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The map label for this gene is trpA [H]

Identifier: 68535874

GI number: 68535874

Start: 952503

End: 953273

Strand: Direct

Name: trpA [H]

Synonym: jk0799

Alternate gene names: 68535874

Gene position: 952503-953273 (Clockwise)

Preceding gene: 68535873

Following gene: 68535875

Centisome position: 38.68

GC content: 67.96

Gene sequence:

>771_bases
ATGACCTCCCGACTTTCTAAGGTTTTCACCGACGCGCGCGCCGAGGGGCGAGCCGCACTCGTGGCCTACTTCCCGGCCGG
CTACCCCACGGTGGCTAAGTCCAAGGAGCTCGTCGCCGAGCTAGCCCAGCACGCCGACCTGATCGAGGTGGGTATTCCGT
TCACCGACCCGATGATGGACGGCCCCACCATCCAGGCCGCCGCCAACGAAGCTTTGGACAACGGCTTCCGGGTGAAGGAC
ACACTCGACGTCGTCCGCGCCGTCACCGAGGCAGGTGGCCAGGCCGTCATCATGTCCTATTGGAACCCCGTGCTGCAGTA
CGGCCCGGAGAAGTTCGCCGCAGACCTGGCCGCCGCCGGGGGACTGGGCTCCATCATCCCGGACCTGCTGCCGGAGGAAG
CCGGTCGTTGGGCGGAGGCCTGCAAGACCAATGACCTATCGCCGGTCTATCTCGTCGCGCCCTCCACCACGCCCGAGCGC
ATGGCCCTTACTGTTGACGCCGGCGACGGCTTCATCTACGCCGCATCCCACATGGGTGTGACGGGCGCGCAGGACGAGGT
CTCCAGTTCCGCCGAGGAGCTGGTCGCCCGCGTTCGCGAGGCCACGGACCTGCCGGTGGCAGTGGGGCTGGGCGTGAAGA
CCGGTAAGCACGCGGCGAACATCGCCTCCTACGCAGACGGCGTGATCGTCGGCTCCGCGCTGATCCAGGCCGCAGCCGAC
GGCAACCTGGGCGAGCTGGCTGCAGAGCTGGCGCGAGGCGTTCGCGCATGA

Upstream 100 bases:

>100_bases
GCTGATTGTGAACATTTCCGGCCGCGGCGACAAGGACGTCAACACGGCTGCGAAGTGGTTCGACATGCTGGATCAGAAGA
GCGAGAAGGACGGCTAACCC

Downstream 100 bases:

>100_bases
TCGCGGCGGCCATTCCTTCGCCGCCGCAGGGTGTCTGGGATCTTGGGCCCATTCCCATCCGCGCCTACGCGCTGTGCATC
CTCACCGGCGTGATCGTGGC

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTSRLSKVFTDARAEGRAALVAYFPAGYPTVAKSKELVAELAQHADLIEVGIPFTDPMMDGPTIQAAANEALDNGFRVKD
TLDVVRAVTEAGGQAVIMSYWNPVLQYGPEKFAADLAAAGGLGSIIPDLLPEEAGRWAEACKTNDLSPVYLVAPSTTPER
MALTVDAGDGFIYAASHMGVTGAQDEVSSSAEELVARVREATDLPVAVGLGVKTGKHAANIASYADGVIVGSALIQAAAD
GNLGELAAELARGVRA

Sequences:

>Translated_256_residues
MTSRLSKVFTDARAEGRAALVAYFPAGYPTVAKSKELVAELAQHADLIEVGIPFTDPMMDGPTIQAAANEALDNGFRVKD
TLDVVRAVTEAGGQAVIMSYWNPVLQYGPEKFAADLAAAGGLGSIIPDLLPEEAGRWAEACKTNDLSPVYLVAPSTTPER
MALTVDAGDGFIYAASHMGVTGAQDEVSSSAEELVARVREATDLPVAVGLGVKTGKHAANIASYADGVIVGSALIQAAAD
GNLGELAAELARGVRA
>Mature_255_residues
TSRLSKVFTDARAEGRAALVAYFPAGYPTVAKSKELVAELAQHADLIEVGIPFTDPMMDGPTIQAAANEALDNGFRVKDT
LDVVRAVTEAGGQAVIMSYWNPVLQYGPEKFAADLAAAGGLGSIIPDLLPEEAGRWAEACKTNDLSPVYLVAPSTTPERM
ALTVDAGDGFIYAASHMGVTGAQDEVSSSAEELVARVREATDLPVAVGLGVKTGKHAANIASYADGVIVGSALIQAAADG
NLGELAAELARGVRA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=212, Percent_Identity=26.4150943396226, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321412, Length=261, Percent_Identity=42.1455938697318, Blast_Score=201, Evalue=9e-53,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 26471; Mature: 26340

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRLSKVFTDARAEGRAALVAYFPAGYPTVAKSKELVAELAQHADLIEVGIPFTDPMMD
CCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
GPTIQAAANEALDNGFRVKDTLDVVRAVTEAGGQAVIMSYWNPVLQYGPEKFAADLAAAG
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHHHHCC
GLGSIIPDLLPEEAGRWAEACKTNDLSPVYLVAPSTTPERMALTVDAGDGFIYAASHMGV
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEECCCCC
TGAQDEVSSSAEELVARVREATDLPVAVGLGVKTGKHAANIASYADGVIVGSALIQAAAD
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCC
GNLGELAAELARGVRA
CCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSRLSKVFTDARAEGRAALVAYFPAGYPTVAKSKELVAELAQHADLIEVGIPFTDPMMD
CHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
GPTIQAAANEALDNGFRVKDTLDVVRAVTEAGGQAVIMSYWNPVLQYGPEKFAADLAAAG
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHHHHCC
GLGSIIPDLLPEEAGRWAEACKTNDLSPVYLVAPSTTPERMALTVDAGDGFIYAASHMGV
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEECCCCC
TGAQDEVSSSAEELVARVREATDLPVAVGLGVKTGKHAANIASYADGVIVGSALIQAAAD
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCC
GNLGELAAELARGVRA
CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA