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The map label for this gene is sdhA [H]

Identifier: 71892107

GI number: 71892107

Start: 400090

End: 401874

Strand: Direct

Name: sdhA [H]

Synonym: BPEN_339

Alternate gene names: 71892107

Gene position: 400090-401874 (Clockwise)

Preceding gene: 71892106

Following gene: 71892108

Centisome position: 50.54

GC content: 37.82

Gene sequence:

>1785_bases
ATGCATCAGATACCAGTTAAAGAATTTTTTTCTATTGTCATAGGAGCTGGCGGCGCGGGTATGCGCGTTGCATTACAAGT
TTCTAAAATGGGGTTTTCTTGTGCCTTAATATCTAAAGTCTTTCCTACACGTTCACATACAGTATCTGCTCAAGGAGGAA
TTACGGTTGCTCTCGGTAATAATCACGAAGATGATTGGCAGTGGCACATGTATGATACTGTAAAAGGATCTGATTACATA
GGAGACCAAAATGCTATTGAATATATGTGTAAAACAGGACCGAAAGCAGTTCTGGAGTTAGAACATATGGGGTTACCATT
TTCTAGACTAAAAAATGGTCGTATTTACCAACGTCCATTTGGAGGACAAACTTTATATTATGGAAAAAAACAAGCAGCAC
GTACTGCTGCAGCTGCTGATCGTACCGGACATGCGCTATTACATACATTGTATCAACAAAACTTGAAGAACAAAACAACC
ATATTTTCAGAATGGTACGCATTAGATTTAGTAAAAAATCAAGATGGAAGAATACTTGGTTGTGTTGCTTTTTCTATTGA
AACAGGAGAATTAGCATATTTTAAAGCACGTGCTACAGTACTTGCAACTGGAGGAGGAGGACGTATTTATCAATCTACCA
CCAATGCCCATATCAACACAGGGGATGGAATTGGCATGGTGTTGCGAGCAGGTATTCCTGCTCAAGATATGGAAATGTGG
CAATTTCATCCCACTGGTATAGCTGGTGTCGGGATCTTAGTAAGTGAAGGATGTCGTGGTGAAGGAGGATATCTTTTAAA
TATTGCAGGAGAAAGATTTATGGAGCGTTATGCTCCTAATGCAAAAGATTTAGCCGGACGCGACGTGGTAGCTCGGGCAA
TTATGTTGGAAATTCAAGAAGGTCGAGGTTATTCAGGTACATGCGGTCCTCATGTTAAATTAAAAATAGATCATTTGGGA
AAAGAATTATTAGAATTACGTTTACCTGGTATCTTGGAATTAGTGCGTACTTTTTCTTATATAGATCCCGTAAAAGAATT
AATTCCAGTATTTCCTACCTGTCATTATATGATGGGTGGTATTCCTACAACAGTGCGCGGAGAAGTAATTACTGTAAACA
ATGCGGGTACAGATACGATAGTACCAGGTTTATTTGCAGTTGGAGAAACTGCTTGTGTATCAGTACACGGGGCTAATCGA
CTAGGTGGAAATTCTTTATTAGATTTAATCGTATTCGGACATGCTACAGGAACATATATACAAGCGTATTTATCAGAAGA
AGAATGGCCGGCTCGCGGACCTACCGATTCTGATATAGAACGATCATTAGCTCGTTATATTCGTTGGAATAATAATAATA
ATAAATCGGGTGCAACAGAAAATCCAGTAACAATACGCCAAGATTTGCAGTCGTGTATGCAAAACAATTTCTCTGTTTTC
AGAGAAGAGCAAAAAATGCTGAAAGGATTACAAGAACTAAAAGAAATACGTAATCGATTAAACTGCGCGGTTTTATCAGA
TAAATCTTATACATTCAACACACAACGTGTTGAATGCTTAGAATTAGATAATTTATTAGAAACTGCTTATGTAACTGCTA
TGGCTGCTATTTTTAGAACCGAAAGCAGAGGAGCCCATAGTCGTTATGATTTTCCTATGCGCGATGATAAACATTGGTTG
TGTCATACGTTATATTTACCAAAAAATGATATTATGATTCGTCGTAATGTGAATATGCAACCAAAATTTCGTTCTCCTTT
TCCTCCGAAAACTCGTGTTTATTAA

Upstream 100 bases:

>100_bases
TATAACATTACCTGTGCTAAGGCAGTTAGGAGTATGGATAACCGGTTCTATATTGTTCGCATACTTATTTTTTGGGATGA
TTATCATTTGGAGTGTATAG

Downstream 100 bases:

>100_bases
AAAATGGAGTTTAAATATGCAAATTAAATTTTCCATTTACCGTTATCATCCTGAAATTAGTAAAAATGCCTGCATGAAAA
ATTATACACTTAATTTATTA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MHQIPVKEFFSIVIGAGGAGMRVALQVSKMGFSCALISKVFPTRSHTVSAQGGITVALGNNHEDDWQWHMYDTVKGSDYI
GDQNAIEYMCKTGPKAVLELEHMGLPFSRLKNGRIYQRPFGGQTLYYGKKQAARTAAAADRTGHALLHTLYQQNLKNKTT
IFSEWYALDLVKNQDGRILGCVAFSIETGELAYFKARATVLATGGGGRIYQSTTNAHINTGDGIGMVLRAGIPAQDMEMW
QFHPTGIAGVGILVSEGCRGEGGYLLNIAGERFMERYAPNAKDLAGRDVVARAIMLEIQEGRGYSGTCGPHVKLKIDHLG
KELLELRLPGILELVRTFSYIDPVKELIPVFPTCHYMMGGIPTTVRGEVITVNNAGTDTIVPGLFAVGETACVSVHGANR
LGGNSLLDLIVFGHATGTYIQAYLSEEEWPARGPTDSDIERSLARYIRWNNNNNKSGATENPVTIRQDLQSCMQNNFSVF
REEQKMLKGLQELKEIRNRLNCAVLSDKSYTFNTQRVECLELDNLLETAYVTAMAAIFRTESRGAHSRYDFPMRDDKHWL
CHTLYLPKNDIMIRRNVNMQPKFRSPFPPKTRVY

Sequences:

>Translated_594_residues
MHQIPVKEFFSIVIGAGGAGMRVALQVSKMGFSCALISKVFPTRSHTVSAQGGITVALGNNHEDDWQWHMYDTVKGSDYI
GDQNAIEYMCKTGPKAVLELEHMGLPFSRLKNGRIYQRPFGGQTLYYGKKQAARTAAAADRTGHALLHTLYQQNLKNKTT
IFSEWYALDLVKNQDGRILGCVAFSIETGELAYFKARATVLATGGGGRIYQSTTNAHINTGDGIGMVLRAGIPAQDMEMW
QFHPTGIAGVGILVSEGCRGEGGYLLNIAGERFMERYAPNAKDLAGRDVVARAIMLEIQEGRGYSGTCGPHVKLKIDHLG
KELLELRLPGILELVRTFSYIDPVKELIPVFPTCHYMMGGIPTTVRGEVITVNNAGTDTIVPGLFAVGETACVSVHGANR
LGGNSLLDLIVFGHATGTYIQAYLSEEEWPARGPTDSDIERSLARYIRWNNNNNKSGATENPVTIRQDLQSCMQNNFSVF
REEQKMLKGLQELKEIRNRLNCAVLSDKSYTFNTQRVECLELDNLLETAYVTAMAAIFRTESRGAHSRYDFPMRDDKHWL
CHTLYLPKNDIMIRRNVNMQPKFRSPFPPKTRVY
>Mature_594_residues
MHQIPVKEFFSIVIGAGGAGMRVALQVSKMGFSCALISKVFPTRSHTVSAQGGITVALGNNHEDDWQWHMYDTVKGSDYI
GDQNAIEYMCKTGPKAVLELEHMGLPFSRLKNGRIYQRPFGGQTLYYGKKQAARTAAAADRTGHALLHTLYQQNLKNKTT
IFSEWYALDLVKNQDGRILGCVAFSIETGELAYFKARATVLATGGGGRIYQSTTNAHINTGDGIGMVLRAGIPAQDMEMW
QFHPTGIAGVGILVSEGCRGEGGYLLNIAGERFMERYAPNAKDLAGRDVVARAIMLEIQEGRGYSGTCGPHVKLKIDHLG
KELLELRLPGILELVRTFSYIDPVKELIPVFPTCHYMMGGIPTTVRGEVITVNNAGTDTIVPGLFAVGETACVSVHGANR
LGGNSLLDLIVFGHATGTYIQAYLSEEEWPARGPTDSDIERSLARYIRWNNNNNKSGATENPVTIRQDLQSCMQNNFSVF
REEQKMLKGLQELKEIRNRLNCAVLSDKSYTFNTQRVECLELDNLLETAYVTAMAAIFRTESRGAHSRYDFPMRDDKHWL
CHTLYLPKNDIMIRRNVNMQPKFRSPFPPKTRVY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=560, Percent_Identity=49.4642857142857, Blast_Score=518, Evalue=1e-147,
Organism=Escherichia coli, GI1786942, Length=592, Percent_Identity=74.3243243243243, Blast_Score=882, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=39.6521739130435, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1788928, Length=571, Percent_Identity=29.0718038528897, Blast_Score=195, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17505833, Length=537, Percent_Identity=50.4655493482309, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17550100, Length=532, Percent_Identity=49.4360902255639, Blast_Score=498, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=51.0887772194305, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=51.2562814070352, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6320788, Length=485, Percent_Identity=27.2164948453608, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137288, Length=618, Percent_Identity=49.8381877022654, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24655642, Length=618, Percent_Identity=49.8381877022654, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24655647, Length=618, Percent_Identity=49.8381877022654, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24663005, Length=623, Percent_Identity=46.3884430176565, Blast_Score=513, Evalue=1e-145,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66035; Mature: 66035

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQIPVKEFFSIVIGAGGAGMRVALQVSKMGFSCALISKVFPTRSHTVSAQGGITVALGN
CCCCCHHHHHHHEECCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCEEECCCCEEEEECC
NHEDDWQWHMYDTVKGSDYIGDQNAIEYMCKTGPKAVLELEHMGLPFSRLKNGRIYQRPF
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHHEEEHHHCCCCHHHHCCCEEEECCC
GGQTLYYGKKQAARTAAAADRTGHALLHTLYQQNLKNKTTIFSEWYALDLVKNQDGRILG
CCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCEEE
CVAFSIETGELAYFKARATVLATGGGGRIYQSTTNAHINTGDGIGMVLRAGIPAQDMEMW
EEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCHHE
QFHPTGIAGVGILVSEGCRGEGGYLLNIAGERFMERYAPNAKDLAGRDVVARAIMLEIQE
EECCCCCCEEEEEEECCCCCCCCEEEEECHHHHHHHHCCCCHHHCCHHHHHHHHHEEEEC
GRGYSGTCGPHVKLKIDHLGKELLELRLPGILELVRTFSYIDPVKELIPVFPTCHYMMGG
CCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
IPTTVRGEVITVNNAGTDTIVPGLFAVGETACVSVHGANRLGGNSLLDLIVFGHATGTYI
CCCCCCCCEEEECCCCCCHHHCHHHHCCCEEEEEEECCCCCCCHHHEEEEEECCCCCHHH
QAYLSEEEWPARGPTDSDIERSLARYIRWNNNNNKSGATENPVTIRQDLQSCMQNNFSVF
HEEECCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHH
REEQKMLKGLQELKEIRNRLNCAVLSDKSYTFNTQRVECLELDNLLETAYVTAMAAIFRT
HHHHHHHHHHHHHHHHHHHCCEEEECCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHHHC
ESRGAHSRYDFPMRDDKHWLCHTLYLPKNDIMIRRNVNMQPKFRSPFPPKTRVY
CCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHQIPVKEFFSIVIGAGGAGMRVALQVSKMGFSCALISKVFPTRSHTVSAQGGITVALGN
CCCCCHHHHHHHEECCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCEEECCCCEEEEECC
NHEDDWQWHMYDTVKGSDYIGDQNAIEYMCKTGPKAVLELEHMGLPFSRLKNGRIYQRPF
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCHHEEEHHHCCCCHHHHCCCEEEECCC
GGQTLYYGKKQAARTAAAADRTGHALLHTLYQQNLKNKTTIFSEWYALDLVKNQDGRILG
CCCEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCEEE
CVAFSIETGELAYFKARATVLATGGGGRIYQSTTNAHINTGDGIGMVLRAGIPAQDMEMW
EEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCHHE
QFHPTGIAGVGILVSEGCRGEGGYLLNIAGERFMERYAPNAKDLAGRDVVARAIMLEIQE
EECCCCCCEEEEEEECCCCCCCCEEEEECHHHHHHHHCCCCHHHCCHHHHHHHHHEEEEC
GRGYSGTCGPHVKLKIDHLGKELLELRLPGILELVRTFSYIDPVKELIPVFPTCHYMMGG
CCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
IPTTVRGEVITVNNAGTDTIVPGLFAVGETACVSVHGANRLGGNSLLDLIVFGHATGTYI
CCCCCCCCEEEECCCCCCHHHCHHHHCCCEEEEEEECCCCCCCHHHEEEEEECCCCCHHH
QAYLSEEEWPARGPTDSDIERSLARYIRWNNNNNKSGATENPVTIRQDLQSCMQNNFSVF
HEEECCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHH
REEQKMLKGLQELKEIRNRLNCAVLSDKSYTFNTQRVECLELDNLLETAYVTAMAAIFRT
HHHHHHHHHHHHHHHHHHHCCEEEECCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHHHC
ESRGAHSRYDFPMRDDKHWLCHTLYLPKNDIMIRRNVNMQPKFRSPFPPKTRVY
CCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]