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The map label for this gene is ilvD [H]

Identifier: 66766699

GI number: 66766699

Start: 415081

End: 416919

Strand: Reverse

Name: ilvD [H]

Synonym: XC_0356

Alternate gene names: 66766699

Gene position: 416919-415081 (Counterclockwise)

Preceding gene: 66766701

Following gene: 66766697

Centisome position: 8.1

GC content: 64.82

Gene sequence:

>1839_bases
ATGCCCGAATACCGCTCAAAGACCTCCACCCACGGCCGCAACATGGCGGGCGCCCGCGCACTCTGGCGCGCCACCGGCAT
GAAGGATGGCGATTTCCACAAGCCGATCATTGCCATCGCCAATTCGTTCACGCAGTTCGTTCCCGGGCATGTGCACCTGA
AGGATCTTGGGCAACTCGTGGCACGTGAGATCGAACGTGTCGGCGGCGTAGCCAAGGAGTTCGACACCATCGCCGTGGAC
GACGGTATCGCGATGGGCCACGACGGCATGCTGTACTCGCTGCCCAGCCGCGAGATCATCGCCGACTCGGTCGAGTACAT
GGTCAACGCGCATTGCGCCGACGCGCTGGTGTGCATTTCCAACTGCGACAAGATCACCCCCGGCATGTTGATGGCCGCCT
TGCGCCTCAACATCCCGACGGTGTTCGTCTCCGGCGGGCCGATGGAAGCCGGCAAGACTAAGCTGGCCGACCATAATCTG
GATCTGATCGACGCGATGGTGATCGCCGCCGACGACAGCGCCTCCGATGAAAAGGTCGCCGAGTTCGAACGCAGCGCCTG
CCCCACGTGCGGCTCGTGCTCGGGCATGTTCACCGCCAACTCGATGAACTGCCTCACCGAAGCGCTGGGTCTTTCATTGC
CCGGCAATGGCACCGTGGTGGCCACGCATGCCGACCGCGAGCAGCTGTTCCTGCGCGCCGGGCGCGTGGCGGTGGAGCTG
TGCCATCGCTGGTATGGCGGCGAAGACCCCACCGCACTGCCGCGCGGCATCGCCACCTTCGAAGCGTTCGAAAACGCGAT
GACGCTGGACATCGCCATGGGCGGCTCCACCAACACCATCCTGCATTTGCTGGCTGCCGCACAGGAAGGCGAAGTGCCGT
TCGGCATGCGCGATATCGACCGCCTGTCCAAGCGTGTGCCGCAGCTGTGCAAGGTCGCGCCGAACACGCCCAAGTACCAC
ATCGAAGACGTGCACCGTGCCGGCGGCATCATGTCCATCCTCGGCGAACTGGCACGTGGCGGCTTGCTGCACACCAACGC
AGCCACCGTGCACACACGCACGCTGGCCGACGCCATCGCGCAATGGGATGTCACCCAGGTCGACGACGACAAGGTGCATA
CGTTCTACAAGGCCGGCCCGGCCGGCATTCCCACGCAGATTGCGTTTAGCCAGGCCACGCGCTGGGACACCCTGGATACC
GATCGCAGCGAAGGCTGCATCCGCGATGTCGCACACGCGTTCTCGCAGGAAGGCGGCCTGGCGGTGCTGTACGGCAATAT
CGCGCGCGATGGCTGCGTGGTGAAGACCGCCGGCGTGGACGAATCCATCCATGTCTTCGAAGGCAACACACGCGTCTACG
AGAGCCAGGATTCGGCGGTCAAGGGCATCCTCGCCGACGAAGTCAAAGCCGGCGATGTGGTGGTGATCCGCTACGAAGGC
CCCAAGGGCGGCCCCGGCATGCAGGAGATGCTCTACCCCACCAGCTACCTGAAATCCAAGGGCCTGGGCAAACACTGCGC
ACTACTCACCGACGGCCGCTTCTCCGGCGGCACCTCGGGTCTGTCGATCGGCCACGCCTCGCCGGAAGCCGCCGCGGGCG
GTGCGATCGGCCTGGTGCGCAACGGCGACAAGATTCTCATCGATATCCCCAAGCGCTCAATCGACCTGCTCGTCTCCGAC
GAAGAACTGGCCGCACGCCGCACCGAGCAGGACGCCAAGGGCTGGAAGCCGGTGGAAGTGCGCCCACGCAAAGTCACCAC
CGCGCTGAAGGCGTACGCGTTGCTGGCGACCAGTGCGGACAAGGGCGCGGTACGCGACAAGGCGATGCTGGACGGCTGA

Upstream 100 bases:

>100_bases
CCGTGCGAGATCACCGGAACGCACCGCGACGGTTGCAGCAGCAACAGTCCTGGCGCGGTCTAATTGCCAGCCATCGCTCG
CTCACGTTGTCGATCCCGCC

Downstream 100 bases:

>100_bases
GGCATTGCGATGAAGACCGCGGATATTTAGCGGTCTTCGTCGTATCCCGGCATAGGACGATGGAAGGGACTTCCGTCCCG
ACGCGTGACTGCAAACCCAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPEYRSKTSTHGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLADHNL
DLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVPFGMRDIDRLSKRVPQLCKVAPNTPKYH
IEDVHRAGGIMSILGELARGGLLHTNAATVHTRTLADAIAQWDVTQVDDDKVHTFYKAGPAGIPTQIAFSQATRWDTLDT
DRSEGCIRDVAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGNTRVYESQDSAVKGILADEVKAGDVVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKHCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRNGDKILIDIPKRSIDLLVSD
EELAARRTEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKAMLDG

Sequences:

>Translated_612_residues
MPEYRSKTSTHGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLADHNL
DLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVPFGMRDIDRLSKRVPQLCKVAPNTPKYH
IEDVHRAGGIMSILGELARGGLLHTNAATVHTRTLADAIAQWDVTQVDDDKVHTFYKAGPAGIPTQIAFSQATRWDTLDT
DRSEGCIRDVAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGNTRVYESQDSAVKGILADEVKAGDVVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKHCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRNGDKILIDIPKRSIDLLVSD
EELAARRTEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKAMLDG
>Mature_611_residues
PEYRSKTSTHGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLADHNLD
LIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVELC
HRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVPFGMRDIDRLSKRVPQLCKVAPNTPKYHI
EDVHRAGGIMSILGELARGGLLHTNAATVHTRTLADAIAQWDVTQVDDDKVHTFYKAGPAGIPTQIAFSQATRWDTLDTD
RSEGCIRDVAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGNTRVYESQDSAVKGILADEVKAGDVVVIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKHCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRNGDKILIDIPKRSIDLLVSDE
ELAARRTEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKAMLDG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=72.4473257698541, Blast_Score=916, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=528, Percent_Identity=32.1969696969697, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI1788157, Length=536, Percent_Identity=29.6641791044776, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786464, Length=564, Percent_Identity=30.3191489361702, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=37.3770491803279, Blast_Score=353, Evalue=6e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65282; Mature: 65151

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYRSKTSTHGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLADHNLDLIDAMVIAADDSASDEKVA
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHH
EFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVPFGMRDID
HHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHH
RLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMSILGELARGGLLHTNAATVHTRTLADAIA
HHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
QWDVTQVDDDKVHTFYKAGPAGIPTQIAFSQATRWDTLDTDRSEGCIRDVAHAFSQEGGL
HCCCCCCCCCHHEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
AVLYGNIARDGCVVKTAGVDESIHVFEGNTRVYESQDSAVKGILADEVKAGDVVVIRYEG
EEEECCCCCCCEEEEECCCCCCEEEEECCCEEEECCCHHHHHHHHHCCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKHCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
NGDKILIDIPKRSIDLLVSDEELAARRTEQDAKGWKPVEVRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCC
KGAVRDKAMLDG
CCCCCCHHCCCC
>Mature Secondary Structure 
PEYRSKTSTHGRNMAGARALWRATGMKDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLADHNLDLIDAMVIAADDSASDEKVA
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHH
EFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVPFGMRDID
HHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHH
RLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMSILGELARGGLLHTNAATVHTRTLADAIA
HHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
QWDVTQVDDDKVHTFYKAGPAGIPTQIAFSQATRWDTLDTDRSEGCIRDVAHAFSQEGGL
HCCCCCCCCCHHEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
AVLYGNIARDGCVVKTAGVDESIHVFEGNTRVYESQDSAVKGILADEVKAGDVVVIRYEG
EEEECCCCCCCEEEEECCCCCCEEEEECCCEEEECCCHHHHHHHHHCCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKHCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
NGDKILIDIPKRSIDLLVSDEELAARRTEQDAKGWKPVEVRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCC
KGAVRDKAMLDG
CCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]