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The map label for this gene is serS

Identifier: 71892162

GI number: 71892162

Start: 465241

End: 466527

Strand: Reverse

Name: serS

Synonym: BPEN_395

Alternate gene names: 71892162

Gene position: 466527-465241 (Counterclockwise)

Preceding gene: 71892163

Following gene: 71892161

Centisome position: 58.93

GC content: 33.49

Gene sequence:

>1287_bases
ATGATTGATCCCAATTTATTGCGCAGTAATCTTGATTTAGTTGCTAAAAAGCTTGCTCGCAGAAAGTTTATACTAAATAT
TAATAAATTTCGTCAGCAAGAGAGTTTGCGGAAAATTTTACAAAAGAAAACTGAAAGTTTACAGACTGAACGTAAAGCTA
AGGCTAAAATTATAGGAGTAGCTAAGTCTCGTGGAGAAAATGTAGAGTTTTTATGTCAAGAAGCATATGTTTTAGGAAAA
AAATTAACTTCTCTTAAACTTGAAAATAAAGAATTAAAAAACAGGATTAAACAATTTGAGTTATCTTTGCCGAATATTCC
AGATGATCAAGTGCCTTATGGATTTAGAGATCAAGATAATTTAGAAATTATGCGTTGGGGTAAGCCGGGTCAATATAATT
TTCCAATACGGGATCATGTAGCGTTGGGCGCATTAACTAATGGTTTAGATTTTTCTAATGCAACAAAATTAACTGGATCA
CGTTTTATCGTAATGAAAGGACAAATAGCGCATTTGCATCGCGCTTTGTCTCAATTTATGATAGATTTGCATGTTAAACG
TCATGGATATGAAGAGTATTATTTACCATATTTAGTAAATCAAGACTCTTTATATGGTGCAGGTCAATTACCAAAATTTT
ATGAAGACTTGTTTCATATTCAACACTTACAATCTGGAACTAATCCATACGCATTAATACCTACCGCTGAAGTACCTTTA
ATAAATTTAGTTCGTGATGTAATTCTTGATGAAGAAGAATTACCTATTAAGATGGTTGCTCATACTCCATGTTTCCGTTA
TGAAGCAGGATCATATGGTCATCATACTCGTGGATTAATTAGGATGCATCAATTTGATAAAGTTGAAATGGTTCAAGTAG
TACATCCAGATAAATCCATGCAGATCTTAGAAGAAATAACTAGTCACGCGGAACAAGTATTGCAACTACTTAAATTACCA
TATAGGAAAATATTATTATGCACAGGAAATATTGGATTTTCTTCTTGCAAAACATATGATTTGGAAGTATGGCTTCCAGC
ATATAATGCTTATTGCGAGGTTTCTTCTTGTTCAAATGTTGGAGATTTTCAGGCGCGTCGTATAAGAGCGCGATATAAAG
GAAGAATGAATAGAAAAGCGAGATTATTGCATACTTTAAATGCTTCCGGAGTAGCAATAGGTCGAGCATTGGCAGCGGTG
CTTGAAAATTATCAATTAGAAGATGGACGTGTGGCGATTCCTTCGGTACTATCTCCTTATATGAGTGATATAACACATAT
TAATTGA

Upstream 100 bases:

>100_bases
GAATTTGTTATAATAGTGTAAATTTGTTGTAGTTGTAAAAAAATATATTATTAGTAATAACTAGCATATGATAAAACGAA
TAGAATAGTATAGGTTAGAT

Downstream 100 bases:

>100_bases
ATGTTAATCTTTAAATATAGGTTTTGGATTTAATTAATTGTTATTTATTTTATTAAATAAATAAATGTATTGTATATTTA
TTATGAGTAACTAGATCATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIDPNLLRSNLDLVAKKLARRKFILNINKFRQQESLRKILQKKTESLQTERKAKAKIIGVAKSRGENVEFLCQEAYVLGK
KLTSLKLENKELKNRIKQFELSLPNIPDDQVPYGFRDQDNLEIMRWGKPGQYNFPIRDHVALGALTNGLDFSNATKLTGS
RFIVMKGQIAHLHRALSQFMIDLHVKRHGYEEYYLPYLVNQDSLYGAGQLPKFYEDLFHIQHLQSGTNPYALIPTAEVPL
INLVRDVILDEEELPIKMVAHTPCFRYEAGSYGHHTRGLIRMHQFDKVEMVQVVHPDKSMQILEEITSHAEQVLQLLKLP
YRKILLCTGNIGFSSCKTYDLEVWLPAYNAYCEVSSCSNVGDFQARRIRARYKGRMNRKARLLHTLNASGVAIGRALAAV
LENYQLEDGRVAIPSVLSPYMSDITHIN

Sequences:

>Translated_428_residues
MIDPNLLRSNLDLVAKKLARRKFILNINKFRQQESLRKILQKKTESLQTERKAKAKIIGVAKSRGENVEFLCQEAYVLGK
KLTSLKLENKELKNRIKQFELSLPNIPDDQVPYGFRDQDNLEIMRWGKPGQYNFPIRDHVALGALTNGLDFSNATKLTGS
RFIVMKGQIAHLHRALSQFMIDLHVKRHGYEEYYLPYLVNQDSLYGAGQLPKFYEDLFHIQHLQSGTNPYALIPTAEVPL
INLVRDVILDEEELPIKMVAHTPCFRYEAGSYGHHTRGLIRMHQFDKVEMVQVVHPDKSMQILEEITSHAEQVLQLLKLP
YRKILLCTGNIGFSSCKTYDLEVWLPAYNAYCEVSSCSNVGDFQARRIRARYKGRMNRKARLLHTLNASGVAIGRALAAV
LENYQLEDGRVAIPSVLSPYMSDITHIN
>Mature_428_residues
MIDPNLLRSNLDLVAKKLARRKFILNINKFRQQESLRKILQKKTESLQTERKAKAKIIGVAKSRGENVEFLCQEAYVLGK
KLTSLKLENKELKNRIKQFELSLPNIPDDQVPYGFRDQDNLEIMRWGKPGQYNFPIRDHVALGALTNGLDFSNATKLTGS
RFIVMKGQIAHLHRALSQFMIDLHVKRHGYEEYYLPYLVNQDSLYGAGQLPKFYEDLFHIQHLQSGTNPYALIPTAEVPL
INLVRDVILDEEELPIKMVAHTPCFRYEAGSYGHHTRGLIRMHQFDKVEMVQVVHPDKSMQILEEITSHAEQVLQLLKLP
YRKILLCTGNIGFSSCKTYDLEVWLPAYNAYCEVSSCSNVGDFQARRIRARYKGRMNRKARLLHTLNASGVAIGRALAAV
LENYQLEDGRVAIPSVLSPYMSDITHIN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=374, Percent_Identity=33.9572192513369, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI8923421, Length=394, Percent_Identity=28.4263959390863, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI225579074, Length=325, Percent_Identity=30.7692307692308, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=61.6279069767442, Blast_Score=570, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17539260, Length=296, Percent_Identity=32.7702702702703, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17542084, Length=320, Percent_Identity=28.4375, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=356, Percent_Identity=31.4606741573034, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6321799, Length=345, Percent_Identity=30.7246376811594, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24581334, Length=304, Percent_Identity=34.2105263157895, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17737985, Length=266, Percent_Identity=31.5789473684211, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BLOPB (Q492S4)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277894.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q492S4
- SMR:   Q492S4
- STRING:   Q492S4
- GeneID:   3562760
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_395
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- ProtClustDB:   PRK05431
- BioCyc:   CBLO291272:BPEN_395-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49050; Mature: 49050

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPNLLRSNLDLVAKKLARRKFILNINKFRQQESLRKILQKKTESLQTERKAKAKIIGV
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
AKSRGENVEFLCQEAYVLGKKLTSLKLENKELKNRIKQFELSLPNIPDDQVPYGFRDQDN
HHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
LEIMRWGKPGQYNFPIRDHVALGALTNGLDFSNATKLTGSRFIVMKGQIAHLHRALSQFM
CEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHH
IDLHVKRHGYEEYYLPYLVNQDSLYGAGQLPKFYEDLFHIQHLQSGTNPYALIPTAEVPL
HHHHHHHCCCCCEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHH
INLVRDVILDEEELPIKMVAHTPCFRYEAGSYGHHTRGLIRMHQFDKVEMVQVVHPDKSM
HHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHH
QILEEITSHAEQVLQLLKLPYRKILLCTGNIGFSSCKTYDLEVWLPAYNAYCEVSSCSNV
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCEEEECCCCCC
GDFQARRIRARYKGRMNRKARLLHTLNASGVAIGRALAAVLENYQLEDGRVAIPSVLSPY
CHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHH
MSDITHIN
HHHHCCCC
>Mature Secondary Structure
MIDPNLLRSNLDLVAKKLARRKFILNINKFRQQESLRKILQKKTESLQTERKAKAKIIGV
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
AKSRGENVEFLCQEAYVLGKKLTSLKLENKELKNRIKQFELSLPNIPDDQVPYGFRDQDN
HHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
LEIMRWGKPGQYNFPIRDHVALGALTNGLDFSNATKLTGSRFIVMKGQIAHLHRALSQFM
CEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHH
IDLHVKRHGYEEYYLPYLVNQDSLYGAGQLPKFYEDLFHIQHLQSGTNPYALIPTAEVPL
HHHHHHHCCCCCEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHH
INLVRDVILDEEELPIKMVAHTPCFRYEAGSYGHHTRGLIRMHQFDKVEMVQVVHPDKSM
HHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHH
QILEEITSHAEQVLQLLKLPYRKILLCTGNIGFSSCKTYDLEVWLPAYNAYCEVSSCSNV
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCEEEECCCCCC
GDFQARRIRARYKGRMNRKARLLHTLNASGVAIGRALAAVLENYQLEDGRVAIPSVLSPY
CHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHH
MSDITHIN
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA