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The map label for this gene is fruA [H]

Identifier: 66044078

GI number: 66044078

Start: 930606

End: 932348

Strand: Direct

Name: fruA [H]

Synonym: Psyr_0823

Alternate gene names: 66044078

Gene position: 930606-932348 (Clockwise)

Preceding gene: 66044077

Following gene: 66044091

Centisome position: 15.27

GC content: 63.28

Gene sequence:

>1743_bases
ATGAAGTTAGCCATAGTTACGGCCTGCCCGAGCGGCAAGGTCAGCAGCGTACTCAGCGCACGATTGCTCGAAGCGGCGGC
CCTGCGCCAGGGCTGGGAAACCAGCGTCGAAATCATCGATCCCAACAAGGCCGATCAGCAGTTGTCCGCCGAGGACATTG
AAGCTGCCGATCTTGTCCTGGTGGTCAATACCGGTCCTGTGGACTTGAGCCGCTTTGTCGGCAAGCGTCTGTTTCAGGAT
TCGCCTGCGCATGCGTTGCAGGATGTCGACAGCTTTCTGCAGCGCGCCGAGCGAGAAGCGCAGGTGCATGCAGCGTCCGA
AGCAGCGGCGCCTCAGGCAAGCGGTGGCAGCGGCGGGCAACCGCGCATCGTTGCAATCACGGCCTGTCCGACCGGTGTAG
CCCACACGTTCATGGCGGCCGAAGCGATCCAGCAGGCTGCCAAGCGTCTGAATTACGACCTGCAAGTCGAAACCCAGGGC
TCGGTAGGCGCGCGTAACCCGCTCAGCGCCAAGGCCATCGCCGATGCCGATGTGGTGCTGCTGGCGGCGGATATCGAAGT
CAACACCGACCGCTTTGCCGGCAAGAAGATCTACCGTTGCGGCACCGGGATCGCGCTCAAGCAGTCCGAAGCGACTCTGA
AAAAAGCCCTGGCGGAAGGGCAGGTGGAGTCCGATGAGGCCGCCGCCAAGTCACCTGCCAGACAAGAGAAGGCGGGCGTC
TACAAACACCTGCTGACCGGCGTGTCGTTCATGCTGCCGATGGTCGTGGCGGGCGGGCTGTTGATCGCTCTTTCCTTCGT
ATTCGGTATCACCGCGTTCAAGGAGCCGGGCACGCTGGCTGCGGCACTGATGCAGATTGGCGGGGAAGCGGCGTTCAAAC
TGATGGTGCCGTTGCTGGCCGGGTACATCGCCTATTCGATTGCTGACCGTCCGGGGCTGGCCCCCGGCATGATCGGTGGT
CTGTTGGCGAGTACGCTGGGGGCCGGGTTCATCGGCGGTATCGTCGCAGGCTTTCTGGCCGGTTACAGTGCTGCCGCGAT
CAACCGCTACGCACGTCTGCCGGCCAGCGTCGAAGCGCTCAAGCCGATTCTGATCATCCCGTTGCTGTCGAGCCTGTTCA
CCGGTCTGGTGATGATCTACGTGGTCGGCAAGCCGGTTGCCGGGATGCTCGAAGCGTTGACGCACTTCCTCGACAGCATG
GGCACCACCAACGCGATCCTGTTAGGCGTGGTGCTGGGCGCAATGATGTGCGTCGACCTCGGTGGGCCGATCAACAAGGC
GTCCTACGCGTTCTCGGTCGGTTTGCTGGCGTCCCAGAGCTACGCGCCGATGGCCACCGCCATGGCTGCGGGTATGGTGC
CACCCATCGGTATGGGCATCGCTACGATCCTGGCTCGCCGCAAGTTCGCCCAGAGCGAGCGTGAGGCCGGCAAGGCGGCG
TTCGTGCTGGGGCTGTGCTTCATTTCGGAAGGTGCCATTCCCTTTGCCGCCAAGGACCCGTTGCGGGTGATTCCGGCCAG
TGTCGTGGGTGGCGCGCTGACCGGTGCGCTGTCGATGTACTTCGGCTGCAAGCTGATGGCACCGCATGGCGGCCTGTTCG
TGATGCTGATCCCCAATGCCATCAACCATGCGCTGCTTTATCTGCTGGCGATCATCGCCGGTAGTGTGCTGACCGGCGTG
ATCTACGCGCTGATCAAGCGCCCGGAGCCCGCTGACATGGAAGTGGCGCCCGCAGCCGCCTGA

Upstream 100 bases:

>100_bases
GACCCAGATCGGTTTCGGTATTACCGATGCCGCGCAACTCAAACGGCTTGAAGGCGGCGTCACTGTACGCAGCCTTTCAG
AACAATAAGAGAGGATCGTC

Downstream 100 bases:

>100_bases
TGATGCAAGGCGCGGGCTGCCCCGCGCCTTCTTCCTGCTCTAGCGTTCGAGTGCCAGAGCAACCCCCTGACCACCACCGA
TGCACAGCGTGGCCAGGCCC

Product: phosphotransferase system PTS, fructose-specific IIB subunit:PTS fructose IIC component

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKLAIVTACPSGKVSSVLSARLLEAAALRQGWETSVEIIDPNKADQQLSAEDIEAADLVLVVNTGPVDLSRFVGKRLFQD
SPAHALQDVDSFLQRAEREAQVHAASEAAAPQASGGSGGQPRIVAITACPTGVAHTFMAAEAIQQAAKRLNYDLQVETQG
SVGARNPLSAKAIADADVVLLAADIEVNTDRFAGKKIYRCGTGIALKQSEATLKKALAEGQVESDEAAAKSPARQEKAGV
YKHLLTGVSFMLPMVVAGGLLIALSFVFGITAFKEPGTLAAALMQIGGEAAFKLMVPLLAGYIAYSIADRPGLAPGMIGG
LLASTLGAGFIGGIVAGFLAGYSAAAINRYARLPASVEALKPILIIPLLSSLFTGLVMIYVVGKPVAGMLEALTHFLDSM
GTTNAILLGVVLGAMMCVDLGGPINKASYAFSVGLLASQSYAPMATAMAAGMVPPIGMGIATILARRKFAQSEREAGKAA
FVLGLCFISEGAIPFAAKDPLRVIPASVVGGALTGALSMYFGCKLMAPHGGLFVMLIPNAINHALLYLLAIIAGSVLTGV
IYALIKRPEPADMEVAPAAA

Sequences:

>Translated_580_residues
MKLAIVTACPSGKVSSVLSARLLEAAALRQGWETSVEIIDPNKADQQLSAEDIEAADLVLVVNTGPVDLSRFVGKRLFQD
SPAHALQDVDSFLQRAEREAQVHAASEAAAPQASGGSGGQPRIVAITACPTGVAHTFMAAEAIQQAAKRLNYDLQVETQG
SVGARNPLSAKAIADADVVLLAADIEVNTDRFAGKKIYRCGTGIALKQSEATLKKALAEGQVESDEAAAKSPARQEKAGV
YKHLLTGVSFMLPMVVAGGLLIALSFVFGITAFKEPGTLAAALMQIGGEAAFKLMVPLLAGYIAYSIADRPGLAPGMIGG
LLASTLGAGFIGGIVAGFLAGYSAAAINRYARLPASVEALKPILIIPLLSSLFTGLVMIYVVGKPVAGMLEALTHFLDSM
GTTNAILLGVVLGAMMCVDLGGPINKASYAFSVGLLASQSYAPMATAMAAGMVPPIGMGIATILARRKFAQSEREAGKAA
FVLGLCFISEGAIPFAAKDPLRVIPASVVGGALTGALSMYFGCKLMAPHGGLFVMLIPNAINHALLYLLAIIAGSVLTGV
IYALIKRPEPADMEVAPAAA
>Mature_580_residues
MKLAIVTACPSGKVSSVLSARLLEAAALRQGWETSVEIIDPNKADQQLSAEDIEAADLVLVVNTGPVDLSRFVGKRLFQD
SPAHALQDVDSFLQRAEREAQVHAASEAAAPQASGGSGGQPRIVAITACPTGVAHTFMAAEAIQQAAKRLNYDLQVETQG
SVGARNPLSAKAIADADVVLLAADIEVNTDRFAGKKIYRCGTGIALKQSEATLKKALAEGQVESDEAAAKSPARQEKAGV
YKHLLTGVSFMLPMVVAGGLLIALSFVFGITAFKEPGTLAAALMQIGGEAAFKLMVPLLAGYIAYSIADRPGLAPGMIGG
LLASTLGAGFIGGIVAGFLAGYSAAAINRYARLPASVEALKPILIIPLLSSLFTGLVMIYVVGKPVAGMLEALTHFLDSM
GTTNAILLGVVLGAMMCVDLGGPINKASYAFSVGLLASQSYAPMATAMAAGMVPPIGMGIATILARRKFAQSEREAGKAA
FVLGLCFISEGAIPFAAKDPLRVIPASVVGGALTGALSMYFGCKLMAPHGGLFVMLIPNAINHALLYLLAIIAGSVLTGV
IYALIKRPEPADMEVAPAAA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=573, Percent_Identity=57.0680628272251, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1786951, Length=493, Percent_Identity=35.0912778904665, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082348, Length=432, Percent_Identity=36.3425925925926, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1790386, Length=304, Percent_Identity=42.1052631578947, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788729, Length=391, Percent_Identity=27.8772378516624, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790387, Length=96, Percent_Identity=48.9583333333333, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788730, Length=96, Percent_Identity=34.375, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790390, Length=87, Percent_Identity=39.0804597701149, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 59741; Mature: 59741

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAIVTACPSGKVSSVLSARLLEAAALRQGWETSVEIIDPNKADQQLSAEDIEAADLVL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHCCHHCCCCCCEEE
VVNTGPVDLSRFVGKRLFQDSPAHALQDVDSFLQRAEREAQVHAASEAAAPQASGGSGGQ
EEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PRIVAITACPTGVAHTFMAAEAIQQAAKRLNYDLQVETQGSVGARNPLSAKAIADADVVL
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCCEEE
LAADIEVNTDRFAGKKIYRCGTGIALKQSEATLKKALAEGQVESDEAAAKSPARQEKAGV
EEEEEEECCCHHCCCHHEECCCCCEEECHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHH
YKHLLTGVSFMLPMVVAGGLLIALSFVFGITAFKEPGTLAAALMQIGGEAAFKLMVPLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHH
GYIAYSIADRPGLAPGMIGGLLASTLGAGFIGGIVAGFLAGYSAAAINRYARLPASVEAL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
KPILIIPLLSSLFTGLVMIYVVGKPVAGMLEALTHFLDSMGTTNAILLGVVLGAMMCVDL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GGPINKASYAFSVGLLASQSYAPMATAMAAGMVPPIGMGIATILARRKFAQSEREAGKAA
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
FVLGLCFISEGAIPFAAKDPLRVIPASVVGGALTGALSMYFGCKLMAPHGGLFVMLIPNA
HHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCHH
INHALLYLLAIIAGSVLTGVIYALIKRPEPADMEVAPAAA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLAIVTACPSGKVSSVLSARLLEAAALRQGWETSVEIIDPNKADQQLSAEDIEAADLVL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHCCHHCCCCCCEEE
VVNTGPVDLSRFVGKRLFQDSPAHALQDVDSFLQRAEREAQVHAASEAAAPQASGGSGGQ
EEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PRIVAITACPTGVAHTFMAAEAIQQAAKRLNYDLQVETQGSVGARNPLSAKAIADADVVL
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCCEEE
LAADIEVNTDRFAGKKIYRCGTGIALKQSEATLKKALAEGQVESDEAAAKSPARQEKAGV
EEEEEEECCCHHCCCHHEECCCCCEEECHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHH
YKHLLTGVSFMLPMVVAGGLLIALSFVFGITAFKEPGTLAAALMQIGGEAAFKLMVPLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHH
GYIAYSIADRPGLAPGMIGGLLASTLGAGFIGGIVAGFLAGYSAAAINRYARLPASVEAL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
KPILIIPLLSSLFTGLVMIYVVGKPVAGMLEALTHFLDSMGTTNAILLGVVLGAMMCVDL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GGPINKASYAFSVGLLASQSYAPMATAMAAGMVPPIGMGIATILARRKFAQSEREAGKAA
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
FVLGLCFISEGAIPFAAKDPLRVIPASVVGGALTGALSMYFGCKLMAPHGGLFVMLIPNA
HHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCHH
INHALLYLLAIIAGSVLTGVIYALIKRPEPADMEVAPAAA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]