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The map label for this gene is zwf [H]

Identifier: 68536071

GI number: 68536071

Start: 1175527

End: 1177089

Strand: Direct

Name: zwf [H]

Synonym: jk0994

Alternate gene names: 68536071

Gene position: 1175527-1177089 (Clockwise)

Preceding gene: 68536070

Following gene: 68536072

Centisome position: 47.74

GC content: 65.07

Gene sequence:

>1563_bases
GTGCAACTTCCCTTTTCCGCCGAGGAATGGCGCAACCCGCTGCGCGACGAATTGGATAAGCGCCTGCCGCGCATTGCCGG
TCCCTGCGGCCTGGTGATCTTCGGCGTAACCGGCGACCTGGCGCGCAAGAAGCTGCTACCCGCCGTGTACGACCTAGCTA
ACCGTGGACTGCTGCCGCCCGGCTTCAGCCTGGTCGGCTACGGCCGCCGCGACTGGTCGAAGGAGCAGTTCGAGGAGCAG
GTTCTGGAGTGCGTCAAGGAGCACGCGCGTACCCCGTGGCGCCAAAACGTGTGGGATCGCCTCGCCGAGGGTATCTTCTT
CGTCACCGGCGACTTCACCACTGATTCTGCTTTTGACGCCCTCGCGGAGAAAACCCGGGAGATCGACAACGAACGCGGTA
CCGCAGGCAACTGGGCTTATTACCTGTCCGTCCCGCCGGATCACTTCCCTAGCGTGTGCCACCAACTCGAGCGCTCTGGG
CTGGCGAAGGCGGACCCGGAACTGGGCGAGCTGCACAACGGCTGGCGCCGCGTGGTTATCGAGAAGCCCTTCGGCCACGA
CGAGCAGTCGGCGCACGAACTCAATGAGATCGTGAACAGCGTGTTCCCGGAATCTAGTGTGTTCCGCATCGACCACTACC
TGGGCAAGGAGACGGTGCAGAACATCCTGGCGCTGCGCTTCGCCAACCAGCTGTTCGACCCGATGTTCAACGCCCACTAC
GTGGACCACGTGCAGATCACCATGGCCGAGGACATCGGCCTGGGCGGACGTGCGGGTTACTACGACGGCATCGGCGCCGC
CCGCGACGTGATCCAGAACCACCTGCTGCAGCTGCTGGCTTTGATCGCCATGGAGGAGCCGGTGACGTTCAACCCGGAGG
AGCTGCAGGCGGAAAAGGTGAAGGTGCTGCGCGCAACAACCCCGGTCGGGCCTTTCGCGCAGACTACGGCGCGCGGACAG
TACACCTCCGGCTGGCAGGGTTCGATTCCGGTGAAGGGGCTGCGCCAAGAGGACGGCTTCGACCCGGAGTCCACCACGGA
AACCTACGCCGCGGCTACCTTCGAGATCTCCTCCCGCCGCTGGGCCGGGGTGCCGTTCTACCTGCGCACCGGCAAGCGCC
TGGGGCGCCGTGTAACGGAGATCGCTATCGTGTTCAAGGAGGCTCCGCACCTGCCGTTCGGTCCGGGACAGACCACCGCC
CAGGGCAATAACATGCTGGTCATCCGCGTGCAGCCCGAGGAGGGCGTGCTGGTGCGCTTTGGGTCTAAGGTTCCGGGCTC
GGCCATGGAGGTCCGCGACGTGAACATGGACTTCAGCTACTCCGAGTCCTTTACCGAGGAATCCCCCGAGGCCTACGAGC
GCCTGATCCTGGATGCCCTGTTGGACGAGGCGAGCCTGTTCCCCACCAACGAGGAAGTGGAGCTGTCCTGGAAGATCCTG
GATCCGATCCTGGATCACTGGGCCCTCCACGGGCGCCCGGAAGACTACCCCGCCGGCACGTGGGGGCCGAAGGGCGCCGA
AGAGATCCTGTCCCGGTCCGGGCGGCAGTGGCGTCGCCCCTAA

Upstream 100 bases:

>100_bases
AGCTGTTGGACACCCTTTCCGCGCAGCTAGAAGCCAAGTAGCTCAATCAGCTCGAGCGGCACTCATCCCCACCGACTAAA
GAAAATAGGACTTTAGACAA

Downstream 100 bases:

>100_bases
AGCCGCCGTTCGTTCCTTCCCCACCTACCCCTCCGACCGCGCGAGGAGCGCTCACTAAACGCCCATGATCATCGACTTAC
CGAACACCAAGACTAAAGAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQLPFSAEEWRNPLRDELDKRLPRIAGPCGLVIFGVTGDLARKKLLPAVYDLANRGLLPPGFSLVGYGRRDWSKEQFEEQ
VLECVKEHARTPWRQNVWDRLAEGIFFVTGDFTTDSAFDALAEKTREIDNERGTAGNWAYYLSVPPDHFPSVCHQLERSG
LAKADPELGELHNGWRRVVIEKPFGHDEQSAHELNEIVNSVFPESSVFRIDHYLGKETVQNILALRFANQLFDPMFNAHY
VDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALIAMEEPVTFNPEELQAEKVKVLRATTPVGPFAQTTARGQ
YTSGWQGSIPVKGLRQEDGFDPESTTETYAAATFEISSRRWAGVPFYLRTGKRLGRRVTEIAIVFKEAPHLPFGPGQTTA
QGNNMLVIRVQPEEGVLVRFGSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDEASLFPTNEEVELSWKIL
DPILDHWALHGRPEDYPAGTWGPKGAEEILSRSGRQWRRP

Sequences:

>Translated_520_residues
MQLPFSAEEWRNPLRDELDKRLPRIAGPCGLVIFGVTGDLARKKLLPAVYDLANRGLLPPGFSLVGYGRRDWSKEQFEEQ
VLECVKEHARTPWRQNVWDRLAEGIFFVTGDFTTDSAFDALAEKTREIDNERGTAGNWAYYLSVPPDHFPSVCHQLERSG
LAKADPELGELHNGWRRVVIEKPFGHDEQSAHELNEIVNSVFPESSVFRIDHYLGKETVQNILALRFANQLFDPMFNAHY
VDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALIAMEEPVTFNPEELQAEKVKVLRATTPVGPFAQTTARGQ
YTSGWQGSIPVKGLRQEDGFDPESTTETYAAATFEISSRRWAGVPFYLRTGKRLGRRVTEIAIVFKEAPHLPFGPGQTTA
QGNNMLVIRVQPEEGVLVRFGSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDEASLFPTNEEVELSWKIL
DPILDHWALHGRPEDYPAGTWGPKGAEEILSRSGRQWRRP
>Mature_520_residues
MQLPFSAEEWRNPLRDELDKRLPRIAGPCGLVIFGVTGDLARKKLLPAVYDLANRGLLPPGFSLVGYGRRDWSKEQFEEQ
VLECVKEHARTPWRQNVWDRLAEGIFFVTGDFTTDSAFDALAEKTREIDNERGTAGNWAYYLSVPPDHFPSVCHQLERSG
LAKADPELGELHNGWRRVVIEKPFGHDEQSAHELNEIVNSVFPESSVFRIDHYLGKETVQNILALRFANQLFDPMFNAHY
VDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALIAMEEPVTFNPEELQAEKVKVLRATTPVGPFAQTTARGQ
YTSGWQGSIPVKGLRQEDGFDPESTTETYAAATFEISSRRWAGVPFYLRTGKRLGRRVTEIAIVFKEAPHLPFGPGQTTA
QGNNMLVIRVQPEEGVLVRFGSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDEASLFPTNEEVELSWKIL
DPILDHWALHGRPEDYPAGTWGPKGAEEILSRSGRQWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=490, Percent_Identity=34.6938775510204, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI108773793, Length=490, Percent_Identity=34.6938775510204, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI52145310, Length=510, Percent_Identity=29.0196078431373, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788158, Length=502, Percent_Identity=40.0398406374502, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17538218, Length=510, Percent_Identity=36.078431372549, Blast_Score=324, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=489, Percent_Identity=37.4233128834356, Blast_Score=321, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24643350, Length=484, Percent_Identity=35.3305785123967, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24643352, Length=484, Percent_Identity=35.3305785123967, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI221513548, Length=493, Percent_Identity=28.1947261663286, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58549; Mature: 58549

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPFSAEEWRNPLRDELDKRLPRIAGPCGLVIFGVTGDLARKKLLPAVYDLANRGLLPP
CCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
GFSLVGYGRRDWSKEQFEEQVLECVKEHARTPWRQNVWDRLAEGIFFVTGDFTTDSAFDA
CCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCHHHHHH
LAEKTREIDNERGTAGNWAYYLSVPPDHFPSVCHQLERSGLAKADPELGELHNGWRRVVI
HHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEE
EKPFGHDEQSAHELNEIVNSVFPESSVFRIDHYLGKETVQNILALRFANQLFDPMFNAHY
ECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCE
VDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALIAMEEPVTFNPEELQAEKV
ECEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
KVLRATTPVGPFAQTTARGQYTSGWQGSIPVKGLRQEDGFDPESTTETYAAATFEISSRR
HHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCC
WAGVPFYLRTGKRLGRRVTEIAIVFKEAPHLPFGPGQTTAQGNNMLVIRVQPEEGVLVRF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEE
GSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDEASLFPTNEEVELSWKIL
CCCCCCCCEEEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHH
DPILDHWALHGRPEDYPAGTWGPKGAEEILSRSGRQWRRP
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQLPFSAEEWRNPLRDELDKRLPRIAGPCGLVIFGVTGDLARKKLLPAVYDLANRGLLPP
CCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
GFSLVGYGRRDWSKEQFEEQVLECVKEHARTPWRQNVWDRLAEGIFFVTGDFTTDSAFDA
CCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCHHHHHH
LAEKTREIDNERGTAGNWAYYLSVPPDHFPSVCHQLERSGLAKADPELGELHNGWRRVVI
HHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEE
EKPFGHDEQSAHELNEIVNSVFPESSVFRIDHYLGKETVQNILALRFANQLFDPMFNAHY
ECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCE
VDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALIAMEEPVTFNPEELQAEKV
ECEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
KVLRATTPVGPFAQTTARGQYTSGWQGSIPVKGLRQEDGFDPESTTETYAAATFEISSRR
HHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCC
WAGVPFYLRTGKRLGRRVTEIAIVFKEAPHLPFGPGQTTAQGNNMLVIRVQPEEGVLVRF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEE
GSKVPGSAMEVRDVNMDFSYSESFTEESPEAYERLILDALLDEASLFPTNEEVELSWKIL
CCCCCCCCEEEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHH
DPILDHWALHGRPEDYPAGTWGPKGAEEILSRSGRQWRRP
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]