Click here to switch to the map view.

The map label for this gene is betT [H]

Identifier: 66767098

GI number: 66767098

Start: 917298

End: 919277

Strand: Reverse

Name: betT [H]

Synonym: XC_0762

Alternate gene names: 66767098

Gene position: 919277-917298 (Counterclockwise)

Preceding gene: 66767099

Following gene: 66767097

Centisome position: 17.85

GC content: 63.79

Gene sequence:

>1980_bases
ATGAATGTGTCCGAGCCGCAGCTCGCACCGGTACGCACCCTTCGGCCGGTGTTCGTGTTGGCGGCGACGGTGGTGTGTAC
GTTCGCGCTGCTGGTGGCGCTGTTCCCCCTCGATGCCGGGCGCATCTTGCTGGACGCGCAGACCTGGGCCTCGCGCAATG
TGGGCTGGTACTACCTGCTGGCAATGACGCTGTATCTGGTATTCGTGTTGGGTGTGGCGCTGTCCAGCTACGGCAACATC
AAACTTGGCGCCGATCACGACGAGCCGGAATTCAGCTATCTCTCCTGGGCCGGCATGTTGTTCGCCGCCGGTATCAGCAT
CACGCTGTTCTTCTTCTGCGTCTCCGAACCGCTCACGCACTATCTGCAGCCACCGCAAGGCGGCACCGGCAACGGCGAGG
CGTCCGCACGCCTGGCCATGCAGCTGCTGTTCCTGCACTGGGGCCTGCACGGCTGGGGTGTGTTCGCGTTGGCGGCGATG
GCGCTGGCGTATTTCGCATTTCGCCACAATCTGCCGCTGGCCTTGCGCTCGGCGTTGTATCCGTTGATCGGCAAACGCAT
CAACGGGCCAATCGGCTATACCGTCGATGCGCTGGGCATCGTCGCCACGGTGTTCGGCCTGGGCGCAGACATGGGCTTTG
GCGTGCTGCATCTCAACGCCGGCCTGGCCACCTTGTTCAACGTGCCGCACACGCATTGGGTGCAGGTGGCGTTGATCGTC
GCCATGATGGGCGCCGCAATCCTGGTGGCGGTGTCCGGCGTCGAAAAAGGCGTGCGCTGGATGTCGGACATCAACATGCT
GCTGGCGATCGCGCTGCTGTTGTTCATGCTGTTCGCAGGCCCCACGCAATATCTGCTCAATGCCTTGATGCAGAACCTGG
GCGACTACCTGGGCAGCGTGGTGGGCAAGAGTTTCGACGTGTATGCCTATGGCGGCCGCCCCGACTGGCTCGGCAACTGG
ACGGTGTTCTATTGGGCGTGGTGGATTGGCTGGGCGCCCTTCGTGGGGCTGTTCATTGCGCGTATCTCGCGCGGCCGCAC
CATCCGCGAGTTCGTGCTGGGCGTGTTGTTGATCCCGTTGGGATTCACGCTGGCGTGGCTGTCGATCTTCGGCAACAGCG
CGCTCGATCAACTGCTGCACCACGGGCAAGCCGCCTGGGCGCAGCAGGCCATCGATGCGCCGCAAACGGTGCTGTATTCG
CTGCTGCAGGACTACCCGTGGAGCCGCGTGGTCATCACGATCACGGTGGCGATCAGCTTCGTGTTCTTCGTCACCTCGGC
CGATTCGGGCACGGTGGTGTTGTCCACGTTGTCCTCGCATGGTGGCGAGCCGCATGACGACGGCCCACGCTGGCTGCGTG
TGTTCTGGGGCGTGCTCACGGCCGTGGTCACCGCAGGCTTGCTGCTGGCCGGCAGCATGGACGCGCTGAAATCCGCAGTG
GTGCTGGCATCGCTGCCCTTCTCGGCCGTGTTGCTGCTGATGGCGTGGGGGTTGTCGCGCGCGCTCAGTGAGGAATCGCA
GCGCAAGCGTGCGCAGCTCTACAACCCCAGCCCGTTGATCGGGCAATCGCGCGATCACCGCGGCTGGCGTCAGCGCCTGG
GCCAGGCAATGCATTTTGCCGCGCGCGATGAGGTCTATCGCTTCATGCACGAACAGGTTCGCCCGGCGATCGAAGCGGTG
GCCGCGCAGCTGCAGGACGAAGGTTGGCAGGTCAGCAGCCGGCTCGACGACGCCGACATGGAGATCAGCGTCGACCATGG
CGAACAACAAGGCTTCCGTTACCAGGTGGTGATGCGCGGCTACCTCACCCCGTCGTTCGCCGCGCAGCGCCTGCGCAACC
AGCGCTATTACCGCGCCGAGGTGTATCTGTTCGAAGGCAGCCAGGACTACGACCTGGTCGGCTACAGCCGCGAACAGATC
ATCAACGACATCATCGATCAATACGAGCGTCACCTGCAGTTCCTGCATCTCACCCGCTGA

Upstream 100 bases:

>100_bases
GGTTGCGCTGGCGACCTCAACCGATGACGTGCTCTAGACACCGCTTGTGGCATAACACAGGCGGTTTTTTCGTTGGAGCA
CGCCACGTGACGCACCGCGC

Downstream 100 bases:

>100_bases
GGTGTCGTCGCTGCGGCGAGCGTCCCACAGGAGGTTTGTCATGCCACGTTTCCCCGACCAGCTGCTGTACATCGGCGGCC
GCTATGTTCCCGCCCGCGGC

Product: high-affinity choline transport

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MNVSEPQLAPVRTLRPVFVLAATVVCTFALLVALFPLDAGRILLDAQTWASRNVGWYYLLAMTLYLVFVLGVALSSYGNI
KLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGGTGNGEASARLAMQLLFLHWGLHGWGVFALAAM
ALAYFAFRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLATLFNVPHTHWVQVALIV
AMMGAAILVAVSGVEKGVRWMSDINMLLAIALLLFMLFAGPTQYLLNALMQNLGDYLGSVVGKSFDVYAYGGRPDWLGNW
TVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPLGFTLAWLSIFGNSALDQLLHHGQAAWAQQAIDAPQTVLYS
LLQDYPWSRVVITITVAISFVFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYNPSPLIGQSRDHRGWRQRLGQAMHFAARDEVYRFMHEQVRPAIEAV
AAQLQDEGWQVSSRLDDADMEISVDHGEQQGFRYQVVMRGYLTPSFAAQRLRNQRYYRAEVYLFEGSQDYDLVGYSREQI
INDIIDQYERHLQFLHLTR

Sequences:

>Translated_659_residues
MNVSEPQLAPVRTLRPVFVLAATVVCTFALLVALFPLDAGRILLDAQTWASRNVGWYYLLAMTLYLVFVLGVALSSYGNI
KLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGGTGNGEASARLAMQLLFLHWGLHGWGVFALAAM
ALAYFAFRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLATLFNVPHTHWVQVALIV
AMMGAAILVAVSGVEKGVRWMSDINMLLAIALLLFMLFAGPTQYLLNALMQNLGDYLGSVVGKSFDVYAYGGRPDWLGNW
TVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPLGFTLAWLSIFGNSALDQLLHHGQAAWAQQAIDAPQTVLYS
LLQDYPWSRVVITITVAISFVFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYNPSPLIGQSRDHRGWRQRLGQAMHFAARDEVYRFMHEQVRPAIEAV
AAQLQDEGWQVSSRLDDADMEISVDHGEQQGFRYQVVMRGYLTPSFAAQRLRNQRYYRAEVYLFEGSQDYDLVGYSREQI
INDIIDQYERHLQFLHLTR
>Mature_659_residues
MNVSEPQLAPVRTLRPVFVLAATVVCTFALLVALFPLDAGRILLDAQTWASRNVGWYYLLAMTLYLVFVLGVALSSYGNI
KLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTHYLQPPQGGTGNGEASARLAMQLLFLHWGLHGWGVFALAAM
ALAYFAFRHNLPLALRSALYPLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLATLFNVPHTHWVQVALIV
AMMGAAILVAVSGVEKGVRWMSDINMLLAIALLLFMLFAGPTQYLLNALMQNLGDYLGSVVGKSFDVYAYGGRPDWLGNW
TVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPLGFTLAWLSIFGNSALDQLLHHGQAAWAQQAIDAPQTVLYS
LLQDYPWSRVVITITVAISFVFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYNPSPLIGQSRDHRGWRQRLGQAMHFAARDEVYRFMHEQVRPAIEAV
AAQLQDEGWQVSSRLDDADMEISVDHGEQQGFRYQVVMRGYLTPSFAAQRLRNQRYYRAEVYLFEGSQDYDLVGYSREQI
INDIIDQYERHLQFLHLTR

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=655, Percent_Identity=44.8854961832061, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI1788102, Length=460, Percent_Identity=29.3478260869565, Blast_Score=185, Evalue=9e-48,
Organism=Escherichia coli, GI1786224, Length=468, Percent_Identity=26.4957264957265, Blast_Score=158, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 73123; Mature: 73123

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSEPQLAPVRTLRPVFVLAATVVCTFALLVALFPLDAGRILLDAQTWASRNVGWYYLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHH
AMTLYLVFVLGVALSSYGNIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTH
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQPPQGGTGNGEASARLAMQLLFLHWGLHGWGVFALAAMALAYFAFRHNLPLALRSALY
HCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLATLFNVPHTHWVQVALIV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHHHH
AMMGAAILVAVSGVEKGVRWMSDINMLLAIALLLFMLFAGPTQYLLNALMQNLGDYLGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VGKSFDVYAYGGRPDWLGNWTVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPL
HCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GFTLAWLSIFGNSALDQLLHHGQAAWAQQAIDAPQTVLYSLLQDYPWSRVVITITVAISF
HHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
VFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
HHHHCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYNPSPLIGQSRDHRGWRQRLGQAMHFA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ARDEVYRFMHEQVRPAIEAVAAQLQDEGWQVSSRLDDADMEISVDHGEQQGFRYQVVMRG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEECCCCCCCCEEEEEHHH
YLTPSFAAQRLRNQRYYRAEVYLFEGSQDYDLVGYSREQIINDIIDQYERHLQFLHLTR
CCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVSEPQLAPVRTLRPVFVLAATVVCTFALLVALFPLDAGRILLDAQTWASRNVGWYYLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHH
AMTLYLVFVLGVALSSYGNIKLGADHDEPEFSYLSWAGMLFAAGISITLFFFCVSEPLTH
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQPPQGGTGNGEASARLAMQLLFLHWGLHGWGVFALAAMALAYFAFRHNLPLALRSALY
HCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
PLIGKRINGPIGYTVDALGIVATVFGLGADMGFGVLHLNAGLATLFNVPHTHWVQVALIV
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHHHH
AMMGAAILVAVSGVEKGVRWMSDINMLLAIALLLFMLFAGPTQYLLNALMQNLGDYLGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VGKSFDVYAYGGRPDWLGNWTVFYWAWWIGWAPFVGLFIARISRGRTIREFVLGVLLIPL
HCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GFTLAWLSIFGNSALDQLLHHGQAAWAQQAIDAPQTVLYSLLQDYPWSRVVITITVAISF
HHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
VFFVTSADSGTVVLSTLSSHGGEPHDDGPRWLRVFWGVLTAVVTAGLLLAGSMDALKSAV
HHHHCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VLASLPFSAVLLLMAWGLSRALSEESQRKRAQLYNPSPLIGQSRDHRGWRQRLGQAMHFA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ARDEVYRFMHEQVRPAIEAVAAQLQDEGWQVSSRLDDADMEISVDHGEQQGFRYQVVMRG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEECCCCCCCCEEEEEHHH
YLTPSFAAQRLRNQRYYRAEVYLFEGSQDYDLVGYSREQIINDIIDQYERHLQFLHLTR
CCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]