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The map label for this gene is ddc [H]

Identifier: 59711499

GI number: 59711499

Start: 981246

End: 982889

Strand: Reverse

Name: ddc [H]

Synonym: VF_0892

Alternate gene names: 59711499

Gene position: 982889-981246 (Counterclockwise)

Preceding gene: 59711500

Following gene: 59711498

Centisome position: 33.92

GC content: 40.15

Gene sequence:

>1644_bases
ATGGTAACAGACAACAAAACAGCAGATGCGAGCTTTGAAAGCCTGCTGCGAATTTTTACTGTTCCGGAAGCTCCCGATTC
GACTCTTGGAATAATTGAAAAAGAACTTTCACAGAACTTAAATCAATTTTTGAGAGAGCATATTGTTGCCGAAGAAAAGC
CATTGACGGAAATCGAAAAAGATTTTACCGATTCATCAATGCCTGAATCGCCAACCTATGTATCCGAACATACTGAGCAC
CTGTTAGATACCCTTGTATCTCAATCCGTTCATACCTCTGCACCAAGCTTTATTGGCCACATGACATCGGCATTGCCTTA
CTTTTTAATGCCACTTTCAAAAATCATGATTGCCCTAAACCAAAACTTGGTAAAAATTGAAACATCAAAAGCATTTACCC
CATTAGAGCGTCAAGTGCTTGGTATGTTGCACCGTCTAATTTTTGGTCAAAAAGACAGTTTCTATCAACACTGGATGCAC
AGCGCTGATCATTCTCTGGGTGCTTTTTGTTCAGGCGGCACCATTGCCAATATTACAGCGTTATGGGTTGCAAGAAATCG
CCTATTAAAACCAGAAGGTGATTTTGAAGGTATTGCCAAACAAGGACTTTTTGCCGCTCTTATGCATTATAAGTGCAATG
GGTTAGCTATTTTCGTTTCAGAACGTGGTCACTACTCACTCAAAAAAGCAGCCGATGTATTAGGGATTGGTCAAGATGGT
GTTATTGCCGTAAAAACTGACAACAACAACCGTGTTTGCCTTGATGATTTAGAGCTTAAAATTGCCCAAGCAAAAGCGAA
AAACATTAAGCCATTGGCTATTGTTGGGGTTGCAGGAACCACAGAAACAGGTTCAATTGACCCACTTCGTGAGTTAGCAA
ATGTTGCTCAACGTGAAGGATGTCATTTCCATGTGGATGCCGCTTGGGGCGGTGCAACATTAATGTCGAATACGTACCGA
CACCTTTTAGATGGTATTGATTTAGCCGATTCCGTAACGATTGATGCACACAAGCAACTATACGTGCCAATGGGGGCAGG
TATGGTTATTTTTAAAGATCCTGAGTTAATGTCTTCTATCCAGCATCATGCTGAATACATTCTTCGTAAAGGGTCTAAAG
ATTTAGGTCGTCACACACTTGAAGGTTCTCGAAGTGGTATGGCGATGTTGCTTTATTCTTGTTTCAACGTGATCAGTCGC
CCTGGTTATGAATTATTAATCAACCAAAGTATTGAAAAAGCACACTACTTTGCTGATTTAATTCAACAGCAAGATGACTT
TGAACTGATAACAGAGCCTGAGCTGTGTTTGCTGACTTATCGTTATGTTCCAAGTAATGTAAAAGCGGCACTGGCCATTG
CGACTGACGAGCAAAAGATTGAGATTTATGAACACTTGGATAATCTCACCAAGTACATTCAAAAAACGCAACGTGAAACT
GGGAAATCTTTTGTTTCTCGAACTCGATTAACACCTGAAGCTTATCAGCATCAACCAACCATCGTTTTCAGAGTCGTATT
GGCAAACCCATTAACAACAAAAGAAATACTGCAAAATGTCTTAATTGAGCAAAGAGAAATTGCGAGCAGCAGTGAAATAT
CTTTACCTCTTTTAAACCAAATTGTAGGCAACATTCTTCACTAA

Upstream 100 bases:

>100_bases
ACACAAGACATTTTCGTCATTTTGTTCTAAATTGTGCCCTCAGAGCCTGTAAAGAATCATTCTCTTTACTTTTCAATCAT
CAACAAATAGAACAGATACC

Downstream 100 bases:

>100_bases
TCCCCTCATATAGGTTGTTTTATGAATGTAAAACAACCTATCTTTTTTGTAATTCATTTCCTTTCTAACTGAAACTTAAT
CACGAAATTATCGATAAAAT

Product: glutamate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MVTDNKTADASFESLLRIFTVPEAPDSTLGIIEKELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPESPTYVSEHTEH
LLDTLVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIFGQKDSFYQHWMH
SADHSLGAFCSGGTIANITALWVARNRLLKPEGDFEGIAKQGLFAALMHYKCNGLAIFVSERGHYSLKKAADVLGIGQDG
VIAVKTDNNNRVCLDDLELKIAQAKAKNIKPLAIVGVAGTTETGSIDPLRELANVAQREGCHFHVDAAWGGATLMSNTYR
HLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISR
PGYELLINQSIEKAHYFADLIQQQDDFELITEPELCLLTYRYVPSNVKAALAIATDEQKIEIYEHLDNLTKYIQKTQRET
GKSFVSRTRLTPEAYQHQPTIVFRVVLANPLTTKEILQNVLIEQREIASSSEISLPLLNQIVGNILH

Sequences:

>Translated_547_residues
MVTDNKTADASFESLLRIFTVPEAPDSTLGIIEKELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPESPTYVSEHTEH
LLDTLVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIFGQKDSFYQHWMH
SADHSLGAFCSGGTIANITALWVARNRLLKPEGDFEGIAKQGLFAALMHYKCNGLAIFVSERGHYSLKKAADVLGIGQDG
VIAVKTDNNNRVCLDDLELKIAQAKAKNIKPLAIVGVAGTTETGSIDPLRELANVAQREGCHFHVDAAWGGATLMSNTYR
HLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISR
PGYELLINQSIEKAHYFADLIQQQDDFELITEPELCLLTYRYVPSNVKAALAIATDEQKIEIYEHLDNLTKYIQKTQRET
GKSFVSRTRLTPEAYQHQPTIVFRVVLANPLTTKEILQNVLIEQREIASSSEISLPLLNQIVGNILH
>Mature_547_residues
MVTDNKTADASFESLLRIFTVPEAPDSTLGIIEKELSQNLNQFLREHIVAEEKPLTEIEKDFTDSSMPESPTYVSEHTEH
LLDTLVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALNQNLVKIETSKAFTPLERQVLGMLHRLIFGQKDSFYQHWMH
SADHSLGAFCSGGTIANITALWVARNRLLKPEGDFEGIAKQGLFAALMHYKCNGLAIFVSERGHYSLKKAADVLGIGQDG
VIAVKTDNNNRVCLDDLELKIAQAKAKNIKPLAIVGVAGTTETGSIDPLRELANVAQREGCHFHVDAAWGGATLMSNTYR
HLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSIQHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISR
PGYELLINQSIEKAHYFADLIQQQDDFELITEPELCLLTYRYVPSNVKAALAIATDEQKIEIYEHLDNLTKYIQKTQRET
GKSFVSRTRLTPEAYQHQPTIVFRVVLANPLTTKEILQNVLIEQREIASSSEISLPLLNQIVGNILH

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI194294551, Length=476, Percent_Identity=28.781512605042, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI197276620, Length=468, Percent_Identity=28.4188034188034, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4503875, Length=468, Percent_Identity=28.4188034188034, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI197383062, Length=453, Percent_Identity=27.8145695364238, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI58331246, Length=469, Percent_Identity=27.9317697228145, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4503281, Length=389, Percent_Identity=23.3933161953728, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI132814448, Length=389, Percent_Identity=23.3933161953728, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI92110055, Length=358, Percent_Identity=24.5810055865922, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555682, Length=476, Percent_Identity=28.3613445378151, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71993062, Length=451, Percent_Identity=28.3813747228381, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71993058, Length=375, Percent_Identity=29.8666666666667, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI17136594, Length=440, Percent_Identity=29.3181818181818, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24657193, Length=398, Percent_Identity=28.643216080402, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24657185, Length=398, Percent_Identity=28.643216080402, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24657188, Length=398, Percent_Identity=28.643216080402, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21356415, Length=436, Percent_Identity=25.9174311926606, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585139, Length=236, Percent_Identity=27.5423728813559, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221476190, Length=236, Percent_Identity=27.5423728813559, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585143, Length=236, Percent_Identity=27.5423728813559, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 60954; Mature: 60954

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTDNKTADASFESLLRIFTVPEAPDSTLGIIEKELSQNLNQFLREHIVAEEKPLTEIEK
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DFTDSSMPESPTYVSEHTEHLLDTLVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALN
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMLHRLIFGQKDSFYQHWMHSADHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCCHHHHHH
LWVARNRLLKPEGDFEGIAKQGLFAALMHYKCNGLAIFVSERGHYSLKKAADVLGIGQDG
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
VIAVKTDNNNRVCLDDLELKIAQAKAKNIKPLAIVGVAGTTETGSIDPLRELANVAQREG
EEEEEECCCCEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
CHFHVDAAWGGATLMSNTYRHLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSI
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEECHHHHHHH
QHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISRPGYELLINQSIEKAHYFADL
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
IQQQDDFELITEPELCLLTYRYVPSNVKAALAIATDEQKIEIYEHLDNLTKYIQKTQRET
HCCCCCCEEECCCCEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
GKSFVSRTRLTPEAYQHQPTIVFRVVLANPLTTKEILQNVLIEQREIASSSEISLPLLNQ
HHHHHHHHCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IVGNILH
HHHHHCC
>Mature Secondary Structure
MVTDNKTADASFESLLRIFTVPEAPDSTLGIIEKELSQNLNQFLREHIVAEEKPLTEIEK
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DFTDSSMPESPTYVSEHTEHLLDTLVSQSVHTSAPSFIGHMTSALPYFLMPLSKIMIALN
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
QNLVKIETSKAFTPLERQVLGMLHRLIFGQKDSFYQHWMHSADHSLGAFCSGGTIANITA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCCHHHHHH
LWVARNRLLKPEGDFEGIAKQGLFAALMHYKCNGLAIFVSERGHYSLKKAADVLGIGQDG
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCC
VIAVKTDNNNRVCLDDLELKIAQAKAKNIKPLAIVGVAGTTETGSIDPLRELANVAQREG
EEEEEECCCCEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
CHFHVDAAWGGATLMSNTYRHLLDGIDLADSVTIDAHKQLYVPMGAGMVIFKDPELMSSI
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCEEEEECHHHHHHH
QHHAEYILRKGSKDLGRHTLEGSRSGMAMLLYSCFNVISRPGYELLINQSIEKAHYFADL
HHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
IQQQDDFELITEPELCLLTYRYVPSNVKAALAIATDEQKIEIYEHLDNLTKYIQKTQRET
HCCCCCCEEECCCCEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
GKSFVSRTRLTPEAYQHQPTIVFRVVLANPLTTKEILQNVLIEQREIASSSEISLPLLNQ
HHHHHHHHCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IVGNILH
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]