Click here to switch to the map view.

The map label for this gene is pepE [H]

Identifier: 62390369

GI number: 62390369

Start: 1566766

End: 1567905

Strand: Reverse

Name: pepE [H]

Synonym: cg1681

Alternate gene names: 62390369

Gene position: 1567905-1566766 (Counterclockwise)

Preceding gene: 62390371

Following gene: 62390368

Centisome position: 47.76

GC content: 54.39

Gene sequence:

>1140_bases
ATGAGTGATCCTTCAACAAACAATTTCCCCACATCGGTATATGCACAGCGTCTTGCGGATGCACAAGAAGGCGCACGCAA
GGCTGGCTTGAACGGTTTGATCATCGGTACAGGCGCAGAACTTGCGTATCTAACCGGCAGCTGGATCTCCACCCATGAGC
GTCTAACCGCTTTGGTGATCCCCAGCGAAGGAACCGCAACCATTGTTCTTCCCGCTGTAGACCGCGGAGACTTAGCACTG
TCTGCTATTCCAGGACTAGACATCAATGTGGCCGGATGGGTTGATGGCGATAATGCCCATGAGTTGGCCGTAGATGCTCT
CGGTGTTTCAGAGTTCGAAGCATTGGGTATTGGTTCCTCCATCACGGCAGATCACCTGATTCCTATCCAGAACCTGGTGG
GCTCCACCTGCCGCATGGAGTTGGCAGTTCAAGTGCTGAAAGAATTGTTTGTCTCTAAAGACGAAGCAGAGATCGAGCAG
CTTCGCGGCGCAGGTGCAGCCATTGACCGTGTCCACGCCAAAGTCCCGGAGCTTCTTCAAGACGGACGCACCGAAGCAGA
GGTTGCAGCACAGCTCAACGATCTCATCTTGGAAGAGCACTCTGAGGTGGACTTCGTGATTGTGGGATCCGCTGAAAACG
GCGCGAACCCTCACCACGGTTTCTCTGACCGAGTCCTCCGCAATGGCGACATCGTGGTGGTTGATATAGGAGGCACCTTC
GGCCCTGGTTACCACTCTGACTGCACACGCACCTACATTGTGGGCGGAAACCCTGACGATGCGGATCCAGAGTTCGCTAA
GTTCTACCAAGTGCTCTACGAAGCACAGCTCGCAGCCGTTGCGCATGTTCGCCCTGGCGTTACTGCAGAATCAGTGGACG
CTGTTGCTCGCGATCACATTGCTGCGGCTGGATACGGCGAATACTTCATTCACCGCACAGGACACGGCATTGGTCTATCC
ACCCATGAGGAGCCATTCATCATGGCGGGTAACTCACTCGTGTTGGAAGCCGGAATGGCCTTTTCCATTGAGCCTGGCAT
CTACATTGAAGGAATCCACGGAGCGCGCATCGAAGACATCGTTGTGGTGAATGAAGACGGTTGTGAAACCCTCAACAACC
AGCCCAAGGAACTGCGTTGA

Upstream 100 bases:

>100_bases
TTTTTCGTGATCAACAATCCGCTGGCATAGCGTCCAGCAGATTTGATTCTGACAGTGTGGTTTGATCGCACACCTGCCTA
GGCTACTAGGGTTGGAGACT

Downstream 100 bases:

>100_bases
GCATTCTTCTCCTAGGCGGAACCTCTGACATTGCCGGTGAGATTGCCACGTTGACGTGTCACGGCGAAGACGTTGTTTTG
GCTGCTCGTCGACCAGAGGC

Product: proline dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSDPSTNNFPTSVYAQRLADAQEGARKAGLNGLIIGTGAELAYLTGSWISTHERLTALVIPSEGTATIVLPAVDRGDLAL
SAIPGLDINVAGWVDGDNAHELAVDALGVSEFEALGIGSSITADHLIPIQNLVGSTCRMELAVQVLKELFVSKDEAEIEQ
LRGAGAAIDRVHAKVPELLQDGRTEAEVAAQLNDLILEEHSEVDFVIVGSAENGANPHHGFSDRVLRNGDIVVVDIGGTF
GPGYHSDCTRTYIVGGNPDDADPEFAKFYQVLYEAQLAAVAHVRPGVTAESVDAVARDHIAAAGYGEYFIHRTGHGIGLS
THEEPFIMAGNSLVLEAGMAFSIEPGIYIEGIHGARIEDIVVVNEDGCETLNNQPKELR

Sequences:

>Translated_379_residues
MSDPSTNNFPTSVYAQRLADAQEGARKAGLNGLIIGTGAELAYLTGSWISTHERLTALVIPSEGTATIVLPAVDRGDLAL
SAIPGLDINVAGWVDGDNAHELAVDALGVSEFEALGIGSSITADHLIPIQNLVGSTCRMELAVQVLKELFVSKDEAEIEQ
LRGAGAAIDRVHAKVPELLQDGRTEAEVAAQLNDLILEEHSEVDFVIVGSAENGANPHHGFSDRVLRNGDIVVVDIGGTF
GPGYHSDCTRTYIVGGNPDDADPEFAKFYQVLYEAQLAAVAHVRPGVTAESVDAVARDHIAAAGYGEYFIHRTGHGIGLS
THEEPFIMAGNSLVLEAGMAFSIEPGIYIEGIHGARIEDIVVVNEDGCETLNNQPKELR
>Mature_378_residues
SDPSTNNFPTSVYAQRLADAQEGARKAGLNGLIIGTGAELAYLTGSWISTHERLTALVIPSEGTATIVLPAVDRGDLALS
AIPGLDINVAGWVDGDNAHELAVDALGVSEFEALGIGSSITADHLIPIQNLVGSTCRMELAVQVLKELFVSKDEAEIEQL
RGAGAAIDRVHAKVPELLQDGRTEAEVAAQLNDLILEEHSEVDFVIVGSAENGANPHHGFSDRVLRNGDIVVVDIGGTFG
PGYHSDCTRTYIVGGNPDDADPEFAKFYQVLYEAQLAAVAHVRPGVTAESVDAVARDHIAAAGYGEYFIHRTGHGIGLST
HEEPFIMAGNSLVLEAGMAFSIEPGIYIEGIHGARIEDIVVVNEDGCETLNNQPKELR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=272, Percent_Identity=27.2058823529412, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788728, Length=235, Percent_Identity=39.5744680851064, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789275, Length=290, Percent_Identity=28.6206896551724, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1786364, Length=253, Percent_Identity=27.6679841897233, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=178, Percent_Identity=32.0224719101124, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355531, Length=178, Percent_Identity=29.7752808988764, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 40175; Mature: 40044

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPSTNNFPTSVYAQRLADAQEGARKAGLNGLIIGTGAELAYLTGSWISTHERLTALVI
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHCCCEEEEEE
PSEGTATIVLPAVDRGDLALSAIPGLDINVAGWVDGDNAHELAVDALGVSEFEALGIGSS
CCCCCEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHCCCCC
ITADHLIPIQNLVGSTCRMELAVQVLKELFVSKDEAEIEQLRGAGAAIDRVHAKVPELLQ
CCHHHCEEHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
DGRTEAEVAAQLNDLILEEHSEVDFVIVGSAENGANPHHGFSDRVLRNGDIVVVDIGGTF
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCC
GPGYHSDCTRTYIVGGNPDDADPEFAKFYQVLYEAQLAAVAHVRPGVTAESVDAVARDHI
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AAAGYGEYFIHRTGHGIGLSTHEEPFIMAGNSLVLEAGMAFSIEPGIYIEGIHGARIEDI
HHCCCCCEEEEECCCCCCCCCCCCCEEEECCEEEEECCCEEEECCCEEEECCCCCCEEEE
VVVNEDGCETLNNQPKELR
EEECCCCCHHHCCCCCCCC
>Mature Secondary Structure 
SDPSTNNFPTSVYAQRLADAQEGARKAGLNGLIIGTGAELAYLTGSWISTHERLTALVI
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHCCCEEEEEE
PSEGTATIVLPAVDRGDLALSAIPGLDINVAGWVDGDNAHELAVDALGVSEFEALGIGSS
CCCCCEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHCCCCC
ITADHLIPIQNLVGSTCRMELAVQVLKELFVSKDEAEIEQLRGAGAAIDRVHAKVPELLQ
CCHHHCEEHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
DGRTEAEVAAQLNDLILEEHSEVDFVIVGSAENGANPHHGFSDRVLRNGDIVVVDIGGTF
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCC
GPGYHSDCTRTYIVGGNPDDADPEFAKFYQVLYEAQLAAVAHVRPGVTAESVDAVARDHI
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AAAGYGEYFIHRTGHGIGLSTHEEPFIMAGNSLVLEAGMAFSIEPGIYIEGIHGARIEDI
HHCCCCCEEEEECCCCCCCCCCCCCEEEECCEEEEECCCEEEECCCEEEECCCCCCEEEE
VVVNEDGCETLNNQPKELR
EEECCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]