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The map label for this gene is bioF [H]

Identifier: 66766742

GI number: 66766742

Start: 461095

End: 462300

Strand: Reverse

Name: bioF [H]

Synonym: XC_0399

Alternate gene names: 66766742

Gene position: 462300-461095 (Counterclockwise)

Preceding gene: 66766743

Following gene: 66766741

Centisome position: 8.98

GC content: 69.9

Gene sequence:

>1206_bases
ATGGCTCGCCCCGATCTGCACGAACGGATTTCGTCGCTGCGCAAATTGCGCGTGGCCCAGGAGCGGGTGCGGGTGCGGCG
GCAGGTGGGCCGCCGCGACGGCGTGCGCCTGGAAATCGATGGGCGTTGGCTGACCGGTTTCTGCTCCAACGATTACCTGG
GGCTGTCGCAGCAGTTCGAAGTGGTGGCCGCGCTGCAGGATGCCGCCGCGCGCGATGGTGCCGGGGCGACTGCTTCGCAT
CTGATCTGCGGCCATCACACCGCGCACGAAACGCTGGAGCGCGACATCGCCGAATGGCTGGGCTATCCGTCGGCGCTGCT
GTTCGGCAGCGGCTTCATCGCCAACCTGGCCGTGCAGCAGGCGCTGCTCAGCGAAGAAGACGATGTCTGCGTGCAGGACC
GGCTCAATCACGCCAGCCTGCTGGATGCCACGCGCCTGGCCGGCTGCCGGTTGCGCCGCTACCCGCACCTGGATGTGGAA
GGCGCGATGCGCCAGCTCAAGGGCGCGCCGGAGGGCGCGGCAATGCTCGCCAGCGACGGTGTTTTCAGCATGGATGGCGA
CGTTGCGCCACTGCGTGCGCTGAGCCTGGTCGCGCGCATGCAGGAGGCCTTGTTCTATGTCGACGATGCGCACGGCGTGG
GCGTGCTGGGGCCGCAGGGCCGCGGTTGCGTGGCCGATGCCGGGCTCGGCGTGGCCGAAGTGCCGCTGCAACTGGTGACC
CTGGGCAAGGCCCTGGGCGGCTATGGCGCGGTGGTGGTGGGCGAAGAAGCGCTGATCCGCCATCTGGCCGAAACCGCGCG
CCCGTACATCTACACCACCGCGCTGCCGCCCGCGCAGGTGGCCGCCACCCTGGCTGCGGTGCGCCTGGCGCGTCGCGACG
ATTGGCGCCGCACGCGGCTGACCGAACTGATCGGCACATTCCGCGATGGCGCGCGCCGGCATGGGTTCGAACTGATGGCC
TCGGACACCCCCATCCAGCCGCTGCTGTGCGGCGAGGAACCCACCGTGATGGCGATGTCTGCGGCGCTGGAGCAAGCCGG
CTTCATGGTCGGTGCAATCCGCCCGCCCACCGTGCCCGAAGGCAAGGCGCGGCTGCGGGTGACGTTGTCGGCATTGCACA
CGCCGCAACAGGTGCAGGCCCTGGTCGATGCCATCGTGCAGGCGCGCGATGTGGTCAGCCGCCAGCCGCAGCGCGCGCTG
GCCTGA

Upstream 100 bases:

>100_bases
ACCGCATCAGCGCCCAGCTAGCACCGGCCGTCGGTGCCGGCTGGGCGCGCTGGGCCCGGCACGCTACGCTAGCGGCCCTC
TTCCGCTGTCGACGAACGCC

Downstream 100 bases:

>100_bases
GTATGCACACCCCGACGCCGGCGCAACGCCGCGTGTGGGAGGCAATGGCCGAGCTGTATCTGGACACCGCAGTCGATGCC
ATGCACGCGCGCATCGTGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFEVVAALQDAAARDGAGATASH
LICGHHTAHETLERDIAEWLGYPSALLFGSGFIANLAVQQALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVE
GAMRQLKGAPEGAAMLASDGVFSMDGDVAPLRALSLVARMQEALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVT
LGKALGGYGAVVVGEEALIRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRTRLTELIGTFRDGARRHGFELMA
SDTPIQPLLCGEEPTVMAMSAALEQAGFMVGAIRPPTVPEGKARLRVTLSALHTPQQVQALVDAIVQARDVVSRQPQRAL
A

Sequences:

>Translated_401_residues
MARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFEVVAALQDAAARDGAGATASH
LICGHHTAHETLERDIAEWLGYPSALLFGSGFIANLAVQQALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVE
GAMRQLKGAPEGAAMLASDGVFSMDGDVAPLRALSLVARMQEALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVT
LGKALGGYGAVVVGEEALIRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRTRLTELIGTFRDGARRHGFELMA
SDTPIQPLLCGEEPTVMAMSAALEQAGFMVGAIRPPTVPEGKARLRVTLSALHTPQQVQALVDAIVQARDVVSRQPQRAL
A
>Mature_400_residues
ARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFEVVAALQDAAARDGAGATASHL
ICGHHTAHETLERDIAEWLGYPSALLFGSGFIANLAVQQALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVEG
AMRQLKGAPEGAAMLASDGVFSMDGDVAPLRALSLVARMQEALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVTL
GKALGGYGAVVVGEEALIRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRTRLTELIGTFRDGARRHGFELMAS
DTPIQPLLCGEEPTVMAMSAALEQAGFMVGAIRPPTVPEGKARLRVTLSALHTPQQVQALVDAIVQARDVVSRQPQRALA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=369, Percent_Identity=36.0433604336043, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=36.8876080691643, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI83977444, Length=354, Percent_Identity=31.3559322033898, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977440, Length=354, Percent_Identity=31.3559322033898, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977442, Length=354, Percent_Identity=31.3559322033898, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4758668, Length=371, Percent_Identity=27.2237196765499, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4502025, Length=405, Percent_Identity=28.641975308642, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI40316939, Length=405, Percent_Identity=28.641975308642, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=25, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI5454084, Length=250, Percent_Identity=22.8, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786993, Length=354, Percent_Identity=42.9378531073446, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1790046, Length=352, Percent_Identity=34.9431818181818, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71994529, Length=368, Percent_Identity=35.8695652173913, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI32566772, Length=359, Percent_Identity=27.5766016713092, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=381, Percent_Identity=25.4593175853018, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=381, Percent_Identity=25.4593175853018, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=283, Percent_Identity=22.9681978798587, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71982617, Length=285, Percent_Identity=23.859649122807, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320438, Length=378, Percent_Identity=29.8941798941799, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=372, Percent_Identity=23.6559139784946, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323954, Length=310, Percent_Identity=23.2258064516129, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24662918, Length=347, Percent_Identity=35.1585014409222, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI17137420, Length=384, Percent_Identity=31.25, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17136286, Length=382, Percent_Identity=26.1780104712042, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24653280, Length=280, Percent_Identity=24.6428571428571, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24653276, Length=280, Percent_Identity=24.6428571428571, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24653278, Length=280, Percent_Identity=24.6428571428571, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 43258; Mature: 43127

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCHHHHH
VVAALQDAAARDGAGATASHLICGHHTAHETLERDIAEWLGYPSALLFGSGFIANLAVQQ
HHHHHHHHHHCCCCCCHHHHEEECCHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHH
ALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVEGAMRQLKGAPEGAAMLASDG
HHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCC
VFSMDGDVAPLRALSLVARMQEALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVT
EEECCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCCCCHHCCCCHHHHHHHHHH
LGKALGGYGAVVVGEEALIRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRTRL
HHHHHCCCCEEEECHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHH
TELIGTFRDGARRHGFELMASDTPIQPLLCGEEPTVMAMSAALEQAGFMVGAIRPPTVPE
HHHHHHHHHHHHHCCCEEEECCCCCCCEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCC
GKARLRVTLSALHTPQQVQALVDAIVQARDVVSRQPQRALA
CCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure 
ARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEECCCCCCCCHHHHH
VVAALQDAAARDGAGATASHLICGHHTAHETLERDIAEWLGYPSALLFGSGFIANLAVQQ
HHHHHHHHHHCCCCCCHHHHEEECCHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHH
ALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVEGAMRQLKGAPEGAAMLASDG
HHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCC
VFSMDGDVAPLRALSLVARMQEALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVT
EEECCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCCCCHHCCCCHHHHHHHHHH
LGKALGGYGAVVVGEEALIRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRTRL
HHHHHCCCCEEEECHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHH
TELIGTFRDGARRHGFELMASDTPIQPLLCGEEPTVMAMSAALEQAGFMVGAIRPPTVPE
HHHHHHHHHHHHHCCCEEEECCCCCCCEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCC
GKARLRVTLSALHTPQQVQALVDAIVQARDVVSRQPQRALA
CCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]