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The map label for this gene is fumC [H]

Identifier: 71892151

GI number: 71892151

Start: 450402

End: 451802

Strand: Reverse

Name: fumC [H]

Synonym: BPEN_384

Alternate gene names: 71892151

Gene position: 451802-450402 (Counterclockwise)

Preceding gene: 71892153

Following gene: 71892150

Centisome position: 57.07

GC content: 34.9

Gene sequence:

>1401_bases
ATGGCAATGCGTGTTGAAAAGGATACTATGGGTGCAATTTTAGTACCGACCGATCGATTATGGGGAGCGCAAACACAACG
CGCATTAAAATATTTTAATATTTCTAATGAAAAAATTCCTTTTTCGTTAATTAAAGCATTGGCCCAAATCAAGCTGGCGG
CAGCACAAGTAAATTATGATTTGAAACTGATAGATTGTGAACGGGCTCAAGCAATTATTCAATCAGCAGGTGAAGTACTA
TCTGGAATACATAAGGACGAATTTCCAATATCAGTTTGGCAAACTGGATCTGGAACTCAAAGCAATATGAATATGAATGA
AGTTTTAGCTAATCGAGCTAATAAATTATTAAGCAGTGAACACAATGCGAACGAGAAATTTATTCATCCAAATGATCATG
TCAATAAAAGTCAAAGTTCCAACGATGTTTTCTCTAGCGCAATGCATGTTGCAGCGGTAGTTACTTTAAATGAGCAATTA
ATACCTAAAGTTAAGATGTTAAAAAAAACTTTATTTGATAAATCTGTTAAATTTAATAACATTATTAAAATTGGTCGTAC
TCATCTTCAAGATGCTACTCCATTGACTTTGGGGCAAGAGATTTCTGCTTGGGTATCTATGCTAGAACATAACATAGATC
ATATAGAAGTTACTATACCTCATTTATATGAATTAGCGTTAGGTGGAACAGCAGTAGGGACAGGTCTAAACACTCATCCA
GAATACGCCGGACGTGTTGTTGACGTATTATCATTCCTTACTAAACATAATTTTGTTAGTGCACCAAATAAGTTTGAGTC
GTTATCGACATGTGATGCATTGGTGCACAGTCATGGTTCCTTGAAGGGTTTAGCCGTTTCTATGATGAAAATTGCTAATG
ATGTACGTTTATTATCTTCTGGCCCTAGATGTGGTATAGGCGAATTAAGTATTCCTGAAAATGAACCAGGTAGCTCGATT
ATGCCTGGAAAAGTTAACCCAACGCAATGTGAAGCTATGACTATGTTGTGTTCTCAAATTATGGGAAATGATGTTAGTAT
AAATATTGGAGGTGCATCTGGACATTTTGAATTAAATGTATATAGGCCATTGATTATATATAATTTCTTACAATCGGTAC
GTTTACTGTCAGATGGTATAGAAAGTTTTCATAAATACTGTATTGTAGGGATTCAACCGAATCATGAACGAATTAAAGAA
TTACTTAATAGATCACTTATGTTGGTTACTGCGTTGAGTCCGTATATTGGATATGATAAATCAGCAGAAATTGCTAAGAA
GGCGCATTCGGAAGGGTTAAGTTTAAAGGAAGCTGCGTTACAATTGGGTTATGTTGATGAGCAACAATTTGATTTGTGGG
TTTGCCCAGAAAATATGATTAATTCTTCAGAAGTATTTTAA

Upstream 100 bases:

>100_bases
TGATATCATTGATTTTGTATATATGATACAAACAAATGATCATATTAATGTAATTAATAAAATCAATTAATATTTTATAA
TTAAGTAAGGTGGTATTATT

Downstream 100 bases:

>100_bases
TTATTGCTAAAACTGAATAATATAAGTAGATTGAATAATAGTAAAAGTATTATAAGTATTTTTAATAAAACGTTATGAAA
TAATTAAGTGTTATTAATGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MAMRVEKDTMGAILVPTDRLWGAQTQRALKYFNISNEKIPFSLIKALAQIKLAAAQVNYDLKLIDCERAQAIIQSAGEVL
SGIHKDEFPISVWQTGSGTQSNMNMNEVLANRANKLLSSEHNANEKFIHPNDHVNKSQSSNDVFSSAMHVAAVVTLNEQL
IPKVKMLKKTLFDKSVKFNNIIKIGRTHLQDATPLTLGQEISAWVSMLEHNIDHIEVTIPHLYELALGGTAVGTGLNTHP
EYAGRVVDVLSFLTKHNFVSAPNKFESLSTCDALVHSHGSLKGLAVSMMKIANDVRLLSSGPRCGIGELSIPENEPGSSI
MPGKVNPTQCEAMTMLCSQIMGNDVSINIGGASGHFELNVYRPLIIYNFLQSVRLLSDGIESFHKYCIVGIQPNHERIKE
LLNRSLMLVTALSPYIGYDKSAEIAKKAHSEGLSLKEAALQLGYVDEQQFDLWVCPENMINSSEVF

Sequences:

>Translated_466_residues
MAMRVEKDTMGAILVPTDRLWGAQTQRALKYFNISNEKIPFSLIKALAQIKLAAAQVNYDLKLIDCERAQAIIQSAGEVL
SGIHKDEFPISVWQTGSGTQSNMNMNEVLANRANKLLSSEHNANEKFIHPNDHVNKSQSSNDVFSSAMHVAAVVTLNEQL
IPKVKMLKKTLFDKSVKFNNIIKIGRTHLQDATPLTLGQEISAWVSMLEHNIDHIEVTIPHLYELALGGTAVGTGLNTHP
EYAGRVVDVLSFLTKHNFVSAPNKFESLSTCDALVHSHGSLKGLAVSMMKIANDVRLLSSGPRCGIGELSIPENEPGSSI
MPGKVNPTQCEAMTMLCSQIMGNDVSINIGGASGHFELNVYRPLIIYNFLQSVRLLSDGIESFHKYCIVGIQPNHERIKE
LLNRSLMLVTALSPYIGYDKSAEIAKKAHSEGLSLKEAALQLGYVDEQQFDLWVCPENMINSSEVF
>Mature_465_residues
AMRVEKDTMGAILVPTDRLWGAQTQRALKYFNISNEKIPFSLIKALAQIKLAAAQVNYDLKLIDCERAQAIIQSAGEVLS
GIHKDEFPISVWQTGSGTQSNMNMNEVLANRANKLLSSEHNANEKFIHPNDHVNKSQSSNDVFSSAMHVAAVVTLNEQLI
PKVKMLKKTLFDKSVKFNNIIKIGRTHLQDATPLTLGQEISAWVSMLEHNIDHIEVTIPHLYELALGGTAVGTGLNTHPE
YAGRVVDVLSFLTKHNFVSAPNKFESLSTCDALVHSHGSLKGLAVSMMKIANDVRLLSSGPRCGIGELSIPENEPGSSIM
PGKVNPTQCEAMTMLCSQIMGNDVSINIGGASGHFELNVYRPLIIYNFLQSVRLLSDGIESFHKYCIVGIQPNHERIKEL
LNRSLMLVTALSPYIGYDKSAEIAKKAHSEGLSLKEAALQLGYVDEQQFDLWVCPENMINSSEVF

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=55.3145336225597, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=50.7936507936508, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=71.304347826087, Blast_Score=680, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=465, Percent_Identity=39.3548387096774, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=55.2173913043478, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=58.3333333333333, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=52.060737527115, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=55.3145336225597, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=55.3145336225597, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=55.3145336225597, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=54.3103448275862, Blast_Score=507, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=48.1561822125813, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51309; Mature: 51177

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMRVEKDTMGAILVPTDRLWGAQTQRALKYFNISNEKIPFSLIKALAQIKLAAAQVNYD
CCEEECCCCCCEEEECCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LKLIDCERAQAIIQSAGEVLSGIHKDEFPISVWQTGSGTQSNMNMNEVLANRANKLLSSE
EEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
HNANEKFIHPNDHVNKSQSSNDVFSSAMHVAAVVTLNEQLIPKVKMLKKTLFDKSVKFNN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCHHH
IIKIGRTHLQDATPLTLGQEISAWVSMLEHNIDHIEVTIPHLYELALGGTAVGTGLNTHP
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCH
EYAGRVVDVLSFLTKHNFVSAPNKFESLSTCDALVHSHGSLKGLAVSMMKIANDVRLLSS
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
GPRCGIGELSIPENEPGSSIMPGKVNPTQCEAMTMLCSQIMGNDVSINIGGASGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEE
YRPLIIYNFLQSVRLLSDGIESFHKYCIVGIQPNHERIKELLNRSLMLVTALSPYIGYDK
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCEEEEHHHHHHHCCCC
SAEIAKKAHSEGLSLKEAALQLGYVDEQQFDLWVCPENMINSSEVF
CHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEECCHHHCCCCCCC
>Mature Secondary Structure 
AMRVEKDTMGAILVPTDRLWGAQTQRALKYFNISNEKIPFSLIKALAQIKLAAAQVNYD
CEEECCCCCCEEEECCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
LKLIDCERAQAIIQSAGEVLSGIHKDEFPISVWQTGSGTQSNMNMNEVLANRANKLLSSE
EEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
HNANEKFIHPNDHVNKSQSSNDVFSSAMHVAAVVTLNEQLIPKVKMLKKTLFDKSVKFNN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCHHH
IIKIGRTHLQDATPLTLGQEISAWVSMLEHNIDHIEVTIPHLYELALGGTAVGTGLNTHP
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCH
EYAGRVVDVLSFLTKHNFVSAPNKFESLSTCDALVHSHGSLKGLAVSMMKIANDVRLLSS
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
GPRCGIGELSIPENEPGSSIMPGKVNPTQCEAMTMLCSQIMGNDVSINIGGASGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEE
YRPLIIYNFLQSVRLLSDGIESFHKYCIVGIQPNHERIKELLNRSLMLVTALSPYIGYDK
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCEEEEHHHHHHHCCCC
SAEIAKKAHSEGLSLKEAALQLGYVDEQQFDLWVCPENMINSSEVF
CHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEECCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]