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The map label for this gene is hde [H]

Identifier: 62389013

GI number: 62389013

Start: 130813

End: 131739

Strand: Reverse

Name: hde [H]

Synonym: cg0153

Alternate gene names: 62389013

Gene position: 131739-130813 (Counterclockwise)

Preceding gene: 62389016

Following gene: 62389011

Centisome position: 4.01

GC content: 54.15

Gene sequence:

>927_bases
TTGCCTAAGGCTTCTAGGATTGTCGTTATGCTCCTTCACCCAGATGCGCAGTTTTATATCGATACCTTGCCCACTCTCAG
CGCGGAGGAGCAGGTGAGTTTTGGTAAAGACGCTCCTGTTTCAGAGGCTGATGCAACCCATGTGGCGACAGATCAAGATA
TTGCTGGGGTGCCGGTGAGGGTTTATACGCCTTTATCTGGGGCTGGGGATTTGCCGTGTTTGGTGTACTTCCACGGCGGT
GGCTGGTCCGGCGGCACCCTCAACATGATCGATGCCACGGTTCACTCTCTAGTGGTTGGCCTGCCGATCATCGCCATCAG
CGTGGACTACCGACTTGCACCCGCACACCCATTTCCAGCGGCTATCGACGACGCGTTTGCAGTGGTCAGTGCCGTATTGG
ATGGGGTGTCTGGGCTGAGTATTGATACTTCCCGAGTGGCAATTGGCGGTGACAGTGCCGGTGGAAATATTGCCGCGGTT
ACTGCACAACAGCTGCGTGAACGGGCTGTGGGTTCTACTCCTGTATTGGCTCACCAGGTGCTTATTTTTCCGGTAACTGA
TGTTTCCACTACATCTACGCCGAGCTATCTCACATTTGGCAAAGATTGCTACCTGACAAAGGACGCGATGGAACGCTACA
TCGAACAATATGCCGATGGGCACGACCGCACCGACCCTCGACTCTCACCGCTACTGGCATCTGATTTGAGCGACCTCCCA
CCCACCACCATTGTGTACGGCGAATGCGACGTGTTAGCCCATGAAGTGCGAGCCTATGGACAAGCTCTACTAGAGGCTGG
AAATTCCGTGACGATGACTGAATTCAAAGGACAGATCCACGCCTTTATTAACCTAGGGGGAATCAGTTCCGATGCGCGGG
CTGCTCGACGACTCATCCGCGCCGAATTGGAAGCAGCACTTTGTTAA

Upstream 100 bases:

>100_bases
GTACGAGTCTTAGACATCGAAGGCTCCTTTCTAACCTGCATCCAAGCCTAGGTGGAATTGAGATGACGCGTCGTAGAGAT
CGAAAACTCAACCAAATTTC

Downstream 100 bases:

>100_bases
AGGTTGAGATTTAACATTCGCCAGGTTCCGCTTCCCAAGAAATACGGATCATTTCCTCAAGCACCTCAAGATCAACATCC
TCTGGTTTGTTGATATATAG

Product: esterase/lipase protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPKASRIVVMLLHPDAQFYIDTLPTLSAEEQVSFGKDAPVSEADATHVATDQDIAGVPVRVYTPLSGAGDLPCLVYFHGG
GWSGGTLNMIDATVHSLVVGLPIIAISVDYRLAPAHPFPAAIDDAFAVVSAVLDGVSGLSIDTSRVAIGGDSAGGNIAAV
TAQQLRERAVGSTPVLAHQVLIFPVTDVSTTSTPSYLTFGKDCYLTKDAMERYIEQYADGHDRTDPRLSPLLASDLSDLP
PTTIVYGECDVLAHEVRAYGQALLEAGNSVTMTEFKGQIHAFINLGGISSDARAARRLIRAELEAALC

Sequences:

>Translated_308_residues
MPKASRIVVMLLHPDAQFYIDTLPTLSAEEQVSFGKDAPVSEADATHVATDQDIAGVPVRVYTPLSGAGDLPCLVYFHGG
GWSGGTLNMIDATVHSLVVGLPIIAISVDYRLAPAHPFPAAIDDAFAVVSAVLDGVSGLSIDTSRVAIGGDSAGGNIAAV
TAQQLRERAVGSTPVLAHQVLIFPVTDVSTTSTPSYLTFGKDCYLTKDAMERYIEQYADGHDRTDPRLSPLLASDLSDLP
PTTIVYGECDVLAHEVRAYGQALLEAGNSVTMTEFKGQIHAFINLGGISSDARAARRLIRAELEAALC
>Mature_307_residues
PKASRIVVMLLHPDAQFYIDTLPTLSAEEQVSFGKDAPVSEADATHVATDQDIAGVPVRVYTPLSGAGDLPCLVYFHGGG
WSGGTLNMIDATVHSLVVGLPIIAISVDYRLAPAHPFPAAIDDAFAVVSAVLDGVSGLSIDTSRVAIGGDSAGGNIAAVT
AQQLRERAVGSTPVLAHQVLIFPVTDVSTTSTPSYLTFGKDCYLTKDAMERYIEQYADGHDRTDPRLSPLLASDLSDLPP
TTIVYGECDVLAHEVRAYGQALLEAGNSVTMTEFKGQIHAFINLGGISSDARAARRLIRAELEAALC

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=324, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI206597554, Length=323, Percent_Identity=26.9349845201238, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI68051721, Length=196, Percent_Identity=33.1632653061224, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI68299767, Length=334, Percent_Identity=25.748502994012, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226423947, Length=204, Percent_Identity=31.8627450980392, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI61966717, Length=179, Percent_Identity=27.3743016759777, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786682, Length=226, Percent_Identity=28.7610619469027, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17567059, Length=269, Percent_Identity=31.5985130111524, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71996133, Length=146, Percent_Identity=38.3561643835616, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17540028, Length=144, Percent_Identity=40.2777777777778, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=155, Percent_Identity=32.9032258064516, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32492; Mature: 32361

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKASRIVVMLLHPDAQFYIDTLPTLSAEEQVSFGKDAPVSEADATHVATDQDIAGVPVR
CCCCCEEEEEEECCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCEECCCCCCCCCCEE
VYTPLSGAGDLPCLVYFHGGGWSGGTLNMIDATVHSLVVGLPIIAISVDYRLAPAHPFPA
EEECCCCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCEEEEEEECEEECCCCCCCH
AIDDAFAVVSAVLDGVSGLSIDTSRVAIGGDSAGGNIAAVTAQQLRERAVGSTPVLAHQV
HHHHHHHHHHHHHHCCCCCEECCCEEEECCCCCCCCEEEEEHHHHHHHHCCCCCHHEEEE
LIFPVTDVSTTSTPSYLTFGKDCYLTKDAMERYIEQYADGHDRTDPRLSPLLASDLSDLP
EEEEECCCCCCCCCCEEEECCCEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
PTTIVYGECDVLAHEVRAYGQALLEAGNSVTMTEFKGQIHAFINLGGISSDARAARRLIR
CCEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHH
AELEAALC
HHHHHHCC
>Mature Secondary Structure 
PKASRIVVMLLHPDAQFYIDTLPTLSAEEQVSFGKDAPVSEADATHVATDQDIAGVPVR
CCCCEEEEEEECCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCEECCCCCCCCCCEE
VYTPLSGAGDLPCLVYFHGGGWSGGTLNMIDATVHSLVVGLPIIAISVDYRLAPAHPFPA
EEECCCCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCEEEEEEECEEECCCCCCCH
AIDDAFAVVSAVLDGVSGLSIDTSRVAIGGDSAGGNIAAVTAQQLRERAVGSTPVLAHQV
HHHHHHHHHHHHHHCCCCCEECCCEEEECCCCCCCCEEEEEHHHHHHHHCCCCCHHEEEE
LIFPVTDVSTTSTPSYLTFGKDCYLTKDAMERYIEQYADGHDRTDPRLSPLLASDLSDLP
EEEEECCCCCCCCCCEEEECCCEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
PTTIVYGECDVLAHEVRAYGQALLEAGNSVTMTEFKGQIHAFINLGGISSDARAARRLIR
CCEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHH
AELEAALC
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]