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The map label for this gene is treA [H]

Identifier: 77761100

GI number: 77761100

Start: 750746

End: 752419

Strand: Reverse

Name: treA [H]

Synonym: XC_0631

Alternate gene names: 77761100

Gene position: 752419-750746 (Counterclockwise)

Preceding gene: 66766970

Following gene: 66766968

Centisome position: 14.61

GC content: 67.62

Gene sequence:

>1674_bases
ATGAGCGCTGCTGCGCCCCCGTGCTGCACCTCGTTGCTTGGTCTGTCGCTGAGCATGTTCGTTGCGCCCTGCGCCCTGGC
GGCCACGCCGCTGGAAGGTGCGGTGGTCAGCGCGCCCGCGCCCACGCCGCCCACGCCCGACCTGGCGTATCCGGAGCTGT
TCCAGGCCGTGCAGCGCGGGGAGCTGTTCGACGACCAGAAGCATTTCGTCGACTTTCTGCCGCTGCGCGACCCAGCCCTG
ATCAACGCCGACTATCTGGCGCAGCACGAGCATGCCGGCTTTGACCTGCGCAAGTTCGTGGATGCCAACTTCGAGGAATC
GCCGCCGGTACAGACCGATGCGATCCGCCAGGACACCGCGCTGCGCGAGCACATCGACGCGCTGTGGCCCAAGCTGGTAC
GCAGCCAGACCAACGTGCCCGCACACAGCAGCCTGCTGGCGTTGCCGCACCCGTACGTGGTGCCGGGCGGACGCTTCCGC
GAGGTGTATTACTGGGATTCGTACTTCACCATGCTGGGGCTGGTGAAAAGTGGCGAAACCACGCTGAGCCGGCAGATGCT
GGACAACTTCGCCTACCTGATCGACACCTACGGGCACATCCCCAACGGCAACCGCACCTACTACCTGAGCCGCTCGCAGC
CGCCGTTATTCTCCTACATGGTGGAACTGCAGGCCGGCGTGGAAGGCGAGGCGGTGTACCAGCGCTACCTGCCGCAGCTG
CAGAAGGAATACGCGTACTGGATGCAGGGCGGCGACGATCTGCAACCCGGCCAGGCCGCACGCCATGTGGTGCGCCTGGC
CGATGGCAGCGTGCTCAATCGCTATTGGGACGAGCGCGATACCCCGCGCCCGGAAGCCTGGCTGCACGACACCCGCACCG
CTGCCGAGGCGCATGACCGCCCGGCCGCCGATGTCTACCGCGACCTGCGCGCCGGCGCCGAAAGTGGCTGGGACTACACC
AGCCGCTGGCTGGCCGACGGCAAGACGCTGAGCACCATCCGCACCACCGCGATTGTGCCGATCGATCTCAACAGCCTGCT
GTATCACCTGGAACGCACCCTGGCGCAGGCCTGCGCGCACACCGGCACCGCCTGCAGCCAGGACTACGCTGCGCTCGCAC
AGCAGCGCAAGCAGGCCATCGACGCGCACCTGTGGAATGCAGCCGGCTACTACGCCGACTACGACTGGCAGACCCGCACG
CTGAGCAACCAGGTCACCGCGGCGGCGCTGTACCCGCTGTTCGCCGGCCTGGCTTCGGATGACCACGCCAAGCGCACTGC
CACCAGCGTGCGCGCCCGCCTGCTGCGTCCCGGCGGCCTGGCCACCACCGCGTTGAAGACCGGCCAGCAGTGGGACGAAC
CCAACGGCTGGGCGCCATTGCAATGGGTGGCCGTGGACGGCCTGCGTCGCTACGGCGAAGACGGCCTGGCCCGCACCATC
GGCGAGCGCTTCCTCACCCAGGTGCAGGCGCTATTCGCGCGCGAGCACAAGCTGGTCGAAAAATACGGCCTGGACGCCGA
TGCAGCCGGCGGCGGCGGTGGCGAATATGCATTGCAGGACGGCTTTGGCTGGACCAATGGCGTCACGTTGATGCTGTTGA
ACCTGTACCCCTCACAGGGCGCCACCCAGGCTCCGGCCAAGACCAAGCGCAAGCCCGAGCCCGCCGCTCCCTGA

Upstream 100 bases:

>100_bases
CCGCGTGCGGCGTGCCGGTCCCCCGACACAGCGCCTGCGGCTCCACCCGCCACTTCGGTCGTTTACCATGCCGCACGCCC
CCGCCCGTTCTGGAGATGCC

Downstream 100 bases:

>100_bases
GCGTGGCGGTGGTTGGCGCATGCCATGCCAGCAGCGCCAGCAGCATTGCGGCCTGATCGACGACGGCTGTTGGTAGCGGG
CCGATGCGCTTGACCGAGAC

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPAL
INADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFR
EVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQL
QKEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDRPAADVYRDLRAGAESGWDYT
SRWLADGKTLSTIRTTAIVPIDLNSLLYHLERTLAQACAHTGTACSQDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRT
LSNQVTAAALYPLFAGLASDDHAKRTATSVRARLLRPGGLATTALKTGQQWDEPNGWAPLQWVAVDGLRRYGEDGLARTI
GERFLTQVQALFAREHKLVEKYGLDADAAGGGGGEYALQDGFGWTNGVTLMLLNLYPSQGATQAPAKTKRKPEPAAP

Sequences:

>Translated_557_residues
MSAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPAL
INADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFR
EVYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQL
QKEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDRPAADVYRDLRAGAESGWDYT
SRWLADGKTLSTIRTTAIVPIDLNSLLYHLERTLAQACAHTGTACSQDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRT
LSNQVTAAALYPLFAGLASDDHAKRTATSVRARLLRPGGLATTALKTGQQWDEPNGWAPLQWVAVDGLRRYGEDGLARTI
GERFLTQVQALFAREHKLVEKYGLDADAAGGGGGEYALQDGFGWTNGVTLMLLNLYPSQGATQAPAKTKRKPEPAAP
>Mature_556_residues
SAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRGELFDDQKHFVDFLPLRDPALI
NADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTALREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFRE
VYYWDSYFTMLGLVKSGETTLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQLQ
KEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDRPAADVYRDLRAGAESGWDYTS
RWLADGKTLSTIRTTAIVPIDLNSLLYHLERTLAQACAHTGTACSQDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTL
SNQVTAAALYPLFAGLASDDHAKRTATSVRARLLRPGGLATTALKTGQQWDEPNGWAPLQWVAVDGLRRYGEDGLARTIG
ERFLTQVQALFAREHKLVEKYGLDADAAGGGGGEYALQDGFGWTNGVTLMLLNLYPSQGATQAPAKTKRKPEPAAP

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=547, Percent_Identity=35.1005484460695, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1787447, Length=537, Percent_Identity=53.2588454376164, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1789936, Length=518, Percent_Identity=50.7722007722008, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17542196, Length=536, Percent_Identity=31.5298507462687, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25148109, Length=566, Percent_Identity=31.2720848056537, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25141398, Length=541, Percent_Identity=31.9778188539741, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17565078, Length=521, Percent_Identity=30.1343570057582, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71987755, Length=424, Percent_Identity=29.0094339622642, Blast_Score=176, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319473, Length=440, Percent_Identity=30.9090909090909, Blast_Score=150, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6320204, Length=468, Percent_Identity=27.3504273504274, Blast_Score=146, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24656680, Length=529, Percent_Identity=32.5141776937618, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24656675, Length=529, Percent_Identity=32.5141776937618, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24656661, Length=518, Percent_Identity=32.8185328185328, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI17933716, Length=518, Percent_Identity=32.8185328185328, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24656670, Length=518, Percent_Identity=32.8185328185328, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24656685, Length=467, Percent_Identity=33.6188436830835, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI22024178, Length=531, Percent_Identity=28.6252354048964, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI45551104, Length=373, Percent_Identity=29.4906166219839, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28573474, Length=298, Percent_Identity=28.8590604026846, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 61602; Mature: 61470

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHC
ELFDDQKHFVDFLPLRDPALINADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTA
CCCCCHHHHHHHCCCCCCCEECHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHH
LREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGET
HHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEECCCCCEEEEEEEHHHHHHHHHHHCCCH
TLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
QKEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDR
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
PAADVYRDLRAGAESGWDYTSRWLADGKTLSTIRTTAIVPIDLNSLLYHLERTLAQACAH
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHEEHEEEEEEECHHHHHHHHHHHHHHHHHH
TGTACSQDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTLSNQVTAAALYPLFAGLASD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DHAKRTATSVRARLLRPGGLATTALKTGQQWDEPNGWAPLQWVAVDGLRRYGEDGLARTI
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHH
GERFLTQVQALFAREHKLVEKYGLDADAAGGGGGEYALQDGFGWTNGVTLMLLNLYPSQG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCC
ATQAPAKTKRKPEPAAP
CCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
SAAAPPCCTSLLGLSLSMFVAPCALAATPLEGAVVSAPAPTPPTPDLAYPELFQAVQRG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHC
ELFDDQKHFVDFLPLRDPALINADYLAQHEHAGFDLRKFVDANFEESPPVQTDAIRQDTA
CCCCCHHHHHHHCCCCCCCEECHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHH
LREHIDALWPKLVRSQTNVPAHSSLLALPHPYVVPGGRFREVYYWDSYFTMLGLVKSGET
HHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEECCCCCEEEEEEEHHHHHHHHHHHCCCH
TLSRQMLDNFAYLIDTYGHIPNGNRTYYLSRSQPPLFSYMVELQAGVEGEAVYQRYLPQL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
QKEYAYWMQGGDDLQPGQAARHVVRLADGSVLNRYWDERDTPRPEAWLHDTRTAAEAHDR
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
PAADVYRDLRAGAESGWDYTSRWLADGKTLSTIRTTAIVPIDLNSLLYHLERTLAQACAH
CHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHEEHEEEEEEECHHHHHHHHHHHHHHHHHH
TGTACSQDYAALAQQRKQAIDAHLWNAAGYYADYDWQTRTLSNQVTAAALYPLFAGLASD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DHAKRTATSVRARLLRPGGLATTALKTGQQWDEPNGWAPLQWVAVDGLRRYGEDGLARTI
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHH
GERFLTQVQALFAREHKLVEKYGLDADAAGGGGGEYALQDGFGWTNGVTLMLLNLYPSQG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCC
ATQAPAKTKRKPEPAAP
CCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]