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The map label for this gene is fbp

Identifier: 66766447

GI number: 66766447

Start: 116642

End: 117658

Strand: Reverse

Name: fbp

Synonym: XC_0098

Alternate gene names: 66766447

Gene position: 117658-116642 (Counterclockwise)

Preceding gene: 66766448

Following gene: 66766446

Centisome position: 2.29

GC content: 65.59

Gene sequence:

>1017_bases
ATGTCGCGTCCCTCGCTGACCCGCTTCCTGATCGAAGAGCAACACGCCGGCCGTATCGACCCGGAATTGCGCCAGCTGAT
CACCATCGTCTCGCGCGCCTGCAAGCGCATCTCCATCGCCGTCAGCAAGGGCGCCCTGGGCGGTGTGCTGGGCGATGCCG
GCACCGGCAACGTGCAGGGCGAGGCGCAGAAGAAGCTCGACGTGCTGAGCAACGACATCCTGCTCGAAGCCAATGCCTGG
GGCGGCCACCTCGCCGCGTGCGCATCGGAAGAGATGGACCACAGCCAGCCAGTGCCCGACCAATACCCCAGCGGCGATTT
CCTGCTGCTGTTCGACCCGCTGGACGGCAGTTCCAACATCGACGTCAACGTCTCGGTCGGCACCATCTTCTCGGTGCTGC
GCGCGCCCAAGGGCACCGAAAAGCCCGGCGACGAACACTTCCTGCAGCCGGGCACGCAACAGGTGGCCGCCGGCTATTGC
ATCTACGGCCCCAGCACCATGCTGGTACTCACGCTGGGCCACGGCACCCACGCGTTCACCCTGGAGCGTGAGGAAGGCAG
CTTCCTGCTGACCCAGGCCGACATGCGCGTGCCCGAAGACACTGCCGAATTCGCCATCAACATGTCCAACCAGCGCCACT
GGGAACCGGCCATGCAGGCCTATGTGGGCGACCTGCTGGCCGGCAAGGACGGCGCGCGCGGCAAGGATTTCAACATGCGC
TGGATCGCCAGCATGGTGGCCGACGTGCACCGCATCCTGACCCGCGGCGGCATCTTCATCTACCCCTGGGACAAGAAGGA
CGCGGCCAAGCCCGGCAAGCTGCGCCTGATGTACGAAGCCAACCCGATGGGCATGCTGGTGGAACAGGCTGGCGGCGCCG
CGACCACGGGGCGCGAGCGCATCCTGGATATTCAACCGACGCAACTGCATCAGCGCGTGCCGGTGTTTTTGGGCTCGAAG
AATGAGGTGGCCGAGGCGACGCGGTATCACGTGGAGTTCGACAAGGCGCAGGGTTGA

Upstream 100 bases:

>100_bases
CGATAGGCGCGCAAAGATGCAAAGCGCGCAGCCGGTGATCGAAATCTAACGGCGCAATGGCGACAATGGCGGCCCACTTC
CTGCACAGGCTGCCCGCTCC

Downstream 100 bases:

>100_bases
GATTTGGCCGCTGGGTTGCCCATAAATTAGACGGCCCGATGACACCTACGCCCATGGGTGTCATGGCTGCACAAGCAGAC
ATCGTTCCGGCTAGTCACTG

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSRPSLTRFLIEEQHAGRIDPELRQLITIVSRACKRISIAVSKGALGGVLGDAGTGNVQGEAQKKLDVLSNDILLEANAW
GGHLAACASEEMDHSQPVPDQYPSGDFLLLFDPLDGSSNIDVNVSVGTIFSVLRAPKGTEKPGDEHFLQPGTQQVAAGYC
IYGPSTMLVLTLGHGTHAFTLEREEGSFLLTQADMRVPEDTAEFAINMSNQRHWEPAMQAYVGDLLAGKDGARGKDFNMR
WIASMVADVHRILTRGGIFIYPWDKKDAAKPGKLRLMYEANPMGMLVEQAGGAATTGRERILDIQPTQLHQRVPVFLGSK
NEVAEATRYHVEFDKAQG

Sequences:

>Translated_338_residues
MSRPSLTRFLIEEQHAGRIDPELRQLITIVSRACKRISIAVSKGALGGVLGDAGTGNVQGEAQKKLDVLSNDILLEANAW
GGHLAACASEEMDHSQPVPDQYPSGDFLLLFDPLDGSSNIDVNVSVGTIFSVLRAPKGTEKPGDEHFLQPGTQQVAAGYC
IYGPSTMLVLTLGHGTHAFTLEREEGSFLLTQADMRVPEDTAEFAINMSNQRHWEPAMQAYVGDLLAGKDGARGKDFNMR
WIASMVADVHRILTRGGIFIYPWDKKDAAKPGKLRLMYEANPMGMLVEQAGGAATTGRERILDIQPTQLHQRVPVFLGSK
NEVAEATRYHVEFDKAQG
>Mature_337_residues
SRPSLTRFLIEEQHAGRIDPELRQLITIVSRACKRISIAVSKGALGGVLGDAGTGNVQGEAQKKLDVLSNDILLEANAWG
GHLAACASEEMDHSQPVPDQYPSGDFLLLFDPLDGSSNIDVNVSVGTIFSVLRAPKGTEKPGDEHFLQPGTQQVAAGYCI
YGPSTMLVLTLGHGTHAFTLEREEGSFLLTQADMRVPEDTAEFAINMSNQRHWEPAMQAYVGDLLAGKDGARGKDFNMRW
IASMVADVHRILTRGGIFIYPWDKKDAAKPGKLRLMYEANPMGMLVEQAGGAATTGRERILDIQPTQLHQRVPVFLGSKN
EVAEATRYHVEFDKAQG

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=329, Percent_Identity=44.0729483282675, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI16579888, Length=329, Percent_Identity=44.0729483282675, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI22907028, Length=321, Percent_Identity=39.5638629283489, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1790679, Length=336, Percent_Identity=44.6428571428571, Blast_Score=257, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17508131, Length=334, Percent_Identity=44.0119760479042, Blast_Score=258, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6323409, Length=322, Percent_Identity=39.4409937888199, Blast_Score=222, Evalue=7e-59,
Organism=Drosophila melanogaster, GI45550998, Length=327, Percent_Identity=44.6483180428135, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI19921562, Length=327, Percent_Identity=44.6483180428135, Blast_Score=253, Evalue=9e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_XANC8 (Q4V0I4)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_241209.1
- HSSP:   P46275
- ProteinModelPortal:   Q4V0I4
- SMR:   Q4V0I4
- STRING:   Q4V0I4
- GeneID:   3382883
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_0098
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   AMSISPE
- PhylomeDB:   Q4V0I4
- ProtClustDB:   PRK09293
- BioCyc:   XCAM314565:XC_0098-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 36854; Mature: 36723

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00124 FBPASE

Important sites: BINDING 207-207 BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPSLTRFLIEEQHAGRIDPELRQLITIVSRACKRISIAVSKGALGGVLGDAGTGNVQG
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCC
EAQKKLDVLSNDILLEANAWGGHLAACASEEMDHSQPVPDQYPSGDFLLLFDPLDGSSNI
HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCE
DVNVSVGTIFSVLRAPKGTEKPGDEHFLQPGTQQVAAGYCIYGPSTMLVLTLGHGTHAFT
EEEEEHHHHHHHHHCCCCCCCCCCCHHCCCCCHHHHCCEEEECCCEEEEEEECCCCEEEE
LEREEGSFLLTQADMRVPEDTAEFAINMSNQRHWEPAMQAYVGDLLAGKDGARGKDFNMR
EEECCCCEEEEECCCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHH
WIASMVADVHRILTRGGIFIYPWDKKDAAKPGKLRLMYEANPMGMLVEQAGGAATTGRER
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCE
ILDIQPTQLHQRVPVFLGSKNEVAEATRYHVEFDKAQG
EEECCHHHHHCCCCEEECCCHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
SRPSLTRFLIEEQHAGRIDPELRQLITIVSRACKRISIAVSKGALGGVLGDAGTGNVQG
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCC
EAQKKLDVLSNDILLEANAWGGHLAACASEEMDHSQPVPDQYPSGDFLLLFDPLDGSSNI
HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCE
DVNVSVGTIFSVLRAPKGTEKPGDEHFLQPGTQQVAAGYCIYGPSTMLVLTLGHGTHAFT
EEEEEHHHHHHHHHCCCCCCCCCCCHHCCCCCHHHHCCEEEECCCEEEEEEECCCCEEEE
LEREEGSFLLTQADMRVPEDTAEFAINMSNQRHWEPAMQAYVGDLLAGKDGARGKDFNMR
EEECCCCEEEEECCCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHH
WIASMVADVHRILTRGGIFIYPWDKKDAAKPGKLRLMYEANPMGMLVEQAGGAATTGRER
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCE
ILDIQPTQLHQRVPVFLGSKNEVAEATRYHVEFDKAQG
EEECCHHHHHCCCCEEECCCHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA