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The map label for this gene is ispH [H]

Identifier: 66043978

GI number: 66043978

Start: 817378

End: 818325

Strand: Direct

Name: ispH [H]

Synonym: Psyr_0713

Alternate gene names: 66043978

Gene position: 817378-818325 (Clockwise)

Preceding gene: 66043977

Following gene: 66043980

Centisome position: 13.41

GC content: 61.6

Gene sequence:

>948_bases
ATGCAAATCAAACTCGCCAACCCCCGCGGCTTTTGTGCCGGAGTGGACCGCGCGATCGAAATCGTCAATCGCGCTCTGGA
AGTGTTTGGTCCGCCGATTTATGTGCGCCATGAAGTCGTTCACAACAAATTTGTCGTCGAGGACCTGCGCTCTCGCGGTG
CGATCTTCGTTGAAGAGCTGGATCAGGTGCCGGATGACGTCATCGTTATCTTCAGTGCCCACGGTGTCTCCCAGGCTGTG
CGTACCGAGGCGGCAGGCCGTGGCTTGAAAGTCTTCGATGCTACCTGTCCGCTGGTGACCAAGGTGCATATCGAGGTCGC
CCGTTACAGCCGTGACGGCCGCGAGTGCATCCTGATCGGCCACGCCGGTCACCCGGAAGTCGAAGGCACCATGGGCCAGT
ACGACGCCGCCAACGGCGGTGCGATCTATCTGGTCGAGGACGAAGAGGATGTTGCCAGCCTGCAAGTGCGCAACCCTGAA
GCCCTGGCCTTCGTGACCCAGACCACCTTGTCCATGGATGACACCAGCCGGGTGATCGATGCCTTGCGCAAGCGTTTCCC
GGCCATTGGCGGGCCGCGCAAGGACGACATCTGCTACGCCACGCAAAACCGTCAGGACGCAGTCAAGCAACTGGCCGATG
AATGCGATGTGGTGTTGGTGGTGGGCAGTCCGAACAGCTCCAACTCCAATCGCCTGCGTGAGCTGGCCGAGCGCATGGCG
ACTCCGGCCTACCTCATCGACGGCGCCGAAGACATGCAACAAGGCTGGTTCGACGGGGTGGAGCGTATTGGTATCACTGC
GGGCGCTTCGGCCCCCGAAGTGCTGGTGCGCGGCGTGATCCAGCAATTGCAGGCCTGGGGCGCGACCGGTGCGGATGAGC
TTGCCGGCCGCGAGGAGAACATCACCTTCTCGATGCCCAAGGAATTGCGCGTCAAGTCGCTGCTCTGA

Upstream 100 bases:

>100_bases
GAAGTGGAAATCTTCGAAGTGAAGGCGATTCTGGCTTCCTGATATTCGCCGTCAAGCCCGGCCAAGGCCGGGCTACCCCG
TACCAACCATGAGGCACCGC

Downstream 100 bases:

>100_bases
GGCTATTCAGCCACACAGCGCTGCATCGATTTTCGTGTCCTCGACCCTCACGCGCCCGGCCGGTGCGACTATCACTCGAT
AGTTGCTCACCGGCTGGTCT

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEELDQVPDDVIVIFSAHGVSQAV
RTEAAGRGLKVFDATCPLVTKVHIEVARYSRDGRECILIGHAGHPEVEGTMGQYDAANGGAIYLVEDEEDVASLQVRNPE
ALAFVTQTTLSMDDTSRVIDALRKRFPAIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELAERMA
TPAYLIDGAEDMQQGWFDGVERIGITAGASAPEVLVRGVIQQLQAWGATGADELAGREENITFSMPKELRVKSLL

Sequences:

>Translated_315_residues
MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEELDQVPDDVIVIFSAHGVSQAV
RTEAAGRGLKVFDATCPLVTKVHIEVARYSRDGRECILIGHAGHPEVEGTMGQYDAANGGAIYLVEDEEDVASLQVRNPE
ALAFVTQTTLSMDDTSRVIDALRKRFPAIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELAERMA
TPAYLIDGAEDMQQGWFDGVERIGITAGASAPEVLVRGVIQQLQAWGATGADELAGREENITFSMPKELRVKSLL
>Mature_315_residues
MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEELDQVPDDVIVIFSAHGVSQAV
RTEAAGRGLKVFDATCPLVTKVHIEVARYSRDGRECILIGHAGHPEVEGTMGQYDAANGGAIYLVEDEEDVASLQVRNPE
ALAFVTQTTLSMDDTSRVIDALRKRFPAIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELAERMA
TPAYLIDGAEDMQQGWFDGVERIGITAGASAPEVLVRGVIQQLQAWGATGADELAGREENITFSMPKELRVKSLL

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=311, Percent_Identity=68.8102893890675, Blast_Score=433, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 34383; Mature: 34383

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEEL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEHHHH
DQVPDDVIVIFSAHGVSQAVRTEAAGRGLKVFDATCPLVTKVHIEVARYSRDGRECILIG
HCCCCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCEEHHEEEEEEECCCCCCEEEEEE
HAGHPEVEGTMGQYDAANGGAIYLVEDEEDVASLQVRNPEALAFVTQTTLSMDDTSRVID
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEEHHCCCCHHHHHHH
ALRKRFPAIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELAERMA
HHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHC
TPAYLIDGAEDMQQGWFDGVERIGITAGASAPEVLVRGVIQQLQAWGATGADELAGREEN
CCEEEECCHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
ITFSMPKELRVKSLL
EEEECCHHHHHHHCC
>Mature Secondary Structure
MQIKLANPRGFCAGVDRAIEIVNRALEVFGPPIYVRHEVVHNKFVVEDLRSRGAIFVEEL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEHHHH
DQVPDDVIVIFSAHGVSQAVRTEAAGRGLKVFDATCPLVTKVHIEVARYSRDGRECILIG
HCCCCCEEEEEECCCHHHHHHHHHCCCCCEEEECCCCEEHHEEEEEEECCCCCCEEEEEE
HAGHPEVEGTMGQYDAANGGAIYLVEDEEDVASLQVRNPEALAFVTQTTLSMDDTSRVID
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEEHHCCCCHHHHHHH
ALRKRFPAIGGPRKDDICYATQNRQDAVKQLADECDVVLVVGSPNSSNSNRLRELAERMA
HHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHC
TPAYLIDGAEDMQQGWFDGVERIGITAGASAPEVLVRGVIQQLQAWGATGADELAGREEN
CCEEEECCHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
ITFSMPKELRVKSLL
EEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA