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The map label for this gene is ybiC [C]

Identifier: 66045383

GI number: 66045383

Start: 2502154

End: 2503185

Strand: Direct

Name: ybiC [C]

Synonym: Psyr_2143

Alternate gene names: 66045383

Gene position: 2502154-2503185 (Clockwise)

Preceding gene: 66045380

Following gene: 66045384

Centisome position: 41.06

GC content: 63.95

Gene sequence:

>1032_bases
ATGCGCGCCAATCCTGCCGATCAGTCGACCCGGGCCGTTTCCCTTGAGCAACTGACAGATTTGTTGCGCCGAATCTTCCT
CGCCCATGGCACCAGTGCGGAAGTTGCCGGCGTGCTTGCCGAGAACTGCGCCAGCGCCCAGCGTGATGGCTCGCACAGCC
ATGGCATCTTTCGCATTCCCGGCTATCTCTCATCGCTGGCCAGCGGTTGGGTGGATGGCAAGGCTGTGCCGGTGGTCGAG
GATGTCGGCGCTGCGTTTGTCCGGGTCGACGCCGGAGGCGGCTTTGCCCAGCCTGCACTGGCGGCGGCCAGAGCCTTGTT
GATCGACAAGGCGCGCAGTGCCGGGATTGCGGTACTGGCCATTCGCAACTCTCATCACTTCGCTGCGTTATGGCCGGATG
TCGAGCCTTTCGCCGAACAGGGGCTGGTCGCCCTGAGCATGGTCAACAGCATGACCTGCGTTGTGCCGCATGGCGCGCGT
CAGCCCCTGTTCGGCACCAACCCGATTGCTTTCGCTGCACCCCGTGCAGGCGGCGAGCCTGTGGTTTTCGATCTGGCGAC
CAGCGCCATTGCCCACGGTGATGTGCAGATCGCCGCACGCGAAGGTCGATTGCTGCCAGCAGGCATGGGCGTCGATCGCG
ACGGCCAGCCCACTGACGAGCCCCGCGCCATTCTCGAGGGTGGCGCGTTGTTGCCCTTCGGCGGGCACAAGGGCTCAGCA
CTGTCGATGATGGTCGAACTGCTGGCCGCAGGGCTGACTGGGGGCAATTTCTCATTCGAATTCGACTGGTCGAAGCATCC
CGGGGCACAGACACCCTGGACCGGTCAGTTGCTGATCGTCATCGATCCTGACAAGGGCAGTGGTCAGTCGTTTGCGCAGC
GCAGCGAGGAGCTGGTACGACAGCTCCATGGGGCAGGGCAGGAGCGTCTGCCGGGGGATCGGCGTTATAGCGAACGCGCG
CGATCAATGGCACACGGTATCAGCATCGCCCAGACTGACCTGGAGCGCCTGCAAGCACTGGCGGGTCATTGA

Upstream 100 bases:

>100_bases
GAGTGTCCTTGCAGCGTCCGCAGCGCTACTCTCGGGGCTTGCATTCGCCTTGTCGTTCTCGCTAGCGTTCTCGATCTACC
GCCATGAACAGGAGTTCCAA

Downstream 100 bases:

>100_bases
GGCATTTACAAATTCACTGACCATTCGTCGCGACCAGTCTTGTATCAGCGCGCTGTTCAAAATACTGTATGCATGAACAG
TAAAAAACGAATGAGGTCTG

Product: malate/L-lactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRANPADQSTRAVSLEQLTDLLRRIFLAHGTSAEVAGVLAENCASAQRDGSHSHGIFRIPGYLSSLASGWVDGKAVPVVE
DVGAAFVRVDAGGGFAQPALAAARALLIDKARSAGIAVLAIRNSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVPHGAR
QPLFGTNPIAFAAPRAGGEPVVFDLATSAIAHGDVQIAAREGRLLPAGMGVDRDGQPTDEPRAILEGGALLPFGGHKGSA
LSMMVELLAAGLTGGNFSFEFDWSKHPGAQTPWTGQLLIVIDPDKGSGQSFAQRSEELVRQLHGAGQERLPGDRRYSERA
RSMAHGISIAQTDLERLQALAGH

Sequences:

>Translated_343_residues
MRANPADQSTRAVSLEQLTDLLRRIFLAHGTSAEVAGVLAENCASAQRDGSHSHGIFRIPGYLSSLASGWVDGKAVPVVE
DVGAAFVRVDAGGGFAQPALAAARALLIDKARSAGIAVLAIRNSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVPHGAR
QPLFGTNPIAFAAPRAGGEPVVFDLATSAIAHGDVQIAAREGRLLPAGMGVDRDGQPTDEPRAILEGGALLPFGGHKGSA
LSMMVELLAAGLTGGNFSFEFDWSKHPGAQTPWTGQLLIVIDPDKGSGQSFAQRSEELVRQLHGAGQERLPGDRRYSERA
RSMAHGISIAQTDLERLQALAGH
>Mature_343_residues
MRANPADQSTRAVSLEQLTDLLRRIFLAHGTSAEVAGVLAENCASAQRDGSHSHGIFRIPGYLSSLASGWVDGKAVPVVE
DVGAAFVRVDAGGGFAQPALAAARALLIDKARSAGIAVLAIRNSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVPHGAR
QPLFGTNPIAFAAPRAGGEPVVFDLATSAIAHGDVQIAAREGRLLPAGMGVDRDGQPTDEPRAILEGGALLPFGGHKGSA
LSMMVELLAAGLTGGNFSFEFDWSKHPGAQTPWTGQLLIVIDPDKGSGQSFAQRSEELVRQLHGAGQERLPGDRRYSERA
RSMAHGISIAQTDLERLQALAGH

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=324, Percent_Identity=30.8641975308642, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786727, Length=336, Percent_Identity=31.547619047619, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790000, Length=338, Percent_Identity=27.810650887574, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17507179, Length=351, Percent_Identity=30.1994301994302, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17536633, Length=271, Percent_Identity=30.2583025830258, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667904, Length=269, Percent_Identity=31.2267657992565, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24667908, Length=269, Percent_Identity=31.2267657992565, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45553211, Length=269, Percent_Identity=31.2267657992565, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24667912, Length=269, Percent_Identity=31.2267657992565, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24658010, Length=332, Percent_Identity=24.3975903614458, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648360, Length=335, Percent_Identity=25.6716417910448, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 35991; Mature: 35991

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRANPADQSTRAVSLEQLTDLLRRIFLAHGTSAEVAGVLAENCASAQRDGSHSHGIFRIP
CCCCCCCCCHHHEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECC
GYLSSLASGWVDGKAVPVVEDVGAAFVRVDAGGGFAQPALAAARALLIDKARSAGIAVLA
HHHHHHHHCCCCCCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
IRNSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVPHGARQPLFGTNPIAFAAPRAGGEP
EECCCCEEEECCCCCHHHHCCCHHHHHHCCEEEEECCCCCCCCCCCCCCEEECCCCCCCC
VVFDLATSAIAHGDVQIAAREGRLLPAGMGVDRDGQPTDEPRAILEGGALLPFGGHKGSA
EEEEEHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCHH
LSMMVELLAAGLTGGNFSFEFDWSKHPGAQTPWTGQLLIVIDPDKGSGQSFAQRSEELVR
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
QLHGAGQERLPGDRRYSERARSMAHGISIAQTDLERLQALAGH
HHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRANPADQSTRAVSLEQLTDLLRRIFLAHGTSAEVAGVLAENCASAQRDGSHSHGIFRIP
CCCCCCCCCHHHEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECC
GYLSSLASGWVDGKAVPVVEDVGAAFVRVDAGGGFAQPALAAARALLIDKARSAGIAVLA
HHHHHHHHCCCCCCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
IRNSHHFAALWPDVEPFAEQGLVALSMVNSMTCVVPHGARQPLFGTNPIAFAAPRAGGEP
EECCCCEEEECCCCCHHHHCCCHHHHHHCCEEEEECCCCCCCCCCCCCCEEECCCCCCCC
VVFDLATSAIAHGDVQIAAREGRLLPAGMGVDRDGQPTDEPRAILEGGALLPFGGHKGSA
EEEEEHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCHH
LSMMVELLAAGLTGGNFSFEFDWSKHPGAQTPWTGQLLIVIDPDKGSGQSFAQRSEELVR
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
QLHGAGQERLPGDRRYSERARSMAHGISIAQTDLERLQALAGH
HHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]