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The map label for this gene is fmt

Identifier: 71892001

GI number: 71892001

Start: 256879

End: 257847

Strand: Reverse

Name: fmt

Synonym: BPEN_225

Alternate gene names: 71892001

Gene position: 257847-256879 (Counterclockwise)

Preceding gene: 71892002

Following gene: 71891972

Centisome position: 32.57

GC content: 33.54

Gene sequence:

>969_bases
ATGGTACACTCAAAATCATTGCGTATTGCTTTTTTTGGAACTACAAGTTTTGCAGCGTGGCATTTACATACACTGGCTCA
CTTATCTACGCATCAGATAATAGCAGTGTTTACTCAAGAGATACAGATATCCACATGTAAATCCTTTTTATCTTTACATA
AAATAGCGAAAAAATATAATATATCATTATTCCAGTCTCGTACTTTATCTATTTCTGATATTATTTATATTATTAAAAAA
ATTAACGTGGATTTGATAGTAGTTGTATCTTATGGATTAATTTTACCGCAAGAAATATTAAATATACCACGACTAGGCTG
TATTAATGTACATGGTTCATTATTGCCTCGTTGGCGCGGACCAGCACCCATTCAACGTGCATTAGAATATGGTGACTCCA
TTACAGGAATAACCATTATTCAAATGGATTTAGGAATAGATACTGGAGATATTTTGCATATTATGCCTTGCAAAATTTTT
CCAAAAGACACTAGTTGCACTCTTTCTAATAGATTAGTGAATATTGGATCTGCCATGTTATCCCAAGTACTGGATCAGTT
TATATTGGGTACATTTACTTTGATACCTCAAGACTCAACTTATGCTACATATGCGCATAAATTAAATAAACAAGAAGCAC
GTATCAATTGGAATTTATCAGCAATCCAATTGGAACGATGTATCCGAGCTTTTAATCCATGGCCAATTAGTTTTTTTCAA
ATAAAAAATGACCGCATTAGAGTATGGGATGCCGAAGTAAGCAATCAAAACATCAATAACTACTCGTCGTCGACATCTAT
ATTACCTGGTACCATACTAGCAGCTCATCCAAACGGTATTTATGTTGTCACTGGTTCTGGAATATTAATACTTACTATGT
TACAAATTTCAGGAAAAAAAATAACATCTGTGCGCGATCTTCTCAATGCATACAAAGAATGGTTCAAACCTAACTCTGTG
TTAGAGTAG

Upstream 100 bases:

>100_bases
GATCATTTGTCTCCATTAAAAATTAAAAAAATTCATAAGAAAATAAAAAAATTATCTAAAACATTTAAAAAGAATCAATT
TCCTCTTTGATATATATATT

Downstream 100 bases:

>100_bases
CAAGATCGAGATATGTTTGTATTCATTACTAAACTTAATTATATATCTCTATATTATTTTTTATATTTTTTGTTTTATTT
TAGATCGTTCCACTAGTTCT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MVHSKSLRIAFFGTTSFAAWHLHTLAHLSTHQIIAVFTQEIQISTCKSFLSLHKIAKKYNISLFQSRTLSISDIIYIIKK
INVDLIVVVSYGLILPQEILNIPRLGCINVHGSLLPRWRGPAPIQRALEYGDSITGITIIQMDLGIDTGDILHIMPCKIF
PKDTSCTLSNRLVNIGSAMLSQVLDQFILGTFTLIPQDSTYATYAHKLNKQEARINWNLSAIQLERCIRAFNPWPISFFQ
IKNDRIRVWDAEVSNQNINNYSSSTSILPGTILAAHPNGIYVVTGSGILILTMLQISGKKITSVRDLLNAYKEWFKPNSV
LE

Sequences:

>Translated_322_residues
MVHSKSLRIAFFGTTSFAAWHLHTLAHLSTHQIIAVFTQEIQISTCKSFLSLHKIAKKYNISLFQSRTLSISDIIYIIKK
INVDLIVVVSYGLILPQEILNIPRLGCINVHGSLLPRWRGPAPIQRALEYGDSITGITIIQMDLGIDTGDILHIMPCKIF
PKDTSCTLSNRLVNIGSAMLSQVLDQFILGTFTLIPQDSTYATYAHKLNKQEARINWNLSAIQLERCIRAFNPWPISFFQ
IKNDRIRVWDAEVSNQNINNYSSSTSILPGTILAAHPNGIYVVTGSGILILTMLQISGKKITSVRDLLNAYKEWFKPNSV
LE
>Mature_322_residues
MVHSKSLRIAFFGTTSFAAWHLHTLAHLSTHQIIAVFTQEIQISTCKSFLSLHKIAKKYNISLFQSRTLSISDIIYIIKK
INVDLIVVVSYGLILPQEILNIPRLGCINVHGSLLPRWRGPAPIQRALEYGDSITGITIIQMDLGIDTGDILHIMPCKIF
PKDTSCTLSNRLVNIGSAMLSQVLDQFILGTFTLIPQDSTYATYAHKLNKQEARINWNLSAIQLERCIRAFNPWPISFFQ
IKNDRIRVWDAEVSNQNINNYSSSTSILPGTILAAHPNGIYVVTGSGILILTMLQISGKKITSVRDLLNAYKEWFKPNSV
LE

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=293, Percent_Identity=28.6689419795222, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI238814322, Length=308, Percent_Identity=26.2987012987013, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI164663775, Length=319, Percent_Identity=28.5266457680251, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1789683, Length=321, Percent_Identity=48.5981308411215, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1788589, Length=275, Percent_Identity=26.1818181818182, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI133930964, Length=281, Percent_Identity=24.1992882562278, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550868, Length=314, Percent_Identity=28.343949044586, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28571984, Length=237, Percent_Identity=30.8016877637131, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585660, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_BLOPB (Q493I2)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277731.1
- ProteinModelPortal:   Q493I2
- SMR:   Q493I2
- STRING:   Q493I2
- GeneID:   3562860
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_225
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   TYILENH
- ProtClustDB:   CLSK280743
- BioCyc:   CBLO291272:BPEN_225-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 36149; Mature: 36149

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHSKSLRIAFFGTTSFAAWHLHTLAHLSTHQIIAVFTQEIQISTCKSFLSLHKIAKKYN
CCCCCEEEEEEEECCCHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHC
ISLFQSRTLSISDIIYIIKKINVDLIVVVSYGLILPQEILNIPRLGCINVHGSLLPRWRG
CEEEECCCCCHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHCCCCCEEEECCCCCCCCCCC
PAPIQRALEYGDSITGITIIQMDLGIDTGDILHIMPCKIFPKDTSCTLSNRLVNIGSAML
CHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECEECCCCCCCCHHHHHHHHHHHHH
SQVLDQFILGTFTLIPQDSTYATYAHKLNKQEARINWNLSAIQLERCIRAFNPWPISFFQ
HHHHHHHHHHHEEEEECCCCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEE
IKNDRIRVWDAEVSNQNINNYSSSTSILPGTILAAHPNGIYVVTGSGILILTMLQISGKK
EECCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEEEHHCCCH
ITSVRDLLNAYKEWFKPNSVLE
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVHSKSLRIAFFGTTSFAAWHLHTLAHLSTHQIIAVFTQEIQISTCKSFLSLHKIAKKYN
CCCCCEEEEEEEECCCHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHC
ISLFQSRTLSISDIIYIIKKINVDLIVVVSYGLILPQEILNIPRLGCINVHGSLLPRWRG
CEEEECCCCCHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHCCCCCEEEECCCCCCCCCCC
PAPIQRALEYGDSITGITIIQMDLGIDTGDILHIMPCKIFPKDTSCTLSNRLVNIGSAML
CHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECEECCCCCCCCHHHHHHHHHHHHH
SQVLDQFILGTFTLIPQDSTYATYAHKLNKQEARINWNLSAIQLERCIRAFNPWPISFFQ
HHHHHHHHHHHEEEEECCCCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEE
IKNDRIRVWDAEVSNQNINNYSSSTSILPGTILAAHPNGIYVVTGSGILILTMLQISGKK
EECCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEEEHHCCCH
ITSVRDLLNAYKEWFKPNSVLE
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA