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The map label for this gene is nhaK [H]

Identifier: 62390319

GI number: 62390319

Start: 1514444

End: 1515994

Strand: Reverse

Name: nhaK [H]

Synonym: cg1624

Alternate gene names: 62390319

Gene position: 1515994-1514444 (Counterclockwise)

Preceding gene: 62390320

Following gene: 62390315

Centisome position: 46.18

GC content: 55.9

Gene sequence:

>1551_bases
ATGACGATATTGTTCATGCTCATTACATTGCTGCTCGCCACCGTGATTGTGGTGGCCATCGGCGATAAAACCGGACTCCC
CTGGCCTGCTTTGATGACTATTGTCGCCGCAGGTGGAGCGTTGTTGCCATTTTTGCCGGAATTTACTATCCCGGCCGATC
TGATGTTGCCTATTTTCATTCCGCCGCTGCTGTGGGCGCTGGCGAGGAAGTCATCGTGGGCGGTGATTAGGTCGCAGATG
TCTACCATCATCACGATGTCGGTGTTGTTGGTGTTCGTGACCATCGCGGCACTCACGGGTGCATCCATGCTGTTGCTTCC
TGGCATTGGTCTTGCTGGTGCGATCATGTTGGCTGCGGCTATTGCTCCACCGGATCCTGTTGCTGTTGATGCAGTGGCGG
AACCTGCGGGAATCCCGAAGCGCATCACCACCACTTTGCAGACGGAGGGTCTGTTTAATGATGCAGCCAGCATCGTGGCG
TTCCATGTGGCTTTAGCTGCCCTGGTCGCTGGTGAGGATTTGTCCTGGTCAACGGGTGTTTTGGAATTCTTGTGGTCGTG
TCTTGCTGCCGTTATTTTGGGCTTGGTTATTGGCCGGGCGGCTGCGTGGTTTACCGATCACGTGAGTTCCGTTGAGGCTC
GAAATGCGTTTACGTGGGTGCTGCCGTTTGCCATTTATGTGGTGGCGGAAGAAATCGGCGGTTCGGGCGTTATCGCCATT
GTGATCGCTGCAGTGGAGATGAATTCGAGGGCGTCGATTGGTGCGGAGGATCGTCTAACGGGTTCTGCGTTCTGGGGAAC
CATTGAGGTGCTGTTTACTGGCGTTGCCTTTGGTTTGATCGGCCTGAATGTGCGCGCTGCGATTGATGAAGTTGGATCTG
AGCTGTGGCATGCCGTGGTCGTGGGCATTGTGCTCTCGGTGGTGGCGATCGTTGTCCGTGGTGTGTGGATGTTCGCGGCG
TATAAGCGCAATCGTTTCAAGATCGATAAGAAGGGTGCGACCAATAGTTCATTGCGGGCGCCTCTTCGACTGCAGGAATC
GTTGCTGATGACGTGGGCGGGCATGCGCGGTTTGGTGACGTTGGCGCTGGTGCTGTCTATTCCGGAGGATATTTTCCCGT
ATCACCACGAGTTGCAGGTCATTGCGCTGGTCGTTCTCTTAATCACCATGGTGGGCCCTGGTTTGACGTTGCCGTGGCTG
ATGCGGAAGCTCAGCTTGGATAAGGGTCCCGATGCTGCGGGCGATGAGAGTATCGCCGCGCTGACAGAGAGGGCTCACAA
GGCCGCAACAACGTATTTGGTGGATACCACGGAGTTGCCGATGGAGCAGATGGTGGCGATCAAGAATTGGTTCTCGCAAG
AAATTGACGCTGATGAACTGCAGGAGAACGTCGATAAGCTGCATCAGCGCGCGCATCATGCGCGTGTCGGGGCAATTAAG
GCGGCCCAGGAGGAGCTGTTGAAGGCGCGGCGGGAGCGCGGCGTTAATCCGGCCTATGTTGATGAGGTGTTGACCAACAT
TGACCGGATGCTTGTTGCGGCTGAACGCTAG

Upstream 100 bases:

>100_bases
GTGTGCGCTCTCCCATGCAGCAGCATAATCAGGGAAAAATAGGAACTGTTTACTGAAAAACTGACAAACCTGACAGACCT
GACCCGAAGAGACCTTATTC

Downstream 100 bases:

>100_bases
ATAAACAGCAGCAGGCTGATCGCCATGACTGCCATGCCAGCGATGAGTCCGTAGATGGCGGTGTGGTGTTTGCCGCTGGA
GATGGCAGTGGGCAGTAGTT

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFIPPLLWALARKSSWAVIRSQM
STIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAAIAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVA
FHVALAALVAGEDLSWSTGVLEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRAAIDEVGSELWHAVVVGIVLSVVAIVVRGVWMFAA
YKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVTLALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLTLPWL
MRKLSLDKGPDAAGDESIAALTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER

Sequences:

>Translated_516_residues
MTILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFIPPLLWALARKSSWAVIRSQM
STIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAAIAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVA
FHVALAALVAGEDLSWSTGVLEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRAAIDEVGSELWHAVVVGIVLSVVAIVVRGVWMFAA
YKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVTLALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLTLPWL
MRKLSLDKGPDAAGDESIAALTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER
>Mature_515_residues
TILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFIPPLLWALARKSSWAVIRSQMS
TIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAAIAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVAF
HVALAALVAGEDLSWSTGVLEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAIV
IAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRAAIDEVGSELWHAVVVGIVLSVVAIVVRGVWMFAAY
KRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVTLALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLTLPWLM
RKLSLDKGPDAAGDESIAALTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIKA
AQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=387, Percent_Identity=23.7726098191214, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI15529998, Length=327, Percent_Identity=23.2415902140673, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790501, Length=559, Percent_Identity=27.7280858676207, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71999821, Length=269, Percent_Identity=25.2788104089219, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71999819, Length=269, Percent_Identity=25.2788104089219, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=265, Percent_Identity=26.0377358490566, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=264, Percent_Identity=26.1363636363636, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=423, Percent_Identity=21.7494089834515, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=423, Percent_Identity=21.7494089834515, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71980847, Length=364, Percent_Identity=22.2527472527473, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221510734, Length=398, Percent_Identity=23.3668341708543, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221510738, Length=476, Percent_Identity=22.6890756302521, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221510732, Length=379, Percent_Identity=24.0105540897098, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510736, Length=379, Percent_Identity=24.0105540897098, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585580, Length=379, Percent_Identity=24.0105540897098, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585578, Length=379, Percent_Identity=24.0105540897098, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510740, Length=379, Percent_Identity=24.0105540897098, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 55319; Mature: 55188

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
PPLLWALARKSSWAVIRSQMSTIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHH
IAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVAFHVALAALVAGEDLSWSTGV
CCCCCCCCHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHH
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRAAIDEVGSELWHAVV
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIVLSVVAIVVRGVWMFAAYKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVT
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLTLPWLMRKLSLDKGPDAAGDESIAA
HHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
LTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TILFMLITLLLATVIVVAIGDKTGLPWPALMTIVAAGGALLPFLPEFTIPADLMLPIFI
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
PPLLWALARKSSWAVIRSQMSTIITMSVLLVFVTIAALTGASMLLLPGIGLAGAIMLAAA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHH
IAPPDPVAVDAVAEPAGIPKRITTTLQTEGLFNDAASIVAFHVALAALVAGEDLSWSTGV
CCCCCCCCHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEFLWSCLAAVILGLVIGRAAAWFTDHVSSVEARNAFTWVLPFAIYVVAEEIGGSGVIAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHH
VIAAVEMNSRASIGAEDRLTGSAFWGTIEVLFTGVAFGLIGLNVRAAIDEVGSELWHAVV
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIVLSVVAIVVRGVWMFAAYKRNRFKIDKKGATNSSLRAPLRLQESLLMTWAGMRGLVT
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LALVLSIPEDIFPYHHELQVIALVVLLITMVGPGLTLPWLMRKLSLDKGPDAAGDESIAA
HHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
LTERAHKAATTYLVDTTELPMEQMVAIKNWFSQEIDADELQENVDKLHQRAHHARVGAIK
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AAQEELLKARRERGVNPAYVDEVLTNIDRMLVAAER
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA