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The map label for this gene is parC [H]

Identifier: 66043821

GI number: 66043821

Start: 625908

End: 628163

Strand: Direct

Name: parC [H]

Synonym: Psyr_0554

Alternate gene names: 66043821

Gene position: 625908-628163 (Clockwise)

Preceding gene: 66043820

Following gene: 66043822

Centisome position: 10.27

GC content: 60.82

Gene sequence:

>2256_bases
ATGAGCGACTCCCTTGACCTCAGCCTGGATGGTGTAGAACGCCGATCACTGGCGGACTTCACCGAACAGGCCTACCTCAA
CTACTCCATGTACGTGATCATGGACCGTGCCTTGCCGCATATCGGTGACGGCCTGAAGCCTGTTCAGCGACGCATCATCT
ACGCGATGAGCGAACTGGGCCTGGGTGCCGACGCCAAGCACAAGAAGTCGGCGCGTACCGTCGGCGACGTGCTCGGCAAG
TTCCACCCGCACGGCGACTCGGCCTGTTACGAGGCGATGGTGCTGATGGCTCAGCCGTTCAGCTACCGCTACACGCTGGT
GGACGGGCAGGGCAACTGGGGTGCGCCGGATGATCCGAAATCCTTTGCGGCCATGCGCTACACCGAGGCGCGTCTGTCGC
GCTACTCGGAAGTCCTGCTCAGCGAGCTGGGTCAGGGCACCGCTGACTGGGTGCCGAACTTTGATGGCACGCTGGACGAA
CCCGCGGTGTTGCCGGCACGTCTGCCGAACATCCTGCTCAATGGCACCACCGGCATTGCCGTCGGTATGGCGACCGATGT
GCCGCCGCATAACCTGCGCGAAGTCGCCAGTGCCTGCGTTCGCCTGCTGGACGATCCCAAGGCCACGGTTCCGGAGCTGT
GCGAGCACATTCTGGGGCCAGACTATCCGACCGAAGCGGAAATCATCACGCCGCGTGCCGACCTGCTGAAAATCTACGAG
ACCGGGCGTGGCTCGGTGCGCATGCGTGCGGTTTACCGCATCGAAGATGGCGACATTATCGTCACCGCACTGCCGCATCA
GGTGTCCGGTGCCAAGGTGCTGGAACAGATCGCCGCGCAGATGCAGGCCAAGAAACTGCCGATGGTTGCCGACCTGCGCG
ACGAGTCGGACCACGAAAACCCTTGCCGTATCGTGATCATCCCGCGCTCCAATCGGGTTGAGCTGGACGAGCTGATGCAG
CACTTGTTCGCCACTACCGAGCTGGAATCCAGTTACCGGGTGAACATCAACATCATCGGTCTGGATGGCAAGCCGCAGCT
CAAGAACCTCAAGACACTGCTCGGCGAATGGCTGACGTTCCGCATTGGTACGGTGCGTCGCCGTCTGCAATTCCGTCTGG
ACAAGGTCGAGCATCGTCTGCACCTGTTGGACGGTTTGCTCACGGCGTACCTGAACCTCGATGAAGTGATTCACATCATC
CGTACCGCCGAGCATCCGAAGGCGGAGCTGATTGCGCGTTTCGATCTGTCGGAAATTCAGGCCGATTACATCCTCGACAC
CCGTCTGCGTCAGTTGGCGCGCCTGGAAGAGATGAAGCTGCGCAGCGAACAGGATGCCCTGCGCAAAGAGCAGGCCAAGC
TTCTGGCGCTGTTGAGCAGTGAGTCCAAGCTGCGCAAGCTGGTGCGTGCCGAACTGATTGCCGACGCTGAAACCTATGGC
GACGAGCGTCGTTCGCCCATCGTTGCCCGTGCCGAAGCCAAGGCGCTGTCTGAAAACGAATTGATGCCCACCGAGCCGGT
GACTGTCGTGCTGTCGGAAAAAGGCTGGGTACGCTGTGCCAAGGGCCACGACATCGATGCGACCGGGCTTTCCTATAAAG
CCGGGGATGGTTTCAAGACCTCGTCCATCGGCCGCTCCAATCAGTTCGCCGTGTTCATCGACTCGACCGGGCGCAGCTAT
TCGGTTGCCGCCCACACCCTGCCCTCTGCGCGAGGCCAGGGCGAGCCGCTGACGGGCAAGCTGCAACCGCCACCGGGTGC
GACCTTCGAATGCGTATTGCTGCCGGAAGATGATGCGTTGTACGTGATCGCGTCGGATGCCGGTTATGGTTTTGTCGTCA
AAGGCGAAGACCTGCAAGCCAAGAACAAGGCGGGCAAGGCGTTGCTGAGCCTGCCGGCCGGGGCGAAAGTCATCCTGCCT
CGCCCTGTGCCTGATCGTGAGCAGAACTGGCTGGCGGCGGTGACCACCGAAGGCCGCCTGCTGGTGTTCAAGATCAGCGA
TTTGCCGCAGCTGGGCAAAGGCAAGGGCAACAAAATCATTGGCATTCCGGGCGAGCGGGTGGCCAGTCGTGAAGAGTATG
TGACCGATCTTGCGGTGATCGGACAAGGCGCTACGCTGGTACTTCAGGCGGGCAAACGAACGCTGTCGCTGAAACCTGAA
GACCTCGAACATTACAAGGGGGAGCGCGGCAGACGTGGCAATAAACTGCCAAGGGGCTTCCAGAGGGTCGATGCATTATT
GGTGGAAAATAGCTGA

Upstream 100 bases:

>100_bases
GAACAGGTGCTGCTGGGTATGAGCGCAATGAAACAACTCGAATTCACACAGCGTGGCGGCAATTTGCTGCTGCGCCAGTC
AACGAAATGATGAGGCCCGC

Downstream 100 bases:

>100_bases
AAACATTGATCTGGCACCAAGGTTCTTCGTTTTGCCATGAAGTACGATGCATAATCGCTGGAGTCATGGTGCATATTCAC
GGATGATATGGGGTCTTGGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MSDSLDLSLDGVERRSLADFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLGADAKHKKSARTVGDVLGK
FHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTADWVPNFDGTLDE
PAVLPARLPNILLNGTTGIAVGMATDVPPHNLREVASACVRLLDDPKATVPELCEHILGPDYPTEAEIITPRADLLKIYE
TGRGSVRMRAVYRIEDGDIIVTALPHQVSGAKVLEQIAAQMQAKKLPMVADLRDESDHENPCRIVIIPRSNRVELDELMQ
HLFATTELESSYRVNINIIGLDGKPQLKNLKTLLGEWLTFRIGTVRRRLQFRLDKVEHRLHLLDGLLTAYLNLDEVIHII
RTAEHPKAELIARFDLSEIQADYILDTRLRQLARLEEMKLRSEQDALRKEQAKLLALLSSESKLRKLVRAELIADAETYG
DERRSPIVARAEAKALSENELMPTEPVTVVLSEKGWVRCAKGHDIDATGLSYKAGDGFKTSSIGRSNQFAVFIDSTGRSY
SVAAHTLPSARGQGEPLTGKLQPPPGATFECVLLPEDDALYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPAGAKVILP
RPVPDREQNWLAAVTTEGRLLVFKISDLPQLGKGKGNKIIGIPGERVASREEYVTDLAVIGQGATLVLQAGKRTLSLKPE
DLEHYKGERGRRGNKLPRGFQRVDALLVENS

Sequences:

>Translated_751_residues
MSDSLDLSLDGVERRSLADFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLGADAKHKKSARTVGDVLGK
FHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTADWVPNFDGTLDE
PAVLPARLPNILLNGTTGIAVGMATDVPPHNLREVASACVRLLDDPKATVPELCEHILGPDYPTEAEIITPRADLLKIYE
TGRGSVRMRAVYRIEDGDIIVTALPHQVSGAKVLEQIAAQMQAKKLPMVADLRDESDHENPCRIVIIPRSNRVELDELMQ
HLFATTELESSYRVNINIIGLDGKPQLKNLKTLLGEWLTFRIGTVRRRLQFRLDKVEHRLHLLDGLLTAYLNLDEVIHII
RTAEHPKAELIARFDLSEIQADYILDTRLRQLARLEEMKLRSEQDALRKEQAKLLALLSSESKLRKLVRAELIADAETYG
DERRSPIVARAEAKALSENELMPTEPVTVVLSEKGWVRCAKGHDIDATGLSYKAGDGFKTSSIGRSNQFAVFIDSTGRSY
SVAAHTLPSARGQGEPLTGKLQPPPGATFECVLLPEDDALYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPAGAKVILP
RPVPDREQNWLAAVTTEGRLLVFKISDLPQLGKGKGNKIIGIPGERVASREEYVTDLAVIGQGATLVLQAGKRTLSLKPE
DLEHYKGERGRRGNKLPRGFQRVDALLVENS
>Mature_750_residues
SDSLDLSLDGVERRSLADFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLGADAKHKKSARTVGDVLGKF
HPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYSEVLLSELGQGTADWVPNFDGTLDEP
AVLPARLPNILLNGTTGIAVGMATDVPPHNLREVASACVRLLDDPKATVPELCEHILGPDYPTEAEIITPRADLLKIYET
GRGSVRMRAVYRIEDGDIIVTALPHQVSGAKVLEQIAAQMQAKKLPMVADLRDESDHENPCRIVIIPRSNRVELDELMQH
LFATTELESSYRVNINIIGLDGKPQLKNLKTLLGEWLTFRIGTVRRRLQFRLDKVEHRLHLLDGLLTAYLNLDEVIHIIR
TAEHPKAELIARFDLSEIQADYILDTRLRQLARLEEMKLRSEQDALRKEQAKLLALLSSESKLRKLVRAELIADAETYGD
ERRSPIVARAEAKALSENELMPTEPVTVVLSEKGWVRCAKGHDIDATGLSYKAGDGFKTSSIGRSNQFAVFIDSTGRSYS
VAAHTLPSARGQGEPLTGKLQPPPGATFECVLLPEDDALYVIASDAGYGFVVKGEDLQAKNKAGKALLSLPAGAKVILPR
PVPDREQNWLAAVTTEGRLLVFKISDLPQLGKGKGNKIIGIPGERVASREEYVTDLAVIGQGATLVLQAGKRTLSLKPED
LEHYKGERGRRGNKLPRGFQRVDALLVENS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=741, Percent_Identity=66.8016194331984, Blast_Score=1028, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=757, Percent_Identity=36.3276089828269, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=507, Percent_Identity=22.4852071005917, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=192, Percent_Identity=26.5625, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82902; Mature: 82771

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLDLSLDGVERRSLADFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCCCCEEECCCCHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHCC
LGADAKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPK
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCH
SFAAMRYTEARLSRYSEVLLSELGQGTADWVPNFDGTLDEPAVLPARLPNILLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEE
VGMATDVPPHNLREVASACVRLLDDPKATVPELCEHILGPDYPTEAEIITPRADLLKIYE
EEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGRGSVRMRAVYRIEDGDIIVTALPHQVSGAKVLEQIAAQMQAKKLPMVADLRDESDHEN
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PCRIVIIPRSNRVELDELMQHLFATTELESSYRVNINIIGLDGKPQLKNLKTLLGEWLTF
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
RIGTVRRRLQFRLDKVEHRLHLLDGLLTAYLNLDEVIHIIRTAEHPKAELIARFDLSEIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHEEECCHHHHH
ADYILDTRLRQLARLEEMKLRSEQDALRKEQAKLLALLSSESKLRKLVRAELIADAETYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
DERRSPIVARAEAKALSENELMPTEPVTVVLSEKGWVRCAKGHDIDATGLSYKAGDGFKT
CCCCCCEEEEHHHHHCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCEEECCCCCCC
SSIGRSNQFAVFIDSTGRSYSVAAHTLPSARGQGEPLTGKLQPPPGATFECVLLPEDDAL
CCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
YVIASDAGYGFVVKGEDLQAKNKAGKALLSLPAGAKVILPRPVPDREQNWLAAVTTEGRL
EEEECCCCCEEEEECCCCCCHHHHCCEEEECCCCCEEEECCCCCCCCCCEEEEEECCCEE
LVFKISDLPQLGKGKGNKIIGIPGERVASREEYVTDLAVIGQGATLVLQAGKRTLSLKPE
EEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCH
DLEHYKGERGRRGNKLPRGFQRVDALLVENS
HHHHHCCCCCCCCCCCCHHHHHHHHEEECCC
>Mature Secondary Structure 
SDSLDLSLDGVERRSLADFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCCCEEECCCCHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHCC
LGADAKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPK
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCH
SFAAMRYTEARLSRYSEVLLSELGQGTADWVPNFDGTLDEPAVLPARLPNILLNGTTGIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEE
VGMATDVPPHNLREVASACVRLLDDPKATVPELCEHILGPDYPTEAEIITPRADLLKIYE
EEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHH
TGRGSVRMRAVYRIEDGDIIVTALPHQVSGAKVLEQIAAQMQAKKLPMVADLRDESDHEN
CCCCCEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PCRIVIIPRSNRVELDELMQHLFATTELESSYRVNINIIGLDGKPQLKNLKTLLGEWLTF
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHH
RIGTVRRRLQFRLDKVEHRLHLLDGLLTAYLNLDEVIHIIRTAEHPKAELIARFDLSEIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHEEECCHHHHH
ADYILDTRLRQLARLEEMKLRSEQDALRKEQAKLLALLSSESKLRKLVRAELIADAETYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
DERRSPIVARAEAKALSENELMPTEPVTVVLSEKGWVRCAKGHDIDATGLSYKAGDGFKT
CCCCCCEEEEHHHHHCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCEEECCCCCCC
SSIGRSNQFAVFIDSTGRSYSVAAHTLPSARGQGEPLTGKLQPPPGATFECVLLPEDDAL
CCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEE
YVIASDAGYGFVVKGEDLQAKNKAGKALLSLPAGAKVILPRPVPDREQNWLAAVTTEGRL
EEEECCCCCEEEEECCCCCCHHHHCCEEEECCCCCEEEECCCCCCCCCCEEEEEECCCEE
LVFKISDLPQLGKGKGNKIIGIPGERVASREEYVTDLAVIGQGATLVLQAGKRTLSLKPE
EEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCH
DLEHYKGERGRRGNKLPRGFQRVDALLVENS
HHHHHCCCCCCCCCCCCHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]