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The map label for this gene is tlrC [H]

Identifier: 62390304

GI number: 62390304

Start: 1498259

End: 1499791

Strand: Reverse

Name: tlrC [H]

Synonym: cg1609

Alternate gene names: 62390304

Gene position: 1499791-1498259 (Counterclockwise)

Preceding gene: 62390307

Following gene: 62390292

Centisome position: 45.69

GC content: 51.27

Gene sequence:

>1533_bases
ATGGCTAAAACCCATATTCGGTTACAGGACCTTTCCCTGTCATACACCTCAACCCCGTTAATTACGAAGCTCAATATCAC
TGTTTCTTCTGGACAGTGCGCAGTGATTGTTGGTGAGAATGGTCGAGGTAAAACCACACTTCTGCGAGCACTGGCTCGAG
AATTCCCGCCATCTGCAGGTGAGATTCTCACTCATGGCACGGTAGCAATTGCTCATCAACACATGCCTGCAGGTGATCTG
TCCGTCGGAGAGATCTGTGATGAGGCAATTCGTGATTCAAAGAATGCTCTCGAAGAGCTTGAGAGAGCTGGAGCTCTACT
TGAGACAAACACTGCGCACGCACTTGATGGATATCAACAAGCCCTTGATGCCGCTGAAGTGCTTGACGCATGGAACGCTG
AACATCGATTAGAAAAAGCTCTGCGCAGCTTTGGCGCGATCACCGATAGATCCCGTGCACTCAGTGAGCTATCGATCGGG
CAAAGGTATCGGGTACGGCTGGCCTGCCTCATCGGTGGCGATGCTGATATTTTGCTTCTCGATGAACCCACCAATCATCT
TGACCGGGGCGCGCTTAACTATCTCACCGAAGCCATAACCTCCCACAAAGGTGTGGTACTTGTTGTTTCTCATGATCAAG
CACTGATCAAAGATGTCGCGGATTTCATCATCGATATTGATTCAACCCCAGACGGCCTACCACGGATCTATCATGAGGGT
TTTGATTCTTATCGACGCCAAAGGAGTGCGCTTCTTGAAACTTGGAGGCAGGATTATGCCGCTGCACAAACTGTGCAACA
GCAATTGCAGGAGGATCTAGAGCACGCACGCCAGCGGGTGAATTCTTCGTGGAAACCTCCAAAAGGAACGGGAAAACACA
CTCGCGCATCTCGGGCTCCCGGAGTGGTGCAGGCCTTAAAGCGAGCACAGGATGCGTTGGATAGCAAAGCGTTGGACGTT
CCCCCGGCTCCGGCCCCATTGCTTCTGCCTACCTTGAAAGTGCGACCAGATAAACCCATGGTGGACTTTTCGGACCTTTT
TGTACCCCACCGCTTGCGTCTGCCAGGCTCACATTCAGTGGTATCAGGTGACAAAATAGTGATCACTGGTGACAACGGCG
CTGGCAAATCAACGCTCATCGAAGTCTTGTCTGGGGTTTTGACTCCGGCAAGTGGTTCGGTTGCAAACCATGCCCGAACT
GGGGTTCTCGGCCAAGAATCACTTGTCGGCGAGGTGCCATCAATAGCACGAGATCACGCAGTTAAGTGGGGACTTTTAAG
TGTTGAGGAGAGCCGATTTGCCCTACAGGAATTCTCAATTGGTCAACGCAGAAGACTAGATTTGGCCATGTCGTTAGCTG
GCAATCCTGAACTGTTGCTTCTCGATGAACCTTCGAACCATCTGTCTATGCACTTGGTTTCCGCACTTACAGAGTGGCTG
GACACGACCGCGGCTGCAGTGATCATGGTAACGCATGATCGACAGCTACTCCGCGATACGGCTCATTGGAGGCACATCGA
GTTGAAATCTTAA

Upstream 100 bases:

>100_bases
TGCAGGCCACATGCCTCCCAGTGCCGTCTCTGCACGTTGATTTTCCCCTGCCACGACTGGTCGCAGGGCGACTTTCTAGC
ACTTTTAAAGGAATTTTTTA

Downstream 100 bases:

>100_bases
GAATTCGCAAGGGCTTTCACGCACGAGGATGAGCCCCGCGCCACACTTCCCGCAAGCTATCGGCTGTGATGTGCGTGTAA
ATCTGAGTGGTCGTCACAGA

Product: ABC transporter ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MAKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAGEILTHGTVAIAHQHMPAGDL
SVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIG
QRYRVRLACLIGGDADILLLDEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADFIIDIDSTPDGLPRIYHEG
FDSYRRQRSALLETWRQDYAAAQTVQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAPGVVQALKRAQDALDSKALDV
PPAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSVVSGDKIVITGDNGAGKSTLIEVLSGVLTPASGSVANHART
GVLGQESLVGEVPSIARDHAVKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
DTTAAAVIMVTHDRQLLRDTAHWRHIELKS

Sequences:

>Translated_510_residues
MAKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAGEILTHGTVAIAHQHMPAGDL
SVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIG
QRYRVRLACLIGGDADILLLDEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADFIIDIDSTPDGLPRIYHEG
FDSYRRQRSALLETWRQDYAAAQTVQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAPGVVQALKRAQDALDSKALDV
PPAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSVVSGDKIVITGDNGAGKSTLIEVLSGVLTPASGSVANHART
GVLGQESLVGEVPSIARDHAVKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
DTTAAAVIMVTHDRQLLRDTAHWRHIELKS
>Mature_509_residues
AKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAGEILTHGTVAIAHQHMPAGDLS
VGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIGQ
RYRVRLACLIGGDADILLLDEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADFIIDIDSTPDGLPRIYHEGF
DSYRRQRSALLETWRQDYAAAQTVQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAPGVVQALKRAQDALDSKALDVP
PAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSVVSGDKIVITGDNGAGKSTLIEVLSGVLTPASGSVANHARTG
VLGQESLVGEVPSIARDHAVKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWLD
TTAAAVIMVTHDRQLLRDTAHWRHIELKS

Specific function: Responsible for tylosin resistance, and is proposed to be a subunit of a multicomponent export system for the energy- dependent efflux of tylosin [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=520, Percent_Identity=26.9230769230769, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI10947137, Length=540, Percent_Identity=26.1111111111111, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI27881506, Length=540, Percent_Identity=26.1111111111111, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI69354671, Length=537, Percent_Identity=27.7467411545624, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI10947135, Length=537, Percent_Identity=27.7467411545624, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1789751, Length=509, Percent_Identity=30.6483300589391, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787041, Length=518, Percent_Identity=25.2895752895753, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787182, Length=526, Percent_Identity=26.0456273764259, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI2367384, Length=511, Percent_Identity=26.2230919765166, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790534, Length=231, Percent_Identity=31.6017316017316, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790525, Length=225, Percent_Identity=24, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=243, Percent_Identity=27.5720164609054, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17555318, Length=523, Percent_Identity=24.6653919694073, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17559834, Length=523, Percent_Identity=25.8126195028681, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17553372, Length=526, Percent_Identity=24.9049429657795, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320874, Length=536, Percent_Identity=26.6791044776119, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321121, Length=521, Percent_Identity=26.295585412668, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24641342, Length=530, Percent_Identity=27.1698113207547, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24666836, Length=535, Percent_Identity=25.981308411215, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24642252, Length=534, Percent_Identity=26.0299625468165, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18859989, Length=534, Percent_Identity=26.0299625468165, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 55601; Mature: 55470

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAG
CCCCEEEEEECEEEECCCCEEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
EILTHGTVAIAHQHMPAGDLSVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQ
CHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCEEECCCHHHHHHHHH
ALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIGQRYRVRLACLIGGDADILLL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEE
DEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADFIIDIDSTPDGLPRIYHEG
ECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHEECCCCCCCHHHHHHHH
FDSYRRQRSALLETWRQDYAAAQTVQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVVQALKRAQDALDSKALDVPPAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHCCCCCEEECCCCCCE
VSGDKIVITGDNGAGKSTLIEVLSGVLTPASGSVANHARTGVLGQESLVGEVPSIARDHA
ECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHH
VKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
HHCCEEEEHHHHHHHHHHCCCCHHHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
DTTAAAVIMVTHDRQLLRDTAHWRHIELKS
HHHHEEEEEEECCHHHHHHHHHHCEEEECC
>Mature Secondary Structure 
AKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAG
CCCEEEEEECEEEECCCCEEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
EILTHGTVAIAHQHMPAGDLSVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQ
CHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCEEECCCHHHHHHHHH
ALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIGQRYRVRLACLIGGDADILLL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEE
DEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADFIIDIDSTPDGLPRIYHEG
ECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHEECCCCCCCHHHHHHHH
FDSYRRQRSALLETWRQDYAAAQTVQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVVQALKRAQDALDSKALDVPPAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHCCCCCEEECCCCCCE
VSGDKIVITGDNGAGKSTLIEVLSGVLTPASGSVANHARTGVLGQESLVGEVPSIARDHA
ECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHH
VKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
HHCCEEEEHHHHHHHHHHCCCCHHHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
DTTAAAVIMVTHDRQLLRDTAHWRHIELKS
HHHHEEEEEEECCHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1864505 [H]