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The map label for this gene is pbpA [H]

Identifier: 62388938

GI number: 62388938

Start: 43923

End: 45347

Strand: Reverse

Name: pbpA [H]

Synonym: cg0060

Alternate gene names: 62388938

Gene position: 45347-43923 (Counterclockwise)

Preceding gene: 62388939

Following gene: 62388937

Centisome position: 1.38

GC content: 55.86

Gene sequence:

>1425_bases
GTGAACCGCTCGATTCGAATCACATCCCTCTTCTCTTTGCTCCTGATCTTGGTGCTCGTAGCAAACCTCACCTGGATTCA
GGCTTTTAGGGACGATGATCTTGCTCAGAACCCACTGAACGCACGTGGTTTCCTGGAGGCGAAGTCCACTCCGCGTGGAC
AGATTTCAACTGGTGGCCAAGTACTCGCAGAGTCCTCCCAGGACGATCAGGGTTTTTACCAGCGCAGCTACATCACCAAC
CCGACTGCCTACGCACCGGTGGTTGGTTACCTCTCTGATGTTTATGGAGCAGCTGGCCTGGAATTGGGATACAACTCTAT
CCTCAACGGCAGTGACTCTTCCCTGTTTACCTCCCAGTGGCTGGATGTCATTTCTGGCAGCCCTACCCATGGCGCAAACA
TTGAGCTGACCTTGGATCCCAATGCGCAGCAAACTGCTTATGAACAGCTGAGCCAAAGCGGCTACGAGGGTGCTGTGGTG
GCGCTTCGCCCAAGCACTGGTGAGGTGCTGGCCATGGCGTCATCGCCAAGCTATGACCCCAACCAGATCGTGGATCCAGC
AACCGCAGAGGACGCTTGGGCTGAGTACACCTCCACTGAAGGTGCACCGCTGCTCAACCATGCAACGCAGGAATCACTGC
CTCCTGGATCTATTTTCAAGATCATCACTACTGCGGCAGCTTTGGAAAACGGCTACTCTGCTGATTCCACCGTGACTGCA
GAGGCAGCAGTGACCCTGCCTGGCACCAACACCACCTTGACCAACTACGGCGGTCAGACATGTGCGGGCGGTGGCACCAC
TACCCTGCTCACCGCTTTCCAGCTCTCCTGCAATACTGCGTTTGTGGAGACCGGCATTGATGTTGGCGCGGATGCTTTGC
GCGCGTCTGCCGAGGACTTCGGAGTGGGACAAACCTACAGCTTGGGACTAGATAACGTTCCTGGCGGCTTGGGTGAAATC
CCCGACGATGCCGCCCTTGGACAATCCAGCATTGGCCAGCGCGACGTGCAAATGAACGTGCTGCAGGCCGCTGTCATGGC
AGGAACCGTATCCAACGGTGGCGTACGCATGGAACCATATTTGGTATCCCGCGTCACCGGTCAGGACCTGAGCGAACTGA
GCACCCACAAGCCGAAATCAGTTGGTGGAGTCGAGCCAGAAATTGCAGAACAGTTGAAGACTTTGATGGAAGCCTCAGAG
CGCAATACTTCGGGCTACACCGGAATTCAGATCGCTTCCAAGACTGGTACCGCGGAACATGGTGATGAAAACACACCACC
ACACACCTGGTACGTGGCATTCAACAACGACATTGCTGTTGCTGTGTTGGTGAAAGACGGCGGTGGATTTGGCACCAGTG
CAACTGGTGGTCAGGTCGCAGCCCCAATTGGCCGAGCTGTGCTTCAGGCAGCCGGAGGATTTTAA

Upstream 100 bases:

>100_bases
CATCCCTGATGGCTAACTACATTCTGATGGCCATCATCTTGCGTATTTCTGACAGTGCCCGCCGACCTGTCATGTCCAAG
CAAGCATCGGAGGTGGCTGC

Downstream 100 bases:

>100_bases
AATATGAGTCAAGAAGACATCACTGGAAAAGATCGACTCCAAGAACTCATCGGCGCTGATTATCGTCTGCAGTGGATCAT
CGGACACGGTGGCATGTCCA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNRSIRITSLFSLLLILVLVANLTWIQAFRDDDLAQNPLNARGFLEAKSTPRGQISTGGQVLAESSQDDQGFYQRSYITN
PTAYAPVVGYLSDVYGAAGLELGYNSILNGSDSSLFTSQWLDVISGSPTHGANIELTLDPNAQQTAYEQLSQSGYEGAVV
ALRPSTGEVLAMASSPSYDPNQIVDPATAEDAWAEYTSTEGAPLLNHATQESLPPGSIFKIITTAAALENGYSADSTVTA
EAAVTLPGTNTTLTNYGGQTCAGGGTTTLLTAFQLSCNTAFVETGIDVGADALRASAEDFGVGQTYSLGLDNVPGGLGEI
PDDAALGQSSIGQRDVQMNVLQAAVMAGTVSNGGVRMEPYLVSRVTGQDLSELSTHKPKSVGGVEPEIAEQLKTLMEASE
RNTSGYTGIQIASKTGTAEHGDENTPPHTWYVAFNNDIAVAVLVKDGGGFGTSATGGQVAAPIGRAVLQAAGGF

Sequences:

>Translated_474_residues
MNRSIRITSLFSLLLILVLVANLTWIQAFRDDDLAQNPLNARGFLEAKSTPRGQISTGGQVLAESSQDDQGFYQRSYITN
PTAYAPVVGYLSDVYGAAGLELGYNSILNGSDSSLFTSQWLDVISGSPTHGANIELTLDPNAQQTAYEQLSQSGYEGAVV
ALRPSTGEVLAMASSPSYDPNQIVDPATAEDAWAEYTSTEGAPLLNHATQESLPPGSIFKIITTAAALENGYSADSTVTA
EAAVTLPGTNTTLTNYGGQTCAGGGTTTLLTAFQLSCNTAFVETGIDVGADALRASAEDFGVGQTYSLGLDNVPGGLGEI
PDDAALGQSSIGQRDVQMNVLQAAVMAGTVSNGGVRMEPYLVSRVTGQDLSELSTHKPKSVGGVEPEIAEQLKTLMEASE
RNTSGYTGIQIASKTGTAEHGDENTPPHTWYVAFNNDIAVAVLVKDGGGFGTSATGGQVAAPIGRAVLQAAGGF
>Mature_474_residues
MNRSIRITSLFSLLLILVLVANLTWIQAFRDDDLAQNPLNARGFLEAKSTPRGQISTGGQVLAESSQDDQGFYQRSYITN
PTAYAPVVGYLSDVYGAAGLELGYNSILNGSDSSLFTSQWLDVISGSPTHGANIELTLDPNAQQTAYEQLSQSGYEGAVV
ALRPSTGEVLAMASSPSYDPNQIVDPATAEDAWAEYTSTEGAPLLNHATQESLPPGSIFKIITTAAALENGYSADSTVTA
EAAVTLPGTNTTLTNYGGQTCAGGGTTTLLTAFQLSCNTAFVETGIDVGADALRASAEDFGVGQTYSLGLDNVPGGLGEI
PDDAALGQSSIGQRDVQMNVLQAAVMAGTVSNGGVRMEPYLVSRVTGQDLSELSTHKPKSVGGVEPEIAEQLKTLMEASE
RNTSGYTGIQIASKTGTAEHGDENTPPHTWYVAFNNDIAVAVLVKDGGGFGTSATGGQVAAPIGRAVLQAAGGF

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=450, Percent_Identity=25.7777777777778, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786272, Length=431, Percent_Identity=22.737819025522, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 49195; Mature: 49195

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSIRITSLFSLLLILVLVANLTWIQAFRDDDLAQNPLNARGFLEAKSTPRGQISTGGQ
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
VLAESSQDDQGFYQRSYITNPTAYAPVVGYLSDVYGAAGLELGYNSILNGSDSSLFTSQW
EEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCHHHHCCCCCCCHHHHHH
LDVISGSPTHGANIELTLDPNAQQTAYEQLSQSGYEGAVVALRPSTGEVLAMASSPSYDP
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCH
NQIVDPATAEDAWAEYTSTEGAPLLNHATQESLPPGSIFKIITTAAALENGYSADSTVTA
HHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEE
EAAVTLPGTNTTLTNYGGQTCAGGGTTTLLTAFQLSCNTAFVETGIDVGADALRASAEDF
EEEEEECCCCCEEECCCCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCHHHC
GVGQTYSLGLDNVPGGLGEIPDDAALGQSSIGQRDVQMNVLQAAVMAGTVSNGGVRMEPY
CCCCEEECCCCCCCCCCCCCCCCHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCC
LVSRVTGQDLSELSTHKPKSVGGVEPEIAEQLKTLMEASERNTSGYTGIQIASKTGTAEH
EEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
GDENTPPHTWYVAFNNDIAVAVLVKDGGGFGTSATGGQVAAPIGRAVLQAAGGF
CCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNRSIRITSLFSLLLILVLVANLTWIQAFRDDDLAQNPLNARGFLEAKSTPRGQISTGGQ
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
VLAESSQDDQGFYQRSYITNPTAYAPVVGYLSDVYGAAGLELGYNSILNGSDSSLFTSQW
EEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCHHHHCCCCCCCHHHHHH
LDVISGSPTHGANIELTLDPNAQQTAYEQLSQSGYEGAVVALRPSTGEVLAMASSPSYDP
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCH
NQIVDPATAEDAWAEYTSTEGAPLLNHATQESLPPGSIFKIITTAAALENGYSADSTVTA
HHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEE
EAAVTLPGTNTTLTNYGGQTCAGGGTTTLLTAFQLSCNTAFVETGIDVGADALRASAEDF
EEEEEECCCCCEEECCCCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCHHHC
GVGQTYSLGLDNVPGGLGEIPDDAALGQSSIGQRDVQMNVLQAAVMAGTVSNGGVRMEPY
CCCCEEECCCCCCCCCCCCCCCCHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCC
LVSRVTGQDLSELSTHKPKSVGGVEPEIAEQLKTLMEASERNTSGYTGIQIASKTGTAEH
EEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
GDENTPPHTWYVAFNNDIAVAVLVKDGGGFGTSATGGQVAAPIGRAVLQAAGGF
CCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA