETLLHKLVKFVYNIQY
DDVILRRFAAKSGGFDKIRKHYLARREWSSLRVETYIDSNNEILTKLGFNVCCV

Sequences:

>Translated_374_residues
MRILADKNIPHIFKLFGLHNTVTICEGRGISAKDVRDIDILIVRSVTKVNKLLLDDSSVKFVGTATAGVDHIDQNYLKKY
GINFVYAPGNNAVAVVEYVFSALLWLAQRGRFFLRDKIVGIVGVGHIGSLLNERLRNFGIHTLLCDPPLEKINSSKPWKS
FETLVAEADILTFHTPLIYYGDYPTWHMVDIDVLEALPSNRILINTCRGSVIDNNALLKVLENGKKLNVILDVWETEPEL
SLPLLSYADIGTPHIAGYSTESKTRSILQIYNAYCNFFNIFNVINLSALDSPVIYYLRVQKEIDETLLHKLVKFVYNIQY
DDVILRRFAAKSGGFDKIRKHYLARREWSSLRVETYIDSNNEILTKLGFNVCCV
>Mature_374_residues
MRILADKNIPHIFKLFGLHNTVTICEGRGISAKDVRDIDILIVRSVTKVNKLLLDDSSVKFVGTATAGVDHIDQNYLKKY
GINFVYAPGNNAVAVVEYVFSALLWLAQRGRFFLRDKIVGIVGVGHIGSLLNERLRNFGIHTLLCDPPLEKINSSKPWKS
FETLVAEADILTFHTPLIYYGDYPTWHMVDIDVLEALPSNRILINTCRGSVIDNNALLKVLENGKKLNVILDVWETEPEL
SLPLLSYADIGTPHIAGYSTESKTRSILQIYNAYCNFFNIFNVINLSALDSPVIYYLRVQKEIDETLLHKLVKFVYNIQY
DDVILRRFAAKSGGFDKIRKHYLARREWSSLRVETYIDSNNEILTKLGFNVCCV

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily

Homologues:

Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=26.7361111111111, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=26.3779527559055, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI61743967, Length=280, Percent_Identity=23.2142857142857, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4557497, Length=280, Percent_Identity=23.2142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788660, Length=372, Percent_Identity=49.7311827956989, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=26.0869565217391, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=24.8275862068966, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082289, Length=247, Percent_Identity=27.9352226720648, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=263, Percent_Identity=26.2357414448669, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=31.25, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=290, Percent_Identity=23.7931034482759, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320925, Length=290, Percent_Identity=23.448275862069, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=24.3445692883895, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921140, Length=291, Percent_Identity=26.8041237113402, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI28574286, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28571528, Length=257, Percent_Identity=26.0700389105058, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXB_BLOPB (Q492H2)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278004.1
- ProteinModelPortal:   Q492H2
- SMR:   Q492H2
- STRING:   Q492H2
- GeneID:   3563030
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_513
- eggNOG:   COG0111
- HOGENOM:   HBG289972
- OMA:   SAPGCNA
- ProtClustDB:   CLSK280903
- BioCyc:   CBLO291272:BPEN_513-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01825
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF4

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.290

Molecular weight: Translated: 42475; Mature: 42475

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 208-208 ACT_SITE 237-237 ACT_SITE 254-254 BINDING 45-45 BINDING 66-66 BINDING 146-146 BINDING 175-175 BINDING 232-232 BINDING 257-257 BINDING 258-258

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MRILADKNIPHIFKLFGLHNTVTICEGRGISAKDVRDIDILIVRSVTKVNKLLLDDSSVK
CCEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEE
FVGTATAGVDHIDQNYLKKYGINFVYAPGNNAVAVVEYVFSALLWLAQRGRFFLRDKIVG
EEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEHHEEE
IVGVGHIGSLLNERLRNFGIHTLLCDPPLEKINSSKPWKSFETLVAEADILTFHTPLIYY
EEEHHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCCCHHHHHHHHHHCCEEEEECCEEEE
GDYPTWHMVDIDVLEALPSNRILINTCRGSVIDNNALLKVLENGKKLNVILDVWETEPEL
CCCCCEEEEEHHHHHHCCCCCEEEEECCCCEECCHHHHHHHHCCCEEEEEEEEECCCCCC
SLPLLSYADIGTPHIAGYSTESKTRSILQIYNAYCNFFNIFNVINLSALDSPVIYYLRVQ
CCCEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEH
KEIDETLLHKLVKFVYNIQYDDVILRRFAAKSGGFDKIRKHYLARREWSSLRVETYIDSN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEECCC
NEILTKLGFNVCCV
CCEEECCCCCEECC
>Mature Secondary Structure
MRILADKNIPHIFKLFGLHNTVTICEGRGISAKDVRDIDILIVRSVTKVNKLLLDDSSVK
CCEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEE
FVGTATAGVDHIDQNYLKKYGINFVYAPGNNAVAVVEYVFSALLWLAQRGRFFLRDKIVG
EEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEHHEEE
IVGVGHIGSLLNERLRNFGIHTLLCDPPLEKINSSKPWKSFETLVAEADILTFHTPLIYY
EEEHHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCCCHHHHHHHHHHCCEEEEECCEEEE
GDYPTWHMVDIDVLEALPSNRILINTCRGSVIDNNALLKVLENGKKLNVILDVWETEPEL
CCCCCEEEEEHHHHHHCCCCCEEEEECCCCEECCHHHHHHHHCCCEEEEEEEEECCCCCC
SLPLLSYADIGTPHIAGYSTESKTRSILQIYNAYCNFFNIFNVINLSALDSPVIYYLRVQ
CCCEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEH
KEIDETLLHKLVKFVYNIQYDDVILRRFAAKSGGFDKIRKHYLARREWSSLRVETYIDSN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEECCC
NEILTKLGFNVCCV
CCEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA