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The map label for this gene is ffh [H]

Identifier: 66044529

GI number: 66044529

Start: 1447349

End: 1448725

Strand: Direct

Name: ffh [H]

Synonym: Psyr_1281

Alternate gene names: 66044529

Gene position: 1447349-1448725 (Clockwise)

Preceding gene: 66044525

Following gene: 66044530

Centisome position: 23.75

GC content: 60.49

Gene sequence:

>1377_bases
ATGTTTGAAAATCTGACTGACCGCCTCTCGCAGACGCTGCGCCATGTTACTGGCAAGGCCAAGCTGAACGAGGACAACAT
CAAAGATACCTTGCGCGAAGTGCGTATGGCGTTGCTCGAAGCCGACGTCGCCTTGCCGGTGGTCAAAGACTTCGTCAATA
ACGTCAAGGAACGCGCCGTCGGCACCGAGGTGTCGCGCAGCCTGACGCCAGGTCAGGCGTTCGTGAAGATCGTCCAGGCC
GAACTCGAAAGCCTGATGGGCGCCGCCAACGAAGACCTGGTGCTCAATGTCACGCCGCCTGCCGTCATCCTCATGGCGGG
TTTGCAGGGCGCGGGCAAGACCACCACTGCCGGCAAGCTGGCGCGCTTCCTTAAAGAGCGCAAGAAGAAAACCGTGATGG
TGGTGTCGGTCGACGTTTACCGTCCCGCGGCCATCAAACAGCTCGAAACCCTGGCCAACGATATCGGCGTGACGTTCTTC
GCCTCCGACATCAGCCAGAAGCCGGTGGACATCGCCCAGGCGGCCATTAAAGAAGCCAGGCTCAAGTTCATTGACGTGGT
CATCGTCGACACCGCCGGTCGTTTGCACGTCGATGTCGAGATGATGGGCGAGATCCAGGCGCTGCATGCGGCGGTCAAGC
CGGCCGAGACGCTGTTCGTGGTCGATGCCATGACCGGCCAGGATGCGGCCAATACCGCCAAGGCCTTCGGTGATGCACTG
CCGCTGACCGGTGTGATTCTCACCAAGGTCGACGGTGATGCCCGCGGTGGTGCGGCGCTGTCGGTGCGTGCCATTACCGG
CAAGCCGATCAAGTTCATCGGTATGGGCGAGAAGAGCGAGGCGCTGGAGCCGTTTCACCCGGACCGCATCGCCTCACGCA
TCCTCGGCATGGGCGATGTGCTCAGCCTTATCGAGCAGGCCGAACAGACCCTCGACAAGGACAAGGCCGACAAGCTGGCG
AAAAAGCTCAAGAAGGGCAAGGGCTTCGACCTCGAAGACTTCCGCGACCAGCTGCAGCAGATGAAGAACATGGGTGGCCT
TGGCGGCCTGATGGACAAACTGCCGAGCATCGGCGGCGTCAACCTGTCGCAGATGGGCAACGCTCAGGGCGCAGCGGAAA
AACAGTTCAAGCAGATGGAAGCCATCATCAACTCGATGACCCCTGCCGAGCGCCGTGATCCGGATCTGGTCAGCGGTTCG
CGCAAGCGCCGCATTGCCATGGGCTCGGGCACTCAGGTTCAGGACATCGGGCGTCTGATCAAGCAGCACAAGCAGATGCA
GAAGATGATGAAGAAATTCTCCGCCAAGGGCGGAATGGCCAAAATGATGCGCGGCATGGGGGGAATGTTCCCCGGTGGCG
GCATGCCAAAAATGTAA

Upstream 100 bases:

>100_bases
TCCGCGACCTGCTCAAGCCGCAGGCTCGCCGAGCGCCATTTCTGCATTACGGGCCGGGCCGCATCAACCGGGGTTCGACG
AGAGCCTGAAAGGATCGCGC

Downstream 100 bases:

>100_bases
TTGCGTCGCGTGCAAGACGCTTTGCACGCTTCCCATCTGGGGGGTGACCCCCAGTCAGCCCGCGCTATGCGGGCTTTTAC
CGGCTGTCATACCGACAGCT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFENLTDRLSQTLRHVTGKAKLNEDNIKDTLREVRMALLEADVALPVVKDFVNNVKERAVGTEVSRSLTPGQAFVKIVQA
ELESLMGAANEDLVLNVTPPAVILMAGLQGAGKTTTAGKLARFLKERKKKTVMVVSVDVYRPAAIKQLETLANDIGVTFF
ASDISQKPVDIAQAAIKEARLKFIDVVIVDTAGRLHVDVEMMGEIQALHAAVKPAETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALEPFHPDRIASRILGMGDVLSLIEQAEQTLDKDKADKLA
KKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPSIGGVNLSQMGNAQGAAEKQFKQMEAIINSMTPAERRDPDLVSGS
RKRRIAMGSGTQVQDIGRLIKQHKQMQKMMKKFSAKGGMAKMMRGMGGMFPGGGMPKM

Sequences:

>Translated_458_residues
MFENLTDRLSQTLRHVTGKAKLNEDNIKDTLREVRMALLEADVALPVVKDFVNNVKERAVGTEVSRSLTPGQAFVKIVQA
ELESLMGAANEDLVLNVTPPAVILMAGLQGAGKTTTAGKLARFLKERKKKTVMVVSVDVYRPAAIKQLETLANDIGVTFF
ASDISQKPVDIAQAAIKEARLKFIDVVIVDTAGRLHVDVEMMGEIQALHAAVKPAETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALEPFHPDRIASRILGMGDVLSLIEQAEQTLDKDKADKLA
KKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPSIGGVNLSQMGNAQGAAEKQFKQMEAIINSMTPAERRDPDLVSGS
RKRRIAMGSGTQVQDIGRLIKQHKQMQKMMKKFSAKGGMAKMMRGMGGMFPGGGMPKM
>Mature_458_residues
MFENLTDRLSQTLRHVTGKAKLNEDNIKDTLREVRMALLEADVALPVVKDFVNNVKERAVGTEVSRSLTPGQAFVKIVQA
ELESLMGAANEDLVLNVTPPAVILMAGLQGAGKTTTAGKLARFLKERKKKTVMVVSVDVYRPAAIKQLETLANDIGVTFF
ASDISQKPVDIAQAAIKEARLKFIDVVIVDTAGRLHVDVEMMGEIQALHAAVKPAETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALEPFHPDRIASRILGMGDVLSLIEQAEQTLDKDKADKLA
KKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPSIGGVNLSQMGNAQGAAEKQFKQMEAIINSMTPAERRDPDLVSGS
RKRRIAMGSGTQVQDIGRLIKQHKQMQKMMKKFSAKGGMAKMMRGMGGMFPGGGMPKM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=459, Percent_Identity=33.1154684095861, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI226371618, Length=361, Percent_Identity=34.6260387811634, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=38.9937106918239, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI295424842, Length=302, Percent_Identity=28.1456953642384, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI23308697, Length=302, Percent_Identity=28.1456953642384, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1788963, Length=456, Percent_Identity=69.5175438596491, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=35.0943396226415, Blast_Score=148, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=444, Percent_Identity=31.3063063063063, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI193206261, Length=290, Percent_Identity=29.6551724137931, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=446, Percent_Identity=32.9596412556054, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=29.4303797468354, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17647949, Length=457, Percent_Identity=32.1663019693654, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.6363636363636, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49399; Mature: 49399

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSQTLRHVTGKAKLNEDNIKDTLREVRMALLEADVALPVVKDFVNNVKERAV
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTEVSRSLTPGQAFVKIVQAELESLMGAANEDLVLNVTPPAVILMAGLQGAGKTTTAGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCCCCCHHHHH
ARFLKERKKKTVMVVSVDVYRPAAIKQLETLANDIGVTFFASDISQKPVDIAQAAIKEAR
HHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCHHEEEHHCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHVDVEMMGEIQALHAAVKPAETLFVVDAMTGQDAANTAKAFGDAL
HHHEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALEPFHPDRIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEQAEQTLDKDKADKLAKKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPSIGGV
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
NLSQMGNAQGAAEKQFKQMEAIINSMTPAERRDPDLVSGSRKRRIAMGSGTQVQDIGRLI
CHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHH
KQHKQMQKMMKKFSAKGGMAKMMRGMGGMFPGGGMPKM
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSQTLRHVTGKAKLNEDNIKDTLREVRMALLEADVALPVVKDFVNNVKERAV
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTEVSRSLTPGQAFVKIVQAELESLMGAANEDLVLNVTPPAVILMAGLQGAGKTTTAGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCCCCCHHHHH
ARFLKERKKKTVMVVSVDVYRPAAIKQLETLANDIGVTFFASDISQKPVDIAQAAIKEAR
HHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCHHEEEHHCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHVDVEMMGEIQALHAAVKPAETLFVVDAMTGQDAANTAKAFGDAL
HHHEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALEPFHPDRIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEQAEQTLDKDKADKLAKKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPSIGGV
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
NLSQMGNAQGAAEKQFKQMEAIINSMTPAERRDPDLVSGSRKRRIAMGSGTQVQDIGRLI
CHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHH
KQHKQMQKMMKKFSAKGGMAKMMRGMGGMFPGGGMPKM
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]