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The map label for this gene is catM [H]

Identifier: 62389320

GI number: 62389320

Start: 441597

End: 442481

Strand: Reverse

Name: catM [H]

Synonym: cg0500

Alternate gene names: 62389320

Gene position: 442481-441597 (Counterclockwise)

Preceding gene: 62389325

Following gene: 62389315

Centisome position: 13.48

GC content: 54.24

Gene sequence:

>885_bases
ATGCACCTCAATCAGCTCGAATTTTTCATCGCAGTAGCCCAACACGGACAGATCAACCGCGCCGCCGAAGAACTCCTCAT
TTCCCAACCCGCTCTCAGCCGACAGATCTCCGCACTTGAAAAATCCGTCGGAGCTCCACTCTTCGAACGCCATTCCCGCG
GTGTCTCCCTCACAAAGGCCGGAGAAATCCTCCACGAAGAAGCCCTCCGAACGCTTAGCAGGATGCAATCGGTAGTCGAT
GAAATCCAATCCGGTGAGCACCTCATCACCAGCATCAACATCGGAGTTCCCCCTGGAATCCCCATCGACTGGTTGCGCTG
CCAACTCATCGATTTAGGCCCCGAGACCCGCATTTCACTGATCGAATCCCCCACCGATGATCAGCTAAAACTTCTTAAAC
AACGCGAACTCGACATCGCCCTTTGTCGACGCCAAAGCGAGGCCTTTGCCACCACACTTGTCCACGAACAAGAACTGGGA
ATCGTCGTCCGAAAAAACTCCGAACTGCACCAAAAAGTCGCAGGAAAAGACAACGCCACACTCTTCGATCTTGAAGGGCT
TCGAGTCCTCGCACACTCCCGCGGTGAAGTAAGAATTCAGGAAGAAATCCTCAAAAACGCCATGCTCGCCGCAGGAGTTA
ATGCCACGTGGATCTTCCGAAAATTTGGGCAATATAGCTCACTGATCGCAGACCTTGTCCAGGCCGATGTCGCACTCACA
ACAGAGGAATCCGCCCGCACCAACTTCCCCAGCTGGCAATGGGTCCCCATCGAAGGCGAAGACGCCTCCGGAAATGACCT
TGTTGTTCGCACCTGGATCACCTGGAACCCCCAACCCACCCCCGCGGTGAAGGCCCTGATCCAGAAATTTATTGACGGAA
ACTGA

Upstream 100 bases:

>100_bases
CCTTTCCCTGAACTCTAAGCAATTGTGATCTATAGTACAAATGCATAAACATTAACCGTGATATCCATCTCTTGCATACC
GGCCGAAAGGTTTAGCACAC

Downstream 100 bases:

>100_bases
GTTCTAAACAGCCGCCATGAGCTCATCCGCATAGCGGTGGGCATCTGGTGTGGAAATGACAATGCGATCGATGCTGATGT
TCTCCAGCTCAATGACCAAA

Product: transcription regulator LysR

Products: NA

Alternate protein names: Cat operon transcriptional regulator [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKAGEILHEEALRTLSRMQSVVD
EIQSGEHLITSINIGVPPGIPIDWLRCQLIDLGPETRISLIESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHEQELG
IVVRKNSELHQKVAGKDNATLFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVQADVALT
TEESARTNFPSWQWVPIEGEDASGNDLVVRTWITWNPQPTPAVKALIQKFIDGN

Sequences:

>Translated_294_residues
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKAGEILHEEALRTLSRMQSVVD
EIQSGEHLITSINIGVPPGIPIDWLRCQLIDLGPETRISLIESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHEQELG
IVVRKNSELHQKVAGKDNATLFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVQADVALT
TEESARTNFPSWQWVPIEGEDASGNDLVVRTWITWNPQPTPAVKALIQKFIDGN
>Mature_294_residues
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKAGEILHEEALRTLSRMQSVVD
EIQSGEHLITSINIGVPPGIPIDWLRCQLIDLGPETRISLIESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHEQELG
IVVRKNSELHQKVAGKDNATLFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVQADVALT
TEESARTNFPSWQWVPIEGEDASGNDLVVRTWITWNPQPTPAVKALIQKFIDGN

Specific function: Positively regulates the expression of catA, catBCIJFD and benPK in response to cis,cis-muconate. It binds to the catB- catM intercistronic region, to a specific sequence upstream of catA and to the benPK promoter region. Can also repress pca genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=153, Percent_Identity=37.2549019607843, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=163, Percent_Identity=36.1963190184049, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI2367136, Length=168, Percent_Identity=38.0952380952381, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081904, Length=180, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790399, Length=198, Percent_Identity=30.3030303030303, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=32.1678321678322, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787879, Length=286, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=153, Percent_Identity=32.0261437908497, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI87082184, Length=225, Percent_Identity=25.7777777777778, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32757; Mature: 32757

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKA
CCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHH
GEILHEEALRTLSRMQSVVDEIQSGEHLITSINIGVPPGIPIDWLRCQLIDLGPETRISL
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHEEEEEECCCCCEEEE
IESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHEQELGIVVRKNSELHQKVAGKDNAT
ECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCCE
LFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVQADVALT
EEECCCHHEECCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
TEESARTNFPSWQWVPIEGEDASGNDLVVRTWITWNPQPTPAVKALIQKFIDGN
CCHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MHLNQLEFFIAVAQHGQINRAAEELLISQPALSRQISALEKSVGAPLFERHSRGVSLTKA
CCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCHHHH
GEILHEEALRTLSRMQSVVDEIQSGEHLITSINIGVPPGIPIDWLRCQLIDLGPETRISL
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHEEEEEECCCCCEEEE
IESPTDDQLKLLKQRELDIALCRRQSEAFATTLVHEQELGIVVRKNSELHQKVAGKDNAT
ECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCCE
LFDLEGLRVLAHSRGEVRIQEEILKNAMLAAGVNATWIFRKFGQYSSLIADLVQADVALT
EEECCCHHEECCCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
TEESARTNFPSWQWVPIEGEDASGNDLVVRTWITWNPQPTPAVKALIQKFIDGN
CCHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2793826; 7592340; 11932465; 12620848 [H]