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The map label for this gene is pcaR [H]

Identifier: 66766728

GI number: 66766728

Start: 446677

End: 447537

Strand: Reverse

Name: pcaR [H]

Synonym: XC_0385

Alternate gene names: 66766728

Gene position: 447537-446677 (Counterclockwise)

Preceding gene: 66766731

Following gene: 66766718

Centisome position: 8.69

GC content: 70.73

Gene sequence:

>861_bases
ATGCCCGAGCCCACCTCTTCCCGCCGCAAACGTCCCGCCGCGCCGGCCATCGCCAGCAGCGAGCGCGGCCTACCGCATGC
CTTGATGCAGCAGATTGCCGCTGCCAAAGGTGACCCGGATTTCATGACCTCGCTCGGGCGCGGGCTGGTGGTGTTGAGCG
TGTTCGCCCAGCACGCGCGCGAGGTGACGATGTCGCAGATCAGCCTGGAGACCGGCATCTCGCGCGCCGCGGTCAGGCGC
GTGCTGCACACCCTGGCGGCCCTGGGTTATGTGGGTGAGCAGGGCCGCGGCTATGTGTTGCTGCCGCGGGTGCTGGGGCT
GGGCGGTGCGTACACCGCGTCCTCGTCGATGACCGCTGCGGCGCAGCCAGTGCTGGATGGCCTGCGCGACCAGGTGCACG
AGTCGTGCTCGCTGGGGGTGCTGGATGGCGATGACCTGCTGTACGTGGCACGCGCGGAAACCGTGCGCATCATGTCGATC
GGGCTGCGGCCCGGCACCCGCCTGCCGGCCTATTGCACGTCGATGGGGCGGGTGCTGCTGGCGGCCCTGCCTGCCGACAC
GCTGCAGGCCTATCTGGAACGCACCACCTTGCGTCCGCGCACCGACCGCACCGTGACCCAGCCCGCCGCCCTGCTCGAGG
TGCTGGCACGGGCGCGCCGCGAGGGCGTCTGCCTGACCGACCAGGAGCTGGAGATCGGCCTGCGCTCGATCGCAGTGCCG
GTGCGCAACCTGCGTGGCGAGGTGATTGCCGCGCTCAATATCGGTGCGCAGGCCGGGCGGGTGAGCCTGCAGACGATGCA
GACCCAGTGGGTGGAGCCGCTCAAGCAGGCGGCGCAGCGCTTGGGCGCCCTGCTCAGCTGA

Upstream 100 bases:

>100_bases
CAGGGTGAAGCGCTCACCCCGTACGGGGCCGAGCTGAGACCGGGGCCATGCATTGGGACGATGCGCTTACCATGCAGGCA
CCTGCCCCTAGCGCGATGCG

Downstream 100 bases:

>100_bases
GCGTGTCCGGCTGGTTCAGCGCGGGCGGCGCAGGAAGGCGACCACCGCGTCCACCCAGGCGGCATGGCTGTCTTCGACAT
GCGCCACATGGTCGGCGTGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPEPTSSRRKRPAAPAIASSERGLPHALMQQIAAAKGDPDFMTSLGRGLVVLSVFAQHAREVTMSQISLETGISRAAVRR
VLHTLAALGYVGEQGRGYVLLPRVLGLGGAYTASSSMTAAAQPVLDGLRDQVHESCSLGVLDGDDLLYVARAETVRIMSI
GLRPGTRLPAYCTSMGRVLLAALPADTLQAYLERTTLRPRTDRTVTQPAALLEVLARARREGVCLTDQELEIGLRSIAVP
VRNLRGEVIAALNIGAQAGRVSLQTMQTQWVEPLKQAAQRLGALLS

Sequences:

>Translated_286_residues
MPEPTSSRRKRPAAPAIASSERGLPHALMQQIAAAKGDPDFMTSLGRGLVVLSVFAQHAREVTMSQISLETGISRAAVRR
VLHTLAALGYVGEQGRGYVLLPRVLGLGGAYTASSSMTAAAQPVLDGLRDQVHESCSLGVLDGDDLLYVARAETVRIMSI
GLRPGTRLPAYCTSMGRVLLAALPADTLQAYLERTTLRPRTDRTVTQPAALLEVLARARREGVCLTDQELEIGLRSIAVP
VRNLRGEVIAALNIGAQAGRVSLQTMQTQWVEPLKQAAQRLGALLS
>Mature_285_residues
PEPTSSRRKRPAAPAIASSERGLPHALMQQIAAAKGDPDFMTSLGRGLVVLSVFAQHAREVTMSQISLETGISRAAVRRV
LHTLAALGYVGEQGRGYVLLPRVLGLGGAYTASSSMTAAAQPVLDGLRDQVHESCSLGVLDGDDLLYVARAETVRIMSIG
LRPGTRLPAYCTSMGRVLLAALPADTLQAYLERTTLRPRTDRTVTQPAALLEVLARARREGVCLTDQELEIGLRSIAVPV
RNLRGEVIAALNIGAQAGRVSLQTMQTQWVEPLKQAAQRLGALLS

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=247, Percent_Identity=31.9838056680162, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=32.3008849557522, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789999, Length=255, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082359, Length=224, Percent_Identity=26.3392857142857, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788581, Length=162, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786715, Length=229, Percent_Identity=24.4541484716157, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693096, Length=221, Percent_Identity=29.8642533936652, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30577; Mature: 30446

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPTSSRRKRPAAPAIASSERGLPHALMQQIAAAKGDPDFMTSLGRGLVVLSVFAQHAR
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHH
EVTMSQISLETGISRAAVRRVLHTLAALGYVGEQGRGYVLLPRVLGLGGAYTASSSMTAA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCCHHHH
AQPVLDGLRDQVHESCSLGVLDGDDLLYVARAETVRIMSIGLRPGTRLPAYCTSMGRVLL
HHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHH
AALPADTLQAYLERTTLRPRTDRTVTQPAALLEVLARARREGVCLTDQELEIGLRSIAVP
HHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VRNLRGEVIAALNIGAQAGRVSLQTMQTQWVEPLKQAAQRLGALLS
HHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEPTSSRRKRPAAPAIASSERGLPHALMQQIAAAKGDPDFMTSLGRGLVVLSVFAQHAR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHH
EVTMSQISLETGISRAAVRRVLHTLAALGYVGEQGRGYVLLPRVLGLGGAYTASSSMTAA
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCCHHHH
AQPVLDGLRDQVHESCSLGVLDGDDLLYVARAETVRIMSIGLRPGTRLPAYCTSMGRVLL
HHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHH
AALPADTLQAYLERTTLRPRTDRTVTQPAALLEVLARARREGVCLTDQELEIGLRSIAVP
HHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VRNLRGEVIAALNIGAQAGRVSLQTMQTQWVEPLKQAAQRLGALLS
HHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]