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The map label for this gene is mltA [H]

Identifier: 66044135

GI number: 66044135

Start: 1002854

End: 1004065

Strand: Direct

Name: mltA [H]

Synonym: Psyr_0880

Alternate gene names: 66044135

Gene position: 1002854-1004065 (Clockwise)

Preceding gene: 66044134

Following gene: 66044136

Centisome position: 16.46

GC content: 63.37

Gene sequence:

>1212_bases
ATGATGCTCTCTTTCAAGCCATGGTTGCGGGGCCTGGCGCTGGTTTTGCCACTGGCTGCGTTGCTGACCGCGTGTGACAA
GTCCGACAAATCTGACAAGCCGGTGACGCCGTCTGCGCCGCCGCACACCACGTATAGCCAGGCTGGCTGGGACGCGCTGC
CTGCGGTGTCCGACGCGGATTTGCAGGCCGGTTTTGCCTCGTGGCGCAGCGCGTGTGTTCGTTTGAAAGCAGATGCAGTG
TGGGGGCCGACGTGTGCGGCGGCTGCGAGTCTTGCGGCTGCGCCGGATGCTGCGCAGATTCGCACCTTTTTGCAGGAGCA
GTTGCAGGTCTACAGCCTGCGCGCCGACGGGGGTAGTGCCGATGGTTTGATCACCGGCTACTACGAGCCTGTTTATCCGG
GCAGCCTGACGCAGACCGCCACGGCCAATGTGCCGGTGTATGGCATTCCGGACGATCTGATCGTGGTCAATCTGGACAGT
ATTTACCCAGAGCTCAAAGGCAAGCGTCTGCGCGGTCGGCTTGAGGGGAGGGTGCTTAAGCCTTACGACGACGCTGCAAC
GATCAGCACGCAGGGCTTGAACGCGCCGGTGATTGCCTGGCTGACCGACCCGATGGATCTGCAATTCCTGCAGATTCAGG
GCTCGGGGCGCGTGAGTCTGGAGGATGGCTCGCAGCTGCGTCTGGGCTATGCCGATCAGAACGGTCGTCCTTATCGCGCA
ATTGGTCGCTGGCTGGTAGAGCAGGGGCAGCTGAAGAAGGAGGACGTGACCATGGGCAGTATCGCGGCCTGGGCCAAGGC
GCATCCGGAGCGGATCAGCGAGCTGCTGGCGAGCAATCCCAGCTACGTGTTTTTCGCCCGTAACCCCGACAGCAACGAAG
GCCCGCGCGGCTCGCTGAATGTGCCGCTGACCCCGGGCTACAGCGTGGCCATCGATCGCAAGGTGATTCCGCTGGGCAGT
CTGCTCTGGCTCTCGACGACGCGGCCGGATGGCAGCAGCGTGGTGCGTCCGGTCGCTGCCCAGGACACGGGCGGTGCGAT
TGCCGGTGAAGTACGCGCCGACCTGTTCTGGGGGACCGGCGATGAGGCGGGCAAGCTGGCTGGCGACATGAAGCAGAAAG
GCAATATCTGGCTGTTGTGGCCCAAAGGCATGCCGTTGCCTCAGTCCGCAGAAACAGCTCCTGCAGCAACCCCGGCTGCT
GCCAGTCACTGA

Upstream 100 bases:

>100_bases
GACTTTTCAGACAAACCCTAGGCCCCTTTGTCCGCTTCAGCCACAATGACAGCCTTTACCCACCAGCCTGCTGTGGGCTG
TAAAAGGATTGGTGCTACTG

Downstream 100 bases:

>100_bases
AATCCCTTCACCTCGATAGCTACCGTCCTGCTCAATGGATAGGTAGCTATCTTCTTCATGCCCCCGTTTTCCTTCCAAAT
ACGCTTGAGATAGCGAAATG

Product: MltA:3D

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MMLSFKPWLRGLALVLPLAALLTACDKSDKSDKPVTPSAPPHTTYSQAGWDALPAVSDADLQAGFASWRSACVRLKADAV
WGPTCAAAASLAAAPDAAQIRTFLQEQLQVYSLRADGGSADGLITGYYEPVYPGSLTQTATANVPVYGIPDDLIVVNLDS
IYPELKGKRLRGRLEGRVLKPYDDAATISTQGLNAPVIAWLTDPMDLQFLQIQGSGRVSLEDGSQLRLGYADQNGRPYRA
IGRWLVEQGQLKKEDVTMGSIAAWAKAHPERISELLASNPSYVFFARNPDSNEGPRGSLNVPLTPGYSVAIDRKVIPLGS
LLWLSTTRPDGSSVVRPVAAQDTGGAIAGEVRADLFWGTGDEAGKLAGDMKQKGNIWLLWPKGMPLPQSAETAPAATPAA
ASH

Sequences:

>Translated_403_residues
MMLSFKPWLRGLALVLPLAALLTACDKSDKSDKPVTPSAPPHTTYSQAGWDALPAVSDADLQAGFASWRSACVRLKADAV
WGPTCAAAASLAAAPDAAQIRTFLQEQLQVYSLRADGGSADGLITGYYEPVYPGSLTQTATANVPVYGIPDDLIVVNLDS
IYPELKGKRLRGRLEGRVLKPYDDAATISTQGLNAPVIAWLTDPMDLQFLQIQGSGRVSLEDGSQLRLGYADQNGRPYRA
IGRWLVEQGQLKKEDVTMGSIAAWAKAHPERISELLASNPSYVFFARNPDSNEGPRGSLNVPLTPGYSVAIDRKVIPLGS
LLWLSTTRPDGSSVVRPVAAQDTGGAIAGEVRADLFWGTGDEAGKLAGDMKQKGNIWLLWPKGMPLPQSAETAPAATPAA
ASH
>Mature_403_residues
MMLSFKPWLRGLALVLPLAALLTACDKSDKSDKPVTPSAPPHTTYSQAGWDALPAVSDADLQAGFASWRSACVRLKADAV
WGPTCAAAASLAAAPDAAQIRTFLQEQLQVYSLRADGGSADGLITGYYEPVYPGSLTQTATANVPVYGIPDDLIVVNLDS
IYPELKGKRLRGRLEGRVLKPYDDAATISTQGLNAPVIAWLTDPMDLQFLQIQGSGRVSLEDGSQLRLGYADQNGRPYRA
IGRWLVEQGQLKKEDVTMGSIAAWAKAHPERISELLASNPSYVFFARNPDSNEGPRGSLNVPLTPGYSVAIDRKVIPLGS
LLWLSTTRPDGSSVVRPVAAQDTGGAIAGEVRADLFWGTGDEAGKLAGDMKQKGNIWLLWPKGMPLPQSAETAPAATPAA
ASH

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=392, Percent_Identity=29.5918367346939, Blast_Score=131, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42917; Mature: 42917

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLSFKPWLRGLALVLPLAALLTACDKSDKSDKPVTPSAPPHTTYSQAGWDALPAVSDAD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
LQAGFASWRSACVRLKADAVWGPTCAAAASLAAAPDAAQIRTFLQEQLQVYSLRADGGSA
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCC
DGLITGYYEPVYPGSLTQTATANVPVYGIPDDLIVVNLDSIYPELKGKRLRGRLEGRVLK
CCEEEECCCCCCCCCCCCCEECCCEEEECCCCEEEEEEHHHCHHHCCCHHHHHCCCCEEC
PYDDAATISTQGLNAPVIAWLTDPMDLQFLQIQGSGRVSLEDGSQLRLGYADQNGRPYRA
CCCCCCEEEECCCCCCEEEEECCCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCHHHH
IGRWLVEQGQLKKEDVTMGSIAAWAKAHPERISELLASNPSYVFFARNPDSNEGPRGSLN
HHHHHHHCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEE
VPLTPGYSVAIDRKVIPLGSLLWLSTTRPDGSSVVRPVAAQDTGGAIAGEVRADLFWGTG
CCCCCCCEEEECCEECCCCCEEEEEECCCCCCHHCCEEECCCCCCCEEECEEEEEEECCC
DEAGKLAGDMKQKGNIWLLWPKGMPLPQSAETAPAATPAAASH
CCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMLSFKPWLRGLALVLPLAALLTACDKSDKSDKPVTPSAPPHTTYSQAGWDALPAVSDAD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
LQAGFASWRSACVRLKADAVWGPTCAAAASLAAAPDAAQIRTFLQEQLQVYSLRADGGSA
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCC
DGLITGYYEPVYPGSLTQTATANVPVYGIPDDLIVVNLDSIYPELKGKRLRGRLEGRVLK
CCEEEECCCCCCCCCCCCCEECCCEEEECCCCEEEEEEHHHCHHHCCCHHHHHCCCCEEC
PYDDAATISTQGLNAPVIAWLTDPMDLQFLQIQGSGRVSLEDGSQLRLGYADQNGRPYRA
CCCCCCEEEECCCCCCEEEEECCCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCHHHH
IGRWLVEQGQLKKEDVTMGSIAAWAKAHPERISELLASNPSYVFFARNPDSNEGPRGSLN
HHHHHHHCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEE
VPLTPGYSVAIDRKVIPLGSLLWLSTTRPDGSSVVRPVAAQDTGGAIAGEVRADLFWGTG
CCCCCCCEEEECCEECCCCCEEEEEECCCCCCHHCCEEECCCCCCCEEECEEEEEEECCC
DEAGKLAGDMKQKGNIWLLWPKGMPLPQSAETAPAATPAAASH
CCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]