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The map label for this gene is xseA

Identifier: 59711243

GI number: 59711243

Start: 692443

End: 693792

Strand: Reverse

Name: xseA

Synonym: VF_0636

Alternate gene names: 59711243

Gene position: 693792-692443 (Counterclockwise)

Preceding gene: 59711247

Following gene: 59711221

Centisome position: 23.94

GC content: 40.74

Gene sequence:

>1350_bases
ATGTCTCTCGATTCTAATCCTCGTATCTTTACTGTCTCTCGATTGAATGCTGAAGTTCGCCTATTATTAGAGAACGAGAT
GGGAATTGTCTGGTTAGTCGGCGAAATCTCCAATCTTACCGTGCCTGTTTCTGGCCACTGGTACCTCACTTTAAAAGACA
GTCAAGCACAAGTGAAATGTGCCATGTTTAAAGGCAATAACCGACGAGTTAACTTTAAACCACAAAACGGCAAACAAGTT
CTTGTTAAAGCCCGCCTCTCTCTTTACGAACCTCGTGGTGACTATCAACTTATCATTGAAAGTATGCAACCTGAGGGAGA
TGGCCGTCTTCAACAAGAGTTTGATCAACTAAAAATGTCACTGGCTGCGGAAGGGTTATTTGCTCAGACAGCCAAAAAAT
CCTTACCAGAACAGCCAAAACGTGTTGGTATCATTACTTCACAAACAGGGGCTGCCCTTTTTGACATTCTCCATGTATTA
AAGCGACGAGATCCAAACCTACCAATTGTGATTTATCCAACCATGGTTCAAGGAAGTGGTGCCGCTATACAGATAGCTCA
AGCTATTGGGCGAGCTAACAGTCGTAATGAATGTGATATTTTAATTGTCGGTCGAGGCGGCGGTTCATTAGAAGATCTTT
GGTGTTTTAACGAAGAAATCGTTGCACGAACCATTGCTGCAAGTGAGATCCCAATTGTAAGTGCTGTAGGGCATGAGATT
GATGTTACTATTGCTGACTTTGTTGCTGATGTTCGTGCACCGACCCCTTCAGCTGCTGCTGAATTAGTGAGTCGTGATTT
ATCAGCGCAATTGCAAACAGTTGCTCATCAGAAGCGCCGTTTAAATAGTGCAATGGAACGTTATTTATCACATCAACAGC
GTTCCTTATCTGCTTATCAACATCGAATTGAAAAGCAACACCCTCAGATGCAGCTAAATAATCAAAGCCAACGCTTAGAT
GATCTTAATCAGAGATTGATGAATCATATTCAGCAGCGCCTTCAACGTCAGCAATACAGAGTTGAAAACTTAACGCTACG
ATTAAACAATTTATCTCCGACAAAAAGAATCTCTCAAGATAAATTACATATTGAAGAACTCAAACGTCGCTTATTAGATT
CAATGGATAGAAATCTACTAATGCAACGTCATCAATTAGCTTTAGCAGCAGAGAAACTAGATACAGTAAGCCCTTTAGCT
ACCTTAATGCGTGGTTATTCCATCACACACAATCAAGATGGGAAGATCATCACTTCAACAAAACAAGTGGAGTTAGGTGA
TAACATTACCACTCGTTTTGCTGATGGTGATATTACATCAACGGTAACTAAAGCATCTGAACTTAACTAA

Upstream 100 bases:

>100_bases
AAACGCTTGGCTACACATTTATTTATTTTTAATTTGCAATTACCCCCTTGATATGTATTATATTGCCGCTAATTCCTATA
GCCATGTCTAAGGCATTCTG

Downstream 100 bases:

>100_bases
TTGCAATTTCAGAAAACTCCGTTTTTGCTCGTGATTTAGACTTAAGTTCATTGCAATCATGACAAAAATAGCTTGCTGCG
CCACAAGCATTAAGCTTTTC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSLDSNPRIFTVSRLNAEVRLLLENEMGIVWLVGEISNLTVPVSGHWYLTLKDSQAQVKCAMFKGNNRRVNFKPQNGKQV
LVKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFDQLKMSLAAEGLFAQTAKKSLPEQPKRVGIITSQTGAALFDILHVL
KRRDPNLPIVIYPTMVQGSGAAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASEIPIVSAVGHEI
DVTIADFVADVRAPTPSAAAELVSRDLSAQLQTVAHQKRRLNSAMERYLSHQQRSLSAYQHRIEKQHPQMQLNNQSQRLD
DLNQRLMNHIQQRLQRQQYRVENLTLRLNNLSPTKRISQDKLHIEELKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLA
TLMRGYSITHNQDGKIITSTKQVELGDNITTRFADGDITSTVTKASELN

Sequences:

>Translated_449_residues
MSLDSNPRIFTVSRLNAEVRLLLENEMGIVWLVGEISNLTVPVSGHWYLTLKDSQAQVKCAMFKGNNRRVNFKPQNGKQV
LVKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFDQLKMSLAAEGLFAQTAKKSLPEQPKRVGIITSQTGAALFDILHVL
KRRDPNLPIVIYPTMVQGSGAAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASEIPIVSAVGHEI
DVTIADFVADVRAPTPSAAAELVSRDLSAQLQTVAHQKRRLNSAMERYLSHQQRSLSAYQHRIEKQHPQMQLNNQSQRLD
DLNQRLMNHIQQRLQRQQYRVENLTLRLNNLSPTKRISQDKLHIEELKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLA
TLMRGYSITHNQDGKIITSTKQVELGDNITTRFADGDITSTVTKASELN
>Mature_448_residues
SLDSNPRIFTVSRLNAEVRLLLENEMGIVWLVGEISNLTVPVSGHWYLTLKDSQAQVKCAMFKGNNRRVNFKPQNGKQVL
VKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFDQLKMSLAAEGLFAQTAKKSLPEQPKRVGIITSQTGAALFDILHVLK
RRDPNLPIVIYPTMVQGSGAAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASEIPIVSAVGHEID
VTIADFVADVRAPTPSAAAELVSRDLSAQLQTVAHQKRRLNSAMERYLSHQQRSLSAYQHRIEKQHPQMQLNNQSQRLDD
LNQRLMNHIQQRLQRQQYRVENLTLRLNNLSPTKRISQDKLHIEELKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLAT
LMRGYSITHNQDGKIITSTKQVELGDNITTRFADGDITSTVTKASELN

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=437, Percent_Identity=56.5217391304348, Blast_Score=497, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_VIBF1 (Q5E765)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204019.1
- STRING:   Q5E765
- GeneID:   3277952
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_0636
- NMPDR:   fig|312309.3.peg.1137
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   EQRASIG
- PhylomeDB:   Q5E765
- ProtClustDB:   PRK00286
- BioCyc:   VFIS312309:VF0636-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50519; Mature: 50387

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDSNPRIFTVSRLNAEVRLLLENEMGIVWLVGEISNLTVPVSGHWYLTLKDSQAQVKC
CCCCCCCCEEEEEECCCEEEEEEECCCCEEEEEECCCCEEEEECCEEEEEEECCCCEEEE
AMFKGNNRRVNFKPQNGKQVLVKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFDQLKMS
EEEECCCCEEEECCCCCCHHHEEEHHHHCCCCCCCEEHEECCCCCCCCHHHHHHHHHHHH
LAAEGLFAQTAKKSLPEQPKRVGIITSQTGAALFDILHVLKRRDPNLPIVIYPTMVQGSG
HHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
AAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASEIPIVSAVGHEI
CHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCEEECCCCEE
DVTIADFVADVRAPTPSAAAELVSRDLSAQLQTVAHQKRRLNSAMERYLSHQQRSLSAYQ
EEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRIEKQHPQMQLNNQSQRLDDLNQRLMNHIQQRLQRQQYRVENLTLRLNNLSPTKRISQD
HHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHCHH
KLHIEELKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLATLMRGYSITHNQDGKIITST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEC
KQVELGDNITTRFADGDITSTVTKASELN
EEEECCCCCEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SLDSNPRIFTVSRLNAEVRLLLENEMGIVWLVGEISNLTVPVSGHWYLTLKDSQAQVKC
CCCCCCCEEEEEECCCEEEEEEECCCCEEEEEECCCCEEEEECCEEEEEEECCCCEEEE
AMFKGNNRRVNFKPQNGKQVLVKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFDQLKMS
EEEECCCCEEEECCCCCCHHHEEEHHHHCCCCCCCEEHEECCCCCCCCHHHHHHHHHHHH
LAAEGLFAQTAKKSLPEQPKRVGIITSQTGAALFDILHVLKRRDPNLPIVIYPTMVQGSG
HHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
AAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASEIPIVSAVGHEI
CHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCEEECCCCEE
DVTIADFVADVRAPTPSAAAELVSRDLSAQLQTVAHQKRRLNSAMERYLSHQQRSLSAYQ
EEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRIEKQHPQMQLNNQSQRLDDLNQRLMNHIQQRLQRQQYRVENLTLRLNNLSPTKRISQD
HHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHCHH
KLHIEELKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLATLMRGYSITHNQDGKIITST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEC
KQVELGDNITTRFADGDITSTVTKASELN
EEEECCCCCEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA