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The map label for this gene is argH

Identifier: 68535923

GI number: 68535923

Start: 1009617

End: 1011083

Strand: Direct

Name: argH

Synonym: jk0848

Alternate gene names: 68535923

Gene position: 1009617-1011083 (Clockwise)

Preceding gene: 68535922

Following gene: 68535931

Centisome position: 41.0

GC content: 64.89

Gene sequence:

>1467_bases
ATGGCAGATCACGGTGCGTCCAACCCCGGCTCGCTGGACAAGCACGGCACGAACGAGGGCGCGCTCTGGGGCGGTCGCTT
TTCCGGTGGCCCCTCGGAGGCTATGTTTGCGCTGTCCGTATCCACCCATTTCGACTGGGTCCTCGCCCCCTATGACGTGC
TCGCATCGAAGGCACACGCCAAGGTGCTGAACAAGGCCGGTCTGCTCTCGGACGCCGACCTGGAGACCATGTTGGGTGGG
CTGGACCAGCTGGGTCGGGATGTCGCGGACGGTTCCTTCGTCCCAGCATCCTCCGACGAGGACGTCCACGGTGCGATGGA
GCGCGGCCTGATCGACCGCGTCGGCCCGGAGGTCGGCGGTCGCCTACGTGCGGGGCGTTCCCGCAACGACCAGGTGGCTG
CGATGTTCCGCATGTGGATCCGTGACGCGATCCGCGACATTGCCGTCCAGGTCACGCAGCTAATCGACGCGCTGTCTGAA
CAAGCGAAGGCGCACCCGGATGCGATTATGCCGGGTAAGACGCACTCCCAGGCTGCCCAGCCGATCCTGTTGGCTCACTC
GCTGCTAGCTCACGCTCAGCCGCTACTGCGTGATATCCAGCGTCTGCAGGACTTGGATAAGCGCCTGGCTGTCTCGCCAT
ATGGTTCGGGCGCGCTGGCTGGTTCCTCCCTGAAGTTGGATCCAGAGGCCATTGCGGAAGAACTCGGTTTCGACTCCGCG
GCGGATAATTCCCTGGACGGAACCTCCTCCCGCGACTTCGCCTCCGAGACAGCCTTCGTCCTCGCCCAGATCGCGGTGGA
CATGTCCCGCCTGGCTGAGGAGATCATTTACTGGTGCACCCCGGAGTACGGCTACGTCACGCTCTCGGATTCCTGGTCCA
CCGGTTCCTCGATCATGCCGCAGAAGAAGAACCCGGACGTGCCTGAGCTCGTACGCGGCAAGACGGGCCGCCTGATCGGT
AACCTCTCTGGACTGATGGCCACCCTGAAGGGTCTGCCGCTGGCTTATAACCGCGACCTGCAGGAGGACAAGGAGCCGAT
TGTCGACTCGGTGGCTCAACTCAACTTGCTGCTGCCGGCAATGACGGGTCTGGTGTCTACTCTGACTTTCCACGAGAACC
GCATGCGCGAACTGGCCCCGGCGGGCTTTACACTTGCGACGGATTTGGCGGAATGGATGGTGCGCCAAGGAGTGCCGTTC
CGTGAGGCCCACGAGGCCTCGGGCTCCTGCGTGCGTATCGCGGAGTCCCGCGGTGTGGACCTTATCGACCTCACCGACGA
GGAGCTGGCCTCTGTGGACTCCCGCCTCACCCCGGAGGTTCGCGAGGTGCTCACTATCGACGGCGCGGTGGCGTCCCGGT
CGACGCGCGGCGGCACCGCCGGTGTGCGGGTAGCCGAGCAGCGGGAGCGCGTTGAAAAGCTCTCCGGCGAATTGCGCGGG
TGGGCGGAAACGCCGGTCCGCGGCTAA

Upstream 100 bases:

>100_bases
CCTTCCCGGTGGGGAGTCCCGTTCGCTGGGGCTGCCCGCCGTTGGTTTCTTTAAGACCGACATTCTTTTACGACGTCACT
CACGGAGAGGAATCCTTTCA

Downstream 100 bases:

>100_bases
GGAAAGAGCTTGCGGGGGTTAGCCCCGCACCCCTCCGGGCAGGTTGTGCAGCGTGATTCCATACTCGCTAGCAACCTGCC
TATATTTTTCAACGAAGTGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MADHGASNPGSLDKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLNKAGLLSDADLETMLGG
LDQLGRDVADGSFVPASSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVAAMFRMWIRDAIRDIAVQVTQLIDALSE
QAKAHPDAIMPGKTHSQAAQPILLAHSLLAHAQPLLRDIQRLQDLDKRLAVSPYGSGALAGSSLKLDPEAIAEELGFDSA
ADNSLDGTSSRDFASETAFVLAQIAVDMSRLAEEIIYWCTPEYGYVTLSDSWSTGSSIMPQKKNPDVPELVRGKTGRLIG
NLSGLMATLKGLPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFHENRMRELAPAGFTLATDLAEWMVRQGVPF
REAHEASGSCVRIAESRGVDLIDLTDEELASVDSRLTPEVREVLTIDGAVASRSTRGGTAGVRVAEQRERVEKLSGELRG
WAETPVRG

Sequences:

>Translated_488_residues
MADHGASNPGSLDKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLNKAGLLSDADLETMLGG
LDQLGRDVADGSFVPASSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVAAMFRMWIRDAIRDIAVQVTQLIDALSE
QAKAHPDAIMPGKTHSQAAQPILLAHSLLAHAQPLLRDIQRLQDLDKRLAVSPYGSGALAGSSLKLDPEAIAEELGFDSA
ADNSLDGTSSRDFASETAFVLAQIAVDMSRLAEEIIYWCTPEYGYVTLSDSWSTGSSIMPQKKNPDVPELVRGKTGRLIG
NLSGLMATLKGLPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFHENRMRELAPAGFTLATDLAEWMVRQGVPF
REAHEASGSCVRIAESRGVDLIDLTDEELASVDSRLTPEVREVLTIDGAVASRSTRGGTAGVRVAEQRERVEKLSGELRG
WAETPVRG
>Mature_487_residues
ADHGASNPGSLDKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHAKVLNKAGLLSDADLETMLGGL
DQLGRDVADGSFVPASSDEDVHGAMERGLIDRVGPEVGGRLRAGRSRNDQVAAMFRMWIRDAIRDIAVQVTQLIDALSEQ
AKAHPDAIMPGKTHSQAAQPILLAHSLLAHAQPLLRDIQRLQDLDKRLAVSPYGSGALAGSSLKLDPEAIAEELGFDSAA
DNSLDGTSSRDFASETAFVLAQIAVDMSRLAEEIIYWCTPEYGYVTLSDSWSTGSSIMPQKKNPDVPELVRGKTGRLIGN
LSGLMATLKGLPLAYNRDLQEDKEPIVDSVAQLNLLLPAMTGLVSTLTFHENRMRELAPAGFTLATDLAEWMVRQGVPFR
EAHEASGSCVRIAESRGVDLIDLTDEELASVDSRLTPEVREVLTIDGAVASRSTRGGTAGVRVAEQRERVEKLSGELRGW
AETPVRG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=43.5729847494553, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=43.5729847494553, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=40.958605664488, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=40.7407407407407, Blast_Score=329, Evalue=3e-90,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=42.5055928411633, Blast_Score=328, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6321806, Length=453, Percent_Identity=41.0596026490066, Blast_Score=348, Evalue=9e-97,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=39.8249452954048, Blast_Score=331, Evalue=9e-91,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=39.8249452954048, Blast_Score=331, Evalue=9e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CORJK (Q4JVZ7)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250628.1
- ProteinModelPortal:   Q4JVZ7
- SMR:   Q4JVZ7
- STRING:   Q4JVZ7
- GeneID:   3432217
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0848
- NMPDR:   fig|306537.3.peg.2040
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- ProtClustDB:   PRK00855
- BioCyc:   CJEI306537:JK0848-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52379; Mature: 52247

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHGASNPGSLDKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHA
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHH
KVLNKAGLLSDADLETMLGGLDQLGRDVADGSFVPASSDEDVHGAMERGLIDRVGPEVGG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCC
RLRAGRSRNDQVAAMFRMWIRDAIRDIAVQVTQLIDALSEQAKAHPDAIMPGKTHSQAAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
PILLAHSLLAHAQPLLRDIQRLQDLDKRLAVSPYGSGALAGSSLKLDPEAIAEELGFDSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
ADNSLDGTSSRDFASETAFVLAQIAVDMSRLAEEIIYWCTPEYGYVTLSDSWSTGSSIMP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
QKKNPDVPELVRGKTGRLIGNLSGLMATLKGLPLAYNRDLQEDKEPIVDSVAQLNLLLPA
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MTGLVSTLTFHENRMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGSCVRIAESRGVD
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEHHHCCCE
LIDLTDEELASVDSRLTPEVREVLTIDGAVASRSTRGGTAGVRVAEQRERVEKLSGELRG
EEECCHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
WAETPVRG
CCCCCCCC
>Mature Secondary Structure 
ADHGASNPGSLDKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHA
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHH
KVLNKAGLLSDADLETMLGGLDQLGRDVADGSFVPASSDEDVHGAMERGLIDRVGPEVGG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCC
RLRAGRSRNDQVAAMFRMWIRDAIRDIAVQVTQLIDALSEQAKAHPDAIMPGKTHSQAAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
PILLAHSLLAHAQPLLRDIQRLQDLDKRLAVSPYGSGALAGSSLKLDPEAIAEELGFDSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
ADNSLDGTSSRDFASETAFVLAQIAVDMSRLAEEIIYWCTPEYGYVTLSDSWSTGSSIMP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
QKKNPDVPELVRGKTGRLIGNLSGLMATLKGLPLAYNRDLQEDKEPIVDSVAQLNLLLPA
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MTGLVSTLTFHENRMRELAPAGFTLATDLAEWMVRQGVPFREAHEASGSCVRIAESRGVD
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEHHHCCCE
LIDLTDEELASVDSRLTPEVREVLTIDGAVASRSTRGGTAGVRVAEQRERVEKLSGELRG
EEECCHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
WAETPVRG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA