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The map label for this gene is corB [H]

Identifier: 59711153

GI number: 59711153

Start: 594535

End: 595839

Strand: Reverse

Name: corB [H]

Synonym: VF_0546

Alternate gene names: 59711153

Gene position: 595839-594535 (Counterclockwise)

Preceding gene: 59711154

Following gene: 172087668

Centisome position: 20.56

GC content: 39.16

Gene sequence:

>1305_bases
ATGCTCCCTTTAAAACGAGGAACAAGACACTTGGACGATATATCAACCGGTGCCCTATTTACGTTATTAGCTATACTCAT
TGTTATCTCAGGTTACTTCTCAAGCTCAGAAACGGGCATGATGTCGTTAAACCGCTACCGCCTAAAGCACCTGTCAAATC
AGGGGCATAAAGGTGCAAAACGTGTTGAAAAACTACTCAGTCGTCCAGATCGCCTCATTGGCCTTATCCTTATCGGCAAT
AACCTTGTTAACATTCTAGCCTCTGCAATAGCAACCATTCTTGGTATGCGACTTTATGGTGACCTAGGCGTAGCCATCTC
TACCGGTGTATTAACCCTTGTGATTCTTGTCTTTGCAGAAGTAACTCCTAAAACCCTTGCAGCAATGTACCCAGAACGCG
TTTCTTATAGCAGTAGTATCGTCCTTAATGTGTTAATGAAACTGCTTTCTCCACTGGTTATTTTAGTAAATCTAATCACT
AACGGTTTCTTAAAAATACTCGGCCTTGGTTCAGGACATGACGATAAAGATAAATTAAGTTCTGAAGAATTAAGAACCGT
TGTTCATGAGGCGGGAGGATTAATTCCTCGTCGTCACCAAGATATGCTGATTTCAATACTGGATTTAGAGCACGTTACCG
TTAACGATATTATGGTGCCTCGTAGTGAAATTACAGGGATTGATATTAACGATGATTGGAAATCGATTTCACGTCAATTA
ACTCACTCCCCTCACGGACGTATTGTTTTATATCGAGATCAAATCGATGAAGTGGTTGGGATGCTTCGCTTACGTGAATC
TTATCGCTTGATGCTTGAAAAAAATGAATTTACCAAAGAAACACTATTAAGAGCCGCGGATGAAATTTATTTCATACCTG
AAGCTACCCCACTTAATTCACAGCTATTAAAGTTTCAGCGTAATAAAGAACGCATTGGATTAGTTGTTGATGAATACGGT
GATATCCAGGGTTTAATAACATTAGAAGATATTTTGGAAGAAATTGTTGGTGAATTCACTACCTCAATGGCTCCAAGTTT
AGCTGAAGAAATTACACCTCAGCCTGATGGCAGCTTTATGATTGAAGGTAGTGCCAATATTCGAGACATTAATAAAGGCT
TAAAATGGGACTTACCAACAGATGGGCCAAGAACACTTAATGGCTTAATCCTTGAGCATTTAGAAGAGATCCCTGAAACG
GAAATTAGCCTCGAAATTGAACAGCATAATATGGAAATTGTCGCTGTCGAAGAAAACAAAATTAACCTTGTAAAGGTATT
CCCAAGTACTGAAGATGATAAATAA

Upstream 100 bases:

>100_bases
CGACAATCGCTCACTTTTTGTATTCAAACTTGACAGACGGATTATCAGATTAGATAAATACCTTTTAATTATATCAATCT
AAGTAAGTGCTTAGGTTTAT

Downstream 100 bases:

>100_bases
TTTGTATACCAATACTATCAATGGTTAAAGCTGATATTCAGCTAAAAAAAGCCCGCTAAATGCGGGCTTTTTTTTCAAAT
TAAAACGTCAATTAATGATT

Product: magnesium and cobalt efflux protein CorB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLPLKRGTRHLDDISTGALFTLLAILIVISGYFSSSETGMMSLNRYRLKHLSNQGHKGAKRVEKLLSRPDRLIGLILIGN
NLVNILASAIATILGMRLYGDLGVAISTGVLTLVILVFAEVTPKTLAAMYPERVSYSSSIVLNVLMKLLSPLVILVNLIT
NGFLKILGLGSGHDDKDKLSSEELRTVVHEAGGLIPRRHQDMLISILDLEHVTVNDIMVPRSEITGIDINDDWKSISRQL
THSPHGRIVLYRDQIDEVVGMLRLRESYRLMLEKNEFTKETLLRAADEIYFIPEATPLNSQLLKFQRNKERIGLVVDEYG
DIQGLITLEDILEEIVGEFTTSMAPSLAEEITPQPDGSFMIEGSANIRDINKGLKWDLPTDGPRTLNGLILEHLEEIPET
EISLEIEQHNMEIVAVEENKINLVKVFPSTEDDK

Sequences:

>Translated_434_residues
MLPLKRGTRHLDDISTGALFTLLAILIVISGYFSSSETGMMSLNRYRLKHLSNQGHKGAKRVEKLLSRPDRLIGLILIGN
NLVNILASAIATILGMRLYGDLGVAISTGVLTLVILVFAEVTPKTLAAMYPERVSYSSSIVLNVLMKLLSPLVILVNLIT
NGFLKILGLGSGHDDKDKLSSEELRTVVHEAGGLIPRRHQDMLISILDLEHVTVNDIMVPRSEITGIDINDDWKSISRQL
THSPHGRIVLYRDQIDEVVGMLRLRESYRLMLEKNEFTKETLLRAADEIYFIPEATPLNSQLLKFQRNKERIGLVVDEYG
DIQGLITLEDILEEIVGEFTTSMAPSLAEEITPQPDGSFMIEGSANIRDINKGLKWDLPTDGPRTLNGLILEHLEEIPET
EISLEIEQHNMEIVAVEENKINLVKVFPSTEDDK
>Mature_434_residues
MLPLKRGTRHLDDISTGALFTLLAILIVISGYFSSSETGMMSLNRYRLKHLSNQGHKGAKRVEKLLSRPDRLIGLILIGN
NLVNILASAIATILGMRLYGDLGVAISTGVLTLVILVFAEVTPKTLAAMYPERVSYSSSIVLNVLMKLLSPLVILVNLIT
NGFLKILGLGSGHDDKDKLSSEELRTVVHEAGGLIPRRHQDMLISILDLEHVTVNDIMVPRSEITGIDINDDWKSISRQL
THSPHGRIVLYRDQIDEVVGMLRLRESYRLMLEKNEFTKETLLRAADEIYFIPEATPLNSQLLKFQRNKERIGLVVDEYG
DIQGLITLEDILEEIVGEFTTSMAPSLAEEITPQPDGSFMIEGSANIRDINKGLKWDLPTDGPRTLNGLILEHLEEIPET
EISLEIEQHNMEIVAVEENKINLVKVFPSTEDDK

Specific function: Unknown

COG id: COG4536

COG function: function code P; Putative Mg2+ and Co2+ transporter CorB

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=407, Percent_Identity=22.6044226044226, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI94681046, Length=325, Percent_Identity=24.9230769230769, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI40068053, Length=334, Percent_Identity=24.251497005988, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI40068055, Length=334, Percent_Identity=24.251497005988, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI145693175, Length=398, Percent_Identity=66.0804020100502, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI1790664, Length=416, Percent_Identity=24.0384615384615, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082033, Length=273, Percent_Identity=25.6410256410256, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786879, Length=248, Percent_Identity=24.5967741935484, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788119, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324512, Length=347, Percent_Identity=25.6484149855908, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48457; Mature: 48457

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLKRGTRHLDDISTGALFTLLAILIVISGYFSSSETGMMSLNRYRLKHLSNQGHKGAK
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHH
RVEKLLSRPDRLIGLILIGNNLVNILASAIATILGMRLYGDLGVAISTGVLTLVILVFAE
HHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VTPKTLAAMYPERVSYSSSIVLNVLMKLLSPLVILVNLITNGFLKILGLGSGHDDKDKLS
CCHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCC
SEELRTVVHEAGGLIPRRHQDMLISILDLEHVTVNDIMVPRSEITGIDINDDWKSISRQL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEECCCEECCHHHCCCCCCCCHHHHHHHHH
THSPHGRIVLYRDQIDEVVGMLRLRESYRLMLEKNEFTKETLLRAADEIYFIPEATPLNS
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEECCCCCCCHH
QLLKFQRNKERIGLVVDEYGDIQGLITLEDILEEIVGEFTTSMAPSLAEEITPQPDGSFM
HHHHHHCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCEE
IEGSANIRDINKGLKWDLPTDGPRTLNGLILEHLEEIPETEISLEIEQHNMEIVAVEENK
EECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCEEEEEEECCC
INLVKVFPSTEDDK
EEEEEEECCCCCCC
>Mature Secondary Structure
MLPLKRGTRHLDDISTGALFTLLAILIVISGYFSSSETGMMSLNRYRLKHLSNQGHKGAK
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHH
RVEKLLSRPDRLIGLILIGNNLVNILASAIATILGMRLYGDLGVAISTGVLTLVILVFAE
HHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VTPKTLAAMYPERVSYSSSIVLNVLMKLLSPLVILVNLITNGFLKILGLGSGHDDKDKLS
CCHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCC
SEELRTVVHEAGGLIPRRHQDMLISILDLEHVTVNDIMVPRSEITGIDINDDWKSISRQL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEECCCEECCHHHCCCCCCCCHHHHHHHHH
THSPHGRIVLYRDQIDEVVGMLRLRESYRLMLEKNEFTKETLLRAADEIYFIPEATPLNS
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEECCCCCCCHH
QLLKFQRNKERIGLVVDEYGDIQGLITLEDILEEIVGEFTTSMAPSLAEEITPQPDGSFM
HHHHHHCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCEE
IEGSANIRDINKGLKWDLPTDGPRTLNGLILEHLEEIPETEISLEIEQHNMEIVAVEENK
EECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCEEEEEEECCC
INLVKVFPSTEDDK
EEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 3045760 [H]