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The map label for this gene is ureC

Identifier: 59711280

GI number: 59711280

Start: 735778

End: 737481

Strand: Reverse

Name: ureC

Synonym: VF_0673

Alternate gene names: 59711280

Gene position: 737481-735778 (Counterclockwise)

Preceding gene: 59711281

Following gene: 59711279

Centisome position: 25.45

GC content: 43.08

Gene sequence:

>1704_bases
ATGGCACATATTTCTCGTACTGCTTATGCCAATATGTTTGGACCTACAACAGGCGATCGCCTTCGTCTAGCAGATACTGA
ACTGTTTTTAGAAGTAGAAAAAGATTTTACAACCTACGGCGAAGAAGTGAAATTCGGCGGCGGTAAAGTGATACGTGATG
GCATGGGTCAAAGCCAAGTGGTAAATAGTGAATGTGTTGATGTGGTTATTACTAACGCATTAATTCTCGATCACTGGGGT
ATTGTAAAAGCTGATATTGGTATTAAAGATGGTCGTATTTTTGGTATTGGTAAAGCGGGTAATCCCGATGTTCAACCGAA
TGTCGATATCGTCGTTGGCCCAGCAACCGAGGTTGTGGCTGGTGAAGGCAAAATTATTACCGCTGGCGGTGTTGATACGC
ATATTCATTTTATCTGTCCTCAACAAGCAGAAGAAGGTTTAACCTCTGGCGTCACTACCTTTATTGGTGGCGGTACAGGT
CCAGTTGCAGGTACCAATGCAACCACGGTAACGCCGGGTATTTGGAATATGCATCGTATGCTAGAAGCGGTTGATGACTT
ACCTATTAACGTTGGTCTATTTGGTAAAGGCTGCGTAAGTAAACCAGAAGCGCTACGTGAACAAATTGAAGCCGGTGCAA
TGGGGTTAAAAATCCATGAAGACTGGGGCGCAACCCCTGCGGCTATTCATAACTGCTTAAACGTAGCTGACGAAATGGAC
ATTCAAATTGCCATTCACTCAGATACCTTGAATGAAGGTGGTTTTTACGAAGAAACGGTTAAAGCCATTGGCGATCGTGT
TATTCACGTATTCCACACCGAAGGTGCTGGCGGCGGTCACGCTCCTGATGTAATTAAGTCTGTTGGTGAACCTAATATTT
TACCAGCATCAACCAATCCAACCATGCCATACACCATCAATACCGTTGATGAACATTTGGATATGTTGATGGTTTGCCAC
CACTTAGATCCTTCTATTCCAGAAGATGTAGCTTTTGCTGAATCTCGTATTCGCCGTGAAACCATTGCTGCTGAAGATAT
TCTTCACGATATGGGGGCAATTTCTGTGATGTCATCGGACTCACAAGCGATGGGCCGTGTAGGTGAAGTGATCATTCGTA
CTTGGCAATGTGCGAATAAAATGAAACTTCAACGTGGCATTTTAGAAGGTGATAACGAGCATAACGATAACGAACGAATT
AAGCGTTACGTGGCTAAATACACCATCAACCCAGCGATTGCTCATGGTATTTCACATGAAGTTGGCTCTGTTGAAAAAGG
TAAACTGGCTGATTTAGTATTATGGAATCCCGCATTTTTTGGTGTAAAACCGGCACTTGTAATGAAAAGTGGTCTAGTCG
CTTACGCCCCAATGGGAGACATTAATGCGGCAATCCCAACACCACAGCCTGTACATTATCGTCCAATGTTCGCCTGTTAC
GGTAAAGCGAAATTCAAGTCTTCAATGATCTTCCTATCTCAAGCAAGTATCGAAGCGGGTGTGCCTGAGAAGTTGAATCT
ACAAAGCCAAATTGGTGAAGTAAAAGGTTGTCGTAATATCTCGAAAAAATCGATGATTCATAACAGCTATACACCAAACA
TTGAACTAGACAGTCAAACTTATGAAGTAAAAGCCGATGGCGTTCCTCTTGTATGCGAACCAGCTACAGAGCTACCAATG
GCACAACGTTATTTCTTATTCTAA

Upstream 100 bases:

>100_bases
TTGCAGGTAAGCGTGAAATTTACGGTTTCCAAGCTGCAATCATGGGTAATGTCGATAAGCATATCACTACAACAATTCCT
GACGATAAAGAGGTGAAGTA

Downstream 100 bases:

>100_bases
CCCTCTGCCTCGCTGATTTTCTACCTATTTACCAGCGGGGCACTTTTTAGAGTGAACAATCATGATTAAATTTACTCATC
TTGTACATCACCACCATGAT

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MAHISRTAYANMFGPTTGDRLRLADTELFLEVEKDFTTYGEEVKFGGGKVIRDGMGQSQVVNSECVDVVITNALILDHWG
IVKADIGIKDGRIFGIGKAGNPDVQPNVDIVVGPATEVVAGEGKIITAGGVDTHIHFICPQQAEEGLTSGVTTFIGGGTG
PVAGTNATTVTPGIWNMHRMLEAVDDLPINVGLFGKGCVSKPEALREQIEAGAMGLKIHEDWGATPAAIHNCLNVADEMD
IQIAIHSDTLNEGGFYEETVKAIGDRVIHVFHTEGAGGGHAPDVIKSVGEPNILPASTNPTMPYTINTVDEHLDMLMVCH
HLDPSIPEDVAFAESRIRRETIAAEDILHDMGAISVMSSDSQAMGRVGEVIIRTWQCANKMKLQRGILEGDNEHNDNERI
KRYVAKYTINPAIAHGISHEVGSVEKGKLADLVLWNPAFFGVKPALVMKSGLVAYAPMGDINAAIPTPQPVHYRPMFACY
GKAKFKSSMIFLSQASIEAGVPEKLNLQSQIGEVKGCRNISKKSMIHNSYTPNIELDSQTYEVKADGVPLVCEPATELPM
AQRYFLF

Sequences:

>Translated_567_residues
MAHISRTAYANMFGPTTGDRLRLADTELFLEVEKDFTTYGEEVKFGGGKVIRDGMGQSQVVNSECVDVVITNALILDHWG
IVKADIGIKDGRIFGIGKAGNPDVQPNVDIVVGPATEVVAGEGKIITAGGVDTHIHFICPQQAEEGLTSGVTTFIGGGTG
PVAGTNATTVTPGIWNMHRMLEAVDDLPINVGLFGKGCVSKPEALREQIEAGAMGLKIHEDWGATPAAIHNCLNVADEMD
IQIAIHSDTLNEGGFYEETVKAIGDRVIHVFHTEGAGGGHAPDVIKSVGEPNILPASTNPTMPYTINTVDEHLDMLMVCH
HLDPSIPEDVAFAESRIRRETIAAEDILHDMGAISVMSSDSQAMGRVGEVIIRTWQCANKMKLQRGILEGDNEHNDNERI
KRYVAKYTINPAIAHGISHEVGSVEKGKLADLVLWNPAFFGVKPALVMKSGLVAYAPMGDINAAIPTPQPVHYRPMFACY
GKAKFKSSMIFLSQASIEAGVPEKLNLQSQIGEVKGCRNISKKSMIHNSYTPNIELDSQTYEVKADGVPLVCEPATELPM
AQRYFLF
>Mature_566_residues
AHISRTAYANMFGPTTGDRLRLADTELFLEVEKDFTTYGEEVKFGGGKVIRDGMGQSQVVNSECVDVVITNALILDHWGI
VKADIGIKDGRIFGIGKAGNPDVQPNVDIVVGPATEVVAGEGKIITAGGVDTHIHFICPQQAEEGLTSGVTTFIGGGTGP
VAGTNATTVTPGIWNMHRMLEAVDDLPINVGLFGKGCVSKPEALREQIEAGAMGLKIHEDWGATPAAIHNCLNVADEMDI
QIAIHSDTLNEGGFYEETVKAIGDRVIHVFHTEGAGGGHAPDVIKSVGEPNILPASTNPTMPYTINTVDEHLDMLMVCHH
LDPSIPEDVAFAESRIRRETIAAEDILHDMGAISVMSSDSQAMGRVGEVIIRTWQCANKMKLQRGILEGDNEHNDNERIK
RYVAKYTINPAIAHGISHEVGSVEKGKLADLVLWNPAFFGVKPALVMKSGLVAYAPMGDINAAIPTPQPVHYRPMFACYG
KAKFKSSMIFLSQASIEAGVPEKLNLQSQIGEVKGCRNISKKSMIHNSYTPNIELDSQTYEVKADGVPLVCEPATELPMA
QRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_VIBF1 (Q5E728)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204056.1
- ProteinModelPortal:   Q5E728
- SMR:   Q5E728
- STRING:   Q5E728
- GeneID:   3277826
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0673
- NMPDR:   fig|312309.3.peg.1172
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   MPYTINT
- ProtClustDB:   PRK13207
- BioCyc:   VFIS312309:VF0673-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61175; Mature: 61043

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 320-320 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHISRTAYANMFGPTTGDRLRLADTELFLEVEKDFTTYGEEVKFGGGKVIRDGMGQSQV
CCCCCCHHHHHCCCCCCCCEEEEECCEEEEEECCHHHCCCCEEEECCCEEEECCCCCCHH
VNSECVDVVITNALILDHWGIVKADIGIKDGRIFGIGKAGNPDVQPNVDIVVGPATEVVA
CCHHHHHHHHHHHHEEECCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEE
GEGKIITAGGVDTHIHFICPQQAEEGLTSGVTTFIGGGTGPVAGTNATTVTPGIWNMHRM
CCCCEEEECCCCEEEEEECCCHHHHHHHHCCHHHCCCCCCCCCCCCCCEECCCHHHHHHH
LEAVDDLPINVGLFGKGCVSKPEALREQIEAGAMGLKIHEDWGATPAAIHNCLNVADEMD
HHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCE
IQIAIHSDTLNEGGFYEETVKAIGDRVIHVFHTEGAGGGHAPDVIKSVGEPNILPASTNP
EEEEEECCCCCCCCCHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHCCCCCEEECCCCC
TMPYTINTVDEHLDMLMVCHHLDPSIPEDVAFAESRIRRETIAAEDILHDMGAISVMSSD
CCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
SQAMGRVGEVIIRTWQCANKMKLQRGILEGDNEHNDNERIKRYVAKYTINPAIAHGISHE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHH
VGSVEKGKLADLVLWNPAFFGVKPALVMKSGLVAYAPMGDINAAIPTPQPVHYRPMFACY
CCCCCCCCEEEEEEECCHHHCCCHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCHHEEC
GKAKFKSSMIFLSQASIEAGVPEKLNLQSQIGEVKGCRNISKKSMIHNSYTPNIELDSQT
CCHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEEECCCE
YEVKADGVPLVCEPATELPMAQRYFLF
EEEEECCCCEEECCCCCCCCCHHHCCC
>Mature Secondary Structure 
AHISRTAYANMFGPTTGDRLRLADTELFLEVEKDFTTYGEEVKFGGGKVIRDGMGQSQV
CCCCCHHHHHCCCCCCCCEEEEECCEEEEEECCHHHCCCCEEEECCCEEEECCCCCCHH
VNSECVDVVITNALILDHWGIVKADIGIKDGRIFGIGKAGNPDVQPNVDIVVGPATEVVA
CCHHHHHHHHHHHHEEECCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEE
GEGKIITAGGVDTHIHFICPQQAEEGLTSGVTTFIGGGTGPVAGTNATTVTPGIWNMHRM
CCCCEEEECCCCEEEEEECCCHHHHHHHHCCHHHCCCCCCCCCCCCCCEECCCHHHHHHH
LEAVDDLPINVGLFGKGCVSKPEALREQIEAGAMGLKIHEDWGATPAAIHNCLNVADEMD
HHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCE
IQIAIHSDTLNEGGFYEETVKAIGDRVIHVFHTEGAGGGHAPDVIKSVGEPNILPASTNP
EEEEEECCCCCCCCCHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHCCCCCEEECCCCC
TMPYTINTVDEHLDMLMVCHHLDPSIPEDVAFAESRIRRETIAAEDILHDMGAISVMSSD
CCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
SQAMGRVGEVIIRTWQCANKMKLQRGILEGDNEHNDNERIKRYVAKYTINPAIAHGISHE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHH
VGSVEKGKLADLVLWNPAFFGVKPALVMKSGLVAYAPMGDINAAIPTPQPVHYRPMFACY
CCCCCCCCEEEEEEECCHHHCCCHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCHHEEC
GKAKFKSSMIFLSQASIEAGVPEKLNLQSQIGEVKGCRNISKKSMIHNSYTPNIELDSQT
CCHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEEECCCE
YEVKADGVPLVCEPATELPMAQRYFLF
EEEEECCCCEEECCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA