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The map label for this gene is mco [H]

Identifier: 66044514

GI number: 66044514

Start: 1429748

End: 1431121

Strand: Direct

Name: mco [H]

Synonym: Psyr_1266

Alternate gene names: 66044514

Gene position: 1429748-1431121 (Clockwise)

Preceding gene: 66044513

Following gene: 66044515

Centisome position: 23.46

GC content: 61.64

Gene sequence:

>1374_bases
ATGTCCTTTACCCGTCGTCAAATCCTTACAGGCATCGCCGGTCTGGCCGTAGTCGGCCTTGGCGCGGGTGGTGCTTCGCG
TTACTGGATGGGGCGTCGCGAGTCTGAAGCGGGCTCTGACTTCGTGCTGATCGCCGCTCCGCTGGATGTGGAACTGGTGG
CGGGCCACAAGACGCCAGCCTGGGCCTTTGGCGGTTCTGCGCCGGGTACGGAGCTGCGCGTGCGGCAGGGTGAGTGGCTG
CGGCTGCGCTTCATCAATCAGTTGCCGGTCGAGACGACCATTCATTGGCATGGCATCAGGTTGCCGCTGGAGATGGATGG
CGTGCCGTACGTGTCGCAGTTGCCGGTCAAGCCGGGTGAATACTTCGATTACAAATTCCGTGTGCCGGACGCGGGTAGCT
ACTGGTACCACCCGCACGTCAGCAGCAGCGAAGAGCTGGGCCGCGGGCTGGTCGGGCCGCTGATTGTCGAAGAACGCGAG
CCGACCGGTTTTGCCTATGAGCGCACGGTCAGCCTGAAAAGCTGGCACGTGGACGAGCAGGGCGCCTTTACCGAGTTCAG
TGTGTTGCGTGAAGCGGCACGGGAGGGCACGGCGGGGCGGCTTTCAACGCTGAACGGTATTCCGCAGGCGGTGATTGAGT
TGCCTGCCGGGCAGATCACTCGCGTGCGCTTGCTCAATCTCGACAATACCGTGACCTATCGACTCAATCTGCCGGACGCC
GAGGCGCAGATCTATGCGCTGGATGGCAACCCGGTCAAACCGCGTCCCTTCGGCGACGAATACTGGCTGGGGCCGGGCAT
GCGCATCTGTCTGGCGATCAAGGCCCCGCCGGCAGGCGAGGAAATCTCGCTGCGTAACGGTCCGGTGCGCCTGGGGACGT
TCCGCTCGGTCGCCAATAACGACGCGCCCGGCCAGTGGCCGCCCGAGCTGCCGGCCAATCCGGTGGCCGAGCCTGATATG
GCTAACGCCGAAAAGATCAATTTCAACTTCGAGTGGGTGGGCTCGATGTCGGTCAACACCGACAATGGCAAACCGCCCAG
CCTGTGGCAGATCAACGGCGAAGCGTGGGACATTACCGACAAGACCTGCGCCGATCGGCCTATCGCCAGGTTGAAGCTGG
GCAAGAGCTATATCTTCGAGTTGAAGAACATGACTCAGTATCAGCACCCGATTCACTTGCACGGCATGAGTTTCAAGGTA
ATCGCCTCCAATCGGCGCAAGATCATCCCGTACTTCACCGACACCTTTTTGCTGGGCCGTAACGAACGGGCGCGAGTGGC
GCTGGTGGCGGATAACCCCGGTGTATGGATGTTCCATTGCCACGTTATCGATCACATGGAAACCGGCCTGATGGCCGCCA
TCGAGGTGGCATGA

Upstream 100 bases:

>100_bases
GTATCCACCCTTATCTTTCCCCAAATGCAGGTGTATCGTATTCGCCCCTCGCATTTGCTCGCAGATGCGCTCAGTCGTCG
TTTTCGAGGTTGCGCCGTTC

Downstream 100 bases:

>100_bases
TGCGGCAACCGCAGATCATCGACCGCAGCAAGGATCAGGATTTCATGCGCGAGGCGCTGGCACTGGCCGCGCAAGGCGCA
CTGCTGGGCGAGGTGCCTGT

Product: twin-arginine translocation pathway signal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSFTRRQILTGIAGLAVVGLGAGGASRYWMGRRESEAGSDFVLIAAPLDVELVAGHKTPAWAFGGSAPGTELRVRQGEWL
RLRFINQLPVETTIHWHGIRLPLEMDGVPYVSQLPVKPGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEERE
PTGFAYERTVSLKSWHVDEQGAFTEFSVLREAAREGTAGRLSTLNGIPQAVIELPAGQITRVRLLNLDNTVTYRLNLPDA
EAQIYALDGNPVKPRPFGDEYWLGPGMRICLAIKAPPAGEEISLRNGPVRLGTFRSVANNDAPGQWPPELPANPVAEPDM
ANAEKINFNFEWVGSMSVNTDNGKPPSLWQINGEAWDITDKTCADRPIARLKLGKSYIFELKNMTQYQHPIHLHGMSFKV
IASNRRKIIPYFTDTFLLGRNERARVALVADNPGVWMFHCHVIDHMETGLMAAIEVA

Sequences:

>Translated_457_residues
MSFTRRQILTGIAGLAVVGLGAGGASRYWMGRRESEAGSDFVLIAAPLDVELVAGHKTPAWAFGGSAPGTELRVRQGEWL
RLRFINQLPVETTIHWHGIRLPLEMDGVPYVSQLPVKPGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEERE
PTGFAYERTVSLKSWHVDEQGAFTEFSVLREAAREGTAGRLSTLNGIPQAVIELPAGQITRVRLLNLDNTVTYRLNLPDA
EAQIYALDGNPVKPRPFGDEYWLGPGMRICLAIKAPPAGEEISLRNGPVRLGTFRSVANNDAPGQWPPELPANPVAEPDM
ANAEKINFNFEWVGSMSVNTDNGKPPSLWQINGEAWDITDKTCADRPIARLKLGKSYIFELKNMTQYQHPIHLHGMSFKV
IASNRRKIIPYFTDTFLLGRNERARVALVADNPGVWMFHCHVIDHMETGLMAAIEVA
>Mature_456_residues
SFTRRQILTGIAGLAVVGLGAGGASRYWMGRRESEAGSDFVLIAAPLDVELVAGHKTPAWAFGGSAPGTELRVRQGEWLR
LRFINQLPVETTIHWHGIRLPLEMDGVPYVSQLPVKPGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEEREP
TGFAYERTVSLKSWHVDEQGAFTEFSVLREAAREGTAGRLSTLNGIPQAVIELPAGQITRVRLLNLDNTVTYRLNLPDAE
AQIYALDGNPVKPRPFGDEYWLGPGMRICLAIKAPPAGEEISLRNGPVRLGTFRSVANNDAPGQWPPELPANPVAEPDMA
NAEKINFNFEWVGSMSVNTDNGKPPSLWQINGEAWDITDKTCADRPIARLKLGKSYIFELKNMTQYQHPIHLHGMSFKVI
ASNRRKIIPYFTDTFLLGRNERARVALVADNPGVWMFHCHVIDHMETGLMAAIEVA

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=129, Percent_Identity=28.6821705426357, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321067, Length=269, Percent_Identity=27.1375464684015, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323703, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859919, Length=115, Percent_Identity=37.3913043478261, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24650186, Length=106, Percent_Identity=33.9622641509434, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 50745; Mature: 50614

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTRRQILTGIAGLAVVGLGAGGASRYWMGRRESEAGSDFVLIAAPLDVELVAGHKTPA
CCCHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCC
WAFGGSAPGTELRVRQGEWLRLRFINQLPVETTIHWHGIRLPLEMDGVPYVSQLPVKPGE
EECCCCCCCCEEEEECCCEEEEEEECCCCCEEEEEEEEEEEEEEECCCCCHHCCCCCCCC
YFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEEREPTGFAYERTVSLKSWHVDEQ
CEEEEEECCCCCCEEECCCCCCHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEEECCCCC
GAFTEFSVLREAAREGTAGRLSTLNGIPQAVIELPAGQITRVRLLNLDNTVTYRLNLPDA
CCHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHCCCCCCEEEEEEEECCCEEEEEEECCCC
EAQIYALDGNPVKPRPFGDEYWLGPGMRICLAIKAPPAGEEISLRNGPVRLGTFRSVANN
CEEEEEECCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCEEEECCCCEEEEEEHHHHCC
DAPGQWPPELPANPVAEPDMANAEKINFNFEWVGSMSVNTDNGKPPSLWQINGEAWDITD
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEECCCCCCCCEEEECCCEEECCC
KTCADRPIARLKLGKSYIFELKNMTQYQHPIHLHGMSFKVIASNRRKIIPYFTDTFLLGR
CCCCCCCHHHEECCHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEEEEEEECC
NERARVALVADNPGVWMFHCHVIDHMETGLMAAIEVA
CCCCEEEEEECCCCEEEEEEEEEHHHCCCCEEEEEEC
>Mature Secondary Structure 
SFTRRQILTGIAGLAVVGLGAGGASRYWMGRRESEAGSDFVLIAAPLDVELVAGHKTPA
CCHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCC
WAFGGSAPGTELRVRQGEWLRLRFINQLPVETTIHWHGIRLPLEMDGVPYVSQLPVKPGE
EECCCCCCCCEEEEECCCEEEEEEECCCCCEEEEEEEEEEEEEEECCCCCHHCCCCCCCC
YFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEEREPTGFAYERTVSLKSWHVDEQ
CEEEEEECCCCCCEEECCCCCCHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEEECCCCC
GAFTEFSVLREAAREGTAGRLSTLNGIPQAVIELPAGQITRVRLLNLDNTVTYRLNLPDA
CCHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHCCCCCCEEEEEEEECCCEEEEEEECCCC
EAQIYALDGNPVKPRPFGDEYWLGPGMRICLAIKAPPAGEEISLRNGPVRLGTFRSVANN
CEEEEEECCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCEEEECCCCEEEEEEHHHHCC
DAPGQWPPELPANPVAEPDMANAEKINFNFEWVGSMSVNTDNGKPPSLWQINGEAWDITD
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEECCCCCCCCEEEECCCEEECCC
KTCADRPIARLKLGKSYIFELKNMTQYQHPIHLHGMSFKVIASNRRKIIPYFTDTFLLGR
CCCCCCCHHHEECCHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEEEEEEECC
NERARVALVADNPGVWMFHCHVIDHMETGLMAAIEVA
CCCCEEEEEECCCCEEEEEEEEEHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]