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The map label for this gene is betA [H]

Identifier: 66767096

GI number: 66767096

Start: 914024

End: 915694

Strand: Reverse

Name: betA [H]

Synonym: XC_0760

Alternate gene names: 66767096

Gene position: 915694-914024 (Counterclockwise)

Preceding gene: 66767097

Following gene: 66767094

Centisome position: 17.78

GC content: 64.87

Gene sequence:

>1671_bases
ATGCAACGCGAATACGACTACATCATCATTGGCGCAGGCTCGGCCGGCAACGTACTGGCCGCGCGCCTCACCGAAGACCC
GGGCGTCAGTGTGCTGCTGCTGGAAGCCGGCGGGCCGGATTACCGGCTGGATTTCCGCACCCAGATGCCCGCCGCATTGG
CGTTTCCGTTGCAGGGCCGCCGCTACAACTGGGCCTATGAAACAGAGCCGGAACCGCACATGGACAACCGGCGCATGGAA
TGCGGGCGCGGCAAGGGGCTGGGTGGTTCATCGCTGATCAACGGCATGTGCTACATCCGCGGCAACGCACTGGATTTCGA
TCATTGGGCCAAGCGCCCGGGGCTGGAAGACTGGGGCTACCGCGATGTGTTGCCGTACTTCCGCAAGGCAGAAACGCGCG
ACATCGGCGCCAACGATTACCACGGCGGCGAAGGCCCGGTGAGCGTGGCCACGCCGAAGAACGACAACAACGTGCTGTTC
CAGGCGATGGTCGATGCTGGCGTGCAGGCGGGTTACCCGCGCACCGACGACCTCAACGGCTATCAGCAGGAAGGCTTCGG
GCCGATGGACCGCACCGTGACGCCGCAAGGGCGGCGTGCCAGCACCGCACGCGGCTATCTGGACATGGCCAAGCCGCGCG
ACAGCCTGCACATCGTCACCCACGCCACCACCGACCGCATTTTATTTGCCGGCAAGCGCGCGGTCGGGGTGCATTACCTG
GTGGGCAACAGCAGCGAAGGCATCGACGCGCACGCGCGCCGCGAAGTACTGGTCTGTGCGGGTGCGATTGCCTCGCCACA
GTTGCTGCAACGCTCCGGCGTGGGTGCCCCGGACCTGTTGCGCGCGCTCGACGTGCAGCTGGTGCACGACCTGCCCGGCG
TGGGGCAGAACCTGCAGGACCACCTGGAGGTGTACATGCAATATGCATGCACCAAGCCGGTGTCGTTGTACCCGGCGCTA
CAGTGGTGGAATCAGCCGGCCATTGGCGCCGAGTGGTTGTTTGCCGGCACCGGCACCGGGGCCAGCAACCAGTTCGAGGC
CGGCGGTTTCATTCGCACCCGCGAAGAATTCGACTGGCCCAATATCCAGTACCACTTCCTGCCGGTGGCGATCAATTACA
ACGGCAGCAACGCAGTGAAGGAACATGGCTTCCAGGCCCATGTGGGCTCCATGCGTACGCCCAGCCGCGGCCGCGTGCAT
GCCAGGTCGCGCGACCCGCGCCAGCATCCATCGATCCTGTTCAACTACCAATCCACCGACCAGGACTGGCAGGAATTTCG
CGACGCAATCCGCATCACCCGCGAGATCATCGCCCAGCCCGCACTCGACCCTTACCGTGGGCGCGAGATCAGCCCCAGCG
CAGACTGCAAGACCGACGCCGAGCTGGATGCATTCGTGCGCGCACGCGCCGAAACCGCGTATCACCCCTCGTGCTCGTGT
GCGATGGGCACCGACGACATGGCGGTGGTGGATGGGCAAGGCCGCGTCCACGGCATGGAGGGGTTGCGCGTGATTGATGC
CTCGATCATGCCGCGCATCATCACTGGCAACCTCAACGCCACCACCATCATGATCGCCGAGAAGATCGTCGACCGAATAC
GCGGGCGTGCACCACTGCCGCGCAGCACCGCCGACTATTACGTGGCGGGTGATGCACCTGTACGCCGGTGA

Upstream 100 bases:

>100_bases
GGTGTTCTAGGCGCGGCTCACAGCGCGCGTACTGCCGTTCAAACGAGCGCAGACGCGTGCCAATCCGCACGCCTCACCGA
CCACGCATCAGGAGATCACC

Downstream 100 bases:

>100_bases
TGTGTGATCGACCGAGTGCATGGTTTGAAACTGCTTGCCAAGCGAGCTGTCGGCCGACTTGCGTTTGATCTAGATAGCCA
AGCGCAGCGCCCTCACCGCT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVSVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPHMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWGYRDVLPYFRKAETRDIGANDYHGGEGPVSVATPKNDNNVLF
QAMVDAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDMAKPRDSLHIVTHATTDRILFAGKRAVGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYMQYACTKPVSLYPAL
QWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
ARSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRARAETAYHPSCSC
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIVDRIRGRAPLPRSTADYYVAGDAPVRR

Sequences:

>Translated_556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVSVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPHMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWGYRDVLPYFRKAETRDIGANDYHGGEGPVSVATPKNDNNVLF
QAMVDAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDMAKPRDSLHIVTHATTDRILFAGKRAVGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYMQYACTKPVSLYPAL
QWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
ARSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRARAETAYHPSCSC
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIVDRIRGRAPLPRSTADYYVAGDAPVRR
>Mature_556_residues
MQREYDYIIIGAGSAGNVLAARLTEDPGVSVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPHMDNRRME
CGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWGYRDVLPYFRKAETRDIGANDYHGGEGPVSVATPKNDNNVLF
QAMVDAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDMAKPRDSLHIVTHATTDRILFAGKRAVGVHYL
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYMQYACTKPVSLYPAL
QWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVH
ARSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRARAETAYHPSCSC
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIVDRIRGRAPLPRSTADYYVAGDAPVRR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=49.3554327808471, Blast_Score=507, Evalue=1e-143,
Organism=Escherichia coli, GI1786503, Length=552, Percent_Identity=78.0797101449275, Blast_Score=911, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=44.404973357016, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24642048, Length=595, Percent_Identity=35.7983193277311, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24642042, Length=573, Percent_Identity=35.6020942408377, Blast_Score=276, Evalue=4e-74,
Organism=Drosophila melanogaster, GI45549471, Length=580, Percent_Identity=33.2758620689655, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI45551458, Length=580, Percent_Identity=33.2758620689655, Blast_Score=268, Evalue=9e-72,
Organism=Drosophila melanogaster, GI24642055, Length=585, Percent_Identity=34.8717948717949, Blast_Score=265, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=35.0877192982456, Blast_Score=265, Evalue=9e-71,
Organism=Drosophila melanogaster, GI17137792, Length=555, Percent_Identity=34.954954954955, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=32.5823223570191, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=34.0314136125654, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=33.3919156414763, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24642037, Length=577, Percent_Identity=32.9289428076257, Blast_Score=235, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24642035, Length=576, Percent_Identity=33.1597222222222, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24642051, Length=575, Percent_Identity=30.9565217391304, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI18859993, Length=577, Percent_Identity=33.2755632582322, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24645930, Length=575, Percent_Identity=26.6086956521739, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642057, Length=583, Percent_Identity=28.3018867924528, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 61446; Mature: 61446

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREYDYIIIGAGSAGNVLAARLTEDPGVSVLLLEAGGPDYRLDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETEPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWGY
EECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCC
RDVLPYFRKAETRDIGANDYHGGEGPVSVATPKNDNNVLFQAMVDAGVQAGYPRTDDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHCCHHCCCCCCCCCCC
YQQEGFGPMDRTVTPQGRRASTARGYLDMAKPRDSLHIVTHATTDRILFAGKRAVGVHYL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEEE
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQD
ECCCCCCCCHHHHCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
HLEVYMQYACTKPVSLYPALQWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWP
HHHHHHHHHCCCCCEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEHHHCCCC
NIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHARSRDPRQHPSILFNYQSTD
CEEEEEEEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCC
QDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRARAETAYHPSCSC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCE
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIVDRIRGRAPLP
ECCCCCEEEECCCCCEECCCCEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHCCCCCCC
RSTADYYVAGDAPVRR
CCCCCEEEECCCCCCC
>Mature Secondary Structure
MQREYDYIIIGAGSAGNVLAARLTEDPGVSVLLLEAGGPDYRLDFRTQMPAALAFPLQGR
CCCCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCEEECCCCCC
RYNWAYETEPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWGY
EECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCC
RDVLPYFRKAETRDIGANDYHGGEGPVSVATPKNDNNVLFQAMVDAGVQAGYPRTDDLNG
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEHHCCHHCCCCCCCCCCC
YQQEGFGPMDRTVTPQGRRASTARGYLDMAKPRDSLHIVTHATTDRILFAGKRAVGVHYL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEEE
VGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQD
ECCCCCCCCHHHHCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
HLEVYMQYACTKPVSLYPALQWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWP
HHHHHHHHHCCCCCEECHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEHHHCCCC
NIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHARSRDPRQHPSILFNYQSTD
CEEEEEEEEEEEECCCCHHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCC
QDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRARAETAYHPSCSC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCE
AMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIVDRIRGRAPLP
ECCCCCEEEECCCCCEECCCCEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHCCCCCCC
RSTADYYVAGDAPVRR
CCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]