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The map label for this gene is pdhA [H]

Identifier: 66766784

GI number: 66766784

Start: 526428

End: 527516

Strand: Reverse

Name: pdhA [H]

Synonym: XC_0444

Alternate gene names: 66766784

Gene position: 527516-526428 (Counterclockwise)

Preceding gene: 77761085

Following gene: 66766783

Centisome position: 10.25

GC content: 67.4

Gene sequence:

>1089_bases
ATGAGCGTAGCCGCGCAGTTCGAAATCGAATATCTGCAATACATGGACGCGGACGGCCAACTGGTCCGCGACGATCTGCC
GGCCGACGCCGCCAACCCGCAACAGTTGCTCGCCCTGTTCAAGCGCATGCTGTTCGTGCGCACCTTCGACAGCAAGTCGA
TCGCGCTGCAGCGCACCGGCAAGCTCGGCACCTACGCAGCCAGCCTGGGCCACGAGGCCACCCATGTGGGCATCGGTGCC
TCGATGCGCAGCGGCGATGTGTTCGCGCCCAGCTACCGTGAATACGGCACCATGTTCGAACGCGGCGTGCGTCCACGCGA
TGTGCTGCTGTACTGGGGCGGCGACGAGCGCGGCAGCGACTACCCGCGCGATGCCGATGCGGCGATCGACTTCCCGATCT
GCGTACCGATCTCCACCCAATGCCTGCACGCGGCCGGCGCGGCGCTGTCGTTCAAGCTGCAGGGCAAGGCGCAGGTGGCA
GTGGCGTGCTGCGGCGATGGCGGCAGCTCCAAGACCGACTTCTACGCCGCGCTCAACTCGGCCGGCGCCTACACGCTGCC
GCTGATCCTGTGCGTGATCAACAACGGCTGGGCGATCTCGGTGCCGCGCTCGGCGCAGACCGGTGCGCAGACGCTGGCAC
AGAAGGGCCTGGCCGGCGGCCTGCACTGCCTACAGGTGGACGGTAACGACCTCATCGCCGTGCTCGAAGCCATGCGCCAG
GCGCGCGCGCGCGCGCTGGCCGGCGATGGCGGCACCGTGATCGAATTCCTCACCTATCGCCTCACCGACCACACCACCGC
CGACGACGCCCGCCGCTACCGTGGCGAGGACGAAGTGAAGCAGGCCTGGACACGCGAACCGATGCTGCGCCTGCGCCGCT
ATCTCACCGCGCAAGGTCTGTGGGACGAGGCGCAGGAAGAAGCCTGGAAAGCCGAGTGCGGCGCGCGCATCGACGAAGAG
GTCAATGCGTACCTCAATACCCCGGTGCAGCCGGTGGAAGCGATGTTCGATTATCTGTACGGCGACCCGCCGGCCGAACT
GCTGGCCCAGCGCGCCGAGGTCATCGCCCTGGAGGCCCGTCATGGATGA

Upstream 100 bases:

>100_bases
AGCATCATTGTGTGCTGCGGTGCAGGACAGCTTTTTGCTTCGCCGTCCTTAACATCGCAACTCATATCATTTGAAACTTC
TTGATGAAGGTGTCGCCGCA

Downstream 100 bases:

>100_bases
GCTCAACCACGCACAGCTCGCCGGCTCACAGCAGGCCAGTGCCCCTTACAACGCCGCTGCCACGCGCGGAGAGATCGCCA
TGAGTTCGCCCATCACCCTG

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSVAAQFEIEYLQYMDADGQLVRDDLPADAANPQQLLALFKRMLFVRTFDSKSIALQRTGKLGTYAASLGHEATHVGIGA
SMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGAALSFKLQGKAQVA
VACCGDGGSSKTDFYAALNSAGAYTLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLIAVLEAMRQ
ARARALAGDGGTVIEFLTYRLTDHTTADDARRYRGEDEVKQAWTREPMLRLRRYLTAQGLWDEAQEEAWKAECGARIDEE
VNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVIALEARHG

Sequences:

>Translated_362_residues
MSVAAQFEIEYLQYMDADGQLVRDDLPADAANPQQLLALFKRMLFVRTFDSKSIALQRTGKLGTYAASLGHEATHVGIGA
SMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGAALSFKLQGKAQVA
VACCGDGGSSKTDFYAALNSAGAYTLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLIAVLEAMRQ
ARARALAGDGGTVIEFLTYRLTDHTTADDARRYRGEDEVKQAWTREPMLRLRRYLTAQGLWDEAQEEAWKAECGARIDEE
VNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVIALEARHG
>Mature_361_residues
SVAAQFEIEYLQYMDADGQLVRDDLPADAANPQQLLALFKRMLFVRTFDSKSIALQRTGKLGTYAASLGHEATHVGIGAS
MRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGAALSFKLQGKAQVAV
ACCGDGGSSKTDFYAALNSAGAYTLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLIAVLEAMRQA
RARALAGDGGTVIEFLTYRLTDHTTADDARRYRGEDEVKQAWTREPMLRLRRYLTAQGLWDEAQEEAWKAECGARIDEEV
NAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVIALEARHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=373, Percent_Identity=31.9034852546917, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI258645172, Length=373, Percent_Identity=31.9034852546917, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI291084744, Length=332, Percent_Identity=25.9036144578313, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4505685, Length=325, Percent_Identity=26.1538461538462, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI291084742, Length=325, Percent_Identity=26.1538461538462, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=25, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI86563355, Length=332, Percent_Identity=35.8433734939759, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI86563357, Length=332, Percent_Identity=35.8433734939759, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI32564172, Length=321, Percent_Identity=25.2336448598131, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17536047, Length=321, Percent_Identity=25.2336448598131, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=27.1565495207668, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355903, Length=357, Percent_Identity=31.3725490196078, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24639744, Length=291, Percent_Identity=25.7731958762887, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571106, Length=291, Percent_Identity=25.7731958762887, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24639740, Length=291, Percent_Identity=25.7731958762887, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24639746, Length=255, Percent_Identity=27.0588235294118, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639748, Length=290, Percent_Identity=24.8275862068966, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39481; Mature: 39350

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAAQFEIEYLQYMDADGQLVRDDLPADAANPQQLLALFKRMLFVRTFDSKSIALQRTG
CCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECC
KLGTYAASLGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSD
CCHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
YPRDADAAIDFPICVPISTQCLHAAGAALSFKLQGKAQVAVACCGDGGSSKTDFYAALNS
CCCCCCCEECCEEECCCCHHHHHHCCCEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHC
AGAYTLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLIAVLEAMRQ
CCCHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
ARARALAGDGGTVIEFLTYRLTDHTTADDARRYRGEDEVKQAWTREPMLRLRRYLTAQGL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
WDEAQEEAWKAECGARIDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVIALEAR
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEEEECC
HG
CC
>Mature Secondary Structure 
SVAAQFEIEYLQYMDADGQLVRDDLPADAANPQQLLALFKRMLFVRTFDSKSIALQRTG
CCCHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECC
KLGTYAASLGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSD
CCHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
YPRDADAAIDFPICVPISTQCLHAAGAALSFKLQGKAQVAVACCGDGGSSKTDFYAALNS
CCCCCCCEECCEEECCCCHHHHHHCCCEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHC
AGAYTLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLHCLQVDGNDLIAVLEAMRQ
CCCHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
ARARALAGDGGTVIEFLTYRLTDHTTADDARRYRGEDEVKQAWTREPMLRLRRYLTAQGL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
WDEAQEEAWKAECGARIDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVIALEAR
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHEEEEECC
HG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA