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The map label for this gene is dinX [H]

Identifier: 68535836

GI number: 68535836

Start: 909971

End: 911317

Strand: Direct

Name: dinX [H]

Synonym: jk0761

Alternate gene names: 68535836

Gene position: 909971-911317 (Clockwise)

Preceding gene: 68535835

Following gene: 68535838

Centisome position: 36.95

GC content: 68.08

Gene sequence:

>1347_bases
ATGCGCTGGGTGGCTCACATCGACATGGATGCGTTCTTCGCCTCCGTCGAGCAGCTCACCCGGCCGACCCTGCGCGATAG
GCCGGTGCTGGTCGGTGGCTTGGGAGGCCGTGGGGTAGTAGCCGGTGCCTCCTACGAGGCCCGCGCTTTCGGCGCCCGTT
CGGCGATGCCGATGGGACAGGCCGTGCGCCTGTGCAACAACCGCGCCGTGGTGGTTAAACCACGCAAGGAGGTGTACGCG
GCCGCCTCCCGTCGCATCTTCCAGGTCATCCGCGCCCACGCAGGAGTGGTAGAGCAGCTGTCCGTGGACGAGGGCTTCGC
CGAACCGCAGGGGTTGGACAGCGCCGAGGAAGCCCGTGCCTGGGCCGAAAACCTGCAGGCCAGGGTAGAGGAGGAGACCG
GCCTGCCCGCTTCCGTCGGCATGGCCGCCAGCAAGCTGGACGCAAAGATGGCCAGCGATCTGGCTAAACCTCACGGGGTT
TTCGTTGTGCCGCCCGAGGCGCGCATGGAGGTTTTCGCCGACCGGCCCGTAGGTGACGTGTGGGGGATAGGCAAGGTCGC
TCAGGGCAAGCTGCACACCATGGGGATAGACACGATCGGCCAGTTCGTCGCCGCCGACACCACGGACGTGCGAGGCGCGC
TGGGCTCGGTCGGAGTGGAGGTGCAGCGCATGGCTGCCGGCGACGACCCGCGCCCCGTTGCTCCCCGCGCGCCCGCCAAG
CAAGTCAGCGCGGAAAAGACCCTGCAGGTGGACGCGCGCACTACCGCCGAGGCCATGCGCGTGCTGCACGAGACCGCGCT
AGCTATGCACCGCCGCCTGCTGAAGGACGGCCGCGCTGCCCGCACCGTGACGGTCAAGACGCGCACCACCGACTTTCAGC
TGCACACGAAGTCCGCCGGGTTGCCCGCGCCGACGGAGGACTTTGACAAGATCTTCGCCCTCGCCCAGCGTCTGATGCCA
CGCCCTGAGCAGGCCGGCGCCTTTCGCCTGGTCGGGGTGAGCGTGTCCGGGCTGGTGGCCGACCGCCAGGAACTGCTGTT
CCCGGAACTCGACGGCCCGCCGGTGCCCATCGCCGCCCCCACCGATAGCGATGCCGGGTTTAGCTCTTTCGTTGATGACG
CCACCACGGTCCGTCCCGTATGGCATGCCACCCAGGATGTATCGCACGTGGAGTTCGGGCACGGGTGGGTGCAGGGAGCC
GGCAACGGGGTGGTCAGCGTGCGTTTCGAAACCGCAGCGACTGGGCCAGGCAAGACCCGCACCTTCCGCATTGACGACGA
AGATCTAAGCCCCGCCGACCCGTTGGACAGTCTTGCCTGGGATCTGGATGGGCTGGCGGAGGACTAG

Upstream 100 bases:

>100_bases
TGTCGTCGGCGAGCAGCTCAGCCACGACGTCGCCGACGATTGCTCGGCTGACATTGTGGTGGCGTCGGTGGCGTCCTAGA
AAATCCCGCAGGGTACTCAC

Downstream 100 bases:

>100_bases
AACGTGAAAGGGGACTAGCGAGCGCGGGCGAGTTCGTAGAGTAATTCGATGCGCGCCTGGCTGGGGCGCATCGCCCCGCC
GCTACGGAAGCCGGCGCGGG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRWVAHIDMDAFFASVEQLTRPTLRDRPVLVGGLGGRGVVAGASYEARAFGARSAMPMGQAVRLCNNRAVVVKPRKEVYA
AASRRIFQVIRAHAGVVEQLSVDEGFAEPQGLDSAEEARAWAENLQARVEEETGLPASVGMAASKLDAKMASDLAKPHGV
FVVPPEARMEVFADRPVGDVWGIGKVAQGKLHTMGIDTIGQFVAADTTDVRGALGSVGVEVQRMAAGDDPRPVAPRAPAK
QVSAEKTLQVDARTTAEAMRVLHETALAMHRRLLKDGRAARTVTVKTRTTDFQLHTKSAGLPAPTEDFDKIFALAQRLMP
RPEQAGAFRLVGVSVSGLVADRQELLFPELDGPPVPIAAPTDSDAGFSSFVDDATTVRPVWHATQDVSHVEFGHGWVQGA
GNGVVSVRFETAATGPGKTRTFRIDDEDLSPADPLDSLAWDLDGLAED

Sequences:

>Translated_448_residues
MRWVAHIDMDAFFASVEQLTRPTLRDRPVLVGGLGGRGVVAGASYEARAFGARSAMPMGQAVRLCNNRAVVVKPRKEVYA
AASRRIFQVIRAHAGVVEQLSVDEGFAEPQGLDSAEEARAWAENLQARVEEETGLPASVGMAASKLDAKMASDLAKPHGV
FVVPPEARMEVFADRPVGDVWGIGKVAQGKLHTMGIDTIGQFVAADTTDVRGALGSVGVEVQRMAAGDDPRPVAPRAPAK
QVSAEKTLQVDARTTAEAMRVLHETALAMHRRLLKDGRAARTVTVKTRTTDFQLHTKSAGLPAPTEDFDKIFALAQRLMP
RPEQAGAFRLVGVSVSGLVADRQELLFPELDGPPVPIAAPTDSDAGFSSFVDDATTVRPVWHATQDVSHVEFGHGWVQGA
GNGVVSVRFETAATGPGKTRTFRIDDEDLSPADPLDSLAWDLDGLAED
>Mature_448_residues
MRWVAHIDMDAFFASVEQLTRPTLRDRPVLVGGLGGRGVVAGASYEARAFGARSAMPMGQAVRLCNNRAVVVKPRKEVYA
AASRRIFQVIRAHAGVVEQLSVDEGFAEPQGLDSAEEARAWAENLQARVEEETGLPASVGMAASKLDAKMASDLAKPHGV
FVVPPEARMEVFADRPVGDVWGIGKVAQGKLHTMGIDTIGQFVAADTTDVRGALGSVGVEVQRMAAGDDPRPVAPRAPAK
QVSAEKTLQVDARTTAEAMRVLHETALAMHRRLLKDGRAARTVTVKTRTTDFQLHTKSAGLPAPTEDFDKIFALAQRLMP
RPEQAGAFRLVGVSVSGLVADRQELLFPELDGPPVPIAAPTDSDAGFSSFVDDATTVRPVWHATQDVSHVEFGHGWVQGA
GNGVVSVRFETAATGPGKTRTFRIDDEDLSPADPLDSLAWDLDGLAED

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=361, Percent_Identity=24.0997229916898, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI7706681, Length=362, Percent_Identity=24.0331491712707, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI7705344, Length=236, Percent_Identity=26.271186440678, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786425, Length=343, Percent_Identity=32.6530612244898, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1787432, Length=336, Percent_Identity=26.7857142857143, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17537959, Length=364, Percent_Identity=23.9010989010989, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193205702, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193205700, Length=233, Percent_Identity=28.3261802575107, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19923006, Length=386, Percent_Identity=26.1658031088083, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355641, Length=337, Percent_Identity=24.3323442136499, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24644984, Length=337, Percent_Identity=24.3323442136499, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 47904; Mature: 47904

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWVAHIDMDAFFASVEQLTRPTLRDRPVLVGGLGGRGVVAGASYEARAFGARSAMPMGQ
CCEEEEECHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCHHHCCCCCCCCHHH
AVRLCNNRAVVVKPRKEVYAAASRRIFQVIRAHAGVVEQLSVDEGFAEPQGLDSAEEARA
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
WAENLQARVEEETGLPASVGMAASKLDAKMASDLAKPHGVFVVPPEARMEVFADRPVGDV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCHH
WGIGKVAQGKLHTMGIDTIGQFVAADTTDVRGALGSVGVEVQRMAAGDDPRPVAPRAPAK
CCCCCCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHCCCEEHHHHCCCCCCCCCCCCCHH
QVSAEKTLQVDARTTAEAMRVLHETALAMHRRLLKDGRAARTVTVKTRTTDFQLHTKSAG
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEEEEEECCCC
LPAPTEDFDKIFALAQRLMPRPEQAGAFRLVGVSVSGLVADRQELLFPELDGPPVPIAAP
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECC
TDSDAGFSSFVDDATTVRPVWHATQDVSHVEFGHGWVQGAGNGVVSVRFETAATGPGKTR
CCCCCCHHHHHCCCCCCCHHHHHHCCCCCEECCCCEEECCCCCEEEEEEEECCCCCCCCE
TFRIDDEDLSPADPLDSLAWDLDGLAED
EEEECCCCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MRWVAHIDMDAFFASVEQLTRPTLRDRPVLVGGLGGRGVVAGASYEARAFGARSAMPMGQ
CCEEEEECHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCHHHCCCCCCCCHHH
AVRLCNNRAVVVKPRKEVYAAASRRIFQVIRAHAGVVEQLSVDEGFAEPQGLDSAEEARA
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
WAENLQARVEEETGLPASVGMAASKLDAKMASDLAKPHGVFVVPPEARMEVFADRPVGDV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHCCCCCCCHH
WGIGKVAQGKLHTMGIDTIGQFVAADTTDVRGALGSVGVEVQRMAAGDDPRPVAPRAPAK
CCCCCCCCCCEEEECHHHHHHHHHCCCHHHHHHHHHCCCEEHHHHCCCCCCCCCCCCCHH
QVSAEKTLQVDARTTAEAMRVLHETALAMHRRLLKDGRAARTVTVKTRTTDFQLHTKSAG
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEEEEEECCCC
LPAPTEDFDKIFALAQRLMPRPEQAGAFRLVGVSVSGLVADRQELLFPELDGPPVPIAAP
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECC
TDSDAGFSSFVDDATTVRPVWHATQDVSHVEFGHGWVQGAGNGVVSVRFETAATGPGKTR
CCCCCCHHHHHCCCCCCCHHHHHHCCCCCEECCCCEEECCCCCEEEEEEEECCCCCCCCE
TFRIDDEDLSPADPLDSLAWDLDGLAED
EEEECCCCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]